ARG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARG2
Entrez Gene ID	384
Full Name	arginase 2
General protein information	Preferred Names arginase 2 Names arginase-2, mitochondrial L-arginine amidinohydrolase L-arginine ureahydrolase arginase II arginase, type II kidney arginase kidney-type arginase non-hepatic arginase nonhepatic arginase type II arginase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q24.1
Summary	Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008].
Disorder MIM:	107830

mRNA and Protein(s)

mRNA	Protein	Name
NM_001172.3	NP_001163.1	arginase-2, mitochondrial precursor
NM_001172.4	NP_001163.1	arginase-2, mitochondrial precursor

Pathways from BioSystems

Homologies

	ARG2	XP_001107412.1
Bos taurus (cattle)	ARG2	NP_001017942.1
Mus musculus (house mouse)	Arg2	NP_033835.1
Gallus gallus (chicken)	ARG2	NP_001186633.1
Drosophila melanogaster (fruit fly)	arg	NP_524875.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008783	XP_314912.4
Canis lupus familiaris (dog)	ARG2	NP_001138592.1
Homo sapiens (human)	ARG2	NP_001163.1
Pan troglodytes (chimpanzee)	ARG2	XP_510020.3
Rattus norvegicus (Norway rat)	Arg2	NP_062041.1
Danio rerio (zebrafish)	arg2	NP_955905.1
Xenopus tropicalis (tropical clawed frog)	arg2	NP_001072685.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2.
Wang Y, Zhao P, Qian D, Hu M, Zhang L, Shi H, Wang B
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317712512(2017 Jul)

Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition.
Kim NH, Choi SH, Yi N, Lee TR, Lee AY
Pigment cell & melanoma research30(6)521-530(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our data provide compelling evidence that human cytomegalovirus reduced the level of microRNA-613 which functions as an anti-onco-miRNA in glioblastoma, primarily by downregulating the expression of arginase-2
Title: MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2.

fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2; results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation
Title: Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.

overexpression of AMPK induced arginase II protein expression and viable cells numbers in human Pulmonary artery smooth muscle cell .
Title: Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPK?

Schizophrenia patients had increased arginase II protein expression in the frontal cortex compared to controls.
Title: Altered brain arginine metabolism in schizophrenia.

Data show that transfection with Arginase II-small interfering RNA prevented hypoxia-induced cell proliferation.
Title: Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II.

The following ARG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20129	NM_001172.4 Latest version!	Homo sapiens arginase 2 (ARG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu20129	NM_001172.3	Homo sapiens arginase 2 (ARG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARG2 ( NM_001172.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001163.1 Homo sapiens arginase 2 (ARG2), mRNA.

Price & Availability↑

CloneID	OHu20129
Clone ID Related Accession (Same CDS sequence)	NM_001172.3 , NM_001172.4
Accession Version	NM_001172.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	arginase-2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC029050.1 and AL135439.1. This sequence is a reference standard in the RefSeqGene project. On Sep 22, 2004 this sequence version replaced NM_001172.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029050.1, SRR1803613.249136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTAA GGGGCAGCCT CTCGCGTCTC CTCCAGACGC GAGTGCATTC CATCCTGAAG 
AAATCCGTCC ACTCCGTGGC TGTGATAGGA GCCCCGTTCT CACAAGGGCA GAAAAGAAAA 
GGAGTGGAGC ATGGTCCCGC TGCCATAAGA GAAGCTGGCT TGATGAAAAG GCTCTCCAGT 
TTGGGCTGCC ACCTAAAAGA CTTTGGAGAT TTGAGTTTTA CTCCAGTCCC CAAAGATGAT 
CTCTACAACA ACCTGATAGT GAATCCACGC TCAGTGGGTC TTGCCAACCA GGAACTGGCT 
GAGGTGGTTA GCAGAGCTGT GTCAGATGGC TACAGCTGTG TCACACTGGG AGGAGACCAC 
AGCCTGGCAA TCGGTACCAT TAGTGGCCAT GCCCGACACT GCCCAGACCT TTGTGTTGTC 
TGGGTTGATG CCCATGCTGA CATCAACACA CCCCTTACCA CTTCATCAGG AAATCTCCAT 
GGACAGCCAG TTTCATTTCT CCTCAGAGAA CTACAGGATA AGGTACCACA ACTCCCAGGA 
TTTTCCTGGA TCAAACCTTG TATCTCTTCT GCAAGTATTG TGTATATTGG TCTGAGAGAC 
GTGGACCCTC CTGAACATTT TATTTTAAAG AACTATGATA TCCAGTATTT TTCCATGAGA 
GATATTGATC GACTTGGTAT CCAGAAGGTC ATGGAACGAA CATTTGATCT GCTGATTGGC 
AAGAGACAAA GACCAATCCA TTTGAGTTTT GATATTGATG CATTTGACCC TACACTGGCT 
CCAGCCACAG GAACTCCTGT TGTCGGGGGA CTAACCTATC GAGAAGGCAT GTATATTGCT 
GAGGAAATAC ACAATACAGG GTTGCTATCA GCACTGGATC TTGTTGAAGT CAATCCTCAG 
TTGGCCACCT CAGAGGAAGA GGCGAAGACT ACAGCTAACC TGGCAGTAGA TGTGATTGCT 
TCAAGCTTTG GTCAGACAAG AGAAGGAGGG CATATTGTCT ATGACCAACT TCCTACTCCC 
AGTTCACCAG ATGAATCAGA AAATCAAGCA CGTGTGAGAA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001163.1
CDS	117..1181
Translation	MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI

Target ORF information:

RefSeq Version	NM_001172.3
Organism	Homo sapiens(human)
Definition	Homo sapiens arginase 2 (ARG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172.3

ORF Insert Sequence:

ATGTCCCTAA GGGGCAGCCT CTCGCGTCTC CTCCAGACGC GAGTGCATTC CATCCTGAAG 
AAATCCGTCC ACTCCGTGGC TGTGATAGGA GCCCCGTTCT CACAAGGGCA GAAAAGAAAA 
GGAGTGGAGC ATGGTCCCGC TGCCATAAGA GAAGCTGGCT TGATGAAAAG GCTCTCCAGT 
TTGGGCTGCC ACCTAAAAGA CTTTGGAGAT TTGAGTTTTA CTCCAGTCCC CAAAGATGAT 
CTCTACAACA ACCTGATAGT GAATCCACGC TCAGTGGGTC TTGCCAACCA GGAACTGGCT 
GAGGTGGTTA GCAGAGCTGT GTCAGATGGC TACAGCTGTG TCACACTGGG AGGAGACCAC 
AGCCTGGCAA TCGGTACCAT TAGTGGCCAT GCCCGACACT GCCCAGACCT TTGTGTTGTC 
TGGGTTGATG CCCATGCTGA CATCAACACA CCCCTTACCA CTTCATCAGG AAATCTCCAT 
GGACAGCCAG TTTCATTTCT CCTCAGAGAA CTACAGGATA AGGTACCACA ACTCCCAGGA 
TTTTCCTGGA TCAAACCTTG TATCTCTTCT GCAAGTATTG TGTATATTGG TCTGAGAGAC 
GTGGACCCTC CTGAACATTT TATTTTAAAG AACTATGATA TCCAGTATTT TTCCATGAGA 
GATATTGATC GACTTGGTAT CCAGAAGGTC ATGGAACGAA CATTTGATCT GCTGATTGGC 
AAGAGACAAA GACCAATCCA TTTGAGTTTT GATATTGATG CATTTGACCC TACACTGGCT 
CCAGCCACAG GAACTCCTGT TGTCGGGGGA CTAACCTATC GAGAAGGCAT GTATATTGCT 
GAGGAAATAC ACAATACAGG GTTGCTATCA GCACTGGATC TTGTTGAAGT CAATCCTCAG 
TTGGCCACCT CAGAGGAAGA GGCGAAGACT ACAGCTAACC TGGCAGTAGA TGTGATTGCT 
TCAAGCTTTG GTCAGACAAG AGAAGGAGGG CATATTGTCT ATGACCAACT TCCTACTCCC 
AGTTCACCAG ATGAATCAGA AAATCAAGCA CGTGTGAGAA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARG2 ( NM_001172.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001163.1 Homo sapiens arginase 2 (ARG2), mRNA.

Price & Availability↑

CloneID	OHu20129
Clone ID Related Accession (Same CDS sequence)	NM_001172.3 , NM_001172.4
Accession Version	NM_001172.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	arginase-2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC029050.1 and AL135439.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001172.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.117412.1, SRR1803613.185889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000261783.4/ ENSP00000261783.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCTAA GGGGCAGCCT CTCGCGTCTC CTCCAGACGC GAGTGCATTC CATCCTGAAG 
AAATCCGTCC ACTCCGTGGC TGTGATAGGA GCCCCGTTCT CACAAGGGCA GAAAAGAAAA 
GGAGTGGAGC ATGGTCCCGC TGCCATAAGA GAAGCTGGCT TGATGAAAAG GCTCTCCAGT 
TTGGGCTGCC ACCTAAAAGA CTTTGGAGAT TTGAGTTTTA CTCCAGTCCC CAAAGATGAT 
CTCTACAACA ACCTGATAGT GAATCCACGC TCAGTGGGTC TTGCCAACCA GGAACTGGCT 
GAGGTGGTTA GCAGAGCTGT GTCAGATGGC TACAGCTGTG TCACACTGGG AGGAGACCAC 
AGCCTGGCAA TCGGTACCAT TAGTGGCCAT GCCCGACACT GCCCAGACCT TTGTGTTGTC 
TGGGTTGATG CCCATGCTGA CATCAACACA CCCCTTACCA CTTCATCAGG AAATCTCCAT 
GGACAGCCAG TTTCATTTCT CCTCAGAGAA CTACAGGATA AGGTACCACA ACTCCCAGGA 
TTTTCCTGGA TCAAACCTTG TATCTCTTCT GCAAGTATTG TGTATATTGG TCTGAGAGAC 
GTGGACCCTC CTGAACATTT TATTTTAAAG AACTATGATA TCCAGTATTT TTCCATGAGA 
GATATTGATC GACTTGGTAT CCAGAAGGTC ATGGAACGAA CATTTGATCT GCTGATTGGC 
AAGAGACAAA GACCAATCCA TTTGAGTTTT GATATTGATG CATTTGACCC TACACTGGCT 
CCAGCCACAG GAACTCCTGT TGTCGGGGGA CTAACCTATC GAGAAGGCAT GTATATTGCT 
GAGGAAATAC ACAATACAGG GTTGCTATCA GCACTGGATC TTGTTGAAGT CAATCCTCAG 
TTGGCCACCT CAGAGGAAGA GGCGAAGACT ACAGCTAACC TGGCAGTAGA TGTGATTGCT 
TCAAGCTTTG GTCAGACAAG AGAAGGAGGG CATATTGTCT ATGACCAACT TCCTACTCCC 
AGTTCACCAG ATGAATCAGA AAATCAAGCA CGTGTGAGAA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001163.1
CDS	59..1123
Translation	MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI

Target ORF information:

RefSeq Version	NM_001172.4
Organism	Homo sapiens(human)
Definition	Homo sapiens arginase 2 (ARG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172.4

ORF Insert Sequence:

ATGTCCCTAA GGGGCAGCCT CTCGCGTCTC CTCCAGACGC GAGTGCATTC CATCCTGAAG 
AAATCCGTCC ACTCCGTGGC TGTGATAGGA GCCCCGTTCT CACAAGGGCA GAAAAGAAAA 
GGAGTGGAGC ATGGTCCCGC TGCCATAAGA GAAGCTGGCT TGATGAAAAG GCTCTCCAGT 
TTGGGCTGCC ACCTAAAAGA CTTTGGAGAT TTGAGTTTTA CTCCAGTCCC CAAAGATGAT 
CTCTACAACA ACCTGATAGT GAATCCACGC TCAGTGGGTC TTGCCAACCA GGAACTGGCT 
GAGGTGGTTA GCAGAGCTGT GTCAGATGGC TACAGCTGTG TCACACTGGG AGGAGACCAC 
AGCCTGGCAA TCGGTACCAT TAGTGGCCAT GCCCGACACT GCCCAGACCT TTGTGTTGTC 
TGGGTTGATG CCCATGCTGA CATCAACACA CCCCTTACCA CTTCATCAGG AAATCTCCAT 
GGACAGCCAG TTTCATTTCT CCTCAGAGAA CTACAGGATA AGGTACCACA ACTCCCAGGA 
TTTTCCTGGA TCAAACCTTG TATCTCTTCT GCAAGTATTG TGTATATTGG TCTGAGAGAC 
GTGGACCCTC CTGAACATTT TATTTTAAAG AACTATGATA TCCAGTATTT TTCCATGAGA 
GATATTGATC GACTTGGTAT CCAGAAGGTC ATGGAACGAA CATTTGATCT GCTGATTGGC 
AAGAGACAAA GACCAATCCA TTTGAGTTTT GATATTGATG CATTTGACCC TACACTGGCT 
CCAGCCACAG GAACTCCTGT TGTCGGGGGA CTAACCTATC GAGAAGGCAT GTATATTGCT 
GAGGAAATAC ACAATACAGG GTTGCTATCA GCACTGGATC TTGTTGAAGT CAATCCTCAG 
TTGGCCACCT CAGAGGAAGA GGCGAAGACT ACAGCTAACC TGGCAGTAGA TGTGATTGCT 
TCAAGCTTTG GTCAGACAAG AGAAGGAGGG CATATTGTCT ATGACCAACT TCCTACTCCC 
AGTTCACCAG ATGAATCAGA AAATCAAGCA CGTGTGAGAA TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317712512(2017 Jul)
Wang Y,Zhao P,Qian D,Hu M,Zhang L,Shi H,Wang B

Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition.
Pigment cell & melanoma research30(6)521-530(2017 Jan)
Kim NH,Choi SH,Yi N,Lee TR,Lee AY

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ARG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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