PFDN4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PFDN4
Entrez Gene ID	5203
Full Name	prefoldin subunit 4
Synonyms	C1,PFD4
General protein information	Preferred Names prefoldin subunit 4 Names prefoldin subunit 4 prefoldin 4 protein C-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.2
Summary	This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008].
Disorder MIM:	604898

mRNA and Protein(s)

mRNA	Protein	Name
XM_017027879.1	XP_016883368.1	prefoldin subunit 4 isoform X1
NM_002623.4	NP_002614.2	prefoldin subunit 4
NM_002623.3	NP_002614.2	prefoldin subunit 4

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pfdn4	NP_001103622.1
Xenopus tropicalis (tropical clawed frog)	pfdn4	NP_001163965.1
Homo sapiens (human)	PFDN4	NP_002614.2
Bos taurus (cattle)	PFDN4	NP_001033629.1
Danio rerio (zebrafish)	pfdn4	XP_005162507.1
Pan troglodytes (chimpanzee)	PFDN4	XP_003317039.1
	PFDN4	XP_001091947.1
Canis lupus familiaris (dog)	PFDN4	XP_005635247.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006946	XP_308810.3
Rattus norvegicus (Norway rat)	Pfdn4	XP_003749684.1
Gallus gallus (chicken)	PFDN4	NP_001264944.1
Drosophila melanogaster (fruit fly)	CG10635	NP_647961.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M
Nature genetics44(11)1222-6(2012 Nov)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

Abnormal expression of PFDN4 in colorectal cancer: a novel marker for prognosis.
Miyoshi N, Ishii H, Mimori K, Nishida N, Tokuoka M, Akita H, Sekimoto M, Doki Y, Mori M
Annals of surgical oncology17(11)3030-6(2010 Nov)

S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.
Djouder N, Metzler SC, Schmidt A, Wirbelauer C, Gstaiger M, Aebersold R, Hess D, Krek W
Molecular cell28(1)28-40(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PFDN4 inhibition resulted in an increase in cell growth and invasiveness in colorectal cancer cell lines.
Title: Abnormal expression of PFDN4 in colorectal cancer: a novel marker for prognosis.

The following PFDN4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PFDN4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12424	NM_002623.4 Latest version!	Homo sapiens prefoldin subunit 4 (PFDN4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu93034	XM_017027879.1 Latest version!	Homo sapiens prefoldin subunit 4 (PFDN4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu12424	NM_002623.3	Homo sapiens prefoldin subunit 4 (PFDN4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PFDN4 ( NM_002623.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002614.2 Homo sapiens prefoldin subunit 4 (PFDN4), mRNA.

Price & Availability↑

CloneID	OHu12424
Clone ID Related Accession (Same CDS sequence)	NM_002623.4 , NM_002623.3
Accession Version	NM_002623.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	prefoldin subunit 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC010953.1, U41816.1 and AL133335.29. On Nov 22, 2018 this sequence version replaced NM_002623.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.312312.1, SRR1660805.375126.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371419.7/ ENSP00000360473.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCCA CCATGAAGAA GGCGGCTGCA GAAGATGTCA ATGTTACTTT CGAAGATCAA 
CAAAAGATAA ACAAATTTGC ACGGAATACA AGTAGAATCA CAGAGCTGAA GGAAGAAATA 
GAAGTAAAAA AGAAACAACT CCAAAACCTA GAAGATGCTT GTGATGACAT CATGCTTGCA 
GATGATGATT GCTTAATGAT ACCTTATCAA ATTGGTGATG TCTTCATTAG CCATTCTCAA 
GAAGAAACGC AAGAAATGTT AGAAGAAGCA AAGAAAAATT TGCAAGAAGA AATTGACGCC 
TTAGAATCCA GAGTGGAATC AATTCAGCGA GTGTTAGCAG ATTTGAAAGT TCAGTTGTAT 
GCAAAATTCG GGAGCAACAT AAACCTTGAA GCTGATGAAA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002614.2
CDS	15..419
Translation	MAATMKKAAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQRVLADLKVQLYAKFGSNINLEADES

Target ORF information:

RefSeq Version	NM_002623.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prefoldin subunit 4 (PFDN4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002623.4

ORF Insert Sequence:

ATGGCGGCCA CCATGAAGAA GGCGGCTGCA GAAGATGTCA ATGTTACTTT CGAAGATCAA 
CAAAAGATAA ACAAATTTGC ACGGAATACA AGTAGAATCA CAGAGCTGAA GGAAGAAATA 
GAAGTAAAAA AGAAACAACT CCAAAACCTA GAAGATGCTT GTGATGACAT CATGCTTGCA 
GATGATGATT GCTTAATGAT ACCTTATCAA ATTGGTGATG TCTTCATTAG CCATTCTCAA 
GAAGAAACGC AAGAAATGTT AGAAGAAGCA AAGAAAAATT TGCAAGAAGA AATTGACGCC 
TTAGAATCCA GAGTGGAATC AATTCAGCGA GTGTTAGCAG ATTTGAAAGT TCAGTTGTAT 
GCAAAATTCG GGAGCAACAT AAACCTTGAA GCTGATGAAA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PFDN4 ( NM_002623.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002614.2 Homo sapiens prefoldin subunit 4 (PFDN4), mRNA.

Price & Availability↑

CloneID	OHu12424
Clone ID Related Accession (Same CDS sequence)	NM_002623.4 , NM_002623.3
Accession Version	NM_002623.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	prefoldin subunit 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN482830.1, BC010953.1, U41816.1 and AL133335.29. On Oct 28, 2004 this sequence version replaced NM_002623.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U41816.1, SRR1163658.312312.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA CCATGAAGAA GGCGGCTGCA GAAGATGTCA ATGTTACTTT CGAAGATCAA 
CAAAAGATAA ACAAATTTGC ACGGAATACA AGTAGAATCA CAGAGCTGAA GGAAGAAATA 
GAAGTAAAAA AGAAACAACT CCAAAACCTA GAAGATGCTT GTGATGACAT CATGCTTGCA 
GATGATGATT GCTTAATGAT ACCTTATCAA ATTGGTGATG TCTTCATTAG CCATTCTCAA 
GAAGAAACGC AAGAAATGTT AGAAGAAGCA AAGAAAAATT TGCAAGAAGA AATTGACGCC 
TTAGAATCCA GAGTGGAATC AATTCAGCGA GTGTTAGCAG ATTTGAAAGT TCAGTTGTAT 
GCAAAATTCG GGAGCAACAT AAACCTTGAA GCTGATGAAA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002614.2
CDS	139..543
Translation	MAATMKKAAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQRVLADLKVQLYAKFGSNINLEADES

Target ORF information:

RefSeq Version	NM_002623.3
Organism	Homo sapiens(human)
Definition	Homo sapiens prefoldin subunit 4 (PFDN4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002623.3

ORF Insert Sequence:

ATGGCGGCCA CCATGAAGAA GGCGGCTGCA GAAGATGTCA ATGTTACTTT CGAAGATCAA 
CAAAAGATAA ACAAATTTGC ACGGAATACA AGTAGAATCA CAGAGCTGAA GGAAGAAATA 
GAAGTAAAAA AGAAACAACT CCAAAACCTA GAAGATGCTT GTGATGACAT CATGCTTGCA 
GATGATGATT GCTTAATGAT ACCTTATCAA ATTGGTGATG TCTTCATTAG CCATTCTCAA 
GAAGAAACGC AAGAAATGTT AGAAGAAGCA AAGAAAAATT TGCAAGAAGA AATTGACGCC 
TTAGAATCCA GAGTGGAATC AATTCAGCGA GTGTTAGCAG ATTTGAAAGT TCAGTTGTAT 
GCAAAATTCG GGAGCAACAT AAACCTTGAA GCTGATGAAA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PFDN4 ( XM_017027879.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883368.1 Homo sapiens prefoldin subunit 4 (PFDN4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu93034
Clone ID Related Accession (Same CDS sequence)	XM_017027879.1
Accession Version	XM_017027879.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prefoldin subunit 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCCGGG CCCAGCAGCC GGCCGTTTAT CTGTTATCCT CCCCGCAACT CAGCAAGTGC 
AATGGGTTCC TCTCCACTTT GCAGGTAGAG AAACTTAGAC ACAGAGCAGT TAGAGGCCCT 
AAAGTGACTC AGCTAGTAAG AAGCAGAGCT GGAGTTCAAA CTCAGGCTGC AGAAGATGTC 
AATGTTACTT TCGAAGATCA ACAAAAGATA AACAAATTTG CACGGAATAC AAGTAGAATC 
ACAGAGCTGA AGGAAGAAAT AGAAGTAAAA AAGAAACAAC TCCAAAACCT AGAAGATGCT 
TGTGATGACA TCATGCTTGC AGATGATGAT TGCTTAATGA TACCTTATCA AATTGGTGAT 
GTCTTCATTA GCCATTCTCA AGAAGAAACG CAAGAAATGT TAGAAGAAGC AAAGAAAAAT 
TTGCAAGAAG AAATTGACGC CTTAGAATCC AGAGTGGAAT CAATTCAGCG AGTGTTAGCA 
GATTTGAAAG TTCAGTTGTA TGCAAAATTC GGGAGCAACA TAAACCTTGA AGCTGATGAA 
AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883368.1
CDS	282..827
Translation	MCRAQQPAVYLLSSPQLSKCNGFLSTLQVEKLRHRAVRGPKVTQLVRSRAGVQTQAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQRVLADLKVQLYAKFGSNINLEADES

Target ORF information:

RefSeq Version	XM_017027879.1
Organism	Homo sapiens(human)
Definition	Homo sapiens prefoldin subunit 4 (PFDN4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027879.1

ORF Insert Sequence:

ATGTGCCGGG CCCAGCAGCC GGCCGTTTAT CTGTTATCCT CCCCGCAACT CAGCAAGTGC 
AATGGGTTCC TCTCCACTTT GCAGGTAGAG AAACTTAGAC ACAGAGCAGT TAGAGGCCCT 
AAAGTGACTC AGCTAGTAAG AAGCAGAGCT GGAGTTCAAA CTCAGGCTGC AGAAGATGTC 
AATGTTACTT TCGAAGATCA ACAAAAGATA AACAAATTTG CACGGAATAC AAGTAGAATC 
ACAGAGCTGA AGGAAGAAAT AGAAGTAAAA AAGAAACAAC TCCAAAACCT AGAAGATGCT 
TGTGATGACA TCATGCTTGC AGATGATGAT TGCTTAATGA TACCTTATCA AATTGGTGAT 
GTCTTCATTA GCCATTCTCA AGAAGAAACG CAAGAAATGT TAGAAGAAGC AAAGAAAAAT 
TTGCAAGAAG AAATTGACGC CTTAGAATCC AGAGTGGAAT CAATTCAGCG AGTGTTAGCA 
GATTTGAAAG TTCAGTTGTA TGCAAAATTC GGGAGCAACA TAAACCTTGA AGCTGATGAA 
AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Nature genetics44(11)1222-6(2012 Nov)
Hirota T,Takahashi A,Kubo M,Tsunoda T,Tomita K,Sakashita M,Yamada T,Fujieda S,Tanaka S,Doi S,Miyatake A,Enomoto T,Nishiyama C,Nakano N,Maeda K,Okumura K,Ogawa H,Ikeda S,Noguchi E,Sakamoto T,Hizawa N,Ebe K,Saeki H,Sasaki T,Ebihara T,Amagai M,Takeuchi S,Furue M,Nakamura Y,Tamari M

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

Abnormal expression of PFDN4 in colorectal cancer: a novel marker for prognosis.
Annals of surgical oncology17(11)3030-6(2010 Nov)
Miyoshi N,Ishii H,Mimori K,Nishida N,Tokuoka M,Akita H,Sekimoto M,Doki Y,Mori M

S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.
Molecular cell28(1)28-40(2007 Oct)
Djouder N,Metzler SC,Schmidt A,Wirbelauer C,Gstaiger M,Aebersold R,Hess D,Krek W

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

PFDN4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報