GALNT10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GALNT10
Entrez Gene ID	55568
Full Name	polypeptide N-acetylgalactosaminyltransferase 10
Synonyms	GALNACT10,PPGALNACT10,PPGANTASE10
General protein information	Preferred Names polypeptide N-acetylgalactosaminyltransferase 10 Names polypeptide N-acetylgalactosaminyltransferase 10 GalNAc transferase 10 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q33.2
Summary	This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010].
Disorder MIM:	608043

mRNA and Protein(s)

mRNA	Protein	Name
NM_198321.3	NP_938080.1	polypeptide N-acetylgalactosaminyltransferase 10
NM_198321.4	NP_938080.1	polypeptide N-acetylgalactosaminyltransferase 10

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Galnt10	NP_570098.1
Bos taurus (cattle)	GALNT10	XP_002689374.2
Homo sapiens (human)	GALNT10	NP_938080.1
Canis lupus familiaris (dog)	GALNT10	XP_546283.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012414	XP_320141.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010367	XP_311577.4
Caenorhabditis elegans (roundworm)	gly-10	NP_001041037.1
Xenopus tropicalis (tropical clawed frog)	galnt10	NP_001072444.1
Pan troglodytes (chimpanzee)	GALNT10	XP_518048.4
	GALNT10	XP_001111603.1
Mus musculus (house mouse)	Galnt10	NP_598950.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011984	XP_320549.4
Gallus gallus (chicken)	GALNT10	XP_004944993.1
Drosophila melanogaster (fruit fly)	pgant6	NP_001261342.1

Gene Ontology
Bibliography

Related articles in PubMed

Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma.
Liu L, Xiong Y, Xi W, Wang J, Qu Y, Lin Z, Chen X, Yao J, Xu J, Guo J
Oncotarget8(9)14995-15003(2017 Feb)

Elevated Expression of N-Acetylgalactosaminyltransferase 10 Predicts Poor Survival and Early Recurrence of Patients with Clear-Cell Renal Cell Carcinoma.
Wu Q, Yang L, Liu H, Zhang W, Le X, Xu J
Annals of surgical oncology22(7)2446-53(2015 Jul)

Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study.
Dong C, Della-Morte D, Beecham A, Wang L, Cabral D, Blanton SH, Sacco RL, Rundek T
Atherosclerosis240(2)462-7(2015 Jun)

Decreased expression of hepatocyte nuclear factor 4? (Hnf4?)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity.
Wu Q, Liu HO, Liu YD, Liu WS, Pan D, Zhang WJ, Yang L, Fu Q, Xu JJ, Gu JX
The Journal of biological chemistry290(2)1170-85(2015 Jan)

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, Albrecht E, Ang WQ, Corre T, Cousminer DL, Feenstra B, Franceschini N, Ganna A, Johnson AD, Kjellqvist S, Lunetta KL, McMahon G, Nolte IM, Paternoster L, Porcu E, Smith AV, Stolk L, Teumer A, T?ernikova N, Tikkanen E, Ulivi S, Wagner EK, Amin N, Bierut LJ, Byrne EM, Hottenga JJ, Koller DL, Mangino M, Pers TH, Yerges-Armstrong LM, Zhao JH, Andrulis IL, Anton-Culver H, Atsma F, Bandinelli S, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Bolla MK, Bonanni B, Brauch H, Brenner H, Buring JE, Chang-Claude J, Chanock S, Chen J, Chenevix-Trench G, Coll?e JM, Couch FJ, Couper D, Coveillo AD, Cox A, Czene K, D'adamo AP, Smith GD, De Vivo I, Demerath EW, Dennis J, Devilee P, Dieffenbach AK, Dunning AM, Eiriksdottir G, Eriksson JG, Fasching PA, Ferrucci L, Flesch-Janys D, Flyger H, Foroud T, Franke L, Garcia ME, Garc?a-Closas M, Geller F, de Geus EE, Giles GG, Gudbjartsson DF, Gudnason V, Gu?nel P, Guo S, Hall P, Hamann U, Haring R, Hartman CA, Heath AC, Hofman A, Hooning MJ, Hopper JL, Hu FB, Hunter DJ, Karasik D, Kiel DP, Knight JA, Kosma VM, Kutalik Z, Lai S, Lambrechts D, Lindblom A, M?gi R, Magnusson PK, Mannermaa A, Martin NG, Masson G, McArdle PF, McArdle WL, Melbye M, Michailidou K, Mihailov E, Milani L, Milne RL, Nevanlinna H, Neven P, Nohr EA, Oldehinkel AJ, Oostra BA, Palotie A, Peacock M, Pedersen NL, Peterlongo P, Peto J, Pharoah PD, Postma DS, Pouta A, Pylk?s K, Radice P, Ring S, Rivadeneira F, Robino A, Rose LM, Rudolph A, Salomaa V, Sanna S, Schlessinger D, Schmidt MK, Southey MC, Sovio U, Stampfer MJ, St?ckl D, Storniolo AM, Timpson NJ, Tyrer J, Visser JA, Vollenweider P, V?lzke H, Waeber G, Waldenberger M, Wallaschofski H, Wang Q, Willemsen G, Winqvist R, Wolffenbuttel BH, Wright MJ, , , , , , , Boomsma DI, Econs MJ, Khaw KT, Loos RJ, McCarthy MI, Montgomery GW, Rice JP, Streeten EA, Thorsteinsdottir U, van Duijn CM, Alizadeh BZ, Bergmann S, Boerwinkle E, Boyd HA, Crisponi L, Gasparini P, Gieger C, Harris TB, Ingelsson E, J?rvelin MR, Kraft P, Lawlor D, Metspalu A, Pennell CE, Ridker PM, Snieder H, S?rensen TI, Spector TD, Strachan DP, Uitterlinden AG, Wareham NJ, Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK
Nature514(7520)92-97(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified that GALNT10 was an independent prognostic factor for overall survival
Title: Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma.

Elevated Expression of N-Acetylgalactosaminyltransferase 10 is associated with early Recurrence of Patients with Clear-Cell Renal Cell Carcinoma.
Title: Elevated Expression of N-Acetylgalactosaminyltransferase 10 Predicts Poor Survival and Early Recurrence of Patients with Clear-Cell Renal Cell Carcinoma.

SNPs in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness.
Title: Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study.

our results reveal a novel Hnf4alpha/miR-122/GALNT10 regulatory pathway that facilitates EGF miR-122 activation and hepatoma growth in HBV-associated hepatocarcinogenesis.
Title: Decreased expression of hepatocyte nuclear factor 4? (Hnf4?)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following GALNT10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GALNT10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21928	NM_198321.4 Latest version!	Homo sapiens polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu21928	NM_198321.3	Homo sapiens polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GALNT10 ( NM_198321.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_938080.1 Homo sapiens polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10), mRNA.

Price & Availability↑

CloneID	OHu21928
Clone ID Related Accession (Same CDS sequence)	NM_198321.3 , NM_198321.4
Accession Version	NM_198321.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	polypeptide N-acetylgalactosaminyltransferase 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC050333.1, AJ505950.1, AC008625.5 and BQ549377.1. On Apr 2, 2010 this sequence version replaced NM_198321.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK127135.1, AB078145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCGGA AGGAGAAGCG GCTCCTGCAG GCGGTGGCGC TGGTGCTGGC GGCCCTGGTC 
CTCCTGCCCA ACGTGGGGCT TTGGGCGCTG TACCGCGAGC GGCAGCCCGA CGGCACCCCT 
GGGGGATCGG GGGCGGCGGT GGCGCCGGCG GCGGGACAGG GCTCACACAG TCGACAAAAG 
AAAACGTTTT TCTTGGGAGA TGGGCAGAAG CTGAAGGACT GGCATGACAA GGAGGCCATC 
CGGAGGGACG CTCAGCGCGT AGGAAATGGA GAACAAGGAA GACCTTACCC CATGACCGAT 
GCTGAGAGAG TGGATCAGGC ATACCGAGAA AATGGATTTA ACATCTACGT CAGTGATAAA 
ATCTCCTTGA ATCGCTCTCT CCCAGATATC CGGCACCCAA ACTGCAACAG CAAGCGCTAC 
CTGGAGACAC TTCCCAACAC AAGCATCATC ATCCCCTTCC ACAACGAGGG CTGGTCCTCC 
CTCCTCCGCA CCGTCCACAG TGTGCTCAAT CGCTCGCCTC CAGAGCTGGT CGCCGAGATT 
GTACTGGTCG ACGACTTCAG TGATCGAGAG CACCTGAAGA AGCCTCTTGA AGACTACATG 
GCCCTTTTCC CCAGTGTGAG GATTCTTCGA ACCAAGAAAC GGGAAGGGCT GATAAGGACC 
CGAATGCTGG GGGCCTCAGT GGCAACTGGG GATGTCATCA CATTCTTGGA TTCACACTGT 
GAAGCCAATG TCAACTGGCT TCCCCCCTTG CTTGACCGCA TTGCTCGGAA CCGCAAGACC 
ATTGTGTGCC CGATGATTGA TGTAATTGAC CATGACGACT TTCGGTACGA GACACAGGCA 
GGGGATGCCA TGCGGGGAGC CTTTGACTGG GAGATGTACT ACAAGCGGAT CCCGATCCCT 
CCAGAACTGC AGAAAGCTGA CCCCAGCGAC CCATTTGAGT CTCCCGTGAT GGCCGGTGGA 
CTGTTCGCCG TGGATCGGAA GTGGTTCTGG GAACTCGGCG GGTATGACCC AGGCTTGGAG 
ATCTGGGGAG GGGAGCAGTA TGAAATCTCC TTCAAGGTGT GGATGTGTGG GGGCCGCATG 
GAGGACATCC CCTGCTCCAG GGTGGGCCAT ATCTACAGGA AGTATGTGCC CTACAAGGTC 
CCGGCCGGAG TCAGCCTGGC CCGGAACCTT AAGCGGGTGG CCGAAGTGTG GATGGATGAG 
TACGCAGAGT ACATTTACCA GCGCCGGCCT GAATACCGCC ACCTCTCCGC TGGGGATGTC 
GCAGTCCAGA AAAAGCTCCG CAGCTCCCTT AACTGCAAGA GTTTCAAGTG GTTTATGACG 
AAGATAGCCT GGGACCTGCC CAAATTCTAC CCACCCGTGG AGCCCCCGGC TGCAGCTTGG 
GGGGAGATCC GAAATGTGGG CACAGGGCTG TGTGCAGACA CAAAGCACGG GGCCTTGGGC 
TCCCCACTAA GGCTAGAGGG CTGCGTCCGA GGCCGTGGGG AGGCTGCCTG GAACAACATG 
CAGGTATTCA CCTTCACCTG GAGAGAGGAC ATCCGGCCTG GAGACCCCCA GCACACCAAG 
AAGTTCTGCT TTGATGCCAT TTCCCACACC AGCCCTGTCA CGCTGTACGA CTGCCACAGC 
ATGAAGGGCA ACCAGCTGTG GAAATACCGC AAAGACAAGA CCCTGTACCA CCCTGTCAGT 
GGCAGCTGCA TGGACTGCAG TGAAAGTGAC CATAGGATCT TCATGAACAC CTGCAACCCA 
TCCTCTCTCA CCCAGCAGTG GCTGTTTGAA CACACCAACT CAACAGTCTT GGAAAAATTC 
AATAGGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_938080.1
CDS	133..1944
Translation	MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAVAPAAGQGSHSRQKKTFFLGDGQKLKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAISHTSPVTLYDCHSMKGNQLWKYRKDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFNRN

Target ORF information:

RefSeq Version	NM_198321.3
Organism	Homo sapiens(human)
Definition	Homo sapiens polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198321.3

ORF Insert Sequence:

ATGAGGCGGA AGGAGAAGCG GCTCCTGCAG GCGGTGGCGC TGGTGCTGGC GGCCCTGGTC 
CTCCTGCCCA ACGTGGGGCT TTGGGCGCTG TACCGCGAGC GGCAGCCCGA CGGCACCCCT 
GGGGGATCGG GGGCGGCGGT GGCGCCGGCG GCGGGACAGG GCTCACACAG TCGACAAAAG 
AAAACGTTTT TCTTGGGAGA TGGGCAGAAG CTGAAGGACT GGCATGACAA GGAGGCCATC 
CGGAGGGACG CTCAGCGCGT AGGAAATGGA GAACAAGGAA GACCTTACCC CATGACCGAT 
GCTGAGAGAG TGGATCAGGC ATACCGAGAA AATGGATTTA ACATCTACGT CAGTGATAAA 
ATCTCCTTGA ATCGCTCTCT CCCAGATATC CGGCACCCAA ACTGCAACAG CAAGCGCTAC 
CTGGAGACAC TTCCCAACAC AAGCATCATC ATCCCCTTCC ACAACGAGGG CTGGTCCTCC 
CTCCTCCGCA CCGTCCACAG TGTGCTCAAT CGCTCGCCTC CAGAGCTGGT CGCCGAGATT 
GTACTGGTCG ACGACTTCAG TGATCGAGAG CACCTGAAGA AGCCTCTTGA AGACTACATG 
GCCCTTTTCC CCAGTGTGAG GATTCTTCGA ACCAAGAAAC GGGAAGGGCT GATAAGGACC 
CGAATGCTGG GGGCCTCAGT GGCAACTGGG GATGTCATCA CATTCTTGGA TTCACACTGT 
GAAGCCAATG TCAACTGGCT TCCCCCCTTG CTTGACCGCA TTGCTCGGAA CCGCAAGACC 
ATTGTGTGCC CGATGATTGA TGTAATTGAC CATGACGACT TTCGGTACGA GACACAGGCA 
GGGGATGCCA TGCGGGGAGC CTTTGACTGG GAGATGTACT ACAAGCGGAT CCCGATCCCT 
CCAGAACTGC AGAAAGCTGA CCCCAGCGAC CCATTTGAGT CTCCCGTGAT GGCCGGTGGA 
CTGTTCGCCG TGGATCGGAA GTGGTTCTGG GAACTCGGCG GGTATGACCC AGGCTTGGAG 
ATCTGGGGAG GGGAGCAGTA TGAAATCTCC TTCAAGGTGT GGATGTGTGG GGGCCGCATG 
GAGGACATCC CCTGCTCCAG GGTGGGCCAT ATCTACAGGA AGTATGTGCC CTACAAGGTC 
CCGGCCGGAG TCAGCCTGGC CCGGAACCTT AAGCGGGTGG CCGAAGTGTG GATGGATGAG 
TACGCAGAGT ACATTTACCA GCGCCGGCCT GAATACCGCC ACCTCTCCGC TGGGGATGTC 
GCAGTCCAGA AAAAGCTCCG CAGCTCCCTT AACTGCAAGA GTTTCAAGTG GTTTATGACG 
AAGATAGCCT GGGACCTGCC CAAATTCTAC CCACCCGTGG AGCCCCCGGC TGCAGCTTGG 
GGGGAGATCC GAAATGTGGG CACAGGGCTG TGTGCAGACA CAAAGCACGG GGCCTTGGGC 
TCCCCACTAA GGCTAGAGGG CTGCGTCCGA GGCCGTGGGG AGGCTGCCTG GAACAACATG 
CAGGTATTCA CCTTCACCTG GAGAGAGGAC ATCCGGCCTG GAGACCCCCA GCACACCAAG 
AAGTTCTGCT TTGATGCCAT TTCCCACACC AGCCCTGTCA CGCTGTACGA CTGCCACAGC 
ATGAAGGGCA ACCAGCTGTG GAAATACCGC AAAGACAAGA CCCTGTACCA CCCTGTCAGT 
GGCAGCTGCA TGGACTGCAG TGAAAGTGAC CATAGGATCT TCATGAACAC CTGCAACCCA 
TCCTCTCTCA CCCAGCAGTG GCTGTTTGAA CACACCAACT CAACAGTCTT GGAAAAATTC 
AATAGGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALNT10 ( NM_198321.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_938080.1 Homo sapiens polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10), mRNA.

Price & Availability↑

CloneID	OHu21928
Clone ID Related Accession (Same CDS sequence)	NM_198321.3 , NM_198321.4
Accession Version	NM_198321.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	polypeptide N-acetylgalactosaminyltransferase 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010295.7, BC050333.1, AJ505950.1, AC008625.5 and BQ549377.1. On Nov 23, 2018 this sequence version replaced NM_198321.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK127135.1, AB078145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297107.11/ ENSP00000297107.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGCGGA AGGAGAAGCG GCTCCTGCAG GCGGTGGCGC TGGTGCTGGC GGCCCTGGTC 
CTCCTGCCCA ACGTGGGGCT TTGGGCGCTG TACCGCGAGC GGCAGCCCGA CGGCACCCCT 
GGGGGATCGG GGGCGGCGGT GGCGCCGGCG GCGGGACAGG GCTCACACAG TCGACAAAAG 
AAAACGTTTT TCTTGGGAGA TGGGCAGAAG CTGAAGGACT GGCATGACAA GGAGGCCATC 
CGGAGGGACG CTCAGCGCGT AGGAAATGGA GAACAAGGAA GACCTTACCC CATGACCGAT 
GCTGAGAGAG TGGATCAGGC ATACCGAGAA AATGGATTTA ACATCTACGT CAGTGATAAA 
ATCTCCTTGA ATCGCTCTCT CCCAGATATC CGGCACCCAA ACTGCAACAG CAAGCGCTAC 
CTGGAGACAC TTCCCAACAC AAGCATCATC ATCCCCTTCC ACAACGAGGG CTGGTCCTCC 
CTCCTCCGCA CCGTCCACAG TGTGCTCAAT CGCTCGCCTC CAGAGCTGGT CGCCGAGATT 
GTACTGGTCG ACGACTTCAG TGATCGAGAG CACCTGAAGA AGCCTCTTGA AGACTACATG 
GCCCTTTTCC CCAGTGTGAG GATTCTTCGA ACCAAGAAAC GGGAAGGGCT GATAAGGACC 
CGAATGCTGG GGGCCTCAGT GGCAACTGGG GATGTCATCA CATTCTTGGA TTCACACTGT 
GAAGCCAATG TCAACTGGCT TCCCCCCTTG CTTGACCGCA TTGCTCGGAA CCGCAAGACC 
ATTGTGTGCC CGATGATTGA TGTAATTGAC CATGACGACT TTCGGTACGA GACACAGGCA 
GGGGATGCCA TGCGGGGAGC CTTTGACTGG GAGATGTACT ACAAGCGGAT CCCGATCCCT 
CCAGAACTGC AGAAAGCTGA CCCCAGCGAC CCATTTGAGT CTCCCGTGAT GGCCGGTGGA 
CTGTTCGCCG TGGATCGGAA GTGGTTCTGG GAACTCGGCG GGTATGACCC AGGCTTGGAG 
ATCTGGGGAG GGGAGCAGTA TGAAATCTCC TTCAAGGTGT GGATGTGTGG GGGCCGCATG 
GAGGACATCC CCTGCTCCAG GGTGGGCCAT ATCTACAGGA AGTATGTGCC CTACAAGGTC 
CCGGCCGGAG TCAGCCTGGC CCGGAACCTT AAGCGGGTGG CCGAAGTGTG GATGGATGAG 
TACGCAGAGT ACATTTACCA GCGCCGGCCT GAATACCGCC ACCTCTCCGC TGGGGATGTC 
GCAGTCCAGA AAAAGCTCCG CAGCTCCCTT AACTGCAAGA GTTTCAAGTG GTTTATGACG 
AAGATAGCCT GGGACCTGCC CAAATTCTAC CCACCCGTGG AGCCCCCGGC TGCAGCTTGG 
GGGGAGATCC GAAATGTGGG CACAGGGCTG TGTGCAGACA CAAAGCACGG GGCCTTGGGC 
TCCCCACTAA GGCTAGAGGG CTGCGTCCGA GGCCGTGGGG AGGCTGCCTG GAACAACATG 
CAGGTATTCA CCTTCACCTG GAGAGAGGAC ATCCGGCCTG GAGACCCCCA GCACACCAAG 
AAGTTCTGCT TTGATGCCAT TTCCCACACC AGCCCTGTCA CGCTGTACGA CTGCCACAGC 
ATGAAGGGCA ACCAGCTGTG GAAATACCGC AAAGACAAGA CCCTGTACCA CCCTGTCAGT 
GGCAGCTGCA TGGACTGCAG TGAAAGTGAC CATAGGATCT TCATGAACAC CTGCAACCCA 
TCCTCTCTCA CCCAGCAGTG GCTGTTTGAA CACACCAACT CAACAGTCTT GGAAAAATTC 
AATAGGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_938080.1
CDS	135..1946
Translation	MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAVAPAAGQGSHSRQKKTFFLGDGQKLKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAISHTSPVTLYDCHSMKGNQLWKYRKDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFNRN

Target ORF information:

RefSeq Version	NM_198321.4
Organism	Homo sapiens(human)
Definition	Homo sapiens polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198321.4

ORF Insert Sequence:

ATGAGGCGGA AGGAGAAGCG GCTCCTGCAG GCGGTGGCGC TGGTGCTGGC GGCCCTGGTC 
CTCCTGCCCA ACGTGGGGCT TTGGGCGCTG TACCGCGAGC GGCAGCCCGA CGGCACCCCT 
GGGGGATCGG GGGCGGCGGT GGCGCCGGCG GCGGGACAGG GCTCACACAG TCGACAAAAG 
AAAACGTTTT TCTTGGGAGA TGGGCAGAAG CTGAAGGACT GGCATGACAA GGAGGCCATC 
CGGAGGGACG CTCAGCGCGT AGGAAATGGA GAACAAGGAA GACCTTACCC CATGACCGAT 
GCTGAGAGAG TGGATCAGGC ATACCGAGAA AATGGATTTA ACATCTACGT CAGTGATAAA 
ATCTCCTTGA ATCGCTCTCT CCCAGATATC CGGCACCCAA ACTGCAACAG CAAGCGCTAC 
CTGGAGACAC TTCCCAACAC AAGCATCATC ATCCCCTTCC ACAACGAGGG CTGGTCCTCC 
CTCCTCCGCA CCGTCCACAG TGTGCTCAAT CGCTCGCCTC CAGAGCTGGT CGCCGAGATT 
GTACTGGTCG ACGACTTCAG TGATCGAGAG CACCTGAAGA AGCCTCTTGA AGACTACATG 
GCCCTTTTCC CCAGTGTGAG GATTCTTCGA ACCAAGAAAC GGGAAGGGCT GATAAGGACC 
CGAATGCTGG GGGCCTCAGT GGCAACTGGG GATGTCATCA CATTCTTGGA TTCACACTGT 
GAAGCCAATG TCAACTGGCT TCCCCCCTTG CTTGACCGCA TTGCTCGGAA CCGCAAGACC 
ATTGTGTGCC CGATGATTGA TGTAATTGAC CATGACGACT TTCGGTACGA GACACAGGCA 
GGGGATGCCA TGCGGGGAGC CTTTGACTGG GAGATGTACT ACAAGCGGAT CCCGATCCCT 
CCAGAACTGC AGAAAGCTGA CCCCAGCGAC CCATTTGAGT CTCCCGTGAT GGCCGGTGGA 
CTGTTCGCCG TGGATCGGAA GTGGTTCTGG GAACTCGGCG GGTATGACCC AGGCTTGGAG 
ATCTGGGGAG GGGAGCAGTA TGAAATCTCC TTCAAGGTGT GGATGTGTGG GGGCCGCATG 
GAGGACATCC CCTGCTCCAG GGTGGGCCAT ATCTACAGGA AGTATGTGCC CTACAAGGTC 
CCGGCCGGAG TCAGCCTGGC CCGGAACCTT AAGCGGGTGG CCGAAGTGTG GATGGATGAG 
TACGCAGAGT ACATTTACCA GCGCCGGCCT GAATACCGCC ACCTCTCCGC TGGGGATGTC 
GCAGTCCAGA AAAAGCTCCG CAGCTCCCTT AACTGCAAGA GTTTCAAGTG GTTTATGACG 
AAGATAGCCT GGGACCTGCC CAAATTCTAC CCACCCGTGG AGCCCCCGGC TGCAGCTTGG 
GGGGAGATCC GAAATGTGGG CACAGGGCTG TGTGCAGACA CAAAGCACGG GGCCTTGGGC 
TCCCCACTAA GGCTAGAGGG CTGCGTCCGA GGCCGTGGGG AGGCTGCCTG GAACAACATG 
CAGGTATTCA CCTTCACCTG GAGAGAGGAC ATCCGGCCTG GAGACCCCCA GCACACCAAG 
AAGTTCTGCT TTGATGCCAT TTCCCACACC AGCCCTGTCA CGCTGTACGA CTGCCACAGC 
ATGAAGGGCA ACCAGCTGTG GAAATACCGC AAAGACAAGA CCCTGTACCA CCCTGTCAGT 
GGCAGCTGCA TGGACTGCAG TGAAAGTGAC CATAGGATCT TCATGAACAC CTGCAACCCA 
TCCTCTCTCA CCCAGCAGTG GCTGTTTGAA CACACCAACT CAACAGTCTT GGAAAAATTC 
AATAGGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma.
Oncotarget8(9)14995-15003(2017 Feb)
Liu L,Xiong Y,Xi W,Wang J,Qu Y,Lin Z,Chen X,Yao J,Xu J,Guo J

Elevated Expression of N-Acetylgalactosaminyltransferase 10 Predicts Poor Survival and Early Recurrence of Patients with Clear-Cell Renal Cell Carcinoma.
Annals of surgical oncology22(7)2446-53(2015 Jul)
Wu Q,Yang L,Liu H,Zhang W,Le X,Xu J

Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study.
Atherosclerosis240(2)462-7(2015 Jun)
Dong C,Della-Morte D,Beecham A,Wang L,Cabral D,Blanton SH,Sacco RL,Rundek T

Decreased expression of hepatocyte nuclear factor 4? (Hnf4?)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity.
The Journal of biological chemistry290(2)1170-85(2015 Jan)
Wu Q,Liu HO,Liu YD,Liu WS,Pan D,Zhang WJ,Yang L,Fu Q,Xu JJ,Gu JX

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Nature514(7520)92-97(2014 Oct)
Perry JR,Day F,Elks CE,Sulem P,Thompson DJ,Ferreira T,He C,Chasman DI,Esko T,Thorleifsson G,Albrecht E,Ang WQ,Corre T,Cousminer DL,Feenstra B,Franceschini N,Ganna A,Johnson AD,Kjellqvist S,Lunetta KL,McMahon G,Nolte IM,Paternoster L,Porcu E,Smith AV,Stolk L,Teumer A,T?ernikova N,Tikkanen E,Ulivi S,Wagner EK,Amin N,Bierut LJ,Byrne EM,Hottenga JJ,Koller DL,Mangino M,Pers TH,Yerges-Armstrong LM,Zhao JH,Andrulis IL,Anton-Culver H,Atsma F,Bandinelli S,Beckmann MW,Benitez J,Blomqvist C,Bojesen SE,Bolla MK,Bonanni B,Brauch H,Brenner H,Buring JE,Chang-Claude J,Chanock S,Chen J,Chenevix-Trench G,Coll?e JM,Couch FJ,Couper D,Coveillo AD,Cox A,Czene K,D'adamo AP,Smith GD,De Vivo I,Demerath EW,Dennis J,Devilee P,Dieffenbach AK,Dunning AM,Eiriksdottir G,Eriksson JG,Fasching PA,Ferrucci L,Flesch-Janys D,Flyger H,Foroud T,Franke L,Garcia ME,Garc?a-Closas M,Geller F,de Geus EE,Giles GG,Gudbjartsson DF,Gudnason V,Gu?nel P,Guo S,Hall P,Hamann U,Haring R,Hartman CA,Heath AC,Hofman A,Hooning MJ,Hopper JL,Hu FB,Hunter DJ,Karasik D,Kiel DP,Knight JA,Kosma VM,Kutalik Z,Lai S,Lambrechts D,Lindblom A,M?gi R,Magnusson PK,Mannermaa A,Martin NG,Masson G,McArdle PF,McArdle WL,Melbye M,Michailidou K,Mihailov E,Milani L,Milne RL,Nevanlinna H,Neven P,Nohr EA,Oldehinkel AJ,Oostra BA,Palotie A,Peacock M,Pedersen NL,Peterlongo P,Peto J,Pharoah PD,Postma DS,Pouta A,Pylk?s K,Radice P,Ring S,Rivadeneira F,Robino A,Rose LM,Rudolph A,Salomaa V,Sanna S,Schlessinger D,Schmidt MK,Southey MC,Sovio U,Stampfer MJ,St?ckl D,Storniolo AM,Timpson NJ,Tyrer J,Visser JA,Vollenweider P,V?lzke H,Waeber G,Waldenberger M,Wallaschofski H,Wang Q,Willemsen G,Winqvist R,Wolffenbuttel BH,Wright MJ,,,,,,,Boomsma DI,Econs MJ,Khaw KT,Loos RJ,McCarthy MI,Montgomery GW,Rice JP,Streeten EA,Thorsteinsdottir U,van Duijn CM,Alizadeh BZ,Bergmann S,Boerwinkle E,Boyd HA,Crisponi L,Gasparini P,Gieger C,Harris TB,Ingelsson E,J?rvelin MR,Kraft P,Lawlor D,Metspalu A,Pennell CE,Ridker PM,Snieder H,S?rensen TI,Spector TD,Strachan DP,Uitterlinden AG,Wareham NJ,Widen E,Zygmunt M,Murray A,Easton DF,Stefansson K,Murabito JM,Ong KK

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GALNT10 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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