FOXE3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXE3
Entrez Gene ID	2301
Full Name	forkhead box E3
Synonyms	AAT11,ASGD2,CTRCT34,FKHL12,FREAC8
General protein information	Preferred Names forkhead box E3 Names forkhead box protein E3 FREAC-8 forkhead, drosophila, homolog-like 12 forkhead-related protein FKHL12 forkhead-related transcription factor 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p33
Summary	This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009].
Disorder MIM:	601094
Disorder Html:	Anterior segment dysgenesis 2, multiple subtypes, 610256 (3); Cataract 34, multiple types, 612968 (3); {Aortic aneurysm, familial thoracic 11, susceptibility to}, 617349 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_012186.2	NP_036318.1	forkhead box protein E3
NM_012186.3	NP_036318.1	forkhead box protein E3

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Lack of FOXE3 coding mutation in a case of congenital aphakia.
Sano Y, Matsukane Y, Watanabe A, Sonoda KH, Kondo H
Ophthalmic genetics39(1)95-98(2018 Jan-Feb)

FOXE3 mutations: genotype-phenotype correlations.
Plaisanci? J, Ragge NK, Dollfus H, Kaplan J, Lehalle D, Francannet C, Morin G, Colineaux H, Calvas P, Chassaing N
Clinical genetics(2017 Nov)

Exome sequencing reveals novel homozygous FOXE3 mutation in microphthalmos with staphylomatous malformation.
Saboo US, Penke D, Mahindrakar A, Uddaraju M, Sankurathri C, Gong X, Xing C, Mootha VV
Ophthalmic genetics38(3)295-297(2017 May-Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Only one novel missense mutation in exon 1 of FOXE3 (Chr1:47,882,459, c.472G>C, p.Gly158Arg) was identified being homozygous in the three affected and heterozygous in the two unaffected, which was confirmed by Sanger sequencing.
Title: Exome sequencing reveals novel homozygous FOXE3 mutation in microphthalmos with staphylomatous malformation.

FOXE3 mutations lead to a reduced number of aortic smooth muscle cells (SMCs) during development and increased SMC apoptosis in the ascending aorta in response to increased biomechanical forces.
Title: FOXE3 mutations predispose to thoracic aortic aneurysms and dissections.

This is the first functional evidence demonstrating that FOXE3 mutations identified in patients impair protein function with differential effects.
Title: Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease.

Our results indicate that the FOXE3 p.Val201Met allele is associated with eye defects (OR = 3.5), suggesting its involvement as an ocular malformation risk factor.
Title: Mutational screening of FOXE3, GDF3, ATOH7, and ALDH1A3 in congenital ocular malformations. Possible contribution of the FOXE3 p.VAL201MET variant to the risk of severe eye malformations.

This study demonstrates that a cluster of patients with sclerocornea, aphakia, and microphthalmia in a small Mexican village is due to a FOXE3 p.Y98H founder mutation.
Title: An epidemiological investigation of a Forkhead box protein E3 founder mutation underlying the high frequency of sclerocornea, aphakia, and microphthalmia in a Mexican village.

The following FOXE3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXE3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17850	NM_012186.3 Latest version!	Homo sapiens forkhead box E3 (FOXE3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu17850	NM_012186.2	Homo sapiens forkhead box E3 (FOXE3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXE3 ( NM_012186.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036318.1 Homo sapiens forkhead box E3 (FOXE3), mRNA.

Price & Availability↑

CloneID	OHu17850
Clone ID Related Accession (Same CDS sequence)	NM_012186.2 , NM_012186.3
Accession Version	NM_012186.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 960bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	forkhead box protein E3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF275722.1 and AL607122.20. This sequence is a reference standard in the RefSeqGene project. On Aug 2, 2006 this sequence version replaced NM_012186.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF275722.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGGC GCAGCGACAT GGATCCGCCC GCCGCGTTCT CTGGCTTCCC TGCCCTGCCA 
GCGGTCGCGC CGTCGGGGCC GCCGCCGTCG CCGCTCGCAG GAGCCGAGCC AGGGCGGGAG 
CCAGAGGAGG CGGCGGCTGG CCGCGGAGAG GCGGCCCCCA CGCCCGCGCC CGGCCCGGGG 
CGGCGGCGGC GGCGGCCCCT GCAGCGCGGG AAGCCGCCCT ACTCGTACAT CGCGCTCATC 
GCCATGGCTC TGGCGCACGC CCCGGGCCGC CGCCTCACGC TGGCCGCCAT CTACCGCTTC 
ATCACCGAAC GCTTTGCCTT CTACCGCGAC AGCCCGCGCA AGTGGCAGAA CAGCATCCGC 
CACAATCTCA CGCTCAACGA CTGCTTCGTC AAGGTGCCCC GCGAGCCGGG CAACCCGGGC 
AAGGGCAACT ACTGGACGCT GGACCCCGCG GCCGCAGACA TGTTCGACAA CGGCAGCTTC 
CTGCGGCGCC GCAAGCGCTT CAAGCGCGCC GAGCTGCCCG CGCACGCGGC CGCGGCGCCA 
GGGCCGCCGC TCCCCTTCCC CTACGCGCCC TACGCGCCCG CGCCCGGCCC CGCGCTGCTG 
GTGCCGCCGC CTTCTGCCGG ACCGGGCCCC TCGCCGCCCG CGCGTCTGTT CAGCGTCGAC 
AGCCTGGTGA ACCTGCAGCC GGAGCTAGCG GGGCTGGGCG CCCCCGAGCC GCCCTGCTGC 
GCCGCGCCCG ACGCCGCAGC CGCAGCCTTC CCGCCCTGCG CTGCCGCCGC CTCCCCGCCA 
CTCTACTCGC AGGTCCCCGA CCGCCTGGTA CTGCCCGCGA CGCGCCCCGG CCCCGGCCCG 
CTGCCCGCTG AGCCCCTCCT GGCCTTGGCC GGGCCGGCAG CCGCTCTCGG CCCGCTCAGC 
CCTGGGGAGG CCTACCTGAG GCAGCCGGGC TTCGCGTCGG GGCTGGAGCG CTACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036318.1
CDS	245..1204
Translation	MAGRSDMDPPAAFSGFPALPAVAPSGPPPSPLAGAEPGREPEEAAAGRGEAAPTPAPGPGRRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRFKRAELPAHAAAAPGPPLPFPYAPYAPAPGPALLVPPPSAGPGPSPPARLFSVDSLVNLQPELAGLGAPEPPCCAAPDAAAAAFPPCAAAASPPLYSQVPDRLVLPATRPGPGPLPAEPLLALAGPAAALGPLSPGEAYLRQPGFASGLERYL

Target ORF information:

RefSeq Version	NM_012186.2
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box E3 (FOXE3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012186.2

ORF Insert Sequence:

ATGGCGGGGC GCAGCGACAT GGATCCGCCC GCCGCGTTCT CTGGCTTCCC TGCCCTGCCA 
GCGGTCGCGC CGTCGGGGCC GCCGCCGTCG CCGCTCGCAG GAGCCGAGCC AGGGCGGGAG 
CCAGAGGAGG CGGCGGCTGG CCGCGGAGAG GCGGCCCCCA CGCCCGCGCC CGGCCCGGGG 
CGGCGGCGGC GGCGGCCCCT GCAGCGCGGG AAGCCGCCCT ACTCGTACAT CGCGCTCATC 
GCCATGGCTC TGGCGCACGC CCCGGGCCGC CGCCTCACGC TGGCCGCCAT CTACCGCTTC 
ATCACCGAAC GCTTTGCCTT CTACCGCGAC AGCCCGCGCA AGTGGCAGAA CAGCATCCGC 
CACAATCTCA CGCTCAACGA CTGCTTCGTC AAGGTGCCCC GCGAGCCGGG CAACCCGGGC 
AAGGGCAACT ACTGGACGCT GGACCCCGCG GCCGCAGACA TGTTCGACAA CGGCAGCTTC 
CTGCGGCGCC GCAAGCGCTT CAAGCGCGCC GAGCTGCCCG CGCACGCGGC CGCGGCGCCA 
GGGCCGCCGC TCCCCTTCCC CTACGCGCCC TACGCGCCCG CGCCCGGCCC CGCGCTGCTG 
GTGCCGCCGC CTTCTGCCGG ACCGGGCCCC TCGCCGCCCG CGCGTCTGTT CAGCGTCGAC 
AGCCTGGTGA ACCTGCAGCC GGAGCTAGCG GGGCTGGGCG CCCCCGAGCC GCCCTGCTGC 
GCCGCGCCCG ACGCCGCAGC CGCAGCCTTC CCGCCCTGCG CTGCCGCCGC CTCCCCGCCA 
CTCTACTCGC AGGTCCCCGA CCGCCTGGTA CTGCCCGCGA CGCGCCCCGG CCCCGGCCCG 
CTGCCCGCTG AGCCCCTCCT GGCCTTGGCC GGGCCGGCAG CCGCTCTCGG CCCGCTCAGC 
CCTGGGGAGG CCTACCTGAG GCAGCCGGGC TTCGCGTCGG GGCTGGAGCG CTACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXE3 ( NM_012186.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036318.1 Homo sapiens forkhead box E3 (FOXE3), mRNA.

Price & Availability↑

CloneID	OHu17850
Clone ID Related Accession (Same CDS sequence)	NM_012186.2 , NM_012186.3
Accession Version	NM_012186.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 960bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	forkhead box protein E3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF275722.1 and AL607122.20. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_012186.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF275722.1, KM433708.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000335071.4/ ENSP00000334472.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGGC GCAGCGACAT GGATCCGCCC GCCGCGTTCT CTGGCTTCCC TGCCCTGCCA 
GCGGTCGCGC CGTCGGGGCC GCCGCCGTCG CCGCTCGCAG GAGCCGAGCC AGGGCGGGAG 
CCAGAGGAGG CGGCGGCTGG CCGCGGAGAG GCGGCCCCCA CGCCCGCGCC CGGCCCGGGG 
CGGCGGCGGC GGCGGCCCCT GCAGCGCGGG AAGCCGCCCT ACTCGTACAT CGCGCTCATC 
GCCATGGCTC TGGCGCACGC CCCGGGCCGC CGCCTCACGC TGGCCGCCAT CTACCGCTTC 
ATCACCGAAC GCTTTGCCTT CTACCGCGAC AGCCCGCGCA AGTGGCAGAA CAGCATCCGC 
CACAATCTCA CGCTCAACGA CTGCTTCGTC AAGGTGCCCC GCGAGCCGGG CAACCCGGGC 
AAGGGCAACT ACTGGACGCT GGACCCCGCG GCCGCAGACA TGTTCGACAA CGGCAGCTTC 
CTGCGGCGCC GCAAGCGCTT CAAGCGCGCC GAGCTGCCCG CGCACGCGGC CGCGGCGCCA 
GGGCCGCCGC TCCCCTTCCC CTACGCGCCC TACGCGCCCG CGCCCGGCCC CGCGCTGCTG 
GTGCCGCCGC CTTCTGCCGG ACCGGGCCCC TCGCCGCCCG CGCGTCTGTT CAGCGTCGAC 
AGCCTGGTGA ACCTGCAGCC GGAGCTAGCG GGGCTGGGCG CCCCCGAGCC GCCCTGCTGC 
GCCGCGCCCG ACGCCGCAGC CGCAGCCTTC CCGCCCTGCG CTGCCGCCGC CTCCCCGCCA 
CTCTACTCGC AGGTCCCCGA CCGCCTGGTA CTGCCCGCGA CGCGCCCCGG CCCCGGCCCG 
CTGCCCGCTG AGCCCCTCCT GGCCTTGGCC GGGCCGGCAG CCGCTCTCGG CCCGCTCAGC 
CCTGGGGAGG CCTACCTGAG GCAGCCGGGC TTCGCGTCGG GGCTGGAGCG CTACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036318.1
CDS	32..991
Translation	MAGRSDMDPPAAFSGFPALPAVAPSGPPPSPLAGAEPGREPEEAAAGRGEAAPTPAPGPGRRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRFKRAELPAHAAAAPGPPLPFPYAPYAPAPGPALLVPPPSAGPGPSPPARLFSVDSLVNLQPELAGLGAPEPPCCAAPDAAAAAFPPCAAAASPPLYSQVPDRLVLPATRPGPGPLPAEPLLALAGPAAALGPLSPGEAYLRQPGFASGLERYL

Target ORF information:

RefSeq Version	NM_012186.3
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box E3 (FOXE3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012186.3

ORF Insert Sequence:

ATGGCGGGGC GCAGCGACAT GGATCCGCCC GCCGCGTTCT CTGGCTTCCC TGCCCTGCCA 
GCGGTCGCGC CGTCGGGGCC GCCGCCGTCG CCGCTCGCAG GAGCCGAGCC AGGGCGGGAG 
CCAGAGGAGG CGGCGGCTGG CCGCGGAGAG GCGGCCCCCA CGCCCGCGCC CGGCCCGGGG 
CGGCGGCGGC GGCGGCCCCT GCAGCGCGGG AAGCCGCCCT ACTCGTACAT CGCGCTCATC 
GCCATGGCTC TGGCGCACGC CCCGGGCCGC CGCCTCACGC TGGCCGCCAT CTACCGCTTC 
ATCACCGAAC GCTTTGCCTT CTACCGCGAC AGCCCGCGCA AGTGGCAGAA CAGCATCCGC 
CACAATCTCA CGCTCAACGA CTGCTTCGTC AAGGTGCCCC GCGAGCCGGG CAACCCGGGC 
AAGGGCAACT ACTGGACGCT GGACCCCGCG GCCGCAGACA TGTTCGACAA CGGCAGCTTC 
CTGCGGCGCC GCAAGCGCTT CAAGCGCGCC GAGCTGCCCG CGCACGCGGC CGCGGCGCCA 
GGGCCGCCGC TCCCCTTCCC CTACGCGCCC TACGCGCCCG CGCCCGGCCC CGCGCTGCTG 
GTGCCGCCGC CTTCTGCCGG ACCGGGCCCC TCGCCGCCCG CGCGTCTGTT CAGCGTCGAC 
AGCCTGGTGA ACCTGCAGCC GGAGCTAGCG GGGCTGGGCG CCCCCGAGCC GCCCTGCTGC 
GCCGCGCCCG ACGCCGCAGC CGCAGCCTTC CCGCCCTGCG CTGCCGCCGC CTCCCCGCCA 
CTCTACTCGC AGGTCCCCGA CCGCCTGGTA CTGCCCGCGA CGCGCCCCGG CCCCGGCCCG 
CTGCCCGCTG AGCCCCTCCT GGCCTTGGCC GGGCCGGCAG CCGCTCTCGG CCCGCTCAGC 
CCTGGGGAGG CCTACCTGAG GCAGCCGGGC TTCGCGTCGG GGCTGGAGCG CTACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of FOXE3 coding mutation in a case of congenital aphakia.
Ophthalmic genetics39(1)95-98(2018 Jan-Feb)
Sano Y,Matsukane Y,Watanabe A,Sonoda KH,Kondo H

FOXE3 mutations: genotype-phenotype correlations.
Clinical genetics(2017 Nov)
Plaisanci? J,Ragge NK,Dollfus H,Kaplan J,Lehalle D,Francannet C,Morin G,Colineaux H,Calvas P,Chassaing N

Exome sequencing reveals novel homozygous FOXE3 mutation in microphthalmos with staphylomatous malformation.
Ophthalmic genetics38(3)295-297(2017 May-Jun)
Saboo US,Penke D,Mahindrakar A,Uddaraju M,Sankurathri C,Gong X,Xing C,Mootha VV

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FOXE3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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