CCL3L3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL3L3
Entrez Gene ID	414062
Full Name	C-C motif chemokine ligand 3 like 3
Synonyms	464.2,D17S1718,G0S19-2,LD78,LD78BETA,SCYA3L,SCYA3L1
General protein information	Preferred Names C-C motif chemokine ligand 3 like 3 Names C-C motif chemokine 3-like 1 G0/G1 switch regulatory protein 19-2 LD78-beta(1-70) chemokine (C-C motif) ligand 3-like 3 chemokine (C-C motif) ligand 3-like, centromeric small inducible cytokine A3-like 1 tonsillar lymphocyte LD78 beta protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014].
Disorder MIM:	609468

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001437.4	NP_001001437.2	C-C motif chemokine 3-like 1 precursor
NM_001001437.3	NP_001001437.2	C-C motif chemokine 3-like 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC749948	XP_001172388.1
Pan troglodytes (chimpanzee)	LOC749913	XP_001172226.1
Canis lupus familiaris (dog)	CCL3	NP_001005251.1
Bos taurus (cattle)	CCL3	NP_776936.1
Homo sapiens (human)	CCL3L3	NP_001001437.2
	LOC100423954	XP_002800705.1
Rattus norvegicus (Norway rat)	Ccl3	NP_037157.2
Mus musculus (house mouse)	Ccl3	NP_035467.1

Gene Ontology
Bibliography

Related articles in PubMed

Variations in CCL3L gene cluster sequence and non-specific gene copy numbers.
Shrestha S, Nyaku M, Edberg JC
BMC research notes374(2010 Mar)

Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.
Ryu OH, Choi SJ, Firatli E, Choi SW, Hart PS, Shen RF, Wang G, Wu WW, Hart TC
The Journal of biological chemistry280(17)17415-21(2005 Apr)

Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor.
Bonecchi R, Locati M, Galliera E, Vulcano M, Sironi M, Fra AM, Gobbi M, Vecchi A, Sozzani S, Haribabu B, Van Damme J, Mantovani A
Journal of immunology (Baltimore, Md. : 1950)172(8)4972-6(2004 Apr)

CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12.
Modi WS
Genomics83(4)735-8(2004 Apr)

Gene copy number regulates the production of the human chemokine CCL3-L1.
Townson JR, Barcellos LF, Nibbs RJ
European journal of immunology32(10)3016-26(2002 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

severe periodontal tissue destruction in Papillon-Lefevre syndrome may be related to excess accumulation of LD78beta and LD78alpha and dysregulation of the microbial-induced inflammatory response in the periodontium
Title: Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.

The following CCL3L3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL3L3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27976	NM_001001437.4 Latest version!	Homo sapiens C-C motif chemokine ligand 3 like 3 (CCL3L3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27976	NM_001001437.3	Homo sapiens C-C motif chemokine ligand 3 like 3 (CCL3L3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL3L3 ( NM_001001437.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001437.2 Homo sapiens C-C motif chemokine ligand 3 like 3 (CCL3L3), mRNA.

Price & Availability↑

CloneID	OHu27976
Clone ID Related Accession (Same CDS sequence)	NM_001001437.4 , NM_001001437.3
Accession Version	NM_001001437.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	C-C motif chemokine 3-like 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243829.3, AA380745.1, BC007783.2 and CF128666.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001001437.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007783.2, SRR1163657.51183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000619989.1/ ENSP00000480558.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGTCT CCACTGCTGC CCTTGCCGTC CTCCTCTGCA CCATGGCTCT CTGCAACCAG 
GTCCTCTCTG CACCACTTGC TGCTGACACG CCGACCGCCT GCTGCTTCAG CTACACCTCC 
CGACAGATTC CACAGAATTT CATAGCTGAC TACTTTGAGA CGAGCAGCCA GTGCTCCAAG 
CCCAGTGTCA TCTTCCTAAC CAAGAGAGGC CGGCAGGTCT GTGCTGACCC CAGTGAGGAG 
TGGGTCCAGA AATACGTCAG TGACCTGGAG CTGAGTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001437.2
CDS	86..367
Translation	MQVSTAALAVLLCTMALCNQVLSAPLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPSVIFLTKRGRQVCADPSEEWVQKYVSDLELSA

Target ORF information:

RefSeq Version	NM_001001437.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 3 like 3 (CCL3L3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001437.4

ORF Insert Sequence:

ATGCAGGTCT CCACTGCTGC CCTTGCCGTC CTCCTCTGCA CCATGGCTCT CTGCAACCAG 
GTCCTCTCTG CACCACTTGC TGCTGACACG CCGACCGCCT GCTGCTTCAG CTACACCTCC 
CGACAGATTC CACAGAATTT CATAGCTGAC TACTTTGAGA CGAGCAGCCA GTGCTCCAAG 
CCCAGTGTCA TCTTCCTAAC CAAGAGAGGC CGGCAGGTCT GTGCTGACCC CAGTGAGGAG 
TGGGTCCAGA AATACGTCAG TGACCTGGAG CTGAGTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL3L3 ( NM_001001437.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001437.2 Homo sapiens C-C motif chemokine ligand 3 like 3 (CCL3L3), mRNA.

Price & Availability↑

CloneID	OHu27976
Clone ID Related Accession (Same CDS sequence)	NM_001001437.4 , NM_001001437.3
Accession Version	NM_001001437.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	C-C motif chemokine 3-like 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA380745.1, BC007783.2 and CF128666.1. This sequence is a reference standard in the RefSeqGene project. On Apr 26, 2006 this sequence version replaced NM_001001437.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007783.2, SRR1163657.51183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGTCT CCACTGCTGC CCTTGCCGTC CTCCTCTGCA CCATGGCTCT CTGCAACCAG 
GTCCTCTCTG CACCACTTGC TGCTGACACG CCGACCGCCT GCTGCTTCAG CTACACCTCC 
CGACAGATTC CACAGAATTT CATAGCTGAC TACTTTGAGA CGAGCAGCCA GTGCTCCAAG 
CCCAGTGTCA TCTTCCTAAC CAAGAGAGGC CGGCAGGTCT GTGCTGACCC CAGTGAGGAG 
TGGGTCCAGA AATACGTCAG TGACCTGGAG CTGAGTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001437.2
CDS	76..357
Translation	MQVSTAALAVLLCTMALCNQVLSAPLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPSVIFLTKRGRQVCADPSEEWVQKYVSDLELSA

Target ORF information:

RefSeq Version	NM_001001437.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 3 like 3 (CCL3L3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001437.3

ORF Insert Sequence:

ATGCAGGTCT CCACTGCTGC CCTTGCCGTC CTCCTCTGCA CCATGGCTCT CTGCAACCAG 
GTCCTCTCTG CACCACTTGC TGCTGACACG CCGACCGCCT GCTGCTTCAG CTACACCTCC 
CGACAGATTC CACAGAATTT CATAGCTGAC TACTTTGAGA CGAGCAGCCA GTGCTCCAAG 
CCCAGTGTCA TCTTCCTAAC CAAGAGAGGC CGGCAGGTCT GTGCTGACCC CAGTGAGGAG 
TGGGTCCAGA AATACGTCAG TGACCTGGAG CTGAGTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Variations in CCL3L gene cluster sequence and non-specific gene copy numbers.
BMC research notes374(2010 Mar)
Shrestha S,Nyaku M,Edberg JC

Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.
The Journal of biological chemistry280(17)17415-21(2005 Apr)
Ryu OH,Choi SJ,Firatli E,Choi SW,Hart PS,Shen RF,Wang G,Wu WW,Hart TC

Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor.
Journal of immunology (Baltimore, Md. : 1950)172(8)4972-6(2004 Apr)
Bonecchi R,Locati M,Galliera E,Vulcano M,Sironi M,Fra AM,Gobbi M,Vecchi A,Sozzani S,Haribabu B,Van Damme J,Mantovani A

CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12.
Genomics83(4)735-8(2004 Apr)
Modi WS

Gene copy number regulates the production of the human chemokine CCL3-L1.
European journal of immunology32(10)3016-26(2002 Oct)
Townson JR,Barcellos LF,Nibbs RJ

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CCL3L3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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