Gene Symbol | ITGA3 |
Entrez Gene ID | 3675 |
Full Name | integrin subunit alpha 3 |
Synonyms | CD49C,FRP-2,GAP-B3,GAPB3,ILNEB,MSK18,VCA-2,VL3A,VLA3a |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(Human) |
Genome | |
Summary | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]. |
Disorder MIM: | |
Disorder Html: | Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital, 614748 (3) |