KLRC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLRC2
Entrez Gene ID	3822
Full Name	killer cell lectin like receptor C2
Synonyms	CD159c,NKG2-C,NKG2C
General protein information	Preferred Names killer cell lectin like receptor C2 Names NKG2-C type II integral membrane protein CD159 antigen-like family member C NK cell receptor C NKG2-C-activating NK receptor killer cell lectin-like receptor subfamily C, member 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	602891

mRNA and Protein(s)

mRNA	Protein	Name
NM_002260.3	NP_002251.2	NKG2-C type II integral membrane protein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC100683403	XP_005637214.1
Pan troglodytes (chimpanzee)	LOC101058094	XP_003952157.1
Canis lupus familiaris (dog)	LOC611332	XP_005637492.1
Homo sapiens (human)	KLRC2	NP_002251.2
Canis lupus familiaris (dog)	LOC486692	XP_005637215.1
Canis lupus familiaris (dog)	LOC609192	XP_005642293.1
	KLRC2	NP_001098647.1
Canis lupus familiaris (dog)	LOC100683766	XP_005637216.1

Gene Ontology
Bibliography

Related articles in PubMed

NKG2C Deletion is a Risk Factor for Human Cytomegalovirus-Viremia and Disease after Lung Transplantation.
Vietzen H, Pollak K, Honsig C, Jaksch P, Puchhammer-St?ckl E
The Journal of infectious diseases(2017 Dec)

The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV.
Waters S, Lee S, Affandi JS, Irish A, Price P
Human immunology78(11-12)747-751(2017 Nov)

Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data.
Goncalves A, Makalo P, Joof H, Burr S, Ramadhani A, Massae P, Malisa A, Mtuy T, Derrick T, Last AR, Nabicassa M, Cassama E, Houghton J, Palmer CD, Pickering H, Burton MJ, Mabey DC, Bailey RL, Goodier MR, Holland MJ, Roberts CH
Human genetics135(8)939-51(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The new method offers the potential to use SNP arrays from genome wide association studies to study the frequency of KLRC2 deletion in other populations and its association with other diseases
Title: Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data.

Assessment of NK cell repertoires in 60 NKG2C(-/-) donors revealed a broad range of NK cell populations displaying characteristic footprints of adaptive NK cells, including a terminally differentiated phenotype, functional reprogramming, and epigenetic remodeling of the interferon (IFN)-gamma promoter.
Title: Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.

the data of this study extend the characterization of adaptive NK cell subsets that differentiate in response to human Cytomegalovirus, supporting a relationship between their distribution and NKG2C copy number
Title: Relationship of NKG2C Copy Number with the Distribution of Distinct Cytomegalovirus-Induced Adaptive NK Cell Subsets.

HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire
Title: HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire.

Data suggest the proinflammatory potential of NKG2C(bright) NK cells.
Title: Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus.

The following KLRC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLRC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu14184	NM_002260.3 Latest version!	Homo sapiens killer cell lectin like receptor C2 (KLRC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLRC2 ( NM_002260.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002251.2 Homo sapiens killer cell lectin like receptor C2 (KLRC2), mRNA.

Price & Availability↑

CloneID	OHu14184
Clone ID Related Accession (Same CDS sequence)	NM_002260.3
Accession Version	NM_002260.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	NKG2-C type II integral membrane protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X54869.1, AF260134.1 and AC068775.52. On or before Mar 29, 2008 this sequence version replaced XM_001713685.1, XM_001713701.1, NM_002260.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X54869.1, SRR1803616.358048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820689 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAATAAAC AAAGAGGAAC CTTCTCAGAA GTGAGTCTGG CCCAGGACCC AAAGCGGCAG 
CAAAGGAAAC CTAAAGGCAA TAAAAGCTCC ATTTCAGGAA CCGAACAGGA AATATTCCAA 
GTAGAATTAA ATCTTCAAAA TCCTTCCCTG AATCATCAAG GGATTGATAA AATATATGAC 
TGCCAAGGTT TACTGCCACC TCCAGAGAAG CTCACTGCCG AGGTCCTAGG AATCATTTGC 
ATTGTCCTGA TGGCCACTGT GTTAAAAACA ATAGTTCTTA TTCCTTTCCT GGAGCAGAAC 
AATTTTTCCC CGAATACAAG AACGCAGAAA GCACGTCATT GTGGCCATTG TCCTGAGGAG 
TGGATTACAT ATTCCAACAG TTGTTATTAC ATTGGTAAGG AAAGAAGAAC TTGGGAAGAG 
AGTTTGCTGG CCTGTACTTC GAAGAACTCC AGTCTGCTTT CTATAGATAA TGAAGAAGAA 
ATGAAATTTC TGGCCAGCAT TTTACCTTCC TCATGGATTG GTGTGTTTCG TAACAGCAGT 
CATCATCCAT GGGTGACAAT AAATGGTTTG GCTTTCAAAC ATAAGATAAA AGACTCAGAT 
AATGCTGAAC TTAACTGTGC AGTGCTACAA GTAAATCGAC TTAAATCAGC CCAGTGTGGA 
TCTTCAATGA TATATCATTG TAAGCATAAG CTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002251.2
CDS	8..703
Translation	MNKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNFSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL

Target ORF information:

RefSeq Version	NM_002260.3
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell lectin like receptor C2 (KLRC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002260.3

ORF Insert Sequence:

ATGAATAAAC AAAGAGGAAC CTTCTCAGAA GTGAGTCTGG CCCAGGACCC AAAGCGGCAG 
CAAAGGAAAC CTAAAGGCAA TAAAAGCTCC ATTTCAGGAA CCGAACAGGA AATATTCCAA 
GTAGAATTAA ATCTTCAAAA TCCTTCCCTG AATCATCAAG GGATTGATAA AATATATGAC 
TGCCAAGGTT TACTGCCACC TCCAGAGAAG CTCACTGCCG AGGTCCTAGG AATCATTTGC 
ATTGTCCTGA TGGCCACTGT GTTAAAAACA ATAGTTCTTA TTCCTTTCCT GGAGCAGAAC 
AATTTTTCCC CGAATACAAG AACGCAGAAA GCACGTCATT GTGGCCATTG TCCTGAGGAG 
TGGATTACAT ATTCCAACAG TTGTTATTAC ATTGGTAAGG AAAGAAGAAC TTGGGAAGAG 
AGTTTGCTGG CCTGTACTTC GAAGAACTCC AGTCTGCTTT CTATAGATAA TGAAGAAGAA 
ATGAAATTTC TGGCCAGCAT TTTACCTTCC TCATGGATTG GTGTGTTTCG TAACAGCAGT 
CATCATCCAT GGGTGACAAT AAATGGTTTG GCTTTCAAAC ATAAGATAAA AGACTCAGAT 
AATGCTGAAC TTAACTGTGC AGTGCTACAA GTAAATCGAC TTAAATCAGC CCAGTGTGGA 
TCTTCAATGA TATATCATTG TAAGCATAAG CTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NKG2C Deletion is a Risk Factor for Human Cytomegalovirus-Viremia and Disease after Lung Transplantation.
The Journal of infectious diseases(2017 Dec)
Vietzen H,Pollak K,Honsig C,Jaksch P,Puchhammer-St?ckl E

The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV.
Human immunology78(11-12)747-751(2017 Nov)
Waters S,Lee S,Affandi JS,Irish A,Price P

Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data.
Human genetics135(8)939-51(2016 Aug)
Goncalves A,Makalo P,Joof H,Burr S,Ramadhani A,Massae P,Malisa A,Mtuy T,Derrick T,Last AR,Nabicassa M,Cassama E,Houghton J,Palmer CD,Pickering H,Burton MJ,Mabey DC,Bailey RL,Goodier MR,Holland MJ,Roberts CH