GYPB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GYPB
Entrez Gene ID	2994
Full Name	glycophorin B (MNS blood group)
Synonyms	CD235b,GPB,GYP,MNS,PAS-3,SS
General protein information	Preferred Names glycophorin B (MNS blood group) Names glycophorin-B GYPB-A fusion GYPB-A-B fusion GYPB/GYPA fusion SS-active sialoglycoprotein Ss blood group blood group system MNSs, Mur-like blood group system MNSs, St(a) type E blood group system MNSs, St(a) type F glycophorin B blood group antigen glycophorin B, blood group system Ss, S, Mit+ glycophorin B/glycophorin A fusion protein glycophorin Hop hybrid glycophorin Kip sialoglycoprotein delta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q31.21
Summary	Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Disorder MIM:	111740
Disorder Html:	[Blood group, Ss] (3); {Malaria, resistance to}, 611162 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011531904.3	XP_011530206.1	glycophorin-B isoform X2
NM_001304382.1	NP_001291311.1	glycophorin-B isoform 2
XM_011531905.2	XP_011530207.1	glycophorin-B isoform X3
NM_002100.6	NP_002091.4	glycophorin-B isoform 1 precursor
NM_002100.5	NP_002091.3	glycophorin-B isoform 1 precursor
XM_011531904.2	XP_011530206.1	glycophorin-B isoform X2
XM_011531903.2	XP_011530205.1	glycophorin-B isoform X1
XM_017008137.1	XP_016863626.1	glycophorin-B isoform X4

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes.
Dankwa S, Chaand M, Kanjee U, Jiang RHY, Nobre LV, Goldberg JM, Bei AK, Moechtar MA, Gr?ring C, Ahouidi AD, Ndiaye D, Dieye TN, Mboup S, Weekes MP, Duraisingh MT
Infection and immunity85(10)(2017 Oct)

Resistance to malaria through structural variation of red blood cell invasion receptors.
Leffler EM, Band G, Busby GBJ, Kivinen K, Le QS, Clarke GM, Bojang KA, Conway DJ, Jallow M, Sisay-Joof F, Bougouma EC, Mangano VD, Modiano D, Sirima SB, Achidi E, Apinjoh TO, Marsh K, Ndila CM, Peshu N, Williams TN, Drakeley C, Manjurano A, Reyburn H, Riley E, Kachala D, Molyneux M, Nyirongo V, Taylor T, Thornton N, Tilley L, Grimsley S, Drury E, Stalker J, Cornelius V, Hubbart C, Jeffreys AE, Rowlands K, Rockett KA, Spencer CCA, Kwiatkowski DP,
Science (New York, N.Y.)356(6343)(2017 06)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

MN typing discrepancies based on GYPA-B-A hybrid.
Polin H, Danzer M, Reiter A, Brisner M, Gaszner W, Weinberger J, Gabriel C
Vox sanguinis107(4)393-8(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

through bioinformatic analysis, identified extensive variation in GYPB transcript levels in individuals from Benin, suggesting selection from malaria pressure; collective data suggest that the GPA and GPB receptors are of greater importance than the GPC receptor, supporting a hierarchy of erythrocyte receptor usage in P. falciparum
Title: Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes.

A novel GYPB mutation (c.270+5G>A) accounting for the S-s-U+(var) phenotype was identified.
Title: Family study of a Swiss patient uncovered a novel genetic basis for the S-s-U+(var) phenotype.

MNSs blood group glycophorin variants in Taiwan: a genotype-serotype correlation study of 'Mi(a)' and St(a) with report of two new alleles for St(a).
Title: MNSs blood group glycophorin variants in Taiwan: a genotype-serotype correlation study of 'Mi(a)' and St(a) with report of two new alleles for St(a).

Substitution of GPB with Gp.Mur significantly reduced the expression of Rh antigen and RhAG on the Mi.III(+/+) erythrocyte membrane
Title: Expression of the Rh/RhAG complex is reduced in Mi.III erythrocytes.

an increased susceptibility to infection by this parasite is associated with the glycophorin B S+ variant in Brazilian Amazons
Title: Population genetics of GYPB and association study between GYPB*S/s polymorphism and susceptibility to P. falciparum infection in the Brazilian Amazon.

The following GYPB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GYPB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22157	NM_002100.5 Latest version!	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu58169	NM_001304382.1 Latest version!	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu58170	XM_011531903.2 Latest version!	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu58171	XM_011531904.3 Latest version!	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu58172	XM_011531905.2 Latest version!	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu95148	XM_017008137.1 Latest version!	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu109440	NM_002100.6 Latest version!	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu58171	XM_011531904.2	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GYPB ( NM_002100.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002091.3 Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22157
Clone ID Related Accession (Same CDS sequence)	NM_002100.5
Accession Version	NM_002100.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	glycophorin-B isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093890.3, BC069310.1 and X08055.1. On Jan 23, 2015 this sequence version replaced NM_002100.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC121077.1, J02982.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTATGGAA AAATAATCTT TGTATTACTA TTGTCAGAAA TTGTGAGCAT ATCAGCATTA 
AGTACCACTG AGGTGGCAAT GCACACTTCA ACCTCTTCTT CAGTCACAAA GAGTTACATC 
TCATCACAGA CAAATGGAGA AACGGGACAA CTTGTCCATC GTTTCACTGT ACCAGCTCCT 
GTAGTGATAA TACTCATTAT TTTGTGTGTG ATGGCTGGTA TTATTGGAAC GATCCTCTTA 
ATTTCTTACA CTATTCGCCG ACTGATAAAG GCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002091.3
CDS	59..334
Translation	MYGKIIFVLLLSEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYTIRRLIKA

Target ORF information:

RefSeq Version	NM_002100.5
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002100.5

ORF Insert Sequence:

ATGTATGGAA AAATAATCTT TGTATTACTA TTGTCAGAAA TTGTGAGCAT ATCAGCATTA 
AGTACCACTG AGGTGGCAAT GCACACTTCA ACCTCTTCTT CAGTCACAAA GAGTTACATC 
TCATCACAGA CAAATGGAGA AACGGGACAA CTTGTCCATC GTTTCACTGT ACCAGCTCCT 
GTAGTGATAA TACTCATTAT TTTGTGTGTG ATGGCTGGTA TTATTGGAAC GATCCTCTTA 
ATTTCTTACA CTATTCGCCG ACTGATAAAG GCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPB ( NM_001304382.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291311.1 Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu58169
Clone ID Related Accession (Same CDS sequence)	NM_001304382.1
Accession Version	NM_001304382.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-14
Organism	Homo sapiens(human)
Product	glycophorin-B isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093890.3, X08055.1 and BC069310.1. Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2144333, SAMEA2144335 [ECO:0000350] ##Evidence-Data-END##

ATGCACACTT CAACCTCTTC TTCAGTCACA AAGAGTTACA TCTCATCACA GACAAATGGA 
GAAACGGGAC AACTTGTCCA TCGTTTCACT GTACCAGCTC CTGTAGTGAT AATACTCATT 
ATTTTGTGTG TGATGGCTGG TATTATTGGA ACGATCCTCT TAATTTCTTA CACTATTCGC 
CGACTGATAA AGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291311.1
CDS	217..414
Translation	MHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYTIRRLIKA

Target ORF information:

RefSeq Version	NM_001304382.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304382.1

ORF Insert Sequence:

ATGCACACTT CAACCTCTTC TTCAGTCACA AAGAGTTACA TCTCATCACA GACAAATGGA 
GAAACGGGAC AACTTGTCCA TCGTTTCACT GTACCAGCTC CTGTAGTGAT AATACTCATT 
ATTTTGTGTG TGATGGCTGG TATTATTGGA ACGATCCTCT TAATTTCTTA CACTATTCGC 
CGACTGATAA AGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPB ( XM_011531903.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530205.1 Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu58170
Clone ID Related Accession (Same CDS sequence)	XM_011531903.2
Accession Version	XM_011531903.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	glycophorin-B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011531903.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTATGGAA AAATAATCTT TGTATTACTA TTGTCAGAAA TTGTGAGCAT ATCAGCATTA 
AGTACCACTG AGGTGGCAAT GCACACTTCA ACCTCTTCTT CAGTCACAAA GAGTTACATC 
TCATCACAGA CAAATGGAGA AACGGGACAA CTTGTCCATC GTTTCACTGT ACCAGCTCCT 
GTAGTGATAA TACTCATTAT TTTGTGTGTG ATGGCTGGTA TTATTGGAAC GATCCTCTTA 
ATTTCTTACA GTATTCGCCG ACTGATAAAG GTGACTGCTT TGAATGTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530205.1
CDS	194..484
Translation	MYGKIIFVLLLSEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYSIRRLIKVTALNV

Target ORF information:

RefSeq Version	XM_011531903.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531903.2

ORF Insert Sequence:

ATGTATGGAA AAATAATCTT TGTATTACTA TTGTCAGAAA TTGTGAGCAT ATCAGCATTA 
AGTACCACTG AGGTGGCAAT GCACACTTCA ACCTCTTCTT CAGTCACAAA GAGTTACATC 
TCATCACAGA CAAATGGAGA AACGGGACAA CTTGTCCATC GTTTCACTGT ACCAGCTCCT 
GTAGTGATAA TACTCATTAT TTTGTGTGTG ATGGCTGGTA TTATTGGAAC GATCCTCTTA 
ATTTCTTACA GTATTCGCCG ACTGATAAAG GTGACTGCTT TGAATGTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPB ( XM_011531904.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530206.1 Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu58171
Clone ID Related Accession (Same CDS sequence)	XM_011531904.3 , XM_011531904.2
Accession Version	XM_011531904.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	glycophorin-B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011531904.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAAAG AAATTGTGAG CATATCAGCA TTAAGTACCA CTGAGGTGGC AATGCACACT 
TCAACCTCTT CTTCAGTCAC AAAGAGTTAC ATCTCATCAC AGACAAATGG AGAAACGGGA 
CAACTTGTCC ATCGTTTCAC TGTACCAGCT CCTGTAGTGA TAATACTCAT TATTTTGTGT 
GTGATGGCTG GTATTATTGG AACGATCCTC TTAATTTCTT ACAGTATTCG CCGACTGATA 
AAGGTGACTG CTTTGAATGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530206.1
CDS	2726..2989
Translation	MSKEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYSIRRLIKVTALNV

Target ORF information:

RefSeq Version	XM_011531904.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531904.3

ORF Insert Sequence:

ATGAGCAAAG AAATTGTGAG CATATCAGCA TTAAGTACCA CTGAGGTGGC AATGCACACT 
TCAACCTCTT CTTCAGTCAC AAAGAGTTAC ATCTCATCAC AGACAAATGG AGAAACGGGA 
CAACTTGTCC ATCGTTTCAC TGTACCAGCT CCTGTAGTGA TAATACTCAT TATTTTGTGT 
GTGATGGCTG GTATTATTGG AACGATCCTC TTAATTTCTT ACAGTATTCG CCGACTGATA 
AAGGTGACTG CTTTGAATGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPB ( XM_011531904.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530206.1 Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu58171
Clone ID Related Accession (Same CDS sequence)	XM_011531904.3 , XM_011531904.2
Accession Version	XM_011531904.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	glycophorin-B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011531904.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAAAG AAATTGTGAG CATATCAGCA TTAAGTACCA CTGAGGTGGC AATGCACACT 
TCAACCTCTT CTTCAGTCAC AAAGAGTTAC ATCTCATCAC AGACAAATGG AGAAACGGGA 
CAACTTGTCC ATCGTTTCAC TGTACCAGCT CCTGTAGTGA TAATACTCAT TATTTTGTGT 
GTGATGGCTG GTATTATTGG AACGATCCTC TTAATTTCTT ACAGTATTCG CCGACTGATA 
AAGGTGACTG CTTTGAATGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530206.1
CDS	2725..2988
Translation	MSKEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYSIRRLIKVTALNV

Target ORF information:

RefSeq Version	XM_011531904.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531904.2

ORF Insert Sequence:

ATGAGCAAAG AAATTGTGAG CATATCAGCA TTAAGTACCA CTGAGGTGGC AATGCACACT 
TCAACCTCTT CTTCAGTCAC AAAGAGTTAC ATCTCATCAC AGACAAATGG AGAAACGGGA 
CAACTTGTCC ATCGTTTCAC TGTACCAGCT CCTGTAGTGA TAATACTCAT TATTTTGTGT 
GTGATGGCTG GTATTATTGG AACGATCCTC TTAATTTCTT ACAGTATTCG CCGACTGATA 
AAGGTGACTG CTTTGAATGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPB ( XM_011531905.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530207.1 Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu58172
Clone ID Related Accession (Same CDS sequence)	XM_011531905.2
Accession Version	XM_011531905.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	glycophorin-B isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011531905.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAAAG AAATTGTGAG CATATCAGCA TTAAGTACCA CTGAGGTGGC AATGCACACT 
TCAACCTCTT CTTCAGTCAC AAAGAGTTAC ATCTCATCAC AGACAAATGG AGAAACGGGA 
CAACTTGTCC ATCGTTTCAC TGTACCAGCT CCTGTAGTGA TAATACTCAT TATTTTGTGT 
GTGATGGCTG GTATTATTGG AACGATCCTC TTAATTTCTT ACAGTATTCG CCGACTGATA 
AAGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530207.1
CDS	373..621
Translation	MSKEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYSIRRLIKA

Target ORF information:

RefSeq Version	XM_011531905.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531905.2

ORF Insert Sequence:

ATGAGCAAAG AAATTGTGAG CATATCAGCA TTAAGTACCA CTGAGGTGGC AATGCACACT 
TCAACCTCTT CTTCAGTCAC AAAGAGTTAC ATCTCATCAC AGACAAATGG AGAAACGGGA 
CAACTTGTCC ATCGTTTCAC TGTACCAGCT CCTGTAGTGA TAATACTCAT TATTTTGTGT 
GTGATGGCTG GTATTATTGG AACGATCCTC TTAATTTCTT ACAGTATTCG CCGACTGATA 
AAGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPB ( XM_017008137.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863626.1 Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu95148
Clone ID Related Accession (Same CDS sequence)	XM_017008137.1
Accession Version	XM_017008137.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	glycophorin-B isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACACTT CAACCTCTTC TTCAGTCACA AAGAGTTACA TCTCATCACA GACAAATGGA 
GAAACGGGAC AACTTGTCCA TCGTTTCACT GTACCAGCTC CTGTAGTGAT AATACTCATT 
ATTTTGTGTG TGATGGCTGG TATTATTGGA ACGATCCTCT TAATTTCTTA CAGTATTCGC 
CGACTGATAA AGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863626.1
CDS	2471..2668
Translation	MHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYSIRRLIKA

Target ORF information:

RefSeq Version	XM_017008137.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008137.1

ORF Insert Sequence:

ATGCACACTT CAACCTCTTC TTCAGTCACA AAGAGTTACA TCTCATCACA GACAAATGGA 
GAAACGGGAC AACTTGTCCA TCGTTTCACT GTACCAGCTC CTGTAGTGAT AATACTCATT 
ATTTTGTGTG TGATGGCTGG TATTATTGGA ACGATCCTCT TAATTTCTTA CAGTATTCGC 
CGACTGATAA AGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPB ( NM_002100.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_002091.4 Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu109440
Clone ID Related Accession (Same CDS sequence)	NM_002100.6
Accession Version	NM_002100.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	glycophorin-B isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093890.3, BC069310.1 and X08055.1. This sequence is a reference standard in the RefSeqGene project. On Sep 11, 2019 this sequence version replaced NM_002100.5. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC121077.1, J02982.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTATGGAA AAATAATCTT TGTATTACTA TTGTCAGAAA TTGTGAGCAT ATCAGCATTA 
AGTACCACTG AGGTGGCAAT GCACACTTCA ACCTCTTCTT CAGTCACAAA GAGTTACATC 
TCATCACAGA CAAATGGAGA AACGGGACAA CTTGTCCATC GTTTCACTGT ACCAGCTCCT 
GTAGTGATAA TACTCATTAT TTTGTGTGTG ATGGCTGGTA TTATTGGAAC GATCCTCTTA 
ATTTCTTACA GTATTCGCCG ACTGATAAAG GCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002091.4
CDS	94..369
Translation	MYGKIIFVLLLSEIVSISALSTTEVAMHTSTSSSVTKSYISSQTNGETGQLVHRFTVPAPVVIILIILCVMAGIIGTILLISYSIRRLIKA

Target ORF information:

RefSeq Version	NM_002100.6
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002100.6

ORF Insert Sequence:

ATGTATGGAA AAATAATCTT TGTATTACTA TTGTCAGAAA TTGTGAGCAT ATCAGCATTA 
AGTACCACTG AGGTGGCAAT GCACACTTCA ACCTCTTCTT CAGTCACAAA GAGTTACATC 
TCATCACAGA CAAATGGAGA AACGGGACAA CTTGTCCATC GTTTCACTGT ACCAGCTCCT 
GTAGTGATAA TACTCATTAT TTTGTGTGTG ATGGCTGGTA TTATTGGAAC GATCCTCTTA 
ATTTCTTACA GTATTCGCCG ACTGATAAAG GCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes.
Infection and immunity85(10)(2017 Oct)
Dankwa S,Chaand M,Kanjee U,Jiang RHY,Nobre LV,Goldberg JM,Bei AK,Moechtar MA,Gr?ring C,Ahouidi AD,Ndiaye D,Dieye TN,Mboup S,Weekes MP,Duraisingh MT

Resistance to malaria through structural variation of red blood cell invasion receptors.
Science (New York, N.Y.)356(6343)(2017 06)
Leffler EM,Band G,Busby GBJ,Kivinen K,Le QS,Clarke GM,Bojang KA,Conway DJ,Jallow M,Sisay-Joof F,Bougouma EC,Mangano VD,Modiano D,Sirima SB,Achidi E,Apinjoh TO,Marsh K,Ndila CM,Peshu N,Williams TN,Drakeley C,Manjurano A,Reyburn H,Riley E,Kachala D,Molyneux M,Nyirongo V,Taylor T,Thornton N,Tilley L,Grimsley S,Drury E,Stalker J,Cornelius V,Hubbart C,Jeffreys AE,Rowlands K,Rockett KA,Spencer CCA,Kwiatkowski DP,

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

MN typing discrepancies based on GYPA-B-A hybrid.
Vox sanguinis107(4)393-8(2014 Nov)
Polin H,Danzer M,Reiter A,Brisner M,Gaszner W,Weinberger J,Gabriel C

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GYPB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

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