KLK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLK1
Entrez Gene ID	3816
Full Name	kallikrein 1
Synonyms	KLKR,Klk6,hK1
General protein information	Preferred Names kallikrein 1 Names kallikrein-1 glandular kallikrein 1 kallikrein 1, renal/pancreas/salivary kallikrein serine protease 1 kidney/pancreas/salivary gland kallikrein tissue kallikrein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008].
Disorder MIM:	147910
Disorder Html:	[Kallikrein, decreased urinary activity of], 615953 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002257.3	NP_002248.1	kallikrein-1 preproprotein
XM_011526942.1	XP_011525244.1	kallikrein-1 isoform X1
NM_002257.4	NP_002248.1	kallikrein-1 preproprotein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Klk1c2	NP_036809.1
Rattus norvegicus (Norway rat)	Klk1c9	NP_786935.1
Rattus norvegicus (Norway rat)	LOC100911689	XP_003748896.1
Homo sapiens (human)	KLK1	NP_002248.1
Canis lupus familiaris (dog)	KLK1	NP_001003262.1
Rattus norvegicus (Norway rat)	Klk1c7	NP_036725.1
Rattus norvegicus (Norway rat)	Klk1c10	NP_001128645.1
Rattus norvegicus (Norway rat)	LOC100911764	XP_003748897.1
Bos taurus (cattle)	KLK1	NP_001008416.1
Rattus norvegicus (Norway rat)	Klk1	NP_113711.1
Rattus norvegicus (Norway rat)	Klk1c12	NP_001005382.1
Rattus norvegicus (Norway rat)	Klk1c6	NP_001003977.1
Rattus norvegicus (Norway rat)	LOC687880	XP_006229230.1
Rattus norvegicus (Norway rat)	Klk1c8	NP_001013085.1
Rattus norvegicus (Norway rat)	Klk1c3	NP_001258244.1

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of KLK1 polymorphism (rs5516) in patients with abdominal aortic aneurysm or thoracic aortic dissection.
Zhang Y, Huang H, Ma Y, Sun Y, Wang G, Tang L
The Journal of cardiovascular surgery(2017 Mar)

A positive association between the human tissue kallikerin gene A2233C polymorphism and blood pressure response to benazepril.
Hong Z, Pan L, Fei J, Ma Z, Hong Z
Clinical and experimental hypertension (New York, N.Y. : 1993)39(5)389-393(2017)

Association of the KLK1 rs5516 G allele and the ACE D allele with aortic aneurysm and atherosclerotic stenosis.
Zhang Y, Huang H, Ma Y, Sun Y, Wang G, Tang L
Medicine95(44)e5120(2016 Nov)

Moving Past Anti-VEGF: Novel Therapies for Treating Diabetic Retinopathy.
Bolinger MT, Antonetti DA
International journal of molecular sciences17(9)(2016 Sep)

Association of serum levels of AngII, KLK1, and ACE/KLK1 polymorphisms with acute myocardial infarction induced by coronary artery stenosis.
Dai SH, Li JF, Feng JB, Li RJ, Li CB, Li Z, Zhang Y, Li DQ
Journal of the renin-angiotensin-aldosterone system : JRAAS17(2)1470320316655037(2016 Apr-Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The rs5516 G allele of KLK1 was significantly associated with aortic aneurysm
Title: Association of the KLK1 rs5516 G allele and the ACE D allele with aortic aneurysm and atherosclerotic stenosis.

Recognition of anti-tumor necrosis factor-alpha (TNF-alpha) or Kallikrein Inhibitor may lead to therapeutics to enhance existing treatments for patients who do not respond to anti-vascular endothelial growth factor (VEGF) therapies.
Title: Moving Past Anti-VEGF: Novel Therapies for Treating Diabetic Retinopathy.

increasing the serum levels of AngII increased the risk of acute myocardial infarction (AMI); the risk of AMI increased when the serum levels of AngII and KLK1 simultaneously increased; individuals with the combined genotypes of ACE DD and KLK1 GG showed increased risk of AMI compared with those with the combined genotypes of ACE II and KLK1 AA
Title: Association of serum levels of AngII, KLK1, and ACE/KLK1 polymorphisms with acute myocardial infarction induced by coronary artery stenosis.

TK promoted cell survival and beta-catenin degradation in serum-starved SH-SY5Y cells via increasing autophagy.
Title: Tissue kallikrein promotes survival and ?-catenin degradation in SH-SY5Y cells under nutrient stress conditions via autophagy.

KLK1 rs5516 SNP is not related to the incidence of Alzheimer's disease in a Hunan Han Chinese population.
Title: Relationship between the gene polymorphisms of kallikrein-kinin system and Alzheimer's disease in a Hunan Han Chinese population.

The following KLK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21121	NM_002257.4 Latest version!	Homo sapiens kallikrein 1 (KLK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu52250	XM_011526942.1 Latest version!	Homo sapiens kallikrein 1 (KLK1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu21121	NM_002257.3	Homo sapiens kallikrein 1 (KLK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLK1 ( NM_002257.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002248.1 Homo sapiens kallikrein 1 (KLK1), mRNA.

Price & Availability↑

CloneID	OHu21121
Clone ID Related Accession (Same CDS sequence)	NM_002257.3 , NM_002257.4
Accession Version	NM_002257.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-25
Organism	Homo sapiens(human)
Product	kallikrein-1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP323011.1, X13561.1 and CA772631.1. This sequence is a reference standard in the RefSeqGene project. On Jul 11, 2013 this sequence version replaced NM_002257.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI759204.1, BC005313.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTGGTTCC TGGTTCTGTG CCTCGCCCTG TCCCTGGGGG GGACTGGTGC TGCGCCCCCG 
ATTCAGTCCC GGATTGTGGG AGGCTGGGAG TGTGAGCAGC ATTCCCAGCC CTGGCAGGCG 
GCTCTGTACC ATTTCAGCAC TTTCCAGTGT GGGGGCATCC TGGTGCACCG CCAGTGGGTG 
CTCACAGCTG CTCATTGCAT CAGCGACAAT TACCAGCTCT GGCTGGGTCG CCACAACTTG 
TTTGACGACG AAAACACAGC CCAGTTTGTT CATGTCAGTG AGAGCTTCCC ACACCCTGGC 
TTCAACATGA GCCTCCTGGA GAACCACACC CGCCAAGCAG ACGAGGACTA CAGCCACGAC 
CTCATGCTGC TCCGCCTGAC AGAGCCTGCT GATACCATCA CAGATGCTGT GAAGGTCGTG 
GAGTTGCCCA CCGAGGAACC CGAAGTGGGG AGCACCTGTT TGGCTTCCGG CTGGGGCAGC 
ATCGAACCAG AGAATTTCTC ATTTCCAGAT GATCTCCAGT GTGTGGACCT CAAAATCCTG 
CCTAATGATG AGTGCAAAAA AGCCCACGTC CAGAAGGTGA CAGACTTCAT GCTGTGTGTC 
GGACACCTGG AAGGTGGCAA AGACACCTGT GTGGGTGATT CAGGGGGCCC GCTGATGTGT 
GATGGTGTGC TCCAAGGTGT CACATCATGG GGCTACGTCC CTTGTGGCAC CCCCAATAAG 
CCTTCTGTCG CCGTCAGAGT GCTGTCTTAT GTGAAGTGGA TCGAGGACAC CATAGCGGAG 
AACTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002248.1
CDS	40..828
Translation	MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS

Target ORF information:

RefSeq Version	NM_002257.3
Organism	Homo sapiens(human)
Definition	Homo sapiens kallikrein 1 (KLK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002257.3

ORF Insert Sequence:

ATGTGGTTCC TGGTTCTGTG CCTCGCCCTG TCCCTGGGGG GGACTGGTGC TGCGCCCCCG 
ATTCAGTCCC GGATTGTGGG AGGCTGGGAG TGTGAGCAGC ATTCCCAGCC CTGGCAGGCG 
GCTCTGTACC ATTTCAGCAC TTTCCAGTGT GGGGGCATCC TGGTGCACCG CCAGTGGGTG 
CTCACAGCTG CTCATTGCAT CAGCGACAAT TACCAGCTCT GGCTGGGTCG CCACAACTTG 
TTTGACGACG AAAACACAGC CCAGTTTGTT CATGTCAGTG AGAGCTTCCC ACACCCTGGC 
TTCAACATGA GCCTCCTGGA GAACCACACC CGCCAAGCAG ACGAGGACTA CAGCCACGAC 
CTCATGCTGC TCCGCCTGAC AGAGCCTGCT GATACCATCA CAGATGCTGT GAAGGTCGTG 
GAGTTGCCCA CCGAGGAACC CGAAGTGGGG AGCACCTGTT TGGCTTCCGG CTGGGGCAGC 
ATCGAACCAG AGAATTTCTC ATTTCCAGAT GATCTCCAGT GTGTGGACCT CAAAATCCTG 
CCTAATGATG AGTGCAAAAA AGCCCACGTC CAGAAGGTGA CAGACTTCAT GCTGTGTGTC 
GGACACCTGG AAGGTGGCAA AGACACCTGT GTGGGTGATT CAGGGGGCCC GCTGATGTGT 
GATGGTGTGC TCCAAGGTGT CACATCATGG GGCTACGTCC CTTGTGGCAC CCCCAATAAG 
CCTTCTGTCG CCGTCAGAGT GCTGTCTTAT GTGAAGTGGA TCGAGGACAC CATAGCGGAG 
AACTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLK1 ( NM_002257.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002248.1 Homo sapiens kallikrein 1 (KLK1), mRNA.

Price & Availability↑

CloneID	OHu21121
Clone ID Related Accession (Same CDS sequence)	NM_002257.3 , NM_002257.4
Accession Version	NM_002257.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	kallikrein-1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP323011.1, X13561.1 and CA772631.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002257.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI759204.1, M25629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301420.3/ ENSP00000301420.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGGTTCC TGGTTCTGTG CCTCGCCCTG TCCCTGGGGG GGACTGGTGC TGCGCCCCCG 
ATTCAGTCCC GGATTGTGGG AGGCTGGGAG TGTGAGCAGC ATTCCCAGCC CTGGCAGGCG 
GCTCTGTACC ATTTCAGCAC TTTCCAGTGT GGGGGCATCC TGGTGCACCG CCAGTGGGTG 
CTCACAGCTG CTCATTGCAT CAGCGACAAT TACCAGCTCT GGCTGGGTCG CCACAACTTG 
TTTGACGACG AAAACACAGC CCAGTTTGTT CATGTCAGTG AGAGCTTCCC ACACCCTGGC 
TTCAACATGA GCCTCCTGGA GAACCACACC CGCCAAGCAG ACGAGGACTA CAGCCACGAC 
CTCATGCTGC TCCGCCTGAC AGAGCCTGCT GATACCATCA CAGATGCTGT GAAGGTCGTG 
GAGTTGCCCA CCGAGGAACC CGAAGTGGGG AGCACCTGTT TGGCTTCCGG CTGGGGCAGC 
ATCGAACCAG AGAATTTCTC ATTTCCAGAT GATCTCCAGT GTGTGGACCT CAAAATCCTG 
CCTAATGATG AGTGCAAAAA AGCCCACGTC CAGAAGGTGA CAGACTTCAT GCTGTGTGTC 
GGACACCTGG AAGGTGGCAA AGACACCTGT GTGGGTGATT CAGGGGGCCC GCTGATGTGT 
GATGGTGTGC TCCAAGGTGT CACATCATGG GGCTACGTCC CTTGTGGCAC CCCCAATAAG 
CCTTCTGTCG CCGTCAGAGT GCTGTCTTAT GTGAAGTGGA TCGAGGACAC CATAGCGGAG 
AACTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002248.1
CDS	40..828
Translation	MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS

Target ORF information:

RefSeq Version	NM_002257.4
Organism	Homo sapiens(human)
Definition	Homo sapiens kallikrein 1 (KLK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002257.4

ORF Insert Sequence:

ATGTGGTTCC TGGTTCTGTG CCTCGCCCTG TCCCTGGGGG GGACTGGTGC TGCGCCCCCG 
ATTCAGTCCC GGATTGTGGG AGGCTGGGAG TGTGAGCAGC ATTCCCAGCC CTGGCAGGCG 
GCTCTGTACC ATTTCAGCAC TTTCCAGTGT GGGGGCATCC TGGTGCACCG CCAGTGGGTG 
CTCACAGCTG CTCATTGCAT CAGCGACAAT TACCAGCTCT GGCTGGGTCG CCACAACTTG 
TTTGACGACG AAAACACAGC CCAGTTTGTT CATGTCAGTG AGAGCTTCCC ACACCCTGGC 
TTCAACATGA GCCTCCTGGA GAACCACACC CGCCAAGCAG ACGAGGACTA CAGCCACGAC 
CTCATGCTGC TCCGCCTGAC AGAGCCTGCT GATACCATCA CAGATGCTGT GAAGGTCGTG 
GAGTTGCCCA CCGAGGAACC CGAAGTGGGG AGCACCTGTT TGGCTTCCGG CTGGGGCAGC 
ATCGAACCAG AGAATTTCTC ATTTCCAGAT GATCTCCAGT GTGTGGACCT CAAAATCCTG 
CCTAATGATG AGTGCAAAAA AGCCCACGTC CAGAAGGTGA CAGACTTCAT GCTGTGTGTC 
GGACACCTGG AAGGTGGCAA AGACACCTGT GTGGGTGATT CAGGGGGCCC GCTGATGTGT 
GATGGTGTGC TCCAAGGTGT CACATCATGG GGCTACGTCC CTTGTGGCAC CCCCAATAAG 
CCTTCTGTCG CCGTCAGAGT GCTGTCTTAT GTGAAGTGGA TCGAGGACAC CATAGCGGAG 
AACTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLK1 ( XM_011526942.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525244.1 Homo sapiens kallikrein 1 (KLK1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu52250
Clone ID Related Accession (Same CDS sequence)	XM_011526942.1
Accession Version	XM_011526942.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	kallikrein-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCCTCC TGGAGAACCA CACCCGCCAA GCAGACGAGG ACTACAGCCA CGACCTCATG 
CTGCTCCGCC TGACAGAGCC TGCTGATACC ATCACAGATG CTGTGAAGGT CGTGGAGTTG 
CCCACCGAGG AACCCGAAGT GGGGAGCACC TGTTTGGCTT CCGGCTGGGG CAGCATCGAA 
CCAGAGAATT TCTCATTTCC AGATGATCTC CAGTGTGTGG ACCTCAAAAT CCTGCCTAAT 
GATGAGTGCA AAAAAGCCCA CGTCCAGAAG GTGACAGACT TCATGCTGTG TGTCGGACAC 
CTGGAAGGTG GCAAAGACAC CTGTGTGGGT GATTCAGGGG GCCCGCTGAT GTGTGATGGT 
GTGCTCCAAG GTGTCACATC ATGGGGCTAC GTCCCTTGTG GCACCCCCAA TAAGCCTTCT 
GTCGCCGTCA GAGTGCTGTC TTATGTGAAG TGGATCGAGG ACACCATAGC GGAGAACTCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525244.1
CDS	1242..1724
Translation	MSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS

Target ORF information:

RefSeq Version	XM_011526942.1
Organism	Homo sapiens(human)
Definition	Homo sapiens kallikrein 1 (KLK1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526942.1

ORF Insert Sequence:

ATGAGCCTCC TGGAGAACCA CACCCGCCAA GCAGACGAGG ACTACAGCCA CGACCTCATG 
CTGCTCCGCC TGACAGAGCC TGCTGATACC ATCACAGATG CTGTGAAGGT CGTGGAGTTG 
CCCACCGAGG AACCCGAAGT GGGGAGCACC TGTTTGGCTT CCGGCTGGGG CAGCATCGAA 
CCAGAGAATT TCTCATTTCC AGATGATCTC CAGTGTGTGG ACCTCAAAAT CCTGCCTAAT 
GATGAGTGCA AAAAAGCCCA CGTCCAGAAG GTGACAGACT TCATGCTGTG TGTCGGACAC 
CTGGAAGGTG GCAAAGACAC CTGTGTGGGT GATTCAGGGG GCCCGCTGAT GTGTGATGGT 
GTGCTCCAAG GTGTCACATC ATGGGGCTAC GTCCCTTGTG GCACCCCCAA TAAGCCTTCT 
GTCGCCGTCA GAGTGCTGTC TTATGTGAAG TGGATCGAGG ACACCATAGC GGAGAACTCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of KLK1 polymorphism (rs5516) in patients with abdominal aortic aneurysm or thoracic aortic dissection.
The Journal of cardiovascular surgery(2017 Mar)
Zhang Y,Huang H,Ma Y,Sun Y,Wang G,Tang L

A positive association between the human tissue kallikerin gene A2233C polymorphism and blood pressure response to benazepril.
Clinical and experimental hypertension (New York, N.Y. : 1993)39(5)389-393(2017)
Hong Z,Pan L,Fei J,Ma Z,Hong Z

Association of the KLK1 rs5516 G allele and the ACE D allele with aortic aneurysm and atherosclerotic stenosis.
Medicine95(44)e5120(2016 Nov)
Zhang Y,Huang H,Ma Y,Sun Y,Wang G,Tang L

Moving Past Anti-VEGF: Novel Therapies for Treating Diabetic Retinopathy.
International journal of molecular sciences17(9)(2016 Sep)
Bolinger MT,Antonetti DA

Association of serum levels of AngII, KLK1, and ACE/KLK1 polymorphisms with acute myocardial infarction induced by coronary artery stenosis.
Journal of the renin-angiotensin-aldosterone system : JRAAS17(2)1470320316655037(2016 Apr-Jun)
Dai SH,Li JF,Feng JB,Li RJ,Li CB,Li Z,Zhang Y,Li DQ

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KLK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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