BACE2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BACE2
Entrez Gene ID	25825
Full Name	beta-site APP-cleaving enzyme 2
Synonyms	AEPLC,ALP56,ASP1,ASP21,BAE2,CDA13,CEAP1,DRAP
General protein information	Preferred Names beta-site APP-cleaving enzyme 2 Names beta-secretase 2 56 kDa aspartic-like protease Down syndrome region aspartic protease SLCO3A1/BACE2 fusion aspartyl protease 1 beta-site amyloid beta A4 precursor protein-cleaving enzyme 2 memapsin-1 membrane-associated aspartic protease 1 theta-secretase transmembrane aspartic proteinase Asp1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.2-q22.3
Summary	This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Disorder MIM:	605668

mRNA and Protein(s)

mRNA	Protein	Name
NM_012105.4	NP_036237.2	beta-secretase 2 isoform A preproprotein
NM_138992.2	NP_620477.1	beta-secretase 2 isoform B preproprotein
XM_017028314.1	XP_016883803.1	beta-secretase 2 isoform X1
NM_138991.2	NP_620476.1	beta-secretase 2 isoform C preproprotein
NM_138991.3	NP_620476.1	beta-secretase 2 isoform C preproprotein
NM_138992.3	NP_620477.1	beta-secretase 2 isoform B preproprotein
NM_012105.5	NP_036237.2	beta-secretase 2 isoform A preproprotein

Pathways from BioSystems

Homologies

	BACE2	XP_001108061.2
Xenopus tropicalis (tropical clawed frog)	bace2	NP_001135590.1
Homo sapiens (human)	BACE2	NP_036237.2
Mus musculus (house mouse)	Bace2	NP_062390.3
Pan troglodytes (chimpanzee)	BACE2	XP_001171642.1
Canis lupus familiaris (dog)	BACE2	XP_005639052.1
Bos taurus (cattle)	BACE2	NP_001192991.1
Rattus norvegicus (Norway rat)	Bace2	NP_001002802.1
Danio rerio (zebrafish)	zgc:103530	NP_001005991.1
Gallus gallus (chicken)	BACE2	XP_416735.4

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter.
Maloney B, Ge YW, Greig NH, Lahiri DK
Journal of molecular neuroscience : MN29(1)81-99(2006)

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, Tong Y, Xiao C, Huang Y, Zhang S, Liu X, Song W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology19(7)739-49(2005 May)

BACE2 functions as an alternative alpha-secretase in cells.
Yan R, Munzner JB, Shuck ME, Bienkowski MJ
The Journal of biological chemistry276(36)34019-27(2001 Sep)

Prodomain processing of Asp1 (BACE2) is autocatalytic.
Hussain I, Christie G, Schneider K, Moore S, Dingwall C
The Journal of biological chemistry276(26)23322-8(2001 Jun)

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, Ratcliffe SJ, Tattersall D, Testa TT, Southan C, Ryan DM, Simmons DL, Walsh FS, Dingwall C, Christie G
Molecular and cellular neurosciences16(5)609-19(2000 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the behavior of the flap tips during simulations is different between BACE1 and BACE2. The BACE1 active site cavity is more spacious as compared to that of BACE2. The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 loops being more flexible and less stable than those of BACE2
Title: A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility.

Studies suggest that beta-Secretases BACE1/2 plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure.
Title: A Non-Canonical Role for ?-Secretase in the Retina.

RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals.
Title: Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.

Data suggest that the amino acid residues would be essential for selectivity of beta-amyloid precursor protein cleavage enzymes BACE1 and BACE2 functions and could be sites for the design of selective inhibitors targeting either BACE1 or BACE2.
Title: Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method.

Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2.
Title: Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.

The following BACE2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BACE2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01546	NM_012105.5 Latest version!	Homo sapiens beta-secretase 2 (BACE2), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu93244	XM_017028314.1 Latest version!	Homo sapiens beta-secretase 2 (BACE2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu00042	NM_138991.3 Latest version!	Homo sapiens beta-secretase 2 (BACE2), transcript variant c, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00
OHu00304	NM_138992.3 Latest version!	Homo sapiens beta-secretase 2 (BACE2), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu00042	NM_138991.2	Homo sapiens beta-secretase 2 (BACE2), transcript variant c, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00
OHu00304	NM_138992.2	Homo sapiens beta-secretase 2 (BACE2), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu01546	NM_012105.4	Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BACE2 ( NM_012105.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036237.2 Homo sapiens beta-secretase 2 (BACE2), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu01546
Clone ID Related Accession (Same CDS sequence)	NM_012105.4 , NM_012105.5
Accession Version	NM_012105.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	beta-secretase 2 isoform A preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF178532.1, AF200342.1, AF188276.1 and AL773578.1. On Nov 22, 2018 this sequence version replaced NM_012105.4. Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF178532.1, SRR1803615.14606.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330333.11/ ENSP00000332979.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGATTCCA GAATTCTCTG ATGGTTTCTG GACTGGGTCC 
CAGCTGGCGT GCTGGACGAA TTCGGAAACA CCTTGGTCTT ACTTCCCTAA AATCTCCATC 
TACCTGAGAG ACGAGAACTC CAGCAGGTCA TTCCGTATCA CAATCCTGCC TCAGCTTTAC 
ATTCAGCCCA TGATGGGGGC CGGCCTGAAT TATGAATGTT ACCGATTCGG CATTTCCCCA 
TCCACAAATG CGCTGGTGAT CGGTGCCACG GTGATGGAGG GCTTCTACGT CATCTTCGAC 
AGAGCCCAGA AGAGGGTGGG CTTCGCAGCG AGCCCCTGTG CAGAAATTGC AGGTGCTGCA 
GTGTCTGAAA TTTCCGGGCC TTTCTCAACA GAGGATGTAG CCAGCAACTG TGTCCCCGCT 
CAGTCTTTGA GCGAGCCCAT TTTGTGGATT GTGTCCTATG CGCTCATGAG CGTCTGTGGA 
GCCATCCTCC TTGTCTTAAT CGTCCTGCTG CTGCTGCCGT TCCGGTGTCA GCGTCGCCCC 
CGTGACCCTG AGGTCGTCAA TGATGAGTCC TCTCTGGTCA GACATCGCTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036237.2
CDS	105..1661
Translation	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK

Target ORF information:

RefSeq Version	NM_012105.5
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-secretase 2 (BACE2), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012105.5

ORF Insert Sequence:

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGATTCCA GAATTCTCTG ATGGTTTCTG GACTGGGTCC 
CAGCTGGCGT GCTGGACGAA TTCGGAAACA CCTTGGTCTT ACTTCCCTAA AATCTCCATC 
TACCTGAGAG ACGAGAACTC CAGCAGGTCA TTCCGTATCA CAATCCTGCC TCAGCTTTAC 
ATTCAGCCCA TGATGGGGGC CGGCCTGAAT TATGAATGTT ACCGATTCGG CATTTCCCCA 
TCCACAAATG CGCTGGTGAT CGGTGCCACG GTGATGGAGG GCTTCTACGT CATCTTCGAC 
AGAGCCCAGA AGAGGGTGGG CTTCGCAGCG AGCCCCTGTG CAGAAATTGC AGGTGCTGCA 
GTGTCTGAAA TTTCCGGGCC TTTCTCAACA GAGGATGTAG CCAGCAACTG TGTCCCCGCT 
CAGTCTTTGA GCGAGCCCAT TTTGTGGATT GTGTCCTATG CGCTCATGAG CGTCTGTGGA 
GCCATCCTCC TTGTCTTAAT CGTCCTGCTG CTGCTGCCGT TCCGGTGTCA GCGTCGCCCC 
CGTGACCCTG AGGTCGTCAA TGATGAGTCC TCTCTGGTCA GACATCGCTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BACE2 ( XM_017028314.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883803.1 Homo sapiens beta-secretase 2 (BACE2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu93244
Clone ID Related Accession (Same CDS sequence)	XM_017028314.1
Accession Version	XM_017028314.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	beta-secretase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000021.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGCCT TGCACCTTTA TAAGAAGCTA CAGATTCTCG TTGACACTGG AAGCAGTAAC 
TTTGCCGTGG CAGGAACCCC GCACTCCTAC ATAGACACGT ACTTTGACAC AGAGAGGTCT 
AGCACATACC GCTCCAAGGG CTTTGACGTC ACAGTGAAGT ACACACAAGG AAGCTGGACG 
GGCTTCGTTG GGGAAGACCT CGTCACCATC CCCAAAGGCT TCAATACTTC TTTTCTTGTC 
AACATTGCCA CTATTTTTGA ATCAGAGAAT TTCTTTTTGC CTGGGATTAA ATGGAATGGA 
ATACTTGGCC TAGCTTATGC CACACTTGCC AAGCCATCAA GTTCTCTGGA GACCTTCTTC 
GACTCCCTGG TGACACAAGC AAACATCCCC AACGTTTTCT CCATGCAGAT GTGTGGAGCC 
GGCTTGCCCG TTGCTGGATC TGGGACCAAC GGAGGTAGTC TTGTCTTGGG TGGAATTGAA 
CCAAGTTTGT ATAAAGGAGA CATCTGGTAT ACCCCTATTA AGGAAGAGTG GTACTACCAG 
ATAGAAATTC TGAAATTGGA AATTGGAGGC CAAAGCCTTA ATCTGGACTG CAGAGAGTAT 
AACGCAGACA AGGCCATCGT GGACAGTGGC ACCACGCTGC TGCGCCTGCC CCAGAAGGTG 
TTTGATGCGG TGGTGGAAGC TGTGGCCCGC GCATCTCTGA TTCCAGAATT CTCTGATGGT 
TTCTGGACTG GGTCCCAGCT GGCGTGCTGG ACGAATTCGG AAACACCTTG GTCTTACTTC 
CCTAAAATCT CCATCTACCT GAGAGACGAG AACTCCAGCA GGTCATTCCG TATCACAATC 
CTGCCTCAGC TTTACATTCA GCCCATGATG GGGGCCGGCC TGAATTATGA ATGTTACCGA 
TTCGGCATTT CCCCATCCAC AAATGCGCTG GTGATCGGTG CCACGGTGAT GGAGGGCTTC 
TACGTCATCT TCGACAGAGC CCAGAAGAGG GTGGGCTTCG CAGCGAGCCC CTGTGCAGAA 
ATTGCAGGTG CTGCAGTGTC TGAAATTTCC GGGCCTTTCT CAACAGAGGA TGTAGCCAGC 
AACTGTGTCC CCGCTCAGTC TTTGAGCGAG CCCATTTTGT GGATTGTGTC CTATGCGCTC 
ATGAGCGTCT GTGGAGCCAT CCTCCTTGTC TTAATCGTCC TGCTGCTGCT GCCGTTCCGG 
TGTCAGCGTC GCCCCCGTGA CCCTGAGGTC GTCAATGATG AGTCCTCTCT GGTCAGACAT 
CGCTGGAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883803.1
CDS	421..1692
Translation	MAALHLYKKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK

Target ORF information:

RefSeq Version	XM_017028314.1
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-secretase 2 (BACE2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017028314.1

ORF Insert Sequence:

ATGGCCGCCT TGCACCTTTA TAAGAAGCTA CAGATTCTCG TTGACACTGG AAGCAGTAAC 
TTTGCCGTGG CAGGAACCCC GCACTCCTAC ATAGACACGT ACTTTGACAC AGAGAGGTCT 
AGCACATACC GCTCCAAGGG CTTTGACGTC ACAGTGAAGT ACACACAAGG AAGCTGGACG 
GGCTTCGTTG GGGAAGACCT CGTCACCATC CCCAAAGGCT TCAATACTTC TTTTCTTGTC 
AACATTGCCA CTATTTTTGA ATCAGAGAAT TTCTTTTTGC CTGGGATTAA ATGGAATGGA 
ATACTTGGCC TAGCTTATGC CACACTTGCC AAGCCATCAA GTTCTCTGGA GACCTTCTTC 
GACTCCCTGG TGACACAAGC AAACATCCCC AACGTTTTCT CCATGCAGAT GTGTGGAGCC 
GGCTTGCCCG TTGCTGGATC TGGGACCAAC GGAGGTAGTC TTGTCTTGGG TGGAATTGAA 
CCAAGTTTGT ATAAAGGAGA CATCTGGTAT ACCCCTATTA AGGAAGAGTG GTACTACCAG 
ATAGAAATTC TGAAATTGGA AATTGGAGGC CAAAGCCTTA ATCTGGACTG CAGAGAGTAT 
AACGCAGACA AGGCCATCGT GGACAGTGGC ACCACGCTGC TGCGCCTGCC CCAGAAGGTG 
TTTGATGCGG TGGTGGAAGC TGTGGCCCGC GCATCTCTGA TTCCAGAATT CTCTGATGGT 
TTCTGGACTG GGTCCCAGCT GGCGTGCTGG ACGAATTCGG AAACACCTTG GTCTTACTTC 
CCTAAAATCT CCATCTACCT GAGAGACGAG AACTCCAGCA GGTCATTCCG TATCACAATC 
CTGCCTCAGC TTTACATTCA GCCCATGATG GGGGCCGGCC TGAATTATGA ATGTTACCGA 
TTCGGCATTT CCCCATCCAC AAATGCGCTG GTGATCGGTG CCACGGTGAT GGAGGGCTTC 
TACGTCATCT TCGACAGAGC CCAGAAGAGG GTGGGCTTCG CAGCGAGCCC CTGTGCAGAA 
ATTGCAGGTG CTGCAGTGTC TGAAATTTCC GGGCCTTTCT CAACAGAGGA TGTAGCCAGC 
AACTGTGTCC CCGCTCAGTC TTTGAGCGAG CCCATTTTGT GGATTGTGTC CTATGCGCTC 
ATGAGCGTCT GTGGAGCCAT CCTCCTTGTC TTAATCGTCC TGCTGCTGCT GCCGTTCCGG 
TGTCAGCGTC GCCCCCGTGA CCCTGAGGTC GTCAATGATG AGTCCTCTCT GGTCAGACAT 
CGCTGGAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BACE2 ( NM_138991.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620476.1 Homo sapiens beta-secretase 2 (BACE2), transcript variant c, mRNA.

Price & Availability↑

CloneID	OHu00042
Clone ID Related Accession (Same CDS sequence)	NM_138991.2 , NM_138991.3
Accession Version	NM_138991.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	beta-secretase 2 isoform C preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF188276.1, AL773572.1, AF200342.1 and AL773578.1. On Jul 6, 2013 this sequence version replaced NM_138991.1. Transcript Variant: This variant (c) lacks an alternate in-frame exon, compared to variant a. The encoded isoform (C) is shorter than isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF188276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGCTTTAC ATTCAGCCCA TGATGGGGGC CGGCCTGAAT 
TATGAATGTT ACCGATTCGG CATTTCCCCA TCCACAAATG CGCTGGTGAT CGGTGCCACG 
GTGATGGAGG GCTTCTACGT CATCTTCGAC AGAGCCCAGA AGAGGGTGGG CTTCGCAGCG 
AGCCCCTGTG CAGAAATTGC AGGTGCTGCA GTGTCTGAAA TTTCCGGGCC TTTCTCAACA 
GAGGATGTAG CCAGCAACTG TGTCCCCGCT CAGTCTTTGA GCGAGCCCAT TTTGTGGATT 
GTGTCCTATG CGCTCATGAG CGTCTGTGGA GCCATCCTCC TTGTCTTAAT CGTCCTGCTG 
CTGCTGCCGT TCCGGTGTCA GCGTCGCCCC CGTGACCCTG AGGTCGTCAA TGATGAGTCC 
TCTCTGGTCA GACATCGCTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620476.1
CDS	464..1870
Translation	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK

Target ORF information:

RefSeq Version	NM_138991.2
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-secretase 2 (BACE2), transcript variant c, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138991.2

ORF Insert Sequence:

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGCTTTAC ATTCAGCCCA TGATGGGGGC CGGCCTGAAT 
TATGAATGTT ACCGATTCGG CATTTCCCCA TCCACAAATG CGCTGGTGAT CGGTGCCACG 
GTGATGGAGG GCTTCTACGT CATCTTCGAC AGAGCCCAGA AGAGGGTGGG CTTCGCAGCG 
AGCCCCTGTG CAGAAATTGC AGGTGCTGCA GTGTCTGAAA TTTCCGGGCC TTTCTCAACA 
GAGGATGTAG CCAGCAACTG TGTCCCCGCT CAGTCTTTGA GCGAGCCCAT TTTGTGGATT 
GTGTCCTATG CGCTCATGAG CGTCTGTGGA GCCATCCTCC TTGTCTTAAT CGTCCTGCTG 
CTGCTGCCGT TCCGGTGTCA GCGTCGCCCC CGTGACCCTG AGGTCGTCAA TGATGAGTCC 
TCTCTGGTCA GACATCGCTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BACE2 ( NM_138991.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620476.1 Homo sapiens beta-secretase 2 (BACE2), transcript variant c, mRNA.

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CloneID	OHu00042
Clone ID Related Accession (Same CDS sequence)	NM_138991.2 , NM_138991.3
Accession Version	NM_138991.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Homo sapiens(human)
Product	beta-secretase 2 isoform C preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF188276.1, AF200342.1 and AL773578.1. On May 31, 2019 this sequence version replaced NM_138991.2. Transcript Variant: This variant (c) lacks an alternate in-frame exon, compared to variant a. The encoded isoform (C) is shorter than isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF188276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGCTTTAC ATTCAGCCCA TGATGGGGGC CGGCCTGAAT 
TATGAATGTT ACCGATTCGG CATTTCCCCA TCCACAAATG CGCTGGTGAT CGGTGCCACG 
GTGATGGAGG GCTTCTACGT CATCTTCGAC AGAGCCCAGA AGAGGGTGGG CTTCGCAGCG 
AGCCCCTGTG CAGAAATTGC AGGTGCTGCA GTGTCTGAAA TTTCCGGGCC TTTCTCAACA 
GAGGATGTAG CCAGCAACTG TGTCCCCGCT CAGTCTTTGA GCGAGCCCAT TTTGTGGATT 
GTGTCCTATG CGCTCATGAG CGTCTGTGGA GCCATCCTCC TTGTCTTAAT CGTCCTGCTG 
CTGCTGCCGT TCCGGTGTCA GCGTCGCCCC CGTGACCCTG AGGTCGTCAA TGATGAGTCC 
TCTCTGGTCA GACATCGCTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620476.1
CDS	105..1511
Translation	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK

Target ORF information:

RefSeq Version	NM_138991.3
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-secretase 2 (BACE2), transcript variant c, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138991.3

ORF Insert Sequence:

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGCTTTAC ATTCAGCCCA TGATGGGGGC CGGCCTGAAT 
TATGAATGTT ACCGATTCGG CATTTCCCCA TCCACAAATG CGCTGGTGAT CGGTGCCACG 
GTGATGGAGG GCTTCTACGT CATCTTCGAC AGAGCCCAGA AGAGGGTGGG CTTCGCAGCG 
AGCCCCTGTG CAGAAATTGC AGGTGCTGCA GTGTCTGAAA TTTCCGGGCC TTTCTCAACA 
GAGGATGTAG CCAGCAACTG TGTCCCCGCT CAGTCTTTGA GCGAGCCCAT TTTGTGGATT 
GTGTCCTATG CGCTCATGAG CGTCTGTGGA GCCATCCTCC TTGTCTTAAT CGTCCTGCTG 
CTGCTGCCGT TCCGGTGTCA GCGTCGCCCC CGTGACCCTG AGGTCGTCAA TGATGAGTCC 
TCTCTGGTCA GACATCGCTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BACE2 ( NM_138992.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620477.1 Homo sapiens beta-secretase 2 (BACE2), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu00304
Clone ID Related Accession (Same CDS sequence)	NM_138992.2 , NM_138992.3
Accession Version	NM_138992.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	beta-secretase 2 isoform B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF188277.1, AL773572.1, AF200342.1, AF188276.1 and AL773578.1. On Jul 6, 2013 this sequence version replaced NM_138992.1. Transcript Variant: This variant (b) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant a. The encoded isoform (B) is shorter and has a distinct C-terminus, compared to isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF188277.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGATTCCA GAATTCTCTG ATGGTTTCTG GACTGGGTCC 
CAGCTGGCGT GCTGGACGAA TTCGGAAACA CCTTGGTCTT ACTTCCCTAA AATCTCCATC 
TACCTGAGAG ACGAGAACTC CAGCAGGTCA TTCCGTATCA CAATCCTGCC TCAGAAATTG 
CAGGTGCTGC AGTGTCTGAA ATTTCCGGGC CTTTCTCAAC AGAGGATGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620477.1
CDS	464..1654
Translation	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQKLQVLQCLKFPGLSQQRM

Target ORF information:

RefSeq Version	NM_138992.2
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-secretase 2 (BACE2), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138992.2

ORF Insert Sequence:

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGATTCCA GAATTCTCTG ATGGTTTCTG GACTGGGTCC 
CAGCTGGCGT GCTGGACGAA TTCGGAAACA CCTTGGTCTT ACTTCCCTAA AATCTCCATC 
TACCTGAGAG ACGAGAACTC CAGCAGGTCA TTCCGTATCA CAATCCTGCC TCAGAAATTG 
CAGGTGCTGC AGTGTCTGAA ATTTCCGGGC CTTTCTCAAC AGAGGATGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BACE2 ( NM_138992.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620477.1 Homo sapiens beta-secretase 2 (BACE2), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu00304
Clone ID Related Accession (Same CDS sequence)	NM_138992.2 , NM_138992.3
Accession Version	NM_138992.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	beta-secretase 2 isoform B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF188277.1, AF200342.1, AF188276.1 and AL773578.1. On May 31, 2019 this sequence version replaced NM_138992.2. Transcript Variant: This variant (b) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant a. The encoded isoform (B) is shorter and has a distinct C-terminus, compared to isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF188277.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGATTCCA GAATTCTCTG ATGGTTTCTG GACTGGGTCC 
CAGCTGGCGT GCTGGACGAA TTCGGAAACA CCTTGGTCTT ACTTCCCTAA AATCTCCATC 
TACCTGAGAG ACGAGAACTC CAGCAGGTCA TTCCGTATCA CAATCCTGCC TCAGAAATTG 
CAGGTGCTGC AGTGTCTGAA ATTTCCGGGC CTTTCTCAAC AGAGGATGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620477.1
CDS	105..1295
Translation	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQKLQVLQCLKFPGLSQQRM

Target ORF information:

RefSeq Version	NM_138992.3
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-secretase 2 (BACE2), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138992.3

ORF Insert Sequence:

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGATTCCA GAATTCTCTG ATGGTTTCTG GACTGGGTCC 
CAGCTGGCGT GCTGGACGAA TTCGGAAACA CCTTGGTCTT ACTTCCCTAA AATCTCCATC 
TACCTGAGAG ACGAGAACTC CAGCAGGTCA TTCCGTATCA CAATCCTGCC TCAGAAATTG 
CAGGTGCTGC AGTGTCTGAA ATTTCCGGGC CTTTCTCAAC AGAGGATGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BACE2 ( NM_012105.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036237.2 Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA.

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CloneID	OHu01546
Clone ID Related Accession (Same CDS sequence)	NM_012105.4 , NM_012105.5
Accession Version	NM_012105.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	beta-secretase 2 isoform A preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF178532.1, AL773572.1, AF200342.1, AF188276.1 and AL773578.1. On Jul 6, 2013 this sequence version replaced NM_012105.3. Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF178532.1, SRR1803615.14606.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGATTCCA GAATTCTCTG ATGGTTTCTG GACTGGGTCC 
CAGCTGGCGT GCTGGACGAA TTCGGAAACA CCTTGGTCTT ACTTCCCTAA AATCTCCATC 
TACCTGAGAG ACGAGAACTC CAGCAGGTCA TTCCGTATCA CAATCCTGCC TCAGCTTTAC 
ATTCAGCCCA TGATGGGGGC CGGCCTGAAT TATGAATGTT ACCGATTCGG CATTTCCCCA 
TCCACAAATG CGCTGGTGAT CGGTGCCACG GTGATGGAGG GCTTCTACGT CATCTTCGAC 
AGAGCCCAGA AGAGGGTGGG CTTCGCAGCG AGCCCCTGTG CAGAAATTGC AGGTGCTGCA 
GTGTCTGAAA TTTCCGGGCC TTTCTCAACA GAGGATGTAG CCAGCAACTG TGTCCCCGCT 
CAGTCTTTGA GCGAGCCCAT TTTGTGGATT GTGTCCTATG CGCTCATGAG CGTCTGTGGA 
GCCATCCTCC TTGTCTTAAT CGTCCTGCTG CTGCTGCCGT TCCGGTGTCA GCGTCGCCCC 
CGTGACCCTG AGGTCGTCAA TGATGAGTCC TCTCTGGTCA GACATCGCTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036237.2
CDS	464..2020
Translation	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK

Target ORF information:

RefSeq Version	NM_012105.4
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012105.4

ORF Insert Sequence:

ATGGGCGCAC TGGCCCGGGC GCTGCTGCTG CCTCTGCTGG CCCAGTGGCT CCTGCGCGCC 
GCCCCGGAGC TGGCCCCCGC GCCCTTCACG CTGCCCCTCC GGGTGGCCGC GGCCACGAAC 
CGCGTAGTTG CGCCCACCCC GGGACCCGGG ACCCCTGCCG AGCGCCACGC CGACGGCTTG 
GCGCTCGCCC TGGAGCCTGC CCTGGCGTCC CCCGCGGGCG CCGCCAACTT CTTGGCCATG 
GTAGACAACC TGCAGGGGGA CTCTGGCCGC GGCTACTACC TGGAGATGCT GATCGGGACC 
CCCCCGCAGA AGCTACAGAT TCTCGTTGAC ACTGGAAGCA GTAACTTTGC CGTGGCAGGA 
ACCCCGCACT CCTACATAGA CACGTACTTT GACACAGAGA GGTCTAGCAC ATACCGCTCC 
AAGGGCTTTG ACGTCACAGT GAAGTACACA CAAGGAAGCT GGACGGGCTT CGTTGGGGAA 
GACCTCGTCA CCATCCCCAA AGGCTTCAAT ACTTCTTTTC TTGTCAACAT TGCCACTATT 
TTTGAATCAG AGAATTTCTT TTTGCCTGGG ATTAAATGGA ATGGAATACT TGGCCTAGCT 
TATGCCACAC TTGCCAAGCC ATCAAGTTCT CTGGAGACCT TCTTCGACTC CCTGGTGACA 
CAAGCAAACA TCCCCAACGT TTTCTCCATG CAGATGTGTG GAGCCGGCTT GCCCGTTGCT 
GGATCTGGGA CCAACGGAGG TAGTCTTGTC TTGGGTGGAA TTGAACCAAG TTTGTATAAA 
GGAGACATCT GGTATACCCC TATTAAGGAA GAGTGGTACT ACCAGATAGA AATTCTGAAA 
TTGGAAATTG GAGGCCAAAG CCTTAATCTG GACTGCAGAG AGTATAACGC AGACAAGGCC 
ATCGTGGACA GTGGCACCAC GCTGCTGCGC CTGCCCCAGA AGGTGTTTGA TGCGGTGGTG 
GAAGCTGTGG CCCGCGCATC TCTGATTCCA GAATTCTCTG ATGGTTTCTG GACTGGGTCC 
CAGCTGGCGT GCTGGACGAA TTCGGAAACA CCTTGGTCTT ACTTCCCTAA AATCTCCATC 
TACCTGAGAG ACGAGAACTC CAGCAGGTCA TTCCGTATCA CAATCCTGCC TCAGCTTTAC 
ATTCAGCCCA TGATGGGGGC CGGCCTGAAT TATGAATGTT ACCGATTCGG CATTTCCCCA 
TCCACAAATG CGCTGGTGAT CGGTGCCACG GTGATGGAGG GCTTCTACGT CATCTTCGAC 
AGAGCCCAGA AGAGGGTGGG CTTCGCAGCG AGCCCCTGTG CAGAAATTGC AGGTGCTGCA 
GTGTCTGAAA TTTCCGGGCC TTTCTCAACA GAGGATGTAG CCAGCAACTG TGTCCCCGCT 
CAGTCTTTGA GCGAGCCCAT TTTGTGGATT GTGTCCTATG CGCTCATGAG CGTCTGTGGA 
GCCATCCTCC TTGTCTTAAT CGTCCTGCTG CTGCTGCCGT TCCGGTGTCA GCGTCGCCCC 
CGTGACCCTG AGGTCGTCAA TGATGAGTCC TCTCTGGTCA GACATCGCTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter.
Journal of molecular neuroscience : MN29(1)81-99(2006)
Maloney B,Ge YW,Greig NH,Lahiri DK

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology19(7)739-49(2005 May)
Sun X,Wang Y,Qing H,Christensen MA,Liu Y,Zhou W,Tong Y,Xiao C,Huang Y,Zhang S,Liu X,Song W

BACE2 functions as an alternative alpha-secretase in cells.
The Journal of biological chemistry276(36)34019-27(2001 Sep)
Yan R,Munzner JB,Shuck ME,Bienkowski MJ

Prodomain processing of Asp1 (BACE2) is autocatalytic.
The Journal of biological chemistry276(26)23322-8(2001 Jun)
Hussain I,Christie G,Schneider K,Moore S,Dingwall C

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
Molecular and cellular neurosciences16(5)609-19(2000 Nov)
Hussain I,Powell DJ,Howlett DR,Chapman GA,Gilmour L,Murdock PR,Tew DG,Meek TD,Chapman C,Schneider K,Ratcliffe SJ,Tattersall D,Testa TT,Southan C,Ryan DM,Simmons DL,Walsh FS,Dingwall C,Christie G

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BACE2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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