OR1A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OR1A2
Entrez Gene ID	26189
Full Name	olfactory receptor family 1 subfamily A member 2
Synonyms	OR17-6
General protein information	Preferred Names olfactory receptor family 1 subfamily A member 2 Names olfactory receptor 1A2 olfactory receptor 17-6 olfactory receptor OR17-10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.3
Summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012352.2	NP_036484.1	olfactory receptor 1A2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.
Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D
Journal of structural biology159(3)400-12(2007 Sep)

The human olfactory receptor gene family.
Malnic B, Godfrey PA, Buck LB
Proceedings of the National Academy of Sciences of the United States of America101(8)2584-9(2004 Feb)

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.
Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D
Genomics63(2)227-45(2000 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We identified and confirmed a novel region on OR1A2 associated with Neuroticism.
Title: Genome-wide association study of the five-factor model of personality in young Korean women.

Evolutionary conserved amino acid residues to be necessary for specific responsiveness of OR1A1 to odorants were identified.
Title: Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.

The following OR1A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OR1A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu66882	NM_012352.2 Latest version!	Homo sapiens olfactory receptor family 1 subfamily A member 2 (OR1A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OR1A2 ( NM_012352.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036484.1 Homo sapiens olfactory receptor family 1 subfamily A member 2 (OR1A2), mRNA.

Price & Availability↑

CloneID	OHu66882
Clone ID Related Accession (Same CDS sequence)	NM_012352.2
Accession Version	NM_012352.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	olfactory receptor 1A2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090282.6. On Dec 24, 2014 this sequence version replaced NM_012352.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC069092.1, BC106733.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAGAAAG AAAATCAATC CTTTAACCTG GATTTTATTC TCCTGGGAGT TACTAGTCAG 
CAAGAACAGA ATAATGTCTT CTTTGTGATT TTTTTGTGCA TTTACCCCAT CACACTGACT 
GGAAATCTGC TCATCATCTT GGCCATCTGT GCTGACATTC GCCTTCACAA CCCCATGTAT 
TTTCTCCTTG CCAACCTCTC CTTGGTTGAC ATCATCTTCT CATCCGTAAC CATCCCTAAG 
GTGCTGGCCA ACCATCTCTT GGGGAGCAAG TTCATCTCCT TTGGGGGATG CCTAATGCAG 
ATGTATTTCA TGATAGCCTT GGCCAAGGCA GACAGCTATA CCTTGGCTGC AATGGCATAC 
GATCGAGCTG TGGCCATCAG CTGCCCACTT CATTACACAA CAATTATGAG TCCACGGTCT 
TGTATCCTGC TTATTGCTGG GTCTTGGGTG ATTGGAAACA CCAGTGCTCT CCCCCACACT 
CTGCTCACAG CTAGTTTGTC CTTCTGTGGC AACCAGGAAG TAGCCAATTT CTACTGTGAC 
ATTATGCCTT TGCTGAAGTT GTCCTGTTCT GACGTCCACT TTAATGTGAA GATGATGTAC 
CTAGGGGTCG GCGTTTTCTC TTTGCCATTA CTATGCATCA TTGTCTCCTA TGTTCAGGTC 
TTTTCCACAG TCTTCCAAGT TCCATCTACC AAGAGTCTAT TCAAAGCCTT CTGCACCTGT 
GGCTCCCACC TCACAGTTGT TTTTTTATAT TATGGTACAA CGATGGGCAT GTATTTCCGC 
CCTCTGACCA GTTACAGCCC CAAAGATGCA GTGATAACTG TGATGTATGT GGCAGTGACC 
CCAGCATTAA ATCCTTTCAT CTATAGTCTG AGAAATTGGG ATATGAAGGC AGCCCTACAG 
AAACTCTTCA GCAAGAGAAT CTCCTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036484.1
CDS	3..932
Translation	MKKENQSFNLDFILLGVTSQQEQNNVFFVIFLCIYPITLTGNLLIILAICADIRLHNPMYFLLANLSLVDIIFSSVTIPKVLANHLLGSKFISFGGCLMQMYFMIALAKADSYTLAAMAYDRAVAISCPLHYTTIMSPRSCILLIAGSWVIGNTSALPHTLLTASLSFCGNQEVANFYCDIMPLLKLSCSDVHFNVKMMYLGVGVFSLPLLCIIVSYVQVFSTVFQVPSTKSLFKAFCTCGSHLTVVFLYYGTTMGMYFRPLTSYSPKDAVITVMYVAVTPALNPFIYSLRNWDMKAALQKLFSKRISS

Target ORF information:

RefSeq Version	NM_012352.2
Organism	Homo sapiens(human)
Definition	Homo sapiens olfactory receptor family 1 subfamily A member 2 (OR1A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012352.2

ORF Insert Sequence:

ATGAAGAAAG AAAATCAATC CTTTAACCTG GATTTTATTC TCCTGGGAGT TACTAGTCAG 
CAAGAACAGA ATAATGTCTT CTTTGTGATT TTTTTGTGCA TTTACCCCAT CACACTGACT 
GGAAATCTGC TCATCATCTT GGCCATCTGT GCTGACATTC GCCTTCACAA CCCCATGTAT 
TTTCTCCTTG CCAACCTCTC CTTGGTTGAC ATCATCTTCT CATCCGTAAC CATCCCTAAG 
GTGCTGGCCA ACCATCTCTT GGGGAGCAAG TTCATCTCCT TTGGGGGATG CCTAATGCAG 
ATGTATTTCA TGATAGCCTT GGCCAAGGCA GACAGCTATA CCTTGGCTGC AATGGCATAC 
GATCGAGCTG TGGCCATCAG CTGCCCACTT CATTACACAA CAATTATGAG TCCACGGTCT 
TGTATCCTGC TTATTGCTGG GTCTTGGGTG ATTGGAAACA CCAGTGCTCT CCCCCACACT 
CTGCTCACAG CTAGTTTGTC CTTCTGTGGC AACCAGGAAG TAGCCAATTT CTACTGTGAC 
ATTATGCCTT TGCTGAAGTT GTCCTGTTCT GACGTCCACT TTAATGTGAA GATGATGTAC 
CTAGGGGTCG GCGTTTTCTC TTTGCCATTA CTATGCATCA TTGTCTCCTA TGTTCAGGTC 
TTTTCCACAG TCTTCCAAGT TCCATCTACC AAGAGTCTAT TCAAAGCCTT CTGCACCTGT 
GGCTCCCACC TCACAGTTGT TTTTTTATAT TATGGTACAA CGATGGGCAT GTATTTCCGC 
CCTCTGACCA GTTACAGCCC CAAAGATGCA GTGATAACTG TGATGTATGT GGCAGTGACC 
CCAGCATTAA ATCCTTTCAT CTATAGTCTG AGAAATTGGG ATATGAAGGC AGCCCTACAG 
AAACTCTTCA GCAAGAGAAT CTCCTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.
Journal of structural biology159(3)400-12(2007 Sep)
Schmiedeberg K,Shirokova E,Weber HP,Schilling B,Meyerhof W,Krautwurst D

The human olfactory receptor gene family.
Proceedings of the National Academy of Sciences of the United States of America101(8)2584-9(2004 Feb)
Malnic B,Godfrey PA,Buck LB

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.
Genomics63(2)227-45(2000 Jan)
Glusman G,Sosinsky A,Ben-Asher E,Avidan N,Sonkin D,Bahar A,Rosenthal A,Clifton S,Roe B,Ferraz C,Demaille J,Lancet D

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OR1A2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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