C12orf75 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C12orf75
Entrez Gene ID	387882
Full Name	chromosome 12 open reading frame 75
Synonyms	AGD3,OCC-1,OCC1
General protein information	Preferred Names chromosome 12 open reading frame 75 Names overexpressed in colon carcinoma 1 protein adipogenesis down-regulated 3 overexpressed in colon carcinoma-1 putative overexpressed in colon carcinoma-1 protein variant C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q23.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001145199.2	NP_001138671.1	overexpressed in colon carcinoma 1 protein
NM_001145199.1	NP_001138671.1	overexpressed in colon carcinoma 1 protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C12H12orf75	XP_003952329.1
Homo sapiens (human)	C12orf75	NP_001138671.1

Gene Ontology
Bibliography

Related articles in PubMed

Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway.
Najafi H, Soltani BM, Dokanehiifard S, Nasiri S, Mowla SJ
RNA (New York, N.Y.)23(1)70-85(2017 01)

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
Cobb J, Cule E, Moncrieffe H, Hinks A, Ursu S, Patrick F, Kassoumeri L, Flynn E, Bulatovi? M, Wulffraat N, van Zelst B, de Jonge R, Bohm M, Dolezalova P, Hirani S, Newman S, Whitworth P, Southwood TR, De Iorio M, , , , Wedderburn LR, Thomson W
The pharmacogenomics journal14(4)356-64(2014 Aug)

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
Ramanan VK, Risacher SL, Nho K, Kim S, Swaminathan S, Shen L, Foroud TM, Hakonarson H, Huentelman MJ, Aisen PS, Petersen RC, Green RC, Jack CR, Koeppe RA, Jagust WJ, Weiner MW, Saykin AJ,
Molecular psychiatry19(3)351-7(2014 Mar)

A novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signalling.
Chai B, Li JY, Fritze D, Zhang W, Xia Z, Mulholland MW
Journal of neuroendocrinology25(3)292-301(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study identified three novel transcripts of the OCC-1 gene; two of them, including a novel miRNA, are shown to be associated with the Wnt signaling pathway. Also, OCC-1 was found to affect the transcription level of its neighboring gene APPL2.
Title: Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway.

The following C12orf75 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C12orf75 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17545	NM_001145199.2 Latest version!	Homo sapiens chromosome 12 open reading frame 75 (C12orf75), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17545	NM_001145199.1	Homo sapiens chromosome 12 open reading frame 75 (C12orf75), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C12orf75 ( NM_001145199.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138671.1 Homo sapiens chromosome 12 open reading frame 75 (C12orf75), mRNA.

Price & Availability↑

CloneID	OHu17545
Clone ID Related Accession (Same CDS sequence)	NM_001145199.2 , NM_001145199.1
Accession Version	NM_001145199.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	overexpressed in colon carcinoma 1 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC013920.1 and BQ021766.1. On Jun 2, 2019 this sequence version replaced NM_001145199.1. ##Evidence-Data-START## Transcript exon combination :: BC013920.1, SRR1163657.293945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCTGCG GGAACTCCAC CGCCACCAGC GCGGGCGCGG GCCAAGGCCC TGCAGGAGCA 
GCCAAAGATG TAACAGAAGA ATCCGTAACA GAAGATGACA AGAGGAGAAA CTATGGAGGA 
GTATATGTTG GCCTACCATC TGAAGCTGTC AATATGGTGT CCAGTCAAAC AAAGACGGTT 
CGGAAAAATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138671.1
CDS	202..393
Translation	MGCGNSTATSAGAGQGPAGAAKDVTEESVTEDDKRRNYGGVYVGLPSEAVNMVSSQTKTVRKN

Target ORF information:

RefSeq Version	NM_001145199.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 12 open reading frame 75 (C12orf75), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145199.2

ORF Insert Sequence:

ATGGGCTGCG GGAACTCCAC CGCCACCAGC GCGGGCGCGG GCCAAGGCCC TGCAGGAGCA 
GCCAAAGATG TAACAGAAGA ATCCGTAACA GAAGATGACA AGAGGAGAAA CTATGGAGGA 
GTATATGTTG GCCTACCATC TGAAGCTGTC AATATGGTGT CCAGTCAAAC AAAGACGGTT 
CGGAAAAATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C12orf75 ( NM_001145199.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138671.1 Homo sapiens chromosome 12 open reading frame 75 (C12orf75), mRNA.

Price & Availability↑

CloneID	OHu17545
Clone ID Related Accession (Same CDS sequence)	NM_001145199.2 , NM_001145199.1
Accession Version	NM_001145199.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	overexpressed in colon carcinoma 1 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC013920.1 and BQ021766.1. On or before Feb 18, 2009 this sequence version replaced XR_040443.1, XR_040442.1, XR_040444.1. ##Evidence-Data-START## Transcript exon combination :: BC013920.1, SRR1163657.145046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTGCG GGAACTCCAC CGCCACCAGC GCGGGCGCGG GCCAAGGCCC TGCAGGAGCA 
GCCAAAGATG TAACAGAAGA ATCCGTAACA GAAGATGACA AGAGGAGAAA CTATGGAGGA 
GTATATGTTG GCCTACCATC TGAAGCTGTC AATATGGTGT CCAGTCAAAC AAAGACGGTT 
CGGAAAAATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138671.1
CDS	257..448
Translation	MGCGNSTATSAGAGQGPAGAAKDVTEESVTEDDKRRNYGGVYVGLPSEAVNMVSSQTKTVRKN

Target ORF information:

RefSeq Version	NM_001145199.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 12 open reading frame 75 (C12orf75), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145199.1

ORF Insert Sequence:

ATGGGCTGCG GGAACTCCAC CGCCACCAGC GCGGGCGCGG GCCAAGGCCC TGCAGGAGCA 
GCCAAAGATG TAACAGAAGA ATCCGTAACA GAAGATGACA AGAGGAGAAA CTATGGAGGA 
GTATATGTTG GCCTACCATC TGAAGCTGTC AATATGGTGT CCAGTCAAAC AAAGACGGTT 
CGGAAAAATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway.
RNA (New York, N.Y.)23(1)70-85(2017 01)
Najafi H,Soltani BM,Dokanehiifard S,Nasiri S,Mowla SJ

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
The pharmacogenomics journal14(4)356-64(2014 Aug)
Cobb J,Cule E,Moncrieffe H,Hinks A,Ursu S,Patrick F,Kassoumeri L,Flynn E,Bulatovi? M,Wulffraat N,van Zelst B,de Jonge R,Bohm M,Dolezalova P,Hirani S,Newman S,Whitworth P,Southwood TR,De Iorio M,,,,Wedderburn LR,Thomson W

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
Molecular psychiatry19(3)351-7(2014 Mar)
Ramanan VK,Risacher SL,Nho K,Kim S,Swaminathan S,Shen L,Foroud TM,Hakonarson H,Huentelman MJ,Aisen PS,Petersen RC,Green RC,Jack CR,Koeppe RA,Jagust WJ,Weiner MW,Saykin AJ,

A novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signalling.
Journal of neuroendocrinology25(3)292-301(2013 Mar)
Chai B,Li JY,Fritze D,Zhang W,Xia Z,Mulholland MW

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C12orf75 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

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