PFN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PFN3
Entrez Gene ID	345456
Full Name	profilin 3
General protein information	Preferred Names profilin 3 Names profilin-3 profilin III
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.3
Summary	The product of this gene belongs to the profilin family of proteins. This protein binds to actin and affects the structure of the cytoskeleton. It also may be involved in spermatogenesis. It is a single exon gene. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	612812

mRNA and Protein(s)

mRNA	Protein	Name
NM_001029886.2	NP_001025057.1	profilin-3
NM_001029886.3	NP_001025057.1	profilin-3

Pathways from BioSystems

Homologies

	PFN3	XP_001086728.1
Homo sapiens (human)	PFN3	NP_001025057.1
Pan troglodytes (chimpanzee)	PFN3	XP_527137.1
Mus musculus (house mouse)	Pfn3	NP_083579.1
Canis lupus familiaris (dog)	PFN3	XP_005619215.1
Bos taurus (cattle)	PFN3	NP_001071413.1
Rattus norvegicus (Norway rat)	Pfn3	NP_001102957.1
Gallus gallus (chicken)	PFN3	XP_004935365.1

Gene Ontology
Bibliography

Related articles in PubMed

Evolutionary expansion and structural functionalism of the ancient family of profilin proteins.
Pandey DK, Chaudhary B
Gene62670-86(2017 Aug)

Natural antisense transcription from a comparative perspective.
Piatek MJ, Henderson V, Zynad HS, Werner A
Genomics108(2)56-63(2016 08)

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
Inouye M, Ripatti S, Kettunen J, Lyytik?inen LP, Oksala N, Laurila PP, Kangas AJ, Soininen P, Savolainen MJ, Viikari J, K?h?nen M, Perola M, Salomaa V, Raitakari O, Lehtim?ki T, Taskinen MR, J?rvelin MR, Ala-Korpela M, Palotie A, de Bakker PI
PLoS genetics8(8)e1002907(2012)

A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
Urabe Y, Tanikawa C, Takahashi A, Okada Y, Morizono T, Tsunoda T, Kamatani N, Kohri K, Chayama K, Kubo M, Nakamura Y, Matsuda K
PLoS genetics8(3)e1002541(2012)

New loci associated with kidney function and chronic kidney disease.
K?ttgen A, Pattaro C, B?ger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Par? G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, T?njes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandst?tter A, Kollerits B, Kedenko L, M?gi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, V?lzke H, Kroemer HK, Nauck M, V?lker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Kr?mer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS
Nature genetics42(5)376-84(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Porfilin 3 has the actin-binding site conserved, but retains only approximately half of the common poly-L-proline binding site.
Title: Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids.

The following PFN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PFN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31557	NM_001029886.3 Latest version!	Homo sapiens profilin 3 (PFN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31557	NM_001029886.2	Homo sapiens profilin 3 (PFN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PFN3 ( NM_001029886.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025057.1 Homo sapiens profilin 3 (PFN3), mRNA.

Price & Availability↑

CloneID	OHu31557
Clone ID Related Accession (Same CDS sequence)	NM_001029886.2 , NM_001029886.3
Accession Version	NM_001029886.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	profilin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC132952.1 and AA909745.1. On Feb 6, 2008 this sequence version replaced NM_001029886.1. COMPLETENESS: complete on the 3' end.

ATGGGCGACT GGAAGGTCTA CATCAGTGCA GTGCTGCGGG ACCAGCGCAT CGACGACGTG 
GCCATCGTGG GCCATGCGGA CAACAGCTGC GTGTGGGCTT CGCGGCCCGG GGGCCTGCTG 
GCGGCCATCT CGCCGCAGGA GGTGGGCGTG CTCACGGGGC CGGACAGGCA CACCTTCCTG 
CAGGCGGGCC TGAGCGTGGG GGGCCGCCGC TGCTGCGTCA TCCGCGACCA CCTGCTGGCC 
GAGGGTGACG GCGTGCTGGA CGCACGCACC AAGGGGCTGG ACGCGCGCGC CGTGTGCGTG 
GGCCGTGCGC CGCGCGCGCT CCTGGTGCTA ATGGGCCGAC GCGGCGTACA TGGGGGCATC 
CTCAACAAGA CGGTGCACGA ACTCATACGC GGGCTGCGCA TGCAGGGCGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025057.1
CDS	61..474
Translation	MGDWKVYISAVLRDQRIDDVAIVGHADNSCVWASRPGGLLAAISPQEVGVLTGPDRHTFLQAGLSVGGRRCCVIRDHLLAEGDGVLDARTKGLDARAVCVGRAPRALLVLMGRRGVHGGILNKTVHELIRGLRMQGA

Target ORF information:

RefSeq Version	NM_001029886.2
Organism	Homo sapiens(human)
Definition	Homo sapiens profilin 3 (PFN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029886.2

ORF Insert Sequence:

ATGGGCGACT GGAAGGTCTA CATCAGTGCA GTGCTGCGGG ACCAGCGCAT CGACGACGTG 
GCCATCGTGG GCCATGCGGA CAACAGCTGC GTGTGGGCTT CGCGGCCCGG GGGCCTGCTG 
GCGGCCATCT CGCCGCAGGA GGTGGGCGTG CTCACGGGGC CGGACAGGCA CACCTTCCTG 
CAGGCGGGCC TGAGCGTGGG GGGCCGCCGC TGCTGCGTCA TCCGCGACCA CCTGCTGGCC 
GAGGGTGACG GCGTGCTGGA CGCACGCACC AAGGGGCTGG ACGCGCGCGC CGTGTGCGTG 
GGCCGTGCGC CGCGCGCGCT CCTGGTGCTA ATGGGCCGAC GCGGCGTACA TGGGGGCATC 
CTCAACAAGA CGGTGCACGA ACTCATACGC GGGCTGCGCA TGCAGGGCGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PFN3 ( NM_001029886.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025057.1 Homo sapiens profilin 3 (PFN3), mRNA.

Price & Availability↑

CloneID	OHu31557
Clone ID Related Accession (Same CDS sequence)	NM_001029886.2 , NM_001029886.3
Accession Version	NM_001029886.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	profilin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC145098.2, BC132952.1 and AA909745.1. On Nov 22, 2018 this sequence version replaced NM_001029886.2. ##Evidence-Data-START## Transcript is intronless :: BC132954.1, HY027629.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000358571.3/ ENSP00000351379.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCGACT GGAAGGTCTA CATCAGTGCA GTGCTGCGGG ACCAGCGCAT CGACGACGTG 
GCCATCGTGG GCCATGCGGA CAACAGCTGC GTGTGGGCTT CGCGGCCCGG GGGCCTGCTG 
GCGGCCATCT CGCCGCAGGA GGTGGGCGTG CTCACGGGGC CGGACAGGCA CACCTTCCTG 
CAGGCGGGCC TGAGCGTGGG GGGCCGCCGC TGCTGCGTCA TCCGCGACCA CCTGCTGGCC 
GAGGGTGACG GCGTGCTGGA CGCACGCACC AAGGGGCTGG ACGCGCGCGC CGTGTGCGTG 
GGCCGTGCGC CGCGCGCGCT CCTGGTGCTA ATGGGCCGAC GCGGCGTACA TGGGGGCATC 
CTCAACAAGA CGGTGCACGA ACTCATACGC GGGCTGCGCA TGCAGGGCGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025057.1
CDS	86..499
Translation	MGDWKVYISAVLRDQRIDDVAIVGHADNSCVWASRPGGLLAAISPQEVGVLTGPDRHTFLQAGLSVGGRRCCVIRDHLLAEGDGVLDARTKGLDARAVCVGRAPRALLVLMGRRGVHGGILNKTVHELIRGLRMQGA

Target ORF information:

RefSeq Version	NM_001029886.3
Organism	Homo sapiens(human)
Definition	Homo sapiens profilin 3 (PFN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029886.3

ORF Insert Sequence:

ATGGGCGACT GGAAGGTCTA CATCAGTGCA GTGCTGCGGG ACCAGCGCAT CGACGACGTG 
GCCATCGTGG GCCATGCGGA CAACAGCTGC GTGTGGGCTT CGCGGCCCGG GGGCCTGCTG 
GCGGCCATCT CGCCGCAGGA GGTGGGCGTG CTCACGGGGC CGGACAGGCA CACCTTCCTG 
CAGGCGGGCC TGAGCGTGGG GGGCCGCCGC TGCTGCGTCA TCCGCGACCA CCTGCTGGCC 
GAGGGTGACG GCGTGCTGGA CGCACGCACC AAGGGGCTGG ACGCGCGCGC CGTGTGCGTG 
GGCCGTGCGC CGCGCGCGCT CCTGGTGCTA ATGGGCCGAC GCGGCGTACA TGGGGGCATC 
CTCAACAAGA CGGTGCACGA ACTCATACGC GGGCTGCGCA TGCAGGGCGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evolutionary expansion and structural functionalism of the ancient family of profilin proteins.
Gene62670-86(2017 Aug)
Pandey DK,Chaudhary B

Natural antisense transcription from a comparative perspective.
Genomics108(2)56-63(2016 08)
Piatek MJ,Henderson V,Zynad HS,Werner A

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
PLoS genetics8(8)e1002907(2012)
Inouye M,Ripatti S,Kettunen J,Lyytik?inen LP,Oksala N,Laurila PP,Kangas AJ,Soininen P,Savolainen MJ,Viikari J,K?h?nen M,Perola M,Salomaa V,Raitakari O,Lehtim?ki T,Taskinen MR,J?rvelin MR,Ala-Korpela M,Palotie A,de Bakker PI

A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
PLoS genetics8(3)e1002541(2012)
Urabe Y,Tanikawa C,Takahashi A,Okada Y,Morizono T,Tsunoda T,Kamatani N,Kohri K,Chayama K,Kubo M,Nakamura Y,Matsuda K

New loci associated with kidney function and chronic kidney disease.
Nature genetics42(5)376-84(2010 May)
K?ttgen A,Pattaro C,B?ger CA,Fuchsberger C,Olden M,Glazer NL,Parsa A,Gao X,Yang Q,Smith AV,O'Connell JR,Li M,Schmidt H,Tanaka T,Isaacs A,Ketkar S,Hwang SJ,Johnson AD,Dehghan A,Teumer A,Par? G,Atkinson EJ,Zeller T,Lohman K,Cornelis MC,Probst-Hensch NM,Kronenberg F,T?njes A,Hayward C,Aspelund T,Eiriksdottir G,Launer LJ,Harris TB,Rampersaud E,Mitchell BD,Arking DE,Boerwinkle E,Struchalin M,Cavalieri M,Singleton A,Giallauria F,Metter J,de Boer IH,Haritunians T,Lumley T,Siscovick D,Psaty BM,Zillikens MC,Oostra BA,Feitosa M,Province M,de Andrade M,Turner ST,Schillert A,Ziegler A,Wild PS,Schnabel RB,Wilde S,Munzel TF,Leak TS,Illig T,Klopp N,Meisinger C,Wichmann HE,Koenig W,Zgaga L,Zemunik T,Kolcic I,Minelli C,Hu FB,Johansson A,Igl W,Zaboli G,Wild SH,Wright AF,Campbell H,Ellinghaus D,Schreiber S,Aulchenko YS,Felix JF,Rivadeneira F,Uitterlinden AG,Hofman A,Imboden M,Nitsch D,Brandst?tter A,Kollerits B,Kedenko L,M?gi R,Stumvoll M,Kovacs P,Boban M,Campbell S,Endlich K,V?lzke H,Kroemer HK,Nauck M,V?lker U,Polasek O,Vitart V,Badola S,Parker AN,Ridker PM,Kardia SL,Blankenberg S,Liu Y,Curhan GC,Franke A,Rochat T,Paulweber B,Prokopenko I,Wang W,Gudnason V,Shuldiner AR,Coresh J,Schmidt R,Ferrucci L,Shlipak MG,van Duijn CM,Borecki I,Kr?mer BK,Rudan I,Gyllensten U,Wilson JF,Witteman JC,Pramstaller PP,Rettig R,Hastie N,Chasman DI,Kao WH,Heid IM,Fox CS

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PFN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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