SIGLEC7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIGLEC7
Entrez Gene ID	27036
Full Name	sialic acid binding Ig like lectin 7
Synonyms	AIRM1,CD328,CDw328,D-siglec,QA79,SIGLEC-7,SIGLEC19P,SIGLECP2,p75,p75/AIRM1
General protein information	Preferred Names sialic acid binding Ig like lectin 7 Names sialic acid-binding Ig-like lectin 7 AIRM-1 QA79 membrane protein adhesion inhibitory receptor molecule 1, siglec-7 sialic acid binding immunoglobulin-like lectin 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.41
Disorder MIM:	604410

mRNA and Protein(s)

mRNA	Protein	Name
NM_014385.3	NP_055200.1	sialic acid-binding Ig-like lectin 7 isoform 1 precursor
XM_011526721.3	XP_011525023.1	sialic acid-binding Ig-like lectin 7 isoform X1
XM_011526721.2	XP_011525023.1	sialic acid-binding Ig-like lectin 7 isoform X1
NM_016543.3	NP_057627.2	sialic acid-binding Ig-like lectin 7 isoform 2 precursor
NM_001277201.1	NP_001264130.1	sialic acid-binding Ig-like lectin 7 isoform 3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SIGLEC7	XP_524360.3
Homo sapiens (human)	SIGLEC7	NP_055200.1

Gene Ontology
Bibliography

Related articles in PubMed

Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans.
Rosenstock P, Horstkorte R, Gnanapragassam VS, Harth J, Kielstein H
Immunologic research65(5)1017-1024(2017 Oct)

Siglec-7 restores ?-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.
Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K
Scientific reports745319(2017 Apr)

Siglec-7 Defines a Highly Functional Natural Killer Cell Subset and Inhibits Cell-Mediated Activities.
Shao JY, Yin WW, Zhang QF, Liu Q, Peng ML, Hu HD, Hu P, Ren H, Zhang DZ
Scandinavian journal of immunology84(3)182-90(2016 Sep)

Siglec-7 is an inhibitory receptor on human mast cells and basophils.
Mizrahi S, Gibbs BF, Karra L, Ben-Zimra M, Levi-Schaffer F
The Journal of allergy and clinical immunology134(1)230-3(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities.
Title: Siglec-7 Defines a Highly Functional Natural Killer Cell Subset and Inhibits Cell-Mediated Activities.

Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils.
Title: Siglec-7 is an inhibitory receptor on human mast cells and basophils.

Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.
Title: Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.

These results show that Siglec-7 binds HIV-1 via gp120 and contributes to enhance the susceptibility to infection of CD4 positive T cells and monocyte-derived macrophages.
Title: Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4pos T cells and macrophages.

Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition.
Title: Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes.

The following SIGLEC7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIGLEC7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00429	NM_001277201.1 Latest version!	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06352	NM_014385.3 Latest version!	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu02311	NM_016543.3 Latest version!	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu67024	XM_011526721.3 Latest version!	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu67024	XM_011526721.2	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIGLEC7 ( NM_001277201.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001264130.1 Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu00429
Clone ID Related Accession (Same CDS sequence)	NM_001277201.1
Accession Version	NM_001277201.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 7 isoform 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX644517.1, AJ130713.1 and AJ007395.1. Transcript Variant: This variant (3) lacks all internal coding exons, compared to variant 1. The resulting isoform (3) is C-terminal truncated, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ130713.1 [ECO:0000332] ##Evidence-Data-END##

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264130.1
CDS	70..507
Translation	MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTG

Target ORF information:

RefSeq Version	NM_001277201.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277201.1

ORF Insert Sequence:

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC7 ( NM_014385.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055200.1 Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06352
Clone ID Related Accession (Same CDS sequence)	NM_014385.3
Accession Version	NM_014385.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 7 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX644517.1, BC028150.1 and AJ007395.1. On Mar 20, 2013 this sequence version replaced NM_014385.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028150.1, AK314875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGCCTTGAC CCACAGGCCC AACATCCTTA TCCCCGGTAC CCTGGAGTCT 
GGCTGCTTCC AGAATCTGAC CTGCTCTGTG CCCTGGGCCT GTGAGCAGGG GACGCCCCCT 
ATGATCTCCT GGATGGGGAC CTCTGTGTCC CCCCTGCACC CCTCCACCAC CCGCTCCTCA 
GTGCTCACCC TCATCCCACA GCCCCAGCAC CACGGCACCA GCCTCACCTG TCAGGTGACC 
TTGCCTGGGG CCGGCGTGAC CACGAACAGG ACCATCCAAC TCAATGTGTC CTACCCTCCT 
CAGAACTTGA CTGTGACTGT CTTCCAAGGA GAAGGCACAG CATCCACAGC TCTGGGGAAC 
AGCTCATCTC TTTCAGTCCT AGAGGGCCAG TCTCTGCGCT TGGTCTGTGC TGTTGACAGC 
AATCCCCCTG CCAGGCTGAG CTGGACCTGG AGGAGTCTGA CCCTGTACCC CTCACAGCCC 
TCAAACCCTC TGGTACTGGA GCTGCAAGTG CACCTGGGGG ATGAAGGGGA ATTCACCTGT 
CGAGCTCAGA ACTCTCTGGG TTCCCAGCAC GTTTCCCTGA ACCTCTCCCT GCAACAGGAG 
TACACAGGCA AAATGAGGCC TGTATCAGGA GTGTTGCTGG GGGCGGTCGG GGGAGCTGGA 
GCCACAGCCC TGGTCTTCCT CTCCTTCTGT GTCATCTTCA TTGTAGTGAG GTCCTGCAGG 
AAGAAATCGG CAAGGCCAGC AGCGGACGTG GGAGACATAG GCATGAAGGA TGCAAACACC 
ATCAGGGGCT CAGCCTCTCA GGGTAACCTG ACTGAGTCCT GGGCAGATGA TAACCCCCGA 
CACCATGGCC TGGCTGCCCA CTCCTCAGGG GAGGAAAGAG AGATCCAGTA TGCACCCCTC 
AGCTTTCATA AGGGGGAGCC TCAGGACCTA TCAGGACAAG AAGCCACCAA CAATGAGTAC 
TCAGAGATCA AGATCCCCAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055200.1
CDS	70..1473
Translation	MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK

Target ORF information:

RefSeq Version	NM_014385.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014385.3

ORF Insert Sequence:

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGCCTTGAC CCACAGGCCC AACATCCTTA TCCCCGGTAC CCTGGAGTCT 
GGCTGCTTCC AGAATCTGAC CTGCTCTGTG CCCTGGGCCT GTGAGCAGGG GACGCCCCCT 
ATGATCTCCT GGATGGGGAC CTCTGTGTCC CCCCTGCACC CCTCCACCAC CCGCTCCTCA 
GTGCTCACCC TCATCCCACA GCCCCAGCAC CACGGCACCA GCCTCACCTG TCAGGTGACC 
TTGCCTGGGG CCGGCGTGAC CACGAACAGG ACCATCCAAC TCAATGTGTC CTACCCTCCT 
CAGAACTTGA CTGTGACTGT CTTCCAAGGA GAAGGCACAG CATCCACAGC TCTGGGGAAC 
AGCTCATCTC TTTCAGTCCT AGAGGGCCAG TCTCTGCGCT TGGTCTGTGC TGTTGACAGC 
AATCCCCCTG CCAGGCTGAG CTGGACCTGG AGGAGTCTGA CCCTGTACCC CTCACAGCCC 
TCAAACCCTC TGGTACTGGA GCTGCAAGTG CACCTGGGGG ATGAAGGGGA ATTCACCTGT 
CGAGCTCAGA ACTCTCTGGG TTCCCAGCAC GTTTCCCTGA ACCTCTCCCT GCAACAGGAG 
TACACAGGCA AAATGAGGCC TGTATCAGGA GTGTTGCTGG GGGCGGTCGG GGGAGCTGGA 
GCCACAGCCC TGGTCTTCCT CTCCTTCTGT GTCATCTTCA TTGTAGTGAG GTCCTGCAGG 
AAGAAATCGG CAAGGCCAGC AGCGGACGTG GGAGACATAG GCATGAAGGA TGCAAACACC 
ATCAGGGGCT CAGCCTCTCA GGGTAACCTG ACTGAGTCCT GGGCAGATGA TAACCCCCGA 
CACCATGGCC TGGCTGCCCA CTCCTCAGGG GAGGAAAGAG AGATCCAGTA TGCACCCCTC 
AGCTTTCATA AGGGGGAGCC TCAGGACCTA TCAGGACAAG AAGCCACCAA CAATGAGTAC 
TCAGAGATCA AGATCCCCAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC7 ( NM_016543.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057627.2 Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02311
Clone ID Related Accession (Same CDS sequence)	NM_016543.3
Accession Version	NM_016543.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 7 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX644517.1, AJ130711.1 and AJ007395.1. On Mar 20, 2013 this sequence version replaced NM_016543.2. Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF193441.1, AJ130711.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGACCCTCC TCAGAACTTG ACTGTGACTG TCTTCCAAGG AGAAGGCACA 
GCATCCACAG CTCTGGGGAA CAGCTCATCT CTTTCAGTCC TAGAGGGCCA GTCTCTGCGC 
TTGGTCTGTG CTGTTGACAG CAATCCCCCT GCCAGGCTGA GCTGGACCTG GAGGAGTCTG 
ACCCTGTACC CCTCACAGCC CTCAAACCCT CTGGTACTGG AGCTGCAAGT GCACCTGGGG 
GATGAAGGGG AATTCACCTG TCGAGCTCAG AACTCTCTGG GTTCCCAGCA CGTTTCCCTG 
AACCTCTCCC TGCAACAGGA GTACACAGGC AAAATGAGGC CTGTATCAGG AGTGTTGCTG 
GGGGCGGTCG GGGGAGCTGG AGCCACAGCC CTGGTCTTCC TCTCCTTCTG TGTCATCTTC 
ATTGTAGTGA GGTCCTGCAG GAAGAAATCG GCAAGGCCAG CAGCGGACGT GGGAGACATA 
GGCATGAAGG ATGCAAACAC CATCAGGGGC TCAGCCTCTC AGGGTAACCT GACTGAGTCC 
TGGGCAGATG ATAACCCCCG ACACCATGGC CTGGCTGCCC ACTCCTCAGG GGAGGAAAGA 
GAGATCCAGT ATGCACCCCT CAGCTTTCAT AAGGGGGAGC CTCAGGACCT ATCAGGACAA 
GAAGCCACCA ACAATGAGTA CTCAGAGATC AAGATCCCCA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057627.2
CDS	70..1194
Translation	MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTDPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK

Target ORF information:

RefSeq Version	NM_016543.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016543.3

ORF Insert Sequence:

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGACCCTCC TCAGAACTTG ACTGTGACTG TCTTCCAAGG AGAAGGCACA 
GCATCCACAG CTCTGGGGAA CAGCTCATCT CTTTCAGTCC TAGAGGGCCA GTCTCTGCGC 
TTGGTCTGTG CTGTTGACAG CAATCCCCCT GCCAGGCTGA GCTGGACCTG GAGGAGTCTG 
ACCCTGTACC CCTCACAGCC CTCAAACCCT CTGGTACTGG AGCTGCAAGT GCACCTGGGG 
GATGAAGGGG AATTCACCTG TCGAGCTCAG AACTCTCTGG GTTCCCAGCA CGTTTCCCTG 
AACCTCTCCC TGCAACAGGA GTACACAGGC AAAATGAGGC CTGTATCAGG AGTGTTGCTG 
GGGGCGGTCG GGGGAGCTGG AGCCACAGCC CTGGTCTTCC TCTCCTTCTG TGTCATCTTC 
ATTGTAGTGA GGTCCTGCAG GAAGAAATCG GCAAGGCCAG CAGCGGACGT GGGAGACATA 
GGCATGAAGG ATGCAAACAC CATCAGGGGC TCAGCCTCTC AGGGTAACCT GACTGAGTCC 
TGGGCAGATG ATAACCCCCG ACACCATGGC CTGGCTGCCC ACTCCTCAGG GGAGGAAAGA 
GAGATCCAGT ATGCACCCCT CAGCTTTCAT AAGGGGGAGC CTCAGGACCT ATCAGGACAA 
GAAGCCACCA ACAATGAGTA CTCAGAGATC AAGATCCCCA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC7 ( XM_011526721.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525023.1 Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu67024
Clone ID Related Accession (Same CDS sequence)	XM_011526721.3 , XM_011526721.2
Accession Version	XM_011526721.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011526721.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGCATCCAC AGCTCTGGGG AACAGCTCAT CTCTTTCAGT CCTAGAGGGC 
CAGTCTCTGC GCTTGGTCTG TGCTGTTGAC AGCAATCCCC CTGCCAGGCT GAGCTGGACC 
TGGAGGAGTC TGACCCTGTA CCCCTCACAG CCCTCAAACC CTCTGGTACT GGAGCTGCAA 
GTGCACCTGG GGGATGAAGG GGAATTCACC TGTCGAGCTC AGAACTCTCT GGGTTCCCAG 
CACGTTTCCC TGAACCTCTC CCTGCAACAG GAGTACACAG GCAAAATGAG GCCTGTATCA 
GGAGTGTTGC TGGGGGCGGT CGGGGGAGCT GGAGCCACAG CCCTGGTCTT CCTCTCCTTC 
TGTGTCATCT TCATTGTAGT GAGGTCCTGC AGGAAGAAAT CGGCAAGGCC AGCAGCGGAC 
GTGGGAGACA TAGGCATGAA GGATGCAAAC ACCATCAGGG GCTCAGCCTC TCAGGGTAAC 
CTGACTGAGT CCTGGGCAGA TGATAACCCC CGACACCATG GCCTGGCTGC CCACTCCTCA 
GGGGAGGAAA GAGAGATCCA GTATGCACCC CTCAGCTTTC ATAAGGGGGA GCCTCAGGAC 
CTATCAGGAC AAGAAGCCAC CAACAATGAG TACTCAGAGA TCAAGATCCC CAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525023.1
CDS	102..1178
Translation	MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK

Target ORF information:

RefSeq Version	XM_011526721.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526721.3

ORF Insert Sequence:

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGCATCCAC AGCTCTGGGG AACAGCTCAT CTCTTTCAGT CCTAGAGGGC 
CAGTCTCTGC GCTTGGTCTG TGCTGTTGAC AGCAATCCCC CTGCCAGGCT GAGCTGGACC 
TGGAGGAGTC TGACCCTGTA CCCCTCACAG CCCTCAAACC CTCTGGTACT GGAGCTGCAA 
GTGCACCTGG GGGATGAAGG GGAATTCACC TGTCGAGCTC AGAACTCTCT GGGTTCCCAG 
CACGTTTCCC TGAACCTCTC CCTGCAACAG GAGTACACAG GCAAAATGAG GCCTGTATCA 
GGAGTGTTGC TGGGGGCGGT CGGGGGAGCT GGAGCCACAG CCCTGGTCTT CCTCTCCTTC 
TGTGTCATCT TCATTGTAGT GAGGTCCTGC AGGAAGAAAT CGGCAAGGCC AGCAGCGGAC 
GTGGGAGACA TAGGCATGAA GGATGCAAAC ACCATCAGGG GCTCAGCCTC TCAGGGTAAC 
CTGACTGAGT CCTGGGCAGA TGATAACCCC CGACACCATG GCCTGGCTGC CCACTCCTCA 
GGGGAGGAAA GAGAGATCCA GTATGCACCC CTCAGCTTTC ATAAGGGGGA GCCTCAGGAC 
CTATCAGGAC AAGAAGCCAC CAACAATGAG TACTCAGAGA TCAAGATCCC CAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC7 ( XM_011526721.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525023.1 Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant X1, mRNA.

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CloneID	OHu67024
Clone ID Related Accession (Same CDS sequence)	XM_011526721.3 , XM_011526721.2
Accession Version	XM_011526721.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526721.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGCATCCAC AGCTCTGGGG AACAGCTCAT CTCTTTCAGT CCTAGAGGGC 
CAGTCTCTGC GCTTGGTCTG TGCTGTTGAC AGCAATCCCC CTGCCAGGCT GAGCTGGACC 
TGGAGGAGTC TGACCCTGTA CCCCTCACAG CCCTCAAACC CTCTGGTACT GGAGCTGCAA 
GTGCACCTGG GGGATGAAGG GGAATTCACC TGTCGAGCTC AGAACTCTCT GGGTTCCCAG 
CACGTTTCCC TGAACCTCTC CCTGCAACAG GAGTACACAG GCAAAATGAG GCCTGTATCA 
GGAGTGTTGC TGGGGGCGGT CGGGGGAGCT GGAGCCACAG CCCTGGTCTT CCTCTCCTTC 
TGTGTCATCT TCATTGTAGT GAGGTCCTGC AGGAAGAAAT CGGCAAGGCC AGCAGCGGAC 
GTGGGAGACA TAGGCATGAA GGATGCAAAC ACCATCAGGG GCTCAGCCTC TCAGGGTAAC 
CTGACTGAGT CCTGGGCAGA TGATAACCCC CGACACCATG GCCTGGCTGC CCACTCCTCA 
GGGGAGGAAA GAGAGATCCA GTATGCACCC CTCAGCTTTC ATAAGGGGGA GCCTCAGGAC 
CTATCAGGAC AAGAAGCCAC CAACAATGAG TACTCAGAGA TCAAGATCCC CAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525023.1
CDS	101..1177
Translation	MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK

Target ORF information:

RefSeq Version	XM_011526721.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526721.2

ORF Insert Sequence:

ATGCTGCTGC TGCTGCTGCT GCCCCTGCTC TGGGGGAGGG AGAGGGTGGA AGGACAGAAG 
AGTAACCGGA AGGATTACTC GCTGACGATG CAGAGTTCCG TGACCGTGCA AGAGGGCATG 
TGTGTCCATG TGCGCTGCTC CTTCTCCTAC CCAGTGGACA GCCAGACTGA CTCTGACCCA 
GTTCATGGCT ACTGGTTCCG GGCAGGGAAT GATATAAGCT GGAAGGCTCC AGTGGCCACA 
AACAACCCAG CTTGGGCAGT GCAGGAGGAA ACTCGGGACC GATTCCACCT CCTTGGGGAC 
CCACAGACCA AAAATTGCAC CCTGAGCATC AGAGATGCCA GAATGAGTGA TGCGGGGAGA 
TACTTCTTTC GTATGGAGAA AGGAAATATA AAATGGAATT ATAAATATGA CCAGCTCTCT 
GTGAACGTGA CAGCATCCAC AGCTCTGGGG AACAGCTCAT CTCTTTCAGT CCTAGAGGGC 
CAGTCTCTGC GCTTGGTCTG TGCTGTTGAC AGCAATCCCC CTGCCAGGCT GAGCTGGACC 
TGGAGGAGTC TGACCCTGTA CCCCTCACAG CCCTCAAACC CTCTGGTACT GGAGCTGCAA 
GTGCACCTGG GGGATGAAGG GGAATTCACC TGTCGAGCTC AGAACTCTCT GGGTTCCCAG 
CACGTTTCCC TGAACCTCTC CCTGCAACAG GAGTACACAG GCAAAATGAG GCCTGTATCA 
GGAGTGTTGC TGGGGGCGGT CGGGGGAGCT GGAGCCACAG CCCTGGTCTT CCTCTCCTTC 
TGTGTCATCT TCATTGTAGT GAGGTCCTGC AGGAAGAAAT CGGCAAGGCC AGCAGCGGAC 
GTGGGAGACA TAGGCATGAA GGATGCAAAC ACCATCAGGG GCTCAGCCTC TCAGGGTAAC 
CTGACTGAGT CCTGGGCAGA TGATAACCCC CGACACCATG GCCTGGCTGC CCACTCCTCA 
GGGGAGGAAA GAGAGATCCA GTATGCACCC CTCAGCTTTC ATAAGGGGGA GCCTCAGGAC 
CTATCAGGAC AAGAAGCCAC CAACAATGAG TACTCAGAGA TCAAGATCCC CAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans.
Immunologic research65(5)1017-1024(2017 Oct)
Rosenstock P,Horstkorte R,Gnanapragassam VS,Harth J,Kielstein H

Siglec-7 restores ?-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.
Scientific reports745319(2017 Apr)
Dharmadhikari G,Stolz K,Hauke M,Morgan NG,Varki A,de Koning E,Kelm S,Maedler K

Siglec-7 Defines a Highly Functional Natural Killer Cell Subset and Inhibits Cell-Mediated Activities.
Scandinavian journal of immunology84(3)182-90(2016 Sep)
Shao JY,Yin WW,Zhang QF,Liu Q,Peng ML,Hu HD,Hu P,Ren H,Zhang DZ

Siglec-7 is an inhibitory receptor on human mast cells and basophils.
The Journal of allergy and clinical immunology134(1)230-3(2014 Jul)
Mizrahi S,Gibbs BF,Karra L,Ben-Zimra M,Levi-Schaffer F

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SIGLEC7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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