REEP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	REEP3
Entrez Gene ID	221035
Full Name	receptor accessory protein 3
Synonyms	C10orf74,Yip2b
General protein information	Preferred Names receptor accessory protein 3 Names receptor expression-enhancing protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q21.3
Disorder MIM:	609348

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001330.2	NP_001001330.1	receptor expression-enhancing protein 3
NM_001001330.3	NP_001001330.1	receptor expression-enhancing protein 3
XM_017015896.1	XP_016871385.1	receptor expression-enhancing protein 3 isoform X1
XM_011539501.2	XP_011537803.1	receptor expression-enhancing protein 3 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	REEP3	XP_536364.1
Bos taurus (cattle)	REEP3	NP_001095431.1
Gallus gallus (chicken)	REEP3	NP_001186461.1
Xenopus tropicalis (tropical clawed frog)	reep3	XP_002940797.2
Mus musculus (house mouse)	Reep3	NP_848721.1
Rattus norvegicus (Norway rat)	Reep3	NP_001099856.2
Homo sapiens (human)	REEP3	NP_001001330.1
Pan troglodytes (chimpanzee)	REEP3	XP_001162084.1
	REEP3	XP_001090368.1
Danio rerio (zebrafish)	reep3b	NP_956455.1

Gene Ontology
Bibliography

Related articles in PubMed

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, van der Lee SJ, Vinkhuyzen AA, Amin N, Conley D, Derringer J, van Duijn CM, Fehrmann R, Franke L, Glaeser EL, Hansell NK, Hayward C, Iacono WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen J, Laibson D, Lichtenstein P, Liewald DC, Magnusson PK, Martin NG, McGue M, McMahon G, Pedersen NL, Pinker S, Porteous DJ, Posthuma D, Rivadeneira F, Smith BH, Starr JM, Tiemeier H, Timpson NJ, Trzaskowski M, Uitterlinden AG, Verhulst FC, Ward ME, Wright MJ, Davey Smith G, Deary IJ, Johannesson M, Plomin R, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
Guan W, Steffen BT, Lemaitre RN, Wu JHY, Tanaka T, Manichaikul A, Foy M, Rich SS, Wang L, Nettleton JA, Tang W, Gu X, Bandinelli S, King IB, McKnight B, Psaty BM, Siscovick D, Djousse L, Chen YI, Ferrucci L, Fornage M, Mozafarrian D, Tsai MY, Steffen LM
Circulation. Cardiovascular genetics7(3)321-331(2014 Jun)

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM
Nature communications53650(2014 Apr)

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, Larson EB, McCarty CA, Roden DM, Jarvik GP, Kullo IJ
Human genetics133(1)95-109(2014 Jan)

REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture.
Schlaitz AL, Thompson J, Wong CC, Yates JR 3rd, Heald R
Developmental cell26(3)315-23(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results show that REEP3/4 function redundantly to clear the endoplasmic reticulum from metaphase chromatin, thereby ensuring correct progression through mitosis and proper nuclear envelope architecture.
Title: REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

Receptor Expression-Enhancing Proteins (REEP) 3 is one of the six human homologs of yeast Yop1p, a probable regulator of cellular vesicle trafficking between the endoplasmatic reticulum and the Golgi network. Positional candidate gene for autism.
Title: Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism.

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

The following REEP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the REEP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21659	NM_001001330.3 Latest version!	Homo sapiens receptor accessory protein 3 (REEP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu44125	XM_011539501.2 Latest version!	Homo sapiens receptor accessory protein 3 (REEP3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu44125	XM_017015896.1 Latest version!	Homo sapiens receptor accessory protein 3 (REEP3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu21659	NM_001001330.2	Homo sapiens receptor accessory protein 3 (REEP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

REEP3 ( NM_001001330.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001330.1 Homo sapiens receptor accessory protein 3 (REEP3), mRNA.

Price & Availability↑

CloneID	OHu21659
Clone ID Related Accession (Same CDS sequence)	NM_001001330.2 , NM_001001330.3
Accession Version	NM_001001330.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	receptor expression-enhancing protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC022022.10, BC068557.1 and AC022387.8. On Apr 27, 2010 this sequence version replaced NM_001001330.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068557.1, SRR1660803.112087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTCCT GGATGATCTC CAGAGCCGTG GTGCTGGTGT TTGGAATGCT TTATCCTGCA 
TATTATTCAT ACAAAGCTGT GAAAACAAAA AACGTGAAGG AATATGTTCG ATGGATGATG 
TACTGGATTG TTTTTGCTCT CTATACTGTG ATTGAAACAG TAGCCGATCA AACAGTTGCT 
TGGTTTCCCC TGTACTATGA GCTGAAGATT GCTTTTGTCA TATGGCTGCT TTCTCCCTAT 
ACCAAAGGAG CAAGTTTAAT ATATAGAAAA TTCCTTCATC CACTTCTTTC TTCAAAGGAA 
AGGGAGATTG ATGATTATAT TGTACAAGCA AAGGAACGAG GCTATGAAAC CATGGTAAAC 
TTTGGACGGC AAGGTTTAAA CCTTGCAGCT ACTGCTGCTG TTACTGCAGC AGTAAAGAGC 
CAAGGAGCAA TAACTGAACG TTTAAGAAGC TTCAGTATGC ATGATTTAAC AACTATCCAA 
GGTGATGAGC CTGTGGGACA AAGACCATAC CAACCTCTAC CAGAAGCAAA AAAGAAAAGT 
AAACCAGCCC CCAGTGAATC AGCAGGTTAT GGAATTCCAC TGAAAGACGG AGATGAGAAA 
ACAGATGAAG AAGCAGAGGG GCCATATTCA GATAATGAGA TGTTAACACA CAAAGGGCTT 
CGAAGATCGC AAAGCATGAA ATCTGTGAAA ACCACCAAAG GCCGCAAAGA GGTGCGGTAC 
GGGTCACTAA AATACAAAGT GAAGAAACGA CCACAAGTGT ATTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001330.1
CDS	184..951
Translation	MVSWMISRAVVLVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVIETVADQTVAWFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRSFSMHDLTTIQGDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHKGLRRSQSMKSVKTTKGRKEVRYGSLKYKVKKRPQVYF

Target ORF information:

RefSeq Version	NM_001001330.2
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor accessory protein 3 (REEP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001330.2

ORF Insert Sequence:

ATGGTGTCCT GGATGATCTC CAGAGCCGTG GTGCTGGTGT TTGGAATGCT TTATCCTGCA 
TATTATTCAT ACAAAGCTGT GAAAACAAAA AACGTGAAGG AATATGTTCG ATGGATGATG 
TACTGGATTG TTTTTGCTCT CTATACTGTG ATTGAAACAG TAGCCGATCA AACAGTTGCT 
TGGTTTCCCC TGTACTATGA GCTGAAGATT GCTTTTGTCA TATGGCTGCT TTCTCCCTAT 
ACCAAAGGAG CAAGTTTAAT ATATAGAAAA TTCCTTCATC CACTTCTTTC TTCAAAGGAA 
AGGGAGATTG ATGATTATAT TGTACAAGCA AAGGAACGAG GCTATGAAAC CATGGTAAAC 
TTTGGACGGC AAGGTTTAAA CCTTGCAGCT ACTGCTGCTG TTACTGCAGC AGTAAAGAGC 
CAAGGAGCAA TAACTGAACG TTTAAGAAGC TTCAGTATGC ATGATTTAAC AACTATCCAA 
GGTGATGAGC CTGTGGGACA AAGACCATAC CAACCTCTAC CAGAAGCAAA AAAGAAAAGT 
AAACCAGCCC CCAGTGAATC AGCAGGTTAT GGAATTCCAC TGAAAGACGG AGATGAGAAA 
ACAGATGAAG AAGCAGAGGG GCCATATTCA GATAATGAGA TGTTAACACA CAAAGGGCTT 
CGAAGATCGC AAAGCATGAA ATCTGTGAAA ACCACCAAAG GCCGCAAAGA GGTGCGGTAC 
GGGTCACTAA AATACAAAGT GAAGAAACGA CCACAAGTGT ATTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REEP3 ( NM_001001330.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001330.1 Homo sapiens receptor accessory protein 3 (REEP3), mRNA.

Price & Availability↑

CloneID	OHu21659
Clone ID Related Accession (Same CDS sequence)	NM_001001330.2 , NM_001001330.3
Accession Version	NM_001001330.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	receptor expression-enhancing protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC068557.1 and AC022387.8. On Nov 23, 2018 this sequence version replaced NM_001001330.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.449631.1, SRR1660803.112087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373758.5/ ENSP00000362863.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGTCCT GGATGATCTC CAGAGCCGTG GTGCTGGTGT TTGGAATGCT TTATCCTGCA 
TATTATTCAT ACAAAGCTGT GAAAACAAAA AACGTGAAGG AATATGTTCG ATGGATGATG 
TACTGGATTG TTTTTGCTCT CTATACTGTG ATTGAAACAG TAGCCGATCA AACAGTTGCT 
TGGTTTCCCC TGTACTATGA GCTGAAGATT GCTTTTGTCA TATGGCTGCT TTCTCCCTAT 
ACCAAAGGAG CAAGTTTAAT ATATAGAAAA TTCCTTCATC CACTTCTTTC TTCAAAGGAA 
AGGGAGATTG ATGATTATAT TGTACAAGCA AAGGAACGAG GCTATGAAAC CATGGTAAAC 
TTTGGACGGC AAGGTTTAAA CCTTGCAGCT ACTGCTGCTG TTACTGCAGC AGTAAAGAGC 
CAAGGAGCAA TAACTGAACG TTTAAGAAGC TTCAGTATGC ATGATTTAAC AACTATCCAA 
GGTGATGAGC CTGTGGGACA AAGACCATAC CAACCTCTAC CAGAAGCAAA AAAGAAAAGT 
AAACCAGCCC CCAGTGAATC AGCAGGTTAT GGAATTCCAC TGAAAGACGG AGATGAGAAA 
ACAGATGAAG AAGCAGAGGG GCCATATTCA GATAATGAGA TGTTAACACA CAAAGGGCTT 
CGAAGATCGC AAAGCATGAA ATCTGTGAAA ACCACCAAAG GCCGCAAAGA GGTGCGGTAC 
GGGTCACTAA AATACAAAGT GAAGAAACGA CCACAAGTGT ATTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001330.1
CDS	146..913
Translation	MVSWMISRAVVLVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVIETVADQTVAWFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRSFSMHDLTTIQGDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHKGLRRSQSMKSVKTTKGRKEVRYGSLKYKVKKRPQVYF

Target ORF information:

RefSeq Version	NM_001001330.3
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor accessory protein 3 (REEP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001330.3

ORF Insert Sequence:

ATGGTGTCCT GGATGATCTC CAGAGCCGTG GTGCTGGTGT TTGGAATGCT TTATCCTGCA 
TATTATTCAT ACAAAGCTGT GAAAACAAAA AACGTGAAGG AATATGTTCG ATGGATGATG 
TACTGGATTG TTTTTGCTCT CTATACTGTG ATTGAAACAG TAGCCGATCA AACAGTTGCT 
TGGTTTCCCC TGTACTATGA GCTGAAGATT GCTTTTGTCA TATGGCTGCT TTCTCCCTAT 
ACCAAAGGAG CAAGTTTAAT ATATAGAAAA TTCCTTCATC CACTTCTTTC TTCAAAGGAA 
AGGGAGATTG ATGATTATAT TGTACAAGCA AAGGAACGAG GCTATGAAAC CATGGTAAAC 
TTTGGACGGC AAGGTTTAAA CCTTGCAGCT ACTGCTGCTG TTACTGCAGC AGTAAAGAGC 
CAAGGAGCAA TAACTGAACG TTTAAGAAGC TTCAGTATGC ATGATTTAAC AACTATCCAA 
GGTGATGAGC CTGTGGGACA AAGACCATAC CAACCTCTAC CAGAAGCAAA AAAGAAAAGT 
AAACCAGCCC CCAGTGAATC AGCAGGTTAT GGAATTCCAC TGAAAGACGG AGATGAGAAA 
ACAGATGAAG AAGCAGAGGG GCCATATTCA GATAATGAGA TGTTAACACA CAAAGGGCTT 
CGAAGATCGC AAAGCATGAA ATCTGTGAAA ACCACCAAAG GCCGCAAAGA GGTGCGGTAC 
GGGTCACTAA AATACAAAGT GAAGAAACGA CCACAAGTGT ATTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REEP3 ( XM_017015896.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016871385.1 Homo sapiens receptor accessory protein 3 (REEP3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu44125
Clone ID Related Accession (Same CDS sequence)	XM_017015896.1 , XM_011539501.2
Accession Version	XM_017015896.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	receptor expression-enhancing protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTCCT GGATGATCTC CAGAGCCGTG GTGCTGGTGT TTGGAATGCT TTATCCTGCA 
TATTATTCAT ACAAAGCTGT GAAAACAAAA AACGTGAAGG AATATGTTCG ATGGATGATG 
TACTGGATTG TTTTTGCTCT CTATACTGTG ATTGAAACAG TAGCCGATCA AACAGTTGCT 
TGGTTTCCCC TGTACTATGA GCTGAAGATT GCTTTTGTCA TATGGCTGCT TTCTCCCTAT 
ACCAAAGGAG CAAGTTTAAT ATATAGAAAA TTCCTTCATC CACTTCTTTC TTCAAAGGAA 
AGGGAGATTG ATGATTATAT TGTACAAGCA AAGGAACGAG GCTATGAAAC CATGGTAAAC 
TTTGGACGGC AAGGTTTAAA CCTTGCAGCT ACTGCTGCTG TTACTGCAGC AGTAAAGGAT 
TTCTGGCTTA CTTCTGCACC TCTACTTCAA TCAATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016871385.1
CDS	194..652
Translation	MVSWMISRAVVLVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVIETVADQTVAWFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKDFWLTSAPLLQSI

Target ORF information:

RefSeq Version	XM_017015896.1
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor accessory protein 3 (REEP3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017015896.1

ORF Insert Sequence:

ATGGTGTCCT GGATGATCTC CAGAGCCGTG GTGCTGGTGT TTGGAATGCT TTATCCTGCA 
TATTATTCAT ACAAAGCTGT GAAAACAAAA AACGTGAAGG AATATGTTCG ATGGATGATG 
TACTGGATTG TTTTTGCTCT CTATACTGTG ATTGAAACAG TAGCCGATCA AACAGTTGCT 
TGGTTTCCCC TGTACTATGA GCTGAAGATT GCTTTTGTCA TATGGCTGCT TTCTCCCTAT 
ACCAAAGGAG CAAGTTTAAT ATATAGAAAA TTCCTTCATC CACTTCTTTC TTCAAAGGAA 
AGGGAGATTG ATGATTATAT TGTACAAGCA AAGGAACGAG GCTATGAAAC CATGGTAAAC 
TTTGGACGGC AAGGTTTAAA CCTTGCAGCT ACTGCTGCTG TTACTGCAGC AGTAAAGGAT 
TTCTGGCTTA CTTCTGCACC TCTACTTCAA TCAATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REEP3 ( XM_011539501.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011537803.1 Homo sapiens receptor accessory protein 3 (REEP3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu44125
Clone ID Related Accession (Same CDS sequence)	XM_017015896.1 , XM_011539501.2
Accession Version	XM_011539501.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	receptor expression-enhancing protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011539501.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTCCT GGATGATCTC CAGAGCCGTG GTGCTGGTGT TTGGAATGCT TTATCCTGCA 
TATTATTCAT ACAAAGCTGT GAAAACAAAA AACGTGAAGG AATATGTTCG ATGGATGATG 
TACTGGATTG TTTTTGCTCT CTATACTGTG ATTGAAACAG TAGCCGATCA AACAGTTGCT 
TGGTTTCCCC TGTACTATGA GCTGAAGATT GCTTTTGTCA TATGGCTGCT TTCTCCCTAT 
ACCAAAGGAG CAAGTTTAAT ATATAGAAAA TTCCTTCATC CACTTCTTTC TTCAAAGGAA 
AGGGAGATTG ATGATTATAT TGTACAAGCA AAGGAACGAG GCTATGAAAC CATGGTAAAC 
TTTGGACGGC AAGGTTTAAA CCTTGCAGCT ACTGCTGCTG TTACTGCAGC AGTAAAGGAT 
TTCTGGCTTA CTTCTGCACC TCTACTTCAA TCAATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011537803.1
CDS	194..652
Translation	MVSWMISRAVVLVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVIETVADQTVAWFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKDFWLTSAPLLQSI

Target ORF information:

RefSeq Version	XM_011539501.2
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor accessory protein 3 (REEP3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011539501.2

ORF Insert Sequence:

ATGGTGTCCT GGATGATCTC CAGAGCCGTG GTGCTGGTGT TTGGAATGCT TTATCCTGCA 
TATTATTCAT ACAAAGCTGT GAAAACAAAA AACGTGAAGG AATATGTTCG ATGGATGATG 
TACTGGATTG TTTTTGCTCT CTATACTGTG ATTGAAACAG TAGCCGATCA AACAGTTGCT 
TGGTTTCCCC TGTACTATGA GCTGAAGATT GCTTTTGTCA TATGGCTGCT TTCTCCCTAT 
ACCAAAGGAG CAAGTTTAAT ATATAGAAAA TTCCTTCATC CACTTCTTTC TTCAAAGGAA 
AGGGAGATTG ATGATTATAT TGTACAAGCA AAGGAACGAG GCTATGAAAC CATGGTAAAC 
TTTGGACGGC AAGGTTTAAA CCTTGCAGCT ACTGCTGCTG TTACTGCAGC AGTAAAGGAT 
TTCTGGCTTA CTTCTGCACC TCTACTTCAA TCAATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)
Rietveld CA,Esko T,Davies G,Pers TH,Turley P,Benyamin B,Chabris CF,Emilsson V,Johnson AD,Lee JJ,de Leeuw C,Marioni RE,Medland SE,Miller MB,Rostapshova O,van der Lee SJ,Vinkhuyzen AA,Amin N,Conley D,Derringer J,van Duijn CM,Fehrmann R,Franke L,Glaeser EL,Hansell NK,Hayward C,Iacono WG,Ibrahim-Verbaas C,Jaddoe V,Karjalainen J,Laibson D,Lichtenstein P,Liewald DC,Magnusson PK,Martin NG,McGue M,McMahon G,Pedersen NL,Pinker S,Porteous DJ,Posthuma D,Rivadeneira F,Smith BH,Starr JM,Tiemeier H,Timpson NJ,Trzaskowski M,Uitterlinden AG,Verhulst FC,Ward ME,Wright MJ,Davey Smith G,Deary IJ,Johannesson M,Plomin R,Visscher PM,Benjamin DJ,Cesarini D,Koellinger PD

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
Circulation. Cardiovascular genetics7(3)321-331(2014 Jun)
Guan W,Steffen BT,Lemaitre RN,Wu JHY,Tanaka T,Manichaikul A,Foy M,Rich SS,Wang L,Nettleton JA,Tang W,Gu X,Bandinelli S,King IB,McKnight B,Psaty BM,Siscovick D,Djousse L,Chen YI,Ferrucci L,Fornage M,Mozafarrian D,Tsai MY,Steffen LM

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Nature communications53650(2014 Apr)
Corominas R,Yang X,Lin GN,Kang S,Shen Y,Ghamsari L,Broly M,Rodriguez M,Tam S,Trigg SA,Fan C,Yi S,Tasan M,Lemmens I,Kuang X,Zhao N,Malhotra D,Michaelson JJ,Vacic V,Calderwood MA,Roth FP,Tavernier J,Horvath S,Salehi-Ashtiani K,Korkin D,Sebat J,Hill DE,Hao T,Vidal M,Iakoucheva LM

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
Human genetics133(1)95-109(2014 Jan)
Shameer K,Denny JC,Ding K,Jouni H,Crosslin DR,de Andrade M,Chute CG,Peissig P,Pacheco JA,Li R,Bastarache L,Kho AN,Ritchie MD,Masys DR,Chisholm RL,Larson EB,McCarty CA,Roden DM,Jarvik GP,Kullo IJ

REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin and proper nuclear envelope architecture.
Developmental cell26(3)315-23(2013 Aug)
Schlaitz AL,Thompson J,Wong CC,Yates JR 3rd,Heald R

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REEP3 cDNA ORF clone, Homo sapiens(human)

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