CINP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CINP
Entrez Gene ID	51550
Full Name	cyclin dependent kinase 2 interacting protein
General protein information	Preferred Names cyclin dependent kinase 2 interacting protein Names cyclin-dependent kinase 2-interacting protein CDK2-interacting protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.31
Summary	The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Disorder MIM:	613362

mRNA and Protein(s)

mRNA	Protein	Name
NM_032630.2	NP_116019.1	cyclin-dependent kinase 2-interacting protein isoform 1
NM_001320046.1	NP_001306975.1	cyclin-dependent kinase 2-interacting protein isoform 2
NM_032630.3	NP_116019.1	cyclin-dependent kinase 2-interacting protein isoform 1

Pathways from BioSystems

Homologies

	CINP	XP_001107655.1
Mus musculus (house mouse)	Cinp	NP_081499.1
Homo sapiens (human)	CINP	NP_116019.1
Canis lupus familiaris (dog)	CINP	XP_855437.2
Pan troglodytes (chimpanzee)	CINP	XP_001164253.1
Rattus norvegicus (Norway rat)	Cinp	NP_001100228.1
Gallus gallus (chicken)	CINP	NP_001264432.1
Danio rerio (zebrafish)	LOC100003640	NP_001189413.1
Bos taurus (cattle)	CINP	NP_001092595.1
Xenopus tropicalis (tropical clawed frog)	cinp	XP_002936625.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).
Wang Y, Wang Y, Xu Y, Tong W, Pan T, Li J, Sun S, Shao J, Ding H, Toyoda T, Yuan Z
The Journal of biological chemistry286(30)26603-15(2011 Jul)

CEP152 is a genome maintenance protein disrupted in Seckel syndrome.
Kalay E, Yigit G, Aslan Y, Brown KE, Pohl E, Bicknell LS, Kayserili H, Li Y, T?ys?z B, N?rnberg G, Kiess W, Koegl M, Baessmann I, Buruk K, Toraman B, Kayipmaz S, Kul S, Ikbal M, Turner DJ, Taylor MS, Aerts J, Scott C, Milstein K, Dollfus H, Wieczorek D, Brunner HG, Hurles M, Jackson AP, Rauch A, N?rnberg P, Karag?zel A, Wollnik B
Nature genetics43(1)23-6(2011 Jan)

Functional genomic screens identify CINP as a genome maintenance protein.
Lovejoy CA, Xu X, Bansbach CE, Glick GG, Zhao R, Ye F, Sirbu BM, Titus LC, Shyr Y, Cortez D
Proceedings of the National Academy of Sciences of the United States of America106(46)19304-9(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NS5B delays cells in S phase through interaction with CINP and relocalization of the protein from the nucleus to the cytoplasm
Title: Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).

CINP interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress, and G2 checkpoint integrity.
Title: Functional genomic screens identify CINP as a genome maintenance protein.

CINP is part of the Cdc7-dependent mechanism of origin firing and a functional and physical link between Cdk2 and Cdc7 complexes at the origins
Title: A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.

The following CINP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CINP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05071	NM_032630.3 Latest version!	Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu47744	NM_001320046.1 Latest version!	Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu05071	NM_032630.2	Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CINP ( NM_032630.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_116019.1 Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05071
Clone ID Related Accession (Same CDS sequence)	NM_032630.2 , NM_032630.3
Accession Version	NM_032630.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2-interacting protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA351468.1, BC000600.2 and EL951117.1. On Nov 22, 2018 this sequence version replaced NM_032630.2. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.143715.1, SRR1660803.130635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216756.11/ ENSP00000216756.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAAGCAA AGACTCTTGG AACTGTAACG CCCAGAAAAC CTGTCTTATC TGTCAGTGCA 
AGAAAAATTA AGGACAATGC GGCTGATTGG CACAATTTAA TCCTGAAGTG GGAAACCCTC 
AATGATGCAG GTTTTACCAC TGCAAATAAT ATTGCCAACT TGAAAATCAG TTTATTGAAT 
AAAGACAAGA TAGAACTAGA CAGCAGCAGC CCAGCCTCGA AGGAAAATGA AGAAAAGGTG 
TGTCTGGAAT ATAACGAGGA ACTGGAGAAG CTGTGTGAGG AACTGCAGGC CACCTTGGAT 
GGGTTGACCA AAATACAGGT GAAAATGGAA AAGCTGTCTT CAACTACCAA GGGAATTTGT 
GAACTAGAAA ACTACCATTA TGGGGAGGAG AGTAAACGAC CCCCTCTGTT CCACACGTGG 
CCTACAACCC ATTTCTATGA GGTTTCGCAT AAGCTCTTGG AGATGTACAG GAAGGAGCTG 
CTCCTGAAGC GCACGGTGGC CAAGGAGCTT GCCCACACCG GGGATCCCGA CCTCACCCTG 
AGCTACCTGT CCATGTGGCT GCACCAGCCC TATGTGGAGA GCGACAGCAG GCTGCATCTG 
GAGAGCATGC TGCTGGAGAC AGGCCACCGA GCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116019.1
CDS	40..678
Translation	MEAKTLGTVTPRKPVLSVSARKIKDNAADWHNLILKWETLNDAGFTTANNIANLKISLLNKDKIELDSSSPASKENEEKVCLEYNEELEKLCEELQATLDGLTKIQVKMEKLSSTTKGICELENYHYGEESKRPPLFHTWPTTHFYEVSHKLLEMYRKELLLKRTVAKELAHTGDPDLTLSYLSMWLHQPYVESDSRLHLESMLLETGHRAL

Target ORF information:

RefSeq Version	NM_032630.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032630.3

ORF Insert Sequence:

ATGGAAGCAA AGACTCTTGG AACTGTAACG CCCAGAAAAC CTGTCTTATC TGTCAGTGCA 
AGAAAAATTA AGGACAATGC GGCTGATTGG CACAATTTAA TCCTGAAGTG GGAAACCCTC 
AATGATGCAG GTTTTACCAC TGCAAATAAT ATTGCCAACT TGAAAATCAG TTTATTGAAT 
AAAGACAAGA TAGAACTAGA CAGCAGCAGC CCAGCCTCGA AGGAAAATGA AGAAAAGGTG 
TGTCTGGAAT ATAACGAGGA ACTGGAGAAG CTGTGTGAGG AACTGCAGGC CACCTTGGAT 
GGGTTGACCA AAATACAGGT GAAAATGGAA AAGCTGTCTT CAACTACCAA GGGAATTTGT 
GAACTAGAAA ACTACCATTA TGGGGAGGAG AGTAAACGAC CCCCTCTGTT CCACACGTGG 
CCTACAACCC ATTTCTATGA GGTTTCGCAT AAGCTCTTGG AGATGTACAG GAAGGAGCTG 
CTCCTGAAGC GCACGGTGGC CAAGGAGCTT GCCCACACCG GGGATCCCGA CCTCACCCTG 
AGCTACCTGT CCATGTGGCT GCACCAGCCC TATGTGGAGA GCGACAGCAG GCTGCATCTG 
GAGAGCATGC TGCTGGAGAC AGGCCACCGA GCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CINP ( NM_032630.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_116019.1 Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05071
Clone ID Related Accession (Same CDS sequence)	NM_032630.2 , NM_032630.3
Accession Version	NM_032630.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2-interacting protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA351468.1, BC000600.2 and EL951117.1. On or before Nov 4, 2002 this sequence version replaced NM_016550.1, NM_032630.1. ##Evidence-Data-START## Transcript exon combination :: BC000600.2, SRR1660803.130635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGCAA AGACTCTTGG AACTGTAACG CCCAGAAAAC CTGTCTTATC TGTCAGTGCA 
AGAAAAATTA AGGACAATGC GGCTGATTGG CACAATTTAA TCCTGAAGTG GGAAACCCTC 
AATGATGCAG GTTTTACCAC TGCAAATAAT ATTGCCAACT TGAAAATCAG TTTATTGAAT 
AAAGACAAGA TAGAACTAGA CAGCAGCAGC CCAGCCTCGA AGGAAAATGA AGAAAAGGTG 
TGTCTGGAAT ATAACGAGGA ACTGGAGAAG CTGTGTGAGG AACTGCAGGC CACCTTGGAT 
GGGTTGACCA AAATACAGGT GAAAATGGAA AAGCTGTCTT CAACTACCAA GGGAATTTGT 
GAACTAGAAA ACTACCATTA TGGGGAGGAG AGTAAACGAC CCCCTCTGTT CCACACGTGG 
CCTACAACCC ATTTCTATGA GGTTTCGCAT AAGCTCTTGG AGATGTACAG GAAGGAGCTG 
CTCCTGAAGC GCACGGTGGC CAAGGAGCTT GCCCACACCG GGGATCCCGA CCTCACCCTG 
AGCTACCTGT CCATGTGGCT GCACCAGCCC TATGTGGAGA GCGACAGCAG GCTGCATCTG 
GAGAGCATGC TGCTGGAGAC AGGCCACCGA GCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116019.1
CDS	66..704
Translation	MEAKTLGTVTPRKPVLSVSARKIKDNAADWHNLILKWETLNDAGFTTANNIANLKISLLNKDKIELDSSSPASKENEEKVCLEYNEELEKLCEELQATLDGLTKIQVKMEKLSSTTKGICELENYHYGEESKRPPLFHTWPTTHFYEVSHKLLEMYRKELLLKRTVAKELAHTGDPDLTLSYLSMWLHQPYVESDSRLHLESMLLETGHRAL

Target ORF information:

RefSeq Version	NM_032630.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032630.2

ORF Insert Sequence:

ATGGAAGCAA AGACTCTTGG AACTGTAACG CCCAGAAAAC CTGTCTTATC TGTCAGTGCA 
AGAAAAATTA AGGACAATGC GGCTGATTGG CACAATTTAA TCCTGAAGTG GGAAACCCTC 
AATGATGCAG GTTTTACCAC TGCAAATAAT ATTGCCAACT TGAAAATCAG TTTATTGAAT 
AAAGACAAGA TAGAACTAGA CAGCAGCAGC CCAGCCTCGA AGGAAAATGA AGAAAAGGTG 
TGTCTGGAAT ATAACGAGGA ACTGGAGAAG CTGTGTGAGG AACTGCAGGC CACCTTGGAT 
GGGTTGACCA AAATACAGGT GAAAATGGAA AAGCTGTCTT CAACTACCAA GGGAATTTGT 
GAACTAGAAA ACTACCATTA TGGGGAGGAG AGTAAACGAC CCCCTCTGTT CCACACGTGG 
CCTACAACCC ATTTCTATGA GGTTTCGCAT AAGCTCTTGG AGATGTACAG GAAGGAGCTG 
CTCCTGAAGC GCACGGTGGC CAAGGAGCTT GCCCACACCG GGGATCCCGA CCTCACCCTG 
AGCTACCTGT CCATGTGGCT GCACCAGCCC TATGTGGAGA GCGACAGCAG GCTGCATCTG 
GAGAGCATGC TGCTGGAGAC AGGCCACCGA GCTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CINP ( NM_001320046.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001306975.1 Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu47744
Clone ID Related Accession (Same CDS sequence)	NM_001320046.1
Accession Version	NM_001320046.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2-interacting protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL137229.4 and DA167716.1. On Feb 9, 2016 this sequence version replaced XM_005267753.1. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.300220.1, DA167716.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGCAA AGACTCTTGG AACTGTAACG CCCAGAAAAC CTGTCTTATC TGTCAGTGCA 
AGAAAAATTA AGGACAATGC GGCTGATTGG CACAATTTAA TCCTGAAGTG GGAAACCCTC 
AATGATGCAG GTTTTACCAC TGCAAATAAT ATTGCCAACT TGAAAATCAG TTTATTGAAT 
AAAGACAAGA TAGAACTAGA CAGCAGCAGC CCAGCCTCGA AGGAAAATGA AGAAAAGGTG 
TGTCTGGAAT ATAACGAGGA ACTGGAGAAG CTGTGTGAGG AACTGCAGGC CACCTTGGAT 
GGGTTGATGA GGTTTCGCAT AAGCTCTTGG AGATGTACAG GAAGGAGCTG CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001306975.1
CDS	66..422
Translation	MEAKTLGTVTPRKPVLSVSARKIKDNAADWHNLILKWETLNDAGFTTANNIANLKISLLNKDKIELDSSSPASKENEEKVCLEYNEELEKLCEELQATLDGLMRFRISSWRCTGRSCS

Target ORF information:

RefSeq Version	NM_001320046.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 interacting protein (CINP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320046.1

ORF Insert Sequence:

ATGGAAGCAA AGACTCTTGG AACTGTAACG CCCAGAAAAC CTGTCTTATC TGTCAGTGCA 
AGAAAAATTA AGGACAATGC GGCTGATTGG CACAATTTAA TCCTGAAGTG GGAAACCCTC 
AATGATGCAG GTTTTACCAC TGCAAATAAT ATTGCCAACT TGAAAATCAG TTTATTGAAT 
AAAGACAAGA TAGAACTAGA CAGCAGCAGC CCAGCCTCGA AGGAAAATGA AGAAAAGGTG 
TGTCTGGAAT ATAACGAGGA ACTGGAGAAG CTGTGTGAGG AACTGCAGGC CACCTTGGAT 
GGGTTGATGA GGTTTCGCAT AAGCTCTTGG AGATGTACAG GAAGGAGCTG CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).
The Journal of biological chemistry286(30)26603-15(2011 Jul)
Wang Y,Wang Y,Xu Y,Tong W,Pan T,Li J,Sun S,Shao J,Ding H,Toyoda T,Yuan Z

CEP152 is a genome maintenance protein disrupted in Seckel syndrome.
Nature genetics43(1)23-6(2011 Jan)
Kalay E,Yigit G,Aslan Y,Brown KE,Pohl E,Bicknell LS,Kayserili H,Li Y,T?ys?z B,N?rnberg G,Kiess W,Koegl M,Baessmann I,Buruk K,Toraman B,Kayipmaz S,Kul S,Ikbal M,Turner DJ,Taylor MS,Aerts J,Scott C,Milstein K,Dollfus H,Wieczorek D,Brunner HG,Hurles M,Jackson AP,Rauch A,N?rnberg P,Karag?zel A,Wollnik B

Functional genomic screens identify CINP as a genome maintenance protein.
Proceedings of the National Academy of Sciences of the United States of America106(46)19304-9(2009 Nov)
Lovejoy CA,Xu X,Bansbach CE,Glick GG,Zhao R,Ye F,Sirbu BM,Titus LC,Shyr Y,Cortez D

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CINP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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