PRH2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRH2
Entrez Gene ID	5555
Full Name	proline rich protein HaeIII subfamily 2
Synonyms	PRP-1/PRP-2,Pr,pr1/Pr2
General protein information	Preferred Names proline rich protein HaeIII subfamily 2 Names salivary acidic proline-rich phosphoprotein 1/2 acidic salivary proline-rich protein, HaeIII type, 2 parotid acidic protein parotid double-band protein parotid proline-rich protein 1/2 protein C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015].
Disorder MIM:	168790

mRNA and Protein(s)

mRNA	Protein	Name
NM_001110213.1	NP_001103683.1	salivary acidic proline-rich phosphoprotein 1/2 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	PRH2	NP_005033.1
Pan troglodytes (chimpanzee)	PRH2	XP_003313543.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2.
Str?mberg N, Esberg A, Sheng N, M?rell L, L?fgren-Burstr?m A, Danielsson K, K?llest?l C
EBioMedicine2638-46(2017 Dec)

The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species.
Manconi B, Castagnola M, Cabras T, Olianas A, Vitali A, Desiderio C, Sanna MT, Messana I
Journal of proteomics13447-56(2016 Feb)

A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE
Cell161(7)1619-32(2015 Jun)

Finding new posttranslational modifications in salivary proline-rich proteins.
Vitorino R, Alves R, Barros A, Caseiro A, Ferreira R, Lobo MC, Bastos A, Duarte J, Carvalho D, Santos LL, Amado FL
Proteomics10(20)3732-42(2010 Oct)

Two-hybrid analysis of human salivary mucin MUC7 interactions.
Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD
Biochimica et biophysica acta1746(1)65-72(2005 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PRH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24275	NM_001110213.1 Latest version!	Homo sapiens proline rich protein HaeIII subfamily 2 (PRH2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRH2 ( NM_001110213.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001103683.1 Homo sapiens proline rich protein HaeIII subfamily 2 (PRH2), mRNA.

Price & Availability↑

CloneID	OHu24275
Clone ID Related Accession (Same CDS sequence)	NM_001110213.1
Accession Version	NM_001110213.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	salivary acidic proline-rich phosphoprotein 1/2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC095488.1, BX648656.1 and AC006518.17. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX485887.1, BX648901.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396400.4/ ENSP00000379682.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTTCTGA TTCTGCTGTC AGTGGCCCTG CTGGCCTTCA GCTCAGCTCA GGACTTAGAT 
GAAGATGTCA GCCAAGAAGA CGTTCCCTTG GTAATATCAG ATGGAGGAGA CTCTGAGCAG 
TTCATAGATG AGGAGCGTCA GGGACCACCT TTGGGAGGAC AGCAATCTCA ACCCTCTGCT 
GGTGATGGGA ACCAGAATGA TGGCCCTCAG CAGGGACCAC CCCAACAAGG AGGCCAGCAG 
CAACAAGGTC CACCACCTCC TCAGGGAAAG CCACAAGGAC CACCCCAACA GGGAGGCCAT 
CCCCCTCCTC CTCAAGGAAG GCCACAAGGA CCACCCCAAC AGGGAGGCCA TCCCCGTCCT 
CCTCGAGGAA GGCCACAAGG ACCACCCCAA CAGGGAGGCC ATCAGCAAGG TCCTCCCCCA 
CCTCCTCCTG GAAAGCCCCA GGGACCACCT CCCCAAGGGG GCCGCCCACA AGGACCTCCA 
CAGGGGCAGT CTCCTCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103683.1
CDS	39..539
Translation	MLLILLSVALLAFSSAQDLDEDVSQEDVPLVISDGGDSEQFIDEERQGPPLGGQQSQPSAGDGNQNDGPQQGPPQQGGQQQQGPPPPQGKPQGPPQQGGHPPPPQGRPQGPPQQGGHPRPPRGRPQGPPQQGGHQQGPPPPPPGKPQGPPPQGGRPQGPPQGQSPQ

Target ORF information:

RefSeq Version	NM_001110213.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich protein HaeIII subfamily 2 (PRH2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110213.1

ORF Insert Sequence:

ATGCTTCTGA TTCTGCTGTC AGTGGCCCTG CTGGCCTTCA GCTCAGCTCA GGACTTAGAT 
GAAGATGTCA GCCAAGAAGA CGTTCCCTTG GTAATATCAG ATGGAGGAGA CTCTGAGCAG 
TTCATAGATG AGGAGCGTCA GGGACCACCT TTGGGAGGAC AGCAATCTCA ACCCTCTGCT 
GGTGATGGGA ACCAGAATGA TGGCCCTCAG CAGGGACCAC CCCAACAAGG AGGCCAGCAG 
CAACAAGGTC CACCACCTCC TCAGGGAAAG CCACAAGGAC CACCCCAACA GGGAGGCCAT 
CCCCCTCCTC CTCAAGGAAG GCCACAAGGA CCACCCCAAC AGGGAGGCCA TCCCCGTCCT 
CCTCGAGGAA GGCCACAAGG ACCACCCCAA CAGGGAGGCC ATCAGCAAGG TCCTCCCCCA 
CCTCCTCCTG GAAAGCCCCA GGGACCACCT CCCCAAGGGG GCCGCCCACA AGGACCTCCA 
CAGGGGCAGT CTCCTCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2.
EBioMedicine2638-46(2017 Dec)
Str?mberg N,Esberg A,Sheng N,M?rell L,L?fgren-Burstr?m A,Danielsson K,K?llest?l C

The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species.
Journal of proteomics13447-56(2016 Feb)
Manconi B,Castagnola M,Cabras T,Olianas A,Vitali A,Desiderio C,Sanna MT,Messana I

A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
Cell161(7)1619-32(2015 Jun)
Tagliabracci VS,Wiley SE,Guo X,Kinch LN,Durrant E,Wen J,Xiao J,Cui J,Nguyen KB,Engel JL,Coon JJ,Grishin N,Pinna LA,Pagliarini DJ,Dixon JE

Finding new posttranslational modifications in salivary proline-rich proteins.
Proteomics10(20)3732-42(2010 Oct)
Vitorino R,Alves R,Barros A,Caseiro A,Ferreira R,Lobo MC,Bastos A,Duarte J,Carvalho D,Santos LL,Amado FL

Two-hybrid analysis of human salivary mucin MUC7 interactions.
Biochimica et biophysica acta1746(1)65-72(2005 Oct)
Bruno LS,Li X,Wang L,Soares RV,Siqueira CC,Oppenheim FG,Troxler RF,Offner GD

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PRH2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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