CFAP53 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CFAP53
Entrez Gene ID	220136
Full Name	cilia and flagella associated protein 53
Synonyms	CCDC11,HTX6
General protein information	Preferred Names cilia and flagella associated protein 53 Names cilia- and flagella-associated protein 53 coiled-coil domain containing 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q21.1
Summary	This gene belongs to the CFAP53 family. It was found to be differentially expressed by the ciliated cells of frog epidermis and in skin fibroblasts from human. Mutations in this gene are associated with visceral heterotaxy-6, which implicates this gene in determination of left-right asymmetric patterning. [provided by RefSeq, Aug 2015].
Disorder MIM:	614759
Disorder Html:	Heterotaxy, visceral, 6, autosomal recessive, 614779 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_145020.4	NP_659457.2	cilia- and flagella-associated protein 53
XM_024451100.1	XP_024306868.1	cilia- and flagella-associated protein 53 isoform X1
NM_145020.5	NP_659457.2	cilia- and flagella-associated protein 53

Pathways from BioSystems

Homologies

	CCDC11	XP_001091617.2
Danio rerio (zebrafish)	LOC101883738	XP_005161304.1
Xenopus tropicalis (tropical clawed frog)	ccdc11	NP_001120281.1
Danio rerio (zebrafish)	ccdc11	NP_001038595.2
Homo sapiens (human)	CCDC11	NP_659457.2
Pan troglodytes (chimpanzee)	CCDC11	XP_523923.3
Canis lupus familiaris (dog)	CCDC11	XP_547689.4
Mus musculus (house mouse)	Ccdc11	NP_083224.2
Rattus norvegicus (Norway rat)	Ccdc11	XP_344701.3

Gene Ontology
Bibliography

Related articles in PubMed

Roles of the cilium-associated gene CCDC11 in left-right patterning and in laterality disorders in humans.
Gur M, Cohen EB, Genin O, Fainsod A, Perles Z, Cinnamon Y
The International journal of developmental biology61(3-4-5)267-276(2017)

A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function.
No?l ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV, Bhuiyan ZA, Bakkers J
Human mutation37(2)194-200(2016 Feb)

Mutations in CCDC11, which encodes a coiled-coil containing ciliary protein, causes situs inversus due to dysmotility of monocilia in the left-right organizer.
Narasimhan V, Hjeij R, Vij S, Loges NT, Wallmeier J, Koerner-Rettberg C, Werner C, Thamilselvam SK, Boey A, Choksi SP, Pennekamp P, Roy S, Omran H
Human mutation36(3)307-18(2015 Mar)

A human laterality disorder associated with recessive CCDC11 mutation.
Perles Z, Cinnamon Y, Ta-Shma A, Shaag A, Einbinder T, Rein AJ, Elpeleg O
Journal of medical genetics49(6)386-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cfap53 is a conserved regulator of organ laterality in both humans and zebrafish.
Title: A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function.

CCDC11 has a conserved essential function in cilia of the vertebrate left-right organizer during embryogenesis.
Title: Mutations in CCDC11, which encodes a coiled-coil containing ciliary protein, causes situs inversus due to dysmotility of monocilia in the left-right organizer.

The authors suggest that CCDC11 is associated with autosomal recessive laterality defects of diverse phenotype resulting in SIT in one individual family member who is otherwise healthy, and in complex laterality anomalies (HS) in another member.
Title: A human laterality disorder associated with recessive CCDC11 mutation.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following CFAP53 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CFAP53 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06444	NM_145020.5 Latest version!	Homo sapiens cilia and flagella associated protein 53 (CFAP53), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu104511	XM_024451100.1 Latest version!	Homo sapiens cilia and flagella associated protein 53 (CFAP53), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu06444	NM_145020.4	Homo sapiens cilia and flagella associated protein 53 (CFAP53), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CFAP53 ( NM_145020.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_659457.2 Homo sapiens cilia and flagella associated protein 53 (CFAP53), mRNA.

Price & Availability↑

CloneID	OHu06444
Clone ID Related Accession (Same CDS sequence)	NM_145020.4 , NM_145020.5
Accession Version	NM_145020.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	cilia- and flagella-associated protein 53
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302114.1 and BC030606.2. This sequence is a reference standard in the RefSeqGene project. On Aug 14, 2015 this sequence version replaced NM_145020.3. ##Evidence-Data-START## Transcript exon combination :: AK302114.1, SRR1803617.172781.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTACAGCC AGCGGTTTGG CACCGTACAG CGGGAGGTTA AGGGCCCCAC CCCCAAAGTG 
GTGATCGTGA GATCCAAGCC TCCTAAAGGC CAAGGAGCTG AGCACCATCT AGAAAGAATC 
CGACGCAGCC ATCAGAAGCA TAATGCTATT TTGGCTTCCA TTAAGTCAAG TGAGCGGGAT 
CGCTTGAAAG CTGAGTGGGA CCAGCACAAT GACTGCAAGA TTTTGGACAG CCTTGTGCGA 
GCAAGAATCA AGGATGCTGT GCAAGGGTTT ATCATTAACA TTGAAGAAAG ACGAAATAAG 
CTACGTGAGC TTTTAGCATT AGAAGAAAAT GAGTATTTTA CAGAAATGCA ATTGAAGAAA 
GAAACCATTG AGGAGAAAAA AGATAGGATG AGAGAGAAAA CTAAATTACT AAAAGAGAAG 
AATGAAAAAG AGAGGCAGGA TTTTGTGGCT GAAAAGCTAG ACCAGCAATT CAGGGAACGC 
TGTGAGGAGC TCCGTGTTGA ATTGTTATCT ATCCATCAGA AGAAGGTGTG TGAGGAGCGG 
AAAGCACAGA TTGCATTTAA TGAGGAGCTG AGCAGGCAAA AGCTGGTGGA AGAGCAGATG 
TTCTCCAAAC TCTGGGAGGA AGACCGATTA GCCAAGGAAA AGCGAGAAGC CCAAGAGGCG 
AGGAGACAGA AAGAGCTGAT GGAGAACACA CGCCTGGGGC TGAATGCCCA GATCACCAGC 
ATCAAGGCAC AAAGGCAGGC GACACAGCTG CTGAAGGAAG AGGAGGCACG CCTTGTGGAA 
AGTAACAACG CACAGATTAA ACATGAGAAT GAACAGGATA TGCTAAAGAA ACAGAAGGCA 
AAGCAGGAAA CTAGGACCAT TTTGCAAAAA GCCCTACAAG AGAGGATAGA ACATATTCAG 
CAGGAATACA GAGACGAACA GGACTTGAAC ATGAAGCTCG TGCAAAGGGC CCTTCAAGAC 
TTACAGGAAG AGGCAGATAA AAAGAAACAA AAAAGAGAAG ATATGATAAG AGAACAGAAG 
ATATACCATA AATATTTGGC ACAGAGACGT GAGGAAGAAA AAGCTCAGGA GAAAGAATTT 
GACAGAATAT TAGAGGAAGA CAAGGCAAAG AAGTTGGCTG AGAAGGACAA GGAGCTGAGA 
CTTGAAAAGG AGGCAAGGAG ACAGCTTGTG GATGAGGTCA TGTGTACAAG AAAACTTCAA 
GTTCAAGAAA AGTTGCAACG AGAAGCTAAA GAACAGGAAG AACGTGCTAT GGAACAGAAA 
CACATAAATG AAAGTCTTAA AGAACTTAAC TGTGAAGAGA AGGAGAATTT TGCAAGACGC 
CAACGTTTAG CCCAGGAGTA CAGGAAGCAA CTTCAGATGC AAATCGCCTA CCAGCAGCAG 
TCCCAAGAAG CAGAGAAGGA AGAGAAACGC CGAGAGTTTG AAGCAGGTGT AGCAGCAAAC 
AAGATGTGTT TGGACAAGGT CCAGGAGGTC CTGTCCACCC ATCAAGTGCT GCCTCAAAAC 
ATTCATCCCA TGCGCAAGGC ATGCCCCAGT AAGCTTCCAC CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659457.2
CDS	119..1663
Translation	MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP

Target ORF information:

RefSeq Version	NM_145020.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cilia and flagella associated protein 53 (CFAP53), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145020.4

ORF Insert Sequence:

ATGTACAGCC AGCGGTTTGG CACCGTACAG CGGGAGGTTA AGGGCCCCAC CCCCAAAGTG 
GTGATCGTGA GATCCAAGCC TCCTAAAGGC CAAGGAGCTG AGCACCATCT AGAAAGAATC 
CGACGCAGCC ATCAGAAGCA TAATGCTATT TTGGCTTCCA TTAAGTCAAG TGAGCGGGAT 
CGCTTGAAAG CTGAGTGGGA CCAGCACAAT GACTGCAAGA TTTTGGACAG CCTTGTGCGA 
GCAAGAATCA AGGATGCTGT GCAAGGGTTT ATCATTAACA TTGAAGAAAG ACGAAATAAG 
CTACGTGAGC TTTTAGCATT AGAAGAAAAT GAGTATTTTA CAGAAATGCA ATTGAAGAAA 
GAAACCATTG AGGAGAAAAA AGATAGGATG AGAGAGAAAA CTAAATTACT AAAAGAGAAG 
AATGAAAAAG AGAGGCAGGA TTTTGTGGCT GAAAAGCTAG ACCAGCAATT CAGGGAACGC 
TGTGAGGAGC TCCGTGTTGA ATTGTTATCT ATCCATCAGA AGAAGGTGTG TGAGGAGCGG 
AAAGCACAGA TTGCATTTAA TGAGGAGCTG AGCAGGCAAA AGCTGGTGGA AGAGCAGATG 
TTCTCCAAAC TCTGGGAGGA AGACCGATTA GCCAAGGAAA AGCGAGAAGC CCAAGAGGCG 
AGGAGACAGA AAGAGCTGAT GGAGAACACA CGCCTGGGGC TGAATGCCCA GATCACCAGC 
ATCAAGGCAC AAAGGCAGGC GACACAGCTG CTGAAGGAAG AGGAGGCACG CCTTGTGGAA 
AGTAACAACG CACAGATTAA ACATGAGAAT GAACAGGATA TGCTAAAGAA ACAGAAGGCA 
AAGCAGGAAA CTAGGACCAT TTTGCAAAAA GCCCTACAAG AGAGGATAGA ACATATTCAG 
CAGGAATACA GAGACGAACA GGACTTGAAC ATGAAGCTCG TGCAAAGGGC CCTTCAAGAC 
TTACAGGAAG AGGCAGATAA AAAGAAACAA AAAAGAGAAG ATATGATAAG AGAACAGAAG 
ATATACCATA AATATTTGGC ACAGAGACGT GAGGAAGAAA AAGCTCAGGA GAAAGAATTT 
GACAGAATAT TAGAGGAAGA CAAGGCAAAG AAGTTGGCTG AGAAGGACAA GGAGCTGAGA 
CTTGAAAAGG AGGCAAGGAG ACAGCTTGTG GATGAGGTCA TGTGTACAAG AAAACTTCAA 
GTTCAAGAAA AGTTGCAACG AGAAGCTAAA GAACAGGAAG AACGTGCTAT GGAACAGAAA 
CACATAAATG AAAGTCTTAA AGAACTTAAC TGTGAAGAGA AGGAGAATTT TGCAAGACGC 
CAACGTTTAG CCCAGGAGTA CAGGAAGCAA CTTCAGATGC AAATCGCCTA CCAGCAGCAG 
TCCCAAGAAG CAGAGAAGGA AGAGAAACGC CGAGAGTTTG AAGCAGGTGT AGCAGCAAAC 
AAGATGTGTT TGGACAAGGT CCAGGAGGTC CTGTCCACCC ATCAAGTGCT GCCTCAAAAC 
ATTCATCCCA TGCGCAAGGC ATGCCCCAGT AAGCTTCCAC CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFAP53 ( NM_145020.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_659457.2 Homo sapiens cilia and flagella associated protein 53 (CFAP53), mRNA.

Price & Availability↑

CloneID	OHu06444
Clone ID Related Accession (Same CDS sequence)	NM_145020.4 , NM_145020.5
Accession Version	NM_145020.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	cilia- and flagella-associated protein 53
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302114.1 and BC030606.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_145020.4. ##Evidence-Data-START## Transcript exon combination :: BC030606.2, AK302114.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000398545.5/ ENSP00000381553.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTACAGCC AGCGGTTTGG CACCGTACAG CGGGAGGTTA AGGGCCCCAC CCCCAAAGTG 
GTGATCGTGA GATCCAAGCC TCCTAAAGGC CAAGGAGCTG AGCACCATCT AGAAAGAATC 
CGACGCAGCC ATCAGAAGCA TAATGCTATT TTGGCTTCCA TTAAGTCAAG TGAGCGGGAT 
CGCTTGAAAG CTGAGTGGGA CCAGCACAAT GACTGCAAGA TTTTGGACAG CCTTGTGCGA 
GCAAGAATCA AGGATGCTGT GCAAGGGTTT ATCATTAACA TTGAAGAAAG ACGAAATAAG 
CTACGTGAGC TTTTAGCATT AGAAGAAAAT GAGTATTTTA CAGAAATGCA ATTGAAGAAA 
GAAACCATTG AGGAGAAAAA AGATAGGATG AGAGAGAAAA CTAAATTACT AAAAGAGAAG 
AATGAAAAAG AGAGGCAGGA TTTTGTGGCT GAAAAGCTAG ACCAGCAATT CAGGGAACGC 
TGTGAGGAGC TCCGTGTTGA ATTGTTATCT ATCCATCAGA AGAAGGTGTG TGAGGAGCGG 
AAAGCACAGA TTGCATTTAA TGAGGAGCTG AGCAGGCAAA AGCTGGTGGA AGAGCAGATG 
TTCTCCAAAC TCTGGGAGGA AGACCGATTA GCCAAGGAAA AGCGAGAAGC CCAAGAGGCG 
AGGAGACAGA AAGAGCTGAT GGAGAACACA CGCCTGGGGC TGAATGCCCA GATCACCAGC 
ATCAAGGCAC AAAGGCAGGC GACACAGCTG CTGAAGGAAG AGGAGGCACG CCTTGTGGAA 
AGTAACAACG CACAGATTAA ACATGAGAAT GAACAGGATA TGCTAAAGAA ACAGAAGGCA 
AAGCAGGAAA CTAGGACCAT TTTGCAAAAA GCCCTACAAG AGAGGATAGA ACATATTCAG 
CAGGAATACA GAGACGAACA GGACTTGAAC ATGAAGCTCG TGCAAAGGGC CCTTCAAGAC 
TTACAGGAAG AGGCAGATAA AAAGAAACAA AAAAGAGAAG ATATGATAAG AGAACAGAAG 
ATATACCATA AATATTTGGC ACAGAGACGT GAGGAAGAAA AAGCTCAGGA GAAAGAATTT 
GACAGAATAT TAGAGGAAGA CAAGGCAAAG AAGTTGGCTG AGAAGGACAA GGAGCTGAGA 
CTTGAAAAGG AGGCAAGGAG ACAGCTTGTG GATGAGGTCA TGTGTACAAG AAAACTTCAA 
GTTCAAGAAA AGTTGCAACG AGAAGCTAAA GAACAGGAAG AACGTGCTAT GGAACAGAAA 
CACATAAATG AAAGTCTTAA AGAACTTAAC TGTGAAGAGA AGGAGAATTT TGCAAGACGC 
CAACGTTTAG CCCAGGAGTA CAGGAAGCAA CTTCAGATGC AAATCGCCTA CCAGCAGCAG 
TCCCAAGAAG CAGAGAAGGA AGAGAAACGC CGAGAGTTTG AAGCAGGTGT AGCAGCAAAC 
AAGATGTGTT TGGACAAGGT CCAGGAGGTC CTGTCCACCC ATCAAGTGCT GCCTCAAAAC 
ATTCATCCCA TGCGCAAGGC ATGCCCCAGT AAGCTTCCAC CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659457.2
CDS	92..1636
Translation	MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP

Target ORF information:

RefSeq Version	NM_145020.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cilia and flagella associated protein 53 (CFAP53), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145020.5

ORF Insert Sequence:

ATGTACAGCC AGCGGTTTGG CACCGTACAG CGGGAGGTTA AGGGCCCCAC CCCCAAAGTG 
GTGATCGTGA GATCCAAGCC TCCTAAAGGC CAAGGAGCTG AGCACCATCT AGAAAGAATC 
CGACGCAGCC ATCAGAAGCA TAATGCTATT TTGGCTTCCA TTAAGTCAAG TGAGCGGGAT 
CGCTTGAAAG CTGAGTGGGA CCAGCACAAT GACTGCAAGA TTTTGGACAG CCTTGTGCGA 
GCAAGAATCA AGGATGCTGT GCAAGGGTTT ATCATTAACA TTGAAGAAAG ACGAAATAAG 
CTACGTGAGC TTTTAGCATT AGAAGAAAAT GAGTATTTTA CAGAAATGCA ATTGAAGAAA 
GAAACCATTG AGGAGAAAAA AGATAGGATG AGAGAGAAAA CTAAATTACT AAAAGAGAAG 
AATGAAAAAG AGAGGCAGGA TTTTGTGGCT GAAAAGCTAG ACCAGCAATT CAGGGAACGC 
TGTGAGGAGC TCCGTGTTGA ATTGTTATCT ATCCATCAGA AGAAGGTGTG TGAGGAGCGG 
AAAGCACAGA TTGCATTTAA TGAGGAGCTG AGCAGGCAAA AGCTGGTGGA AGAGCAGATG 
TTCTCCAAAC TCTGGGAGGA AGACCGATTA GCCAAGGAAA AGCGAGAAGC CCAAGAGGCG 
AGGAGACAGA AAGAGCTGAT GGAGAACACA CGCCTGGGGC TGAATGCCCA GATCACCAGC 
ATCAAGGCAC AAAGGCAGGC GACACAGCTG CTGAAGGAAG AGGAGGCACG CCTTGTGGAA 
AGTAACAACG CACAGATTAA ACATGAGAAT GAACAGGATA TGCTAAAGAA ACAGAAGGCA 
AAGCAGGAAA CTAGGACCAT TTTGCAAAAA GCCCTACAAG AGAGGATAGA ACATATTCAG 
CAGGAATACA GAGACGAACA GGACTTGAAC ATGAAGCTCG TGCAAAGGGC CCTTCAAGAC 
TTACAGGAAG AGGCAGATAA AAAGAAACAA AAAAGAGAAG ATATGATAAG AGAACAGAAG 
ATATACCATA AATATTTGGC ACAGAGACGT GAGGAAGAAA AAGCTCAGGA GAAAGAATTT 
GACAGAATAT TAGAGGAAGA CAAGGCAAAG AAGTTGGCTG AGAAGGACAA GGAGCTGAGA 
CTTGAAAAGG AGGCAAGGAG ACAGCTTGTG GATGAGGTCA TGTGTACAAG AAAACTTCAA 
GTTCAAGAAA AGTTGCAACG AGAAGCTAAA GAACAGGAAG AACGTGCTAT GGAACAGAAA 
CACATAAATG AAAGTCTTAA AGAACTTAAC TGTGAAGAGA AGGAGAATTT TGCAAGACGC 
CAACGTTTAG CCCAGGAGTA CAGGAAGCAA CTTCAGATGC AAATCGCCTA CCAGCAGCAG 
TCCCAAGAAG CAGAGAAGGA AGAGAAACGC CGAGAGTTTG AAGCAGGTGT AGCAGCAAAC 
AAGATGTGTT TGGACAAGGT CCAGGAGGTC CTGTCCACCC ATCAAGTGCT GCCTCAAAAC 
ATTCATCCCA TGCGCAAGGC ATGCCCCAGT AAGCTTCCAC CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFAP53 ( XM_024451100.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024306868.1 Homo sapiens cilia and flagella associated protein 53 (CFAP53), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu104511
Clone ID Related Accession (Same CDS sequence)	XM_024451100.1
Accession Version	XM_024451100.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cilia- and flagella-associated protein 53 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCTCCA AACTCTGGGA GGAAGACCGA TTAGCCAAGG AAAAGCGAGA AGCCCAAGAG 
GCGAGGAGAC AGAAAGAGCT GATGGAGAAC ACACGCCTGG GGCTGAATGC CCAGATCACC 
AGCATCAAGG CACAAAGGCA GGCGACACAG CTGCTGAAGG AAGAGGAGGC ACGCCTTGTG 
GAAAGTAACA ACGCACAGAT TAAACATGAG AATGAACAGG ATATGCTAAA GAAACAGAAG 
GCAAAGCAGG AAACTAGGAC CATTTTGCAA AAAGCCCTAC AAGAGAGGAT AGAACATATT 
CAGCAGGAAT ACAGAGACGA ACAGGACTTG AACATGAAGC TCGTGCAAAG GGCCCTTCAA 
GACTTACAGG AAGAGGCAGA TAAAAAGAAA CAAAAAAGAG AAGATATGAT AAGAGAACAG 
AAGATATACC ATAAATATTT GGCACAGAGA CGTGAGGAAG AAAAAGCTCA GGAGAAAGAA 
TTTGACAGAA TATTAGAGGA AGACAAGGCA AAGAAGTTGG CTGAGAAGGA CAAGGAGCTG 
AGACTTGAAA AGGAGGCAAG GAGACAGCTT GTGGATGAGG TCATGTGTAC AAGAAAACTT 
CAAGTTCAAG AAAAGTTGCA ACGAGAAGCT AAAGAACAGG AAGAACGTGC TATGGAACAG 
AAACACATAA ATGAAAGTCT TAAAGAACTT AACTGTGAAG AGAAGGAGAA TTTTGCAAGA 
CGCCAACGTT TAGCCCAGGA GTACAGGAAG CAACTTCAGA TGCAAATCGC CTACCAGCAG 
CAGTCCCAAG AAGCAGAGAA GGAAGAGAAA CGCCGAGAGT TTGAAGCAGG TGTAGCAGCA 
AACAAGATGT GTTTGGACAA GGTCCAGGAG GTCCTGTCCA CCCATCAAGT GCTGCCTCAA 
AACATTCATC CCATGCGCAA GGCATGCCCC AGTAAGCTTC CACCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024306868.1
CDS	210..1157
Translation	MFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP

Target ORF information:

RefSeq Version	XM_024451100.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cilia and flagella associated protein 53 (CFAP53), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024451100.1

ORF Insert Sequence:

ATGTTCTCCA AACTCTGGGA GGAAGACCGA TTAGCCAAGG AAAAGCGAGA AGCCCAAGAG 
GCGAGGAGAC AGAAAGAGCT GATGGAGAAC ACACGCCTGG GGCTGAATGC CCAGATCACC 
AGCATCAAGG CACAAAGGCA GGCGACACAG CTGCTGAAGG AAGAGGAGGC ACGCCTTGTG 
GAAAGTAACA ACGCACAGAT TAAACATGAG AATGAACAGG ATATGCTAAA GAAACAGAAG 
GCAAAGCAGG AAACTAGGAC CATTTTGCAA AAAGCCCTAC AAGAGAGGAT AGAACATATT 
CAGCAGGAAT ACAGAGACGA ACAGGACTTG AACATGAAGC TCGTGCAAAG GGCCCTTCAA 
GACTTACAGG AAGAGGCAGA TAAAAAGAAA CAAAAAAGAG AAGATATGAT AAGAGAACAG 
AAGATATACC ATAAATATTT GGCACAGAGA CGTGAGGAAG AAAAAGCTCA GGAGAAAGAA 
TTTGACAGAA TATTAGAGGA AGACAAGGCA AAGAAGTTGG CTGAGAAGGA CAAGGAGCTG 
AGACTTGAAA AGGAGGCAAG GAGACAGCTT GTGGATGAGG TCATGTGTAC AAGAAAACTT 
CAAGTTCAAG AAAAGTTGCA ACGAGAAGCT AAAGAACAGG AAGAACGTGC TATGGAACAG 
AAACACATAA ATGAAAGTCT TAAAGAACTT AACTGTGAAG AGAAGGAGAA TTTTGCAAGA 
CGCCAACGTT TAGCCCAGGA GTACAGGAAG CAACTTCAGA TGCAAATCGC CTACCAGCAG 
CAGTCCCAAG AAGCAGAGAA GGAAGAGAAA CGCCGAGAGT TTGAAGCAGG TGTAGCAGCA 
AACAAGATGT GTTTGGACAA GGTCCAGGAG GTCCTGTCCA CCCATCAAGT GCTGCCTCAA 
AACATTCATC CCATGCGCAA GGCATGCCCC AGTAAGCTTC CACCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Roles of the cilium-associated gene CCDC11 in left-right patterning and in laterality disorders in humans.
The International journal of developmental biology61(3-4-5)267-276(2017)
Gur M,Cohen EB,Genin O,Fainsod A,Perles Z,Cinnamon Y

A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function.
Human mutation37(2)194-200(2016 Feb)
No?l ES,Momenah TS,Al-Dagriri K,Al-Suwaid A,Al-Shahrani S,Jiang H,Willekers S,Oostveen YY,Chocron S,Postma AV,Bhuiyan ZA,Bakkers J

Mutations in CCDC11, which encodes a coiled-coil containing ciliary protein, causes situs inversus due to dysmotility of monocilia in the left-right organizer.
Human mutation36(3)307-18(2015 Mar)
Narasimhan V,Hjeij R,Vij S,Loges NT,Wallmeier J,Koerner-Rettberg C,Werner C,Thamilselvam SK,Boey A,Choksi SP,Pennekamp P,Roy S,Omran H

A human laterality disorder associated with recessive CCDC11 mutation.
Journal of medical genetics49(6)386-90(2012 Jun)
Perles Z,Cinnamon Y,Ta-Shma A,Shaag A,Einbinder T,Rein AJ,Elpeleg O

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CFAP53 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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