DNAJB11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNAJB11
Entrez Gene ID	51726
Full Name	DnaJ heat shock protein family (Hsp40) member B11
Synonyms	ABBP-2,ABBP2,DJ9,Dj-9,EDJ,ERdj3,ERj3,ERj3p,PRO1080,UNQ537
General protein information	Preferred Names DnaJ heat shock protein family (Hsp40) member B11 Names dnaJ homolog subfamily B member 11 APOBEC1-binding protein 2 DnaJ (Hsp40) homolog, subfamily B, member 11 DnaJ protein 9 ER-associated DNAJ protein 3 ER-associated Hsp40 co-chaperone ER-resident protein ERdj3 PWP1-interacting protein 4 endoplasmic reticulum DNA J domain-containing protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q27.3
Summary	This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014].
Disorder MIM:	611341

mRNA and Protein(s)

mRNA	Protein	Name
NM_016306.5	NP_057390.1	dnaJ homolog subfamily B member 11 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DNAJB11	XP_005639859.1
Danio rerio (zebrafish)	dnajb11	NP_942116.1
Arabidopsis thaliana (thale cress)	ATERDJ3B	NP_191819.1
Xenopus tropicalis (tropical clawed frog)	dnajb11	NP_989180.1
Bos taurus (cattle)	DNAJB11	NP_001029440.1
Mus musculus (house mouse)	Dnajb11	NP_001177733.1
Gallus gallus (chicken)	DNAJB11	XP_422682.1
Drosophila melanogaster (fruit fly)	CG4164	NP_608525.1
Caenorhabditis elegans (roundworm)	dnj-20	NP_741036.2
Pan troglodytes (chimpanzee)	DNAJB11	XP_001153126.1
Oryza sativa (rice)	Os05g0156500	NP_001054697.1
Rattus norvegicus (Norway rat)	Dnajb11	NP_001015021.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008327	XP_317136.4
Homo sapiens (human)	DNAJB11	NP_057390.1

Gene Ontology
Bibliography

Related articles in PubMed

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.
Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL
The EMBO journal36(15)2296-2309(2017 08)

[Expression and clinical significance of DNAJB11 in epithelial ovarian cancer].
Guorong Y, Yunfeng FU, Yanli LI, Caiyun Z, Weiguo LV
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences46(2)173-178(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ZAAT ER clearance resulted from enhancing ERdj3-mediated ZAAT degradation by silencing ERdj3 while simultaneously enhancing autophagy. In this context, ERdj3 suppression may eliminate the toxic gain of function associated with polymerization of ZAAT
Title: Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation.

These results reveal ERdj3 tetramerization as an important structural framework for ERdj3 functions involved in coordinating endplasmic reticulum and extracellular proteostasis in the presence and absence of endplasmic reticulum stress.
Title: The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

BiP facilitates Sec61 channel closure (i.e. limits ER Ca(2+) leakage) via the Sec61 channel with the help of ERj3 and ERj6
Title: Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum.

regulated co-secretion of ERdj3 with misfolded clients directly links ER and extracellular proteostasis during conditions of ER stress.
Title: Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

ERdj3 mutant bound to unfolded endoplasmic reticulum proteins under steady state conditions in much greater amounts than wild-type.
Title: Dissection of structural and functional requirements that underlie the interaction of ERdj3 protein with substrates in the endoplasmic reticulum.

The following DNAJB11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNAJB11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu23910	NM_016306.5 Latest version!	Homo sapiens DnaJ heat shock protein family (Hsp40) member B11 (DNAJB11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNAJB11 ( NM_016306.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057390.1 Homo sapiens DnaJ heat shock protein family (Hsp40) member B11 (DNAJB11), mRNA.

Price & Availability↑

CloneID	OHu23910
Clone ID Related Accession (Same CDS sequence)	NM_016306.5
Accession Version	NM_016306.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	dnaJ homolog subfamily B member 11 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA058195.1, BM754506.1, AY359043.1 and AI446699.1. This sequence is a reference standard in the RefSeqGene project. On Mar 6, 2014 this sequence version replaced NM_016306.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.516430.1, SRR5189664.111512.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCGC AGAACCTGAG CACCTTTTGC CTGTTGCTGC TATACCTCAT CGGGGCGGTG 
ATTGCCGGAC GAGATTTCTA TAAGATCTTG GGGGTGCCTC GAAGTGCCTC TATAAAGGAT 
ATTAAAAAGG CCTATAGGAA ACTAGCCCTG CAGCTTCATC CCGACCGGAA CCCTGATGAT 
CCACAAGCCC AGGAGAAATT CCAGGATCTG GGTGCTGCTT ATGAGGTTCT GTCAGATAGT 
GAGAAACGGA AACAGTACGA TACTTATGGT GAAGAAGGAT TAAAAGATGG TCATCAGAGC 
TCCCATGGAG ACATTTTTTC ACACTTCTTT GGGGATTTTG GTTTCATGTT TGGAGGAACC 
CCTCGTCAGC AAGACAGAAA TATTCCAAGA GGAAGTGATA TTATTGTAGA TCTAGAAGTC 
ACTTTGGAAG AAGTATATGC AGGAAATTTT GTGGAAGTAG TTAGAAACAA ACCTGTGGCA 
AGGCAGGCTC CTGGCAAACG GAAGTGCAAT TGTCGGCAAG AGATGCGGAC CACCCAGCTG 
GGCCCTGGGC GCTTCCAAAT GACCCAGGAG GTGGTCTGCG ACGAATGCCC TAATGTCAAA 
CTAGTGAATG AAGAACGAAC GCTGGAAGTA GAAATAGAGC CTGGGGTGAG AGACGGCATG 
GAGTACCCCT TTATTGGAGA AGGTGAGCCT CACGTGGATG GGGAGCCTGG AGATTTACGG 
TTCCGAATCA AAGTTGTCAA GCACCCAATA TTTGAAAGGA GAGGAGATGA TTTGTACACA 
AATGTGACAA TCTCATTAGT TGAGTCACTG GTTGGCTTTG AGATGGATAT TACTCACTTG 
GATGGTCACA AGGTACATAT TTCCCGGGAT AAGATCACCA GGCCAGGAGC GAAGCTATGG 
AAGAAAGGGG AAGGGCTCCC CAACTTTGAC AACAACAATA TCAAGGGCTC TTTGATAATC 
ACTTTTGATG TGGATTTTCC AAAAGAACAG TTAACAGAGG AAGCGAGAGA AGGTATCAAA 
CAGCTACTGA AACAAGGGTC AGTGCAGAAG GTATACAATG GACTGCAAGG ATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057390.1
CDS	223..1299
Translation	MAPQNLSTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHPIFERRGDDLYTNVTISLVESLVGFEMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEEAREGIKQLLKQGSVQKVYNGLQGY

Target ORF information:

RefSeq Version	NM_016306.5
Organism	Homo sapiens(human)
Definition	Homo sapiens DnaJ heat shock protein family (Hsp40) member B11 (DNAJB11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016306.5

ORF Insert Sequence:

ATGGCTCCGC AGAACCTGAG CACCTTTTGC CTGTTGCTGC TATACCTCAT CGGGGCGGTG 
ATTGCCGGAC GAGATTTCTA TAAGATCTTG GGGGTGCCTC GAAGTGCCTC TATAAAGGAT 
ATTAAAAAGG CCTATAGGAA ACTAGCCCTG CAGCTTCATC CCGACCGGAA CCCTGATGAT 
CCACAAGCCC AGGAGAAATT CCAGGATCTG GGTGCTGCTT ATGAGGTTCT GTCAGATAGT 
GAGAAACGGA AACAGTACGA TACTTATGGT GAAGAAGGAT TAAAAGATGG TCATCAGAGC 
TCCCATGGAG ACATTTTTTC ACACTTCTTT GGGGATTTTG GTTTCATGTT TGGAGGAACC 
CCTCGTCAGC AAGACAGAAA TATTCCAAGA GGAAGTGATA TTATTGTAGA TCTAGAAGTC 
ACTTTGGAAG AAGTATATGC AGGAAATTTT GTGGAAGTAG TTAGAAACAA ACCTGTGGCA 
AGGCAGGCTC CTGGCAAACG GAAGTGCAAT TGTCGGCAAG AGATGCGGAC CACCCAGCTG 
GGCCCTGGGC GCTTCCAAAT GACCCAGGAG GTGGTCTGCG ACGAATGCCC TAATGTCAAA 
CTAGTGAATG AAGAACGAAC GCTGGAAGTA GAAATAGAGC CTGGGGTGAG AGACGGCATG 
GAGTACCCCT TTATTGGAGA AGGTGAGCCT CACGTGGATG GGGAGCCTGG AGATTTACGG 
TTCCGAATCA AAGTTGTCAA GCACCCAATA TTTGAAAGGA GAGGAGATGA TTTGTACACA 
AATGTGACAA TCTCATTAGT TGAGTCACTG GTTGGCTTTG AGATGGATAT TACTCACTTG 
GATGGTCACA AGGTACATAT TTCCCGGGAT AAGATCACCA GGCCAGGAGC GAAGCTATGG 
AAGAAAGGGG AAGGGCTCCC CAACTTTGAC AACAACAATA TCAAGGGCTC TTTGATAATC 
ACTTTTGATG TGGATTTTCC AAAAGAACAG TTAACAGAGG AAGCGAGAGA AGGTATCAAA 
CAGCTACTGA AACAAGGGTC AGTGCAGAAG GTATACAATG GACTGCAAGG ATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.
The EMBO journal36(15)2296-2309(2017 08)
Chen KC,Qu S,Chowdhury S,Noxon IC,Schonhoft JD,Plate L,Powers ET,Kelly JW,Lander GC,Wiseman RL

[Expression and clinical significance of DNAJB11 in epithelial ovarian cancer].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences46(2)173-178(2017 Mar)
Guorong Y,Yunfeng FU,Yanli LI,Caiyun Z,Weiguo LV

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DNAJB11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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