IL17B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL17B
Entrez Gene ID	27190
Full Name	interleukin 17B
Synonyms	IL-17B,IL-20,NIRF,ZCYTO7
General protein information	Preferred Names interleukin 17B Names interleukin-17B cytokine-like protein ZCYTO7 interleukin 20 interleukin-17 beta neuronal interleukin-17 related factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q32
Summary	The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015].
Disorder MIM:	604627

mRNA and Protein(s)

mRNA	Protein	Name
XM_017009348.1	XP_016864837.1	interleukin-17B isoform X2
XM_017009346.1	XP_016864835.1	interleukin-17B isoform X1
NM_014443.3	NP_055258.1	interleukin-17B isoform 1 precursor
XM_011537622.2	XP_011535924.1	interleukin-17B isoform X2
NM_014443.2	NP_055258.1	interleukin-17B isoform 1 precursor
NM_001317987.1	NP_001304916.1	interleukin-17B isoform 2
XM_017009347.1	XP_016864836.1	interleukin-17B isoform X2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Il17b	NP_062381.1
Rattus norvegicus (Norway rat)	Il17b	NP_446241.1
	IL17B	XP_001106071.1
Gallus gallus (chicken)	IL17B	XP_004944894.1
Homo sapiens (human)	IL17B	NP_055258.1
Bos taurus (cattle)	IL17B	NP_001178974.1
Canis lupus familiaris (dog)	IL17B	XP_546311.1
Xenopus tropicalis (tropical clawed frog)	il17b	NP_001006699.1
Pan troglodytes (chimpanzee)	IL17B	XP_001163413.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of IL17B-IL17RB signaling pathway in breast cancer.
Alinejad V, Dolati S, Motallebnezhad M, Yousefi M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie88795-803(2017 Apr)

IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells.
Bie Q, Zhang B, Sun C, Ji X, Barnie PA, Qi C, Peng J, Zhang D, Zheng D, Su Z, Wang S, Xu H
Oncotarget8(12)18914-18923(2017 Mar)

Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/?-catenin pathway to enhance the stemness of gastric cancer.
Bie Q, Sun C, Gong A, Li C, Su Z, Zheng D, Ji X, Wu Y, Guo Q, Wang S, Xu H
Scientific reports625447(2016 05)

Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.
Karolak JA, Gambin T, Pitarque JA, Molinari A, Jhangiani S, Stankiewicz P, Lupski JR, Gajecka M
European journal of human genetics : EJHG25(1)73-78(2016 01)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW}
Title: The role of IL17B-IL17RB signaling pathway in breast cancer.

Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells.
Title: IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells.

Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family
Title: Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.

Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy.
Title: Targeting interleukin-17 receptors.

IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy.
Title: Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines.

The following IL17B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL17B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55960	NM_014443.3 Latest version!	Homo sapiens interleukin 17B (IL17B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu39853	NM_001317987.1 Latest version!	Homo sapiens interleukin 17B (IL17B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu39853	XM_017009347.1 Latest version!	Homo sapiens interleukin 17B (IL17B), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu39853	XM_017009348.1 Latest version!	Homo sapiens interleukin 17B (IL17B), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu39853	XM_011537622.2 Latest version!	Homo sapiens interleukin 17B (IL17B), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu95826	XM_017009346.1 Latest version!	Homo sapiens interleukin 17B (IL17B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu55960	NM_014443.2	Homo sapiens interleukin 17B (IL17B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL17B ( NM_014443.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055258.1 Homo sapiens interleukin 17B (IL17B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55960
Clone ID Related Accession (Same CDS sequence)	NM_014443.3 , NM_014443.2
Accession Version	NM_014443.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Homo sapiens(human)
Product	interleukin-17B isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC131025.1. On Nov 25, 2018 this sequence version replaced NM_014443.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF212311.1, AF152098.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2149178, SAMEA2158188 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261796.4/ ENSP00000261796.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACTGGC CTCACAACCT GCTGTTTCTT CTTACCATTT CCATCTTCCT GGGGCTGGGC 
CAGCCCAGGA GCCCCAAAAG CAAGAGGAAG GGGCAAGGGC GGCCTGGGCC CCTGGCCCCT 
GGCCCTCACC AGGTGCCACT GGACCTGGTG TCACGGATGA AACCGTATGC CCGCATGGAG 
GAGTATGAGA GGAACATCGA GGAGATGGTG GCCCAGCTGA GGAACAGCTC AGAGCTGGCC 
CAGAGAAAGT GTGAGGTCAA CTTGCAGCTG TGGATGTCCA ACAAGAGGAG CCTGTCTCCC 
TGGGGCTACA GCATCAACCA CGACCCCAGC CGTATCCCCG TGGACCTGCC GGAGGCACGG 
TGCCTGTGTC TGGGCTGTGT GAACCCCTTC ACCATGCAGG AGGACCGCAG CATGGTGAGC 
GTGCCGGTGT TCAGCCAGGT TCCTGTGCGC CGCCGCCTCT GCCCGCCACC GCCCCGCACA 
GGGCCTTGCC GCCAGCGCGC AGTCATGGAG ACCATCGCTG TGGGCTGCAC CTGCATCTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055258.1
CDS	68..610
Translation	MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF

Target ORF information:

RefSeq Version	NM_014443.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17B (IL17B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014443.3

ORF Insert Sequence:

ATGGACTGGC CTCACAACCT GCTGTTTCTT CTTACCATTT CCATCTTCCT GGGGCTGGGC 
CAGCCCAGGA GCCCCAAAAG CAAGAGGAAG GGGCAAGGGC GGCCTGGGCC CCTGGCCCCT 
GGCCCTCACC AGGTGCCACT GGACCTGGTG TCACGGATGA AACCGTATGC CCGCATGGAG 
GAGTATGAGA GGAACATCGA GGAGATGGTG GCCCAGCTGA GGAACAGCTC AGAGCTGGCC 
CAGAGAAAGT GTGAGGTCAA CTTGCAGCTG TGGATGTCCA ACAAGAGGAG CCTGTCTCCC 
TGGGGCTACA GCATCAACCA CGACCCCAGC CGTATCCCCG TGGACCTGCC GGAGGCACGG 
TGCCTGTGTC TGGGCTGTGT GAACCCCTTC ACCATGCAGG AGGACCGCAG CATGGTGAGC 
GTGCCGGTGT TCAGCCAGGT TCCTGTGCGC CGCCGCCTCT GCCCGCCACC GCCCCGCACA 
GGGCCTTGCC GCCAGCGCGC AGTCATGGAG ACCATCGCTG TGGGCTGCAC CTGCATCTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL17B ( NM_014443.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055258.1 Homo sapiens interleukin 17B (IL17B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55960
Clone ID Related Accession (Same CDS sequence)	NM_014443.3 , NM_014443.2
Accession Version	NM_014443.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-24
Organism	Homo sapiens(human)
Product	interleukin-17B isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF212311.1. On Jan 3, 2003 this sequence version replaced NM_014443.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF212311.1, AF152098.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2149178, SAMEA2158188 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTGGC CTCACAACCT GCTGTTTCTT CTTACCATTT CCATCTTCCT GGGGCTGGGC 
CAGCCCAGGA GCCCCAAAAG CAAGAGGAAG GGGCAAGGGC GGCCTGGGCC CCTGGCCCCT 
GGCCCTCACC AGGTGCCACT GGACCTGGTG TCACGGATGA AACCGTATGC CCGCATGGAG 
GAGTATGAGA GGAACATCGA GGAGATGGTG GCCCAGCTGA GGAACAGCTC AGAGCTGGCC 
CAGAGAAAGT GTGAGGTCAA CTTGCAGCTG TGGATGTCCA ACAAGAGGAG CCTGTCTCCC 
TGGGGCTACA GCATCAACCA CGACCCCAGC CGTATCCCCG TGGACCTGCC GGAGGCACGG 
TGCCTGTGTC TGGGCTGTGT GAACCCCTTC ACCATGCAGG AGGACCGCAG CATGGTGAGC 
GTGCCGGTGT TCAGCCAGGT TCCTGTGCGC CGCCGCCTCT GCCCGCCACC GCCCCGCACA 
GGGCCTTGCC GCCAGCGCGC AGTCATGGAG ACCATCGCTG TGGGCTGCAC CTGCATCTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055258.1
CDS	51..593
Translation	MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF

Target ORF information:

RefSeq Version	NM_014443.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17B (IL17B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014443.2

ORF Insert Sequence:

ATGGACTGGC CTCACAACCT GCTGTTTCTT CTTACCATTT CCATCTTCCT GGGGCTGGGC 
CAGCCCAGGA GCCCCAAAAG CAAGAGGAAG GGGCAAGGGC GGCCTGGGCC CCTGGCCCCT 
GGCCCTCACC AGGTGCCACT GGACCTGGTG TCACGGATGA AACCGTATGC CCGCATGGAG 
GAGTATGAGA GGAACATCGA GGAGATGGTG GCCCAGCTGA GGAACAGCTC AGAGCTGGCC 
CAGAGAAAGT GTGAGGTCAA CTTGCAGCTG TGGATGTCCA ACAAGAGGAG CCTGTCTCCC 
TGGGGCTACA GCATCAACCA CGACCCCAGC CGTATCCCCG TGGACCTGCC GGAGGCACGG 
TGCCTGTGTC TGGGCTGTGT GAACCCCTTC ACCATGCAGG AGGACCGCAG CATGGTGAGC 
GTGCCGGTGT TCAGCCAGGT TCCTGTGCGC CGCCGCCTCT GCCCGCCACC GCCCCGCACA 
GGGCCTTGCC GCCAGCGCGC AGTCATGGAG ACCATCGCTG TGGGCTGCAC CTGCATCTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL17B ( NM_001317987.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304916.1 Homo sapiens interleukin 17B (IL17B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu39853
Clone ID Related Accession (Same CDS sequence)	XM_017009348.1 , XM_011537622.2 , NM_001317987.1 , XM_017009347.1
Accession Version	NM_001317987.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	interleukin-17B isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM826445.1, AC131025.1 and AF212311.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon. The encoded isoform (2) has a shorter N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM826445.1, ERR279837.4633.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142853 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACCGT ATGCCCGCAT GGAGGAGTAT GAGAGGAACA TCGAGGAGAT GGTGGCCCAG 
CTGAGGAACA GCTCAGAGCT GGCCCAGAGA AAGTGTGAGG TCAACTTGCA GCTGTGGATG 
TCCAACAAGA GGAGCCTGTC TCCCTGGGGC TACAGCATCA ACCACGACCC CAGCCGTATC 
CCCGTGGACC TGCCGGAGGC ACGGTGCCTG TGTCTGGGCT GTGTGAACCC CTTCACCATG 
CAGGAGGACC GCAGCATGGT GAGCGTGCCG GTGTTCAGCC AGGTTCCTGT GCGCCGCCGC 
CTCTGCCCGC CACCGCCCCG CACAGGGCCT TGCCGCCAGC GCGCAGTCAT GGAGACCATC 
GCTGTGGGCT GCACCTGCAT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304916.1
CDS	231..617
Translation	MKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF

Target ORF information:

RefSeq Version	NM_001317987.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17B (IL17B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317987.1

ORF Insert Sequence:

ATGAAACCGT ATGCCCGCAT GGAGGAGTAT GAGAGGAACA TCGAGGAGAT GGTGGCCCAG 
CTGAGGAACA GCTCAGAGCT GGCCCAGAGA AAGTGTGAGG TCAACTTGCA GCTGTGGATG 
TCCAACAAGA GGAGCCTGTC TCCCTGGGGC TACAGCATCA ACCACGACCC CAGCCGTATC 
CCCGTGGACC TGCCGGAGGC ACGGTGCCTG TGTCTGGGCT GTGTGAACCC CTTCACCATG 
CAGGAGGACC GCAGCATGGT GAGCGTGCCG GTGTTCAGCC AGGTTCCTGT GCGCCGCCGC 
CTCTGCCCGC CACCGCCCCG CACAGGGCCT TGCCGCCAGC GCGCAGTCAT GGAGACCATC 
GCTGTGGGCT GCACCTGCAT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL17B ( XM_017009348.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864837.1 Homo sapiens interleukin 17B (IL17B), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu39853
Clone ID Related Accession (Same CDS sequence)	XM_017009348.1 , XM_011537622.2 , NM_001317987.1 , XM_017009347.1
Accession Version	XM_017009348.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	interleukin-17B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACCGT ATGCCCGCAT GGAGGAGTAT GAGAGGAACA TCGAGGAGAT GGTGGCCCAG 
CTGAGGAACA GCTCAGAGCT GGCCCAGAGA AAGTGTGAGG TCAACTTGCA GCTGTGGATG 
TCCAACAAGA GGAGCCTGTC TCCCTGGGGC TACAGCATCA ACCACGACCC CAGCCGTATC 
CCCGTGGACC TGCCGGAGGC ACGGTGCCTG TGTCTGGGCT GTGTGAACCC CTTCACCATG 
CAGGAGGACC GCAGCATGGT GAGCGTGCCG GTGTTCAGCC AGGTTCCTGT GCGCCGCCGC 
CTCTGCCCGC CACCGCCCCG CACAGGGCCT TGCCGCCAGC GCGCAGTCAT GGAGACCATC 
GCTGTGGGCT GCACCTGCAT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864837.1
CDS	321..707
Translation	MKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF

Target ORF information:

RefSeq Version	XM_017009348.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17B (IL17B), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009348.1

ORF Insert Sequence:

ATGAAACCGT ATGCCCGCAT GGAGGAGTAT GAGAGGAACA TCGAGGAGAT GGTGGCCCAG 
CTGAGGAACA GCTCAGAGCT GGCCCAGAGA AAGTGTGAGG TCAACTTGCA GCTGTGGATG 
TCCAACAAGA GGAGCCTGTC TCCCTGGGGC TACAGCATCA ACCACGACCC CAGCCGTATC 
CCCGTGGACC TGCCGGAGGC ACGGTGCCTG TGTCTGGGCT GTGTGAACCC CTTCACCATG 
CAGGAGGACC GCAGCATGGT GAGCGTGCCG GTGTTCAGCC AGGTTCCTGT GCGCCGCCGC 
CTCTGCCCGC CACCGCCCCG CACAGGGCCT TGCCGCCAGC GCGCAGTCAT GGAGACCATC 
GCTGTGGGCT GCACCTGCAT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL17B ( XM_011537622.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011535924.1 Homo sapiens interleukin 17B (IL17B), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu39853
Clone ID Related Accession (Same CDS sequence)	XM_017009348.1 , XM_011537622.2 , NM_001317987.1 , XM_017009347.1
Accession Version	XM_011537622.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	interleukin-17B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011537622.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACCGT ATGCCCGCAT GGAGGAGTAT GAGAGGAACA TCGAGGAGAT GGTGGCCCAG 
CTGAGGAACA GCTCAGAGCT GGCCCAGAGA AAGTGTGAGG TCAACTTGCA GCTGTGGATG 
TCCAACAAGA GGAGCCTGTC TCCCTGGGGC TACAGCATCA ACCACGACCC CAGCCGTATC 
CCCGTGGACC TGCCGGAGGC ACGGTGCCTG TGTCTGGGCT GTGTGAACCC CTTCACCATG 
CAGGAGGACC GCAGCATGGT GAGCGTGCCG GTGTTCAGCC AGGTTCCTGT GCGCCGCCGC 
CTCTGCCCGC CACCGCCCCG CACAGGGCCT TGCCGCCAGC GCGCAGTCAT GGAGACCATC 
GCTGTGGGCT GCACCTGCAT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011535924.1
CDS	530..916
Translation	MKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF

Target ORF information:

RefSeq Version	XM_011537622.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17B (IL17B), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011537622.2

ORF Insert Sequence:

ATGAAACCGT ATGCCCGCAT GGAGGAGTAT GAGAGGAACA TCGAGGAGAT GGTGGCCCAG 
CTGAGGAACA GCTCAGAGCT GGCCCAGAGA AAGTGTGAGG TCAACTTGCA GCTGTGGATG 
TCCAACAAGA GGAGCCTGTC TCCCTGGGGC TACAGCATCA ACCACGACCC CAGCCGTATC 
CCCGTGGACC TGCCGGAGGC ACGGTGCCTG TGTCTGGGCT GTGTGAACCC CTTCACCATG 
CAGGAGGACC GCAGCATGGT GAGCGTGCCG GTGTTCAGCC AGGTTCCTGT GCGCCGCCGC 
CTCTGCCCGC CACCGCCCCG CACAGGGCCT TGCCGCCAGC GCGCAGTCAT GGAGACCATC 
GCTGTGGGCT GCACCTGCAT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL17B ( XM_017009347.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864836.1 Homo sapiens interleukin 17B (IL17B), transcript variant X2, mRNA.

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CloneID	OHu39853
Clone ID Related Accession (Same CDS sequence)	XM_017009348.1 , XM_011537622.2 , NM_001317987.1 , XM_017009347.1
Accession Version	XM_017009347.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	interleukin-17B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACCGT ATGCCCGCAT GGAGGAGTAT GAGAGGAACA TCGAGGAGAT GGTGGCCCAG 
CTGAGGAACA GCTCAGAGCT GGCCCAGAGA AAGTGTGAGG TCAACTTGCA GCTGTGGATG 
TCCAACAAGA GGAGCCTGTC TCCCTGGGGC TACAGCATCA ACCACGACCC CAGCCGTATC 
CCCGTGGACC TGCCGGAGGC ACGGTGCCTG TGTCTGGGCT GTGTGAACCC CTTCACCATG 
CAGGAGGACC GCAGCATGGT GAGCGTGCCG GTGTTCAGCC AGGTTCCTGT GCGCCGCCGC 
CTCTGCCCGC CACCGCCCCG CACAGGGCCT TGCCGCCAGC GCGCAGTCAT GGAGACCATC 
GCTGTGGGCT GCACCTGCAT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864836.1
CDS	438..824
Translation	MKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF

Target ORF information:

RefSeq Version	XM_017009347.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17B (IL17B), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009347.1

ORF Insert Sequence:

ATGAAACCGT ATGCCCGCAT GGAGGAGTAT GAGAGGAACA TCGAGGAGAT GGTGGCCCAG 
CTGAGGAACA GCTCAGAGCT GGCCCAGAGA AAGTGTGAGG TCAACTTGCA GCTGTGGATG 
TCCAACAAGA GGAGCCTGTC TCCCTGGGGC TACAGCATCA ACCACGACCC CAGCCGTATC 
CCCGTGGACC TGCCGGAGGC ACGGTGCCTG TGTCTGGGCT GTGTGAACCC CTTCACCATG 
CAGGAGGACC GCAGCATGGT GAGCGTGCCG GTGTTCAGCC AGGTTCCTGT GCGCCGCCGC 
CTCTGCCCGC CACCGCCCCG CACAGGGCCT TGCCGCCAGC GCGCAGTCAT GGAGACCATC 
GCTGTGGGCT GCACCTGCAT CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL17B ( XM_017009346.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864835.1 Homo sapiens interleukin 17B (IL17B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu95826
Clone ID Related Accession (Same CDS sequence)	XM_017009346.1
Accession Version	XM_017009346.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	interleukin-17B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTCTTC CCATTCTAGA GATGTGGGAA CTGAGGCTCA GAAAGATTTC AGGAGGGAAT 
GGGCCAGGCC ACCGTCTACT TCTGGATACA CCCACCATTT TATGGAGGAG GGAACTGAGG 
CTGACAGTAA AGCTCACATG CAGCCACACA GTCTCTGAGA GCGGAGACCA CCCCAGGAGG 
GAGAGTGCTG TGTCAGGAAG GCCAGGACAA TCAGCCCTGT TTCTTCTTAC CATTTCCATC 
TTCCTGGGGC TGGGCCAGCC CAGGAGCCCC AAAAGCAAGA GGAAGGGGCA AGGGCGGCCT 
GGGCCCCTGG CCCCTGGCCC TCACCAGGTG CCACTGGACC TGGTGTCACG GATGAAACCG 
TATGCCCGCA TGGAGGAGTA TGAGAGGAAC ATCGAGGAGA TGGTGGCCCA GCTGAGGAAC 
AGCTCAGAGC TGGCCCAGAG AAAGTGTGAG GTCAACTTGC AGCTGTGGAT GTCCAACAAG 
AGGAGCCTGT CTCCCTGGGG CTACAGCATC AACCACGACC CCAGCCGTAT CCCCGTGGAC 
CTGCCGGAGG CACGGTGCCT GTGTCTGGGC TGTGTGAACC CCTTCACCAT GCAGGAGGAC 
CGCAGCATGG TGAGCGTGCC GGTGTTCAGC CAGGTTCCTG TGCGCCGCCG CCTCTGCCCG 
CCACCGCCCC GCACAGGGCC TTGCCGCCAG CGCGCAGTCA TGGAGACCAT CGCTGTGGGC 
TGCACCTGCA TCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864835.1
CDS	373..1110
Translation	MILPILEMWELRLRKISGGNGPGHRLLLDTPTILWRRELRLTVKLTCSHTVSESGDHPRRESAVSGRPGQSALFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF

Target ORF information:

RefSeq Version	XM_017009346.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17B (IL17B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009346.1

ORF Insert Sequence:

ATGATTCTTC CCATTCTAGA GATGTGGGAA CTGAGGCTCA GAAAGATTTC AGGAGGGAAT 
GGGCCAGGCC ACCGTCTACT TCTGGATACA CCCACCATTT TATGGAGGAG GGAACTGAGG 
CTGACAGTAA AGCTCACATG CAGCCACACA GTCTCTGAGA GCGGAGACCA CCCCAGGAGG 
GAGAGTGCTG TGTCAGGAAG GCCAGGACAA TCAGCCCTGT TTCTTCTTAC CATTTCCATC 
TTCCTGGGGC TGGGCCAGCC CAGGAGCCCC AAAAGCAAGA GGAAGGGGCA AGGGCGGCCT 
GGGCCCCTGG CCCCTGGCCC TCACCAGGTG CCACTGGACC TGGTGTCACG GATGAAACCG 
TATGCCCGCA TGGAGGAGTA TGAGAGGAAC ATCGAGGAGA TGGTGGCCCA GCTGAGGAAC 
AGCTCAGAGC TGGCCCAGAG AAAGTGTGAG GTCAACTTGC AGCTGTGGAT GTCCAACAAG 
AGGAGCCTGT CTCCCTGGGG CTACAGCATC AACCACGACC CCAGCCGTAT CCCCGTGGAC 
CTGCCGGAGG CACGGTGCCT GTGTCTGGGC TGTGTGAACC CCTTCACCAT GCAGGAGGAC 
CGCAGCATGG TGAGCGTGCC GGTGTTCAGC CAGGTTCCTG TGCGCCGCCG CCTCTGCCCG 
CCACCGCCCC GCACAGGGCC TTGCCGCCAG CGCGCAGTCA TGGAGACCAT CGCTGTGGGC 
TGCACCTGCA TCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of IL17B-IL17RB signaling pathway in breast cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie88795-803(2017 Apr)
Alinejad V,Dolati S,Motallebnezhad M,Yousefi M

IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells.
Oncotarget8(12)18914-18923(2017 Mar)
Bie Q,Zhang B,Sun C,Ji X,Barnie PA,Qi C,Peng J,Zhang D,Zheng D,Su Z,Wang S,Xu H

Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/?-catenin pathway to enhance the stemness of gastric cancer.
Scientific reports625447(2016 05)
Bie Q,Sun C,Gong A,Li C,Su Z,Zheng D,Ji X,Wu Y,Guo Q,Wang S,Xu H

Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.
European journal of human genetics : EJHG25(1)73-78(2016 01)
Karolak JA,Gambin T,Pitarque JA,Molinari A,Jhangiani S,Stankiewicz P,Lupski JR,Gajecka M

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IL17B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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