TNFRSF13B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFRSF13B
Entrez Gene ID	23495
Full Name	TNF receptor superfamily member 13B
Synonyms	CD267,CVID,CVID2,IGAD2,RYZN,TACI,TNFRSF14B
General protein information	Preferred Names TNF receptor superfamily member 13B Names tumor necrosis factor receptor superfamily member 13B transmembrane activator and CAML interactor tumor necrosis factor receptor 13B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p11.2
Summary	The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
Disorder MIM:	604907
Disorder Html:	Immunoglobulin A deficiency 2, 609529 (3); Immunodeficiency, common variable, 2, 240500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_012452.3	NP_036584.1	tumor necrosis factor receptor superfamily member 13B
NM_012452.2	NP_036584.1	tumor necrosis factor receptor superfamily member 13B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TNFRSF13B	XP_005620235.1
Gallus gallus (chicken)	TNFRSF13B	NP_001091006.1
Homo sapiens (human)	TNFRSF13B	NP_036584.1
Pan troglodytes (chimpanzee)	TNFRSF13B	XP_001161361.2
	TNFRSF13B	XP_001088700.2
Mus musculus (house mouse)	Tnfrsf13b	NP_067324.1

Gene Ontology
Bibliography

Related articles in PubMed

A gain-of-function mutation in TNFRSF13B is a candidate for predisposition to familial or sporadic immune thrombocytopenia.
Peng HL, Zhang Y, Sun NN, Yin YF, Wang YW, Cheng Z, Yan WZ, Liu SF, Xu YX, Xiao X, Zhang GS
Journal of thrombosis and haemostasis : JTH15(11)2259-2269(2017 Nov)

BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
Smulski CR, Kury P, Seidel LM, Staiger HS, Edinger AK, Willen L, Seidl M, Hess H, Salzer U, Rolink AG, Rizzi M, Schneider P, Eibel H
Cell reports18(9)2189-2202(2017 Feb)

Profile of BAFF and its receptors' expression in lupus nephritis is associated with pathological classes.
Suso JP, Posso-Osorio I, Jim?nez CA, Naranjo-Escobar J, Ospina FE, S?nchez A, Ca?as CA, Tob?n GJ
Lupus961203317739132(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that TACI A181E heterozygosity results in TACI haploinsufficiency with increased susceptibility to pneumococcal infection
Title: Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice.

BAFF-induced processing of BAFFR regulates BAFF-mediated B cell responses in a TACI-dependent manner.
Title: BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.

The expression levels of serum BAFF and the three receptors (TACI, BCMA and BAFF-R) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls.
Title: The Correlation Between Non-Hodgkin Lymphoma and Expression Levels of B-Cell Activating Factor and Its Receptors.

11% of common variable immunodeficiency patients and 13% of antibody deficiency syndromes patients carried at least one mutated TNFRSF13B allele.
Title: Clinical Associations of Biallelic and Monoallelic TNFRSF13B Variants in Italian Primary Antibody Deficiency Syndromes.

C104R mutation was associated with common variable immunodeficiency and IgG subclass deficiency.
Title: Incidence of the C104R TACI Mutation in Patients With Primary Antibody Deficiency.

The following TNFRSF13B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF13B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19409	NM_012452.3 Latest version!	Homo sapiens TNF receptor superfamily member 13B (TNFRSF13B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu19409	NM_012452.2	Homo sapiens TNF receptor superfamily member 13B (TNFRSF13B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFRSF13B ( NM_012452.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036584.1 Homo sapiens TNF receptor superfamily member 13B (TNFRSF13B), mRNA.

Price & Availability↑

CloneID	OHu19409
Clone ID Related Accession (Same CDS sequence)	NM_012452.3 , NM_012452.2
Accession Version	NM_012452.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 13B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104024.8 and AL353996.3. On Aug 31, 2019 this sequence version replaced NM_012452.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF023614.1, AK223453.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGTGGCC TGGGCCGGAG CAGGCGAGGT GGCCGGAGCC GTGTGGACCA GGAGGAGCGC 
TTTCCACAGG GCCTGTGGAC GGGGGTGGCT ATGAGATCCT GCCCCGAAGA GCAGTACTGG 
GATCCTCTGC TGGGTACCTG CATGTCCTGC AAAACCATTT GCAACCATCA GAGCCAGCGC 
ACCTGTGCAG CCTTCTGCAG GTCACTCAGC TGCCGCAAGG AGCAAGGCAA GTTCTATGAC 
CATCTCCTGA GGGACTGCAT CAGCTGTGCC TCCATCTGTG GACAGCACCC TAAGCAATGT 
GCATACTTCT GTGAGAACAA GCTCAGGAGC CCAGTGAACC TTCCACCAGA GCTCAGGAGA 
CAGCGGAGTG GAGAAGTTGA AAACAATTCA GACAACTCGG GAAGGTACCA AGGATTGGAG 
CACAGAGGCT CAGAAGCAAG TCCAGCTCTC CCGGGGCTGA AGCTGAGTGC AGATCAGGTG 
GCCCTGGTCT ACAGCACGCT GGGGCTCTGC CTGTGTGCCG TCCTCTGCTG CTTCCTGGTG 
GCGGTGGCCT GCTTCCTCAA GAAGAGGGGG GATCCCTGCT CCTGCCAGCC CCGCTCAAGG 
CCCCGTCAAA GTCCGGCCAA GTCTTCCCAG GATCACGCGA TGGAAGCCGG CAGCCCTGTG 
AGCACATCCC CCGAGCCAGT GGAGACCTGC AGCTTCTGCT TCCCTGAGTG CAGGGCGCCC 
ACGCAGGAGA GCGCAGTCAC GCCTGGGACC CCCGACCCCA CTTGTGCTGG AAGGTGGGGG 
TGCCACACCA GGACCACAGT CCTGCAGCCT TGCCCACACA TCCCAGACAG TGGCCTTGGC 
ATTGTGTGTG TGCCTGCCCA GGAGGGGGGC CCAGGTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036584.1
CDS	44..925
Translation	MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGSPVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPDSGLGIVCVPAQEGGPGA

Target ORF information:

RefSeq Version	NM_012452.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 13B (TNFRSF13B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012452.3

ORF Insert Sequence:

ATGAGTGGCC TGGGCCGGAG CAGGCGAGGT GGCCGGAGCC GTGTGGACCA GGAGGAGCGC 
TTTCCACAGG GCCTGTGGAC GGGGGTGGCT ATGAGATCCT GCCCCGAAGA GCAGTACTGG 
GATCCTCTGC TGGGTACCTG CATGTCCTGC AAAACCATTT GCAACCATCA GAGCCAGCGC 
ACCTGTGCAG CCTTCTGCAG GTCACTCAGC TGCCGCAAGG AGCAAGGCAA GTTCTATGAC 
CATCTCCTGA GGGACTGCAT CAGCTGTGCC TCCATCTGTG GACAGCACCC TAAGCAATGT 
GCATACTTCT GTGAGAACAA GCTCAGGAGC CCAGTGAACC TTCCACCAGA GCTCAGGAGA 
CAGCGGAGTG GAGAAGTTGA AAACAATTCA GACAACTCGG GAAGGTACCA AGGATTGGAG 
CACAGAGGCT CAGAAGCAAG TCCAGCTCTC CCGGGGCTGA AGCTGAGTGC AGATCAGGTG 
GCCCTGGTCT ACAGCACGCT GGGGCTCTGC CTGTGTGCCG TCCTCTGCTG CTTCCTGGTG 
GCGGTGGCCT GCTTCCTCAA GAAGAGGGGG GATCCCTGCT CCTGCCAGCC CCGCTCAAGG 
CCCCGTCAAA GTCCGGCCAA GTCTTCCCAG GATCACGCGA TGGAAGCCGG CAGCCCTGTG 
AGCACATCCC CCGAGCCAGT GGAGACCTGC AGCTTCTGCT TCCCTGAGTG CAGGGCGCCC 
ACGCAGGAGA GCGCAGTCAC GCCTGGGACC CCCGACCCCA CTTGTGCTGG AAGGTGGGGG 
TGCCACACCA GGACCACAGT CCTGCAGCCT TGCCCACACA TCCCAGACAG TGGCCTTGGC 
ATTGTGTGTG TGCCTGCCCA GGAGGGGGGC CCAGGTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFRSF13B ( NM_012452.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036584.1 Homo sapiens TNF receptor superfamily member 13B (TNFRSF13B), mRNA.

Price & Availability↑

CloneID	OHu19409
Clone ID Related Accession (Same CDS sequence)	NM_012452.3 , NM_012452.2
Accession Version	NM_012452.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-27
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 13B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF023614.1. This sequence is a reference standard in the RefSeqGene project. On Sep 20, 2002 this sequence version replaced NM_012452.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF023614.1, SRR1163658.7981.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGTGGCC TGGGCCGGAG CAGGCGAGGT GGCCGGAGCC GTGTGGACCA GGAGGAGCGC 
TTTCCACAGG GCCTGTGGAC GGGGGTGGCT ATGAGATCCT GCCCCGAAGA GCAGTACTGG 
GATCCTCTGC TGGGTACCTG CATGTCCTGC AAAACCATTT GCAACCATCA GAGCCAGCGC 
ACCTGTGCAG CCTTCTGCAG GTCACTCAGC TGCCGCAAGG AGCAAGGCAA GTTCTATGAC 
CATCTCCTGA GGGACTGCAT CAGCTGTGCC TCCATCTGTG GACAGCACCC TAAGCAATGT 
GCATACTTCT GTGAGAACAA GCTCAGGAGC CCAGTGAACC TTCCACCAGA GCTCAGGAGA 
CAGCGGAGTG GAGAAGTTGA AAACAATTCA GACAACTCGG GAAGGTACCA AGGATTGGAG 
CACAGAGGCT CAGAAGCAAG TCCAGCTCTC CCGGGGCTGA AGCTGAGTGC AGATCAGGTG 
GCCCTGGTCT ACAGCACGCT GGGGCTCTGC CTGTGTGCCG TCCTCTGCTG CTTCCTGGTG 
GCGGTGGCCT GCTTCCTCAA GAAGAGGGGG GATCCCTGCT CCTGCCAGCC CCGCTCAAGG 
CCCCGTCAAA GTCCGGCCAA GTCTTCCCAG GATCACGCGA TGGAAGCCGG CAGCCCTGTG 
AGCACATCCC CCGAGCCAGT GGAGACCTGC AGCTTCTGCT TCCCTGAGTG CAGGGCGCCC 
ACGCAGGAGA GCGCAGTCAC GCCTGGGACC CCCGACCCCA CTTGTGCTGG AAGGTGGGGG 
TGCCACACCA GGACCACAGT CCTGCAGCCT TGCCCACACA TCCCAGACAG TGGCCTTGGC 
ATTGTGTGTG TGCCTGCCCA GGAGGGGGGC CCAGGTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036584.1
CDS	14..895
Translation	MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGSPVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPDSGLGIVCVPAQEGGPGA

Target ORF information:

RefSeq Version	NM_012452.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 13B (TNFRSF13B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012452.2

ORF Insert Sequence:

ATGAGTGGCC TGGGCCGGAG CAGGCGAGGT GGCCGGAGCC GTGTGGACCA GGAGGAGCGC 
TTTCCACAGG GCCTGTGGAC GGGGGTGGCT ATGAGATCCT GCCCCGAAGA GCAGTACTGG 
GATCCTCTGC TGGGTACCTG CATGTCCTGC AAAACCATTT GCAACCATCA GAGCCAGCGC 
ACCTGTGCAG CCTTCTGCAG GTCACTCAGC TGCCGCAAGG AGCAAGGCAA GTTCTATGAC 
CATCTCCTGA GGGACTGCAT CAGCTGTGCC TCCATCTGTG GACAGCACCC TAAGCAATGT 
GCATACTTCT GTGAGAACAA GCTCAGGAGC CCAGTGAACC TTCCACCAGA GCTCAGGAGA 
CAGCGGAGTG GAGAAGTTGA AAACAATTCA GACAACTCGG GAAGGTACCA AGGATTGGAG 
CACAGAGGCT CAGAAGCAAG TCCAGCTCTC CCGGGGCTGA AGCTGAGTGC AGATCAGGTG 
GCCCTGGTCT ACAGCACGCT GGGGCTCTGC CTGTGTGCCG TCCTCTGCTG CTTCCTGGTG 
GCGGTGGCCT GCTTCCTCAA GAAGAGGGGG GATCCCTGCT CCTGCCAGCC CCGCTCAAGG 
CCCCGTCAAA GTCCGGCCAA GTCTTCCCAG GATCACGCGA TGGAAGCCGG CAGCCCTGTG 
AGCACATCCC CCGAGCCAGT GGAGACCTGC AGCTTCTGCT TCCCTGAGTG CAGGGCGCCC 
ACGCAGGAGA GCGCAGTCAC GCCTGGGACC CCCGACCCCA CTTGTGCTGG AAGGTGGGGG 
TGCCACACCA GGACCACAGT CCTGCAGCCT TGCCCACACA TCCCAGACAG TGGCCTTGGC 
ATTGTGTGTG TGCCTGCCCA GGAGGGGGGC CCAGGTGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A gain-of-function mutation in TNFRSF13B is a candidate for predisposition to familial or sporadic immune thrombocytopenia.
Journal of thrombosis and haemostasis : JTH15(11)2259-2269(2017 Nov)
Peng HL,Zhang Y,Sun NN,Yin YF,Wang YW,Cheng Z,Yan WZ,Liu SF,Xu YX,Xiao X,Zhang GS

BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
Cell reports18(9)2189-2202(2017 Feb)
Smulski CR,Kury P,Seidel LM,Staiger HS,Edinger AK,Willen L,Seidl M,Hess H,Salzer U,Rolink AG,Rizzi M,Schneider P,Eibel H

Profile of BAFF and its receptors' expression in lupus nephritis is associated with pathological classes.
Lupus961203317739132(2017 Jan)
Suso JP,Posso-Osorio I,Jim?nez CA,Naranjo-Escobar J,Ospina FE,S?nchez A,Ca?as CA,Tob?n GJ

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TNFRSF13B cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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