NLRP11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NLRP11
Entrez Gene ID	204801
Full Name	NLR family pyrin domain containing 11
Synonyms	CLR19.6,NALP11,NOD17,PAN10,PYPAF6,PYPAF7
General protein information	Preferred Names NLR family pyrin domain containing 11 Names NACHT, LRR and PYD domains-containing protein 11 NACHT, leucine rich repeat and PYD containing 11 PAAD- and NACHT-containing protein 10B PAAD-and NACHT domain-containing protein 10 PYRIN-containing APAF1-like protein 6 nucleotide-binding oligomerization domain protein 17 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.42-q13.43
Summary	This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017].
Disorder MIM:	609664

mRNA and Protein(s)

mRNA	Protein	Name
NM_001297743.1	NP_001284672.1	NACHT, LRR and PYD domains-containing protein 11 isoform 2
NM_145007.3	NP_659444.2	NACHT, LRR and PYD domains-containing protein 11 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NLRP11	XP_524402.2
	NLRP11	NP_001107581.1
Homo sapiens (human)	NLRP11	NP_659444.2

Gene Ontology
Bibliography

Related articles in PubMed

Ellwanger K, Becker E, Kienes I, Sowa A, Postma Y, Gloria YC, Weber ANR, Kufer TA
The Journal of biological chemistry(2018 Jan)

NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis.
Qin Y, Su Z, Wu Y, Wu C, Jin S, Xie W, Jiang W, Zhou R, Cui J
EMBO reports18(12)2160-2171(2017 Dec)

A genome-wide association study of early menopause and the combined impact of identified variants.
Perry JR, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N, He C, Kutalik Z, Mangino M, Rose LM, Vernon Smith A, Stolk L, Sulem P, Weedon MN, Zhuang WV, Arnold A, Ashworth A, Bergmann S, Buring JE, Burri A, Chen C, Cornelis MC, Couper DJ, Goodarzi MO, Gudnason V, Harris T, Hofman A, Jones M, Kraft P, Launer L, Laven JS, Li G, McKnight B, Masciullo C, Milani L, Orr N, Psaty BM, , Ridker PM, Rivadeneira F, Sala C, Salumets A, Schoemaker M, Traglia M, Waeber G, Chanock SJ, Demerath EW, Garcia M, Hankinson SE, Hu FB, Hunter DJ, Lunetta KL, Metspalu A, Montgomery GW, Murabito JM, Newman AB, Ong KK, Spector TD, Stefansson K, Swerdlow AJ, Thorsteinsdottir U, Van Dam RM, Uitterlinden AG, Visser JA, Vollenweider P, Toniolo D, Murray A
Human molecular genetics22(7)1465-72(2013 Apr)

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
, ,
The American journal of psychiatry170(2)207-17(2013 Feb)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: The genetics of NOD-like receptors in Crohn's disease.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

The following NLRP11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NLRP11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu52099	NM_001297743.1 Latest version!	Homo sapiens NLR family pyrin domain containing 11 (NLRP11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu06437	NM_145007.3 Latest version!	Homo sapiens NLR family pyrin domain containing 11 (NLRP11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NLRP11 ( NM_001297743.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284672.1 Homo sapiens NLR family pyrin domain containing 11 (NLRP11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu52099
Clone ID Related Accession (Same CDS sequence)	NM_001297743.1
Accession Version	NM_001297743.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2805bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 11 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK310394.1, AY168968.1, AC012310.5, AY168967.1, AY154466.1, AC008749.6, AK129784.1 and BU622142.1. On Jul 10, 2014 this sequence version replaced XM_005258632.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY168968.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGAGAA AATTCATGCT GCAATGGGAA AGTCACACTT TTGGAAAATT TCATTATAAA 
TTTTTTCGTG ACGTTTCGTC AGATGTGTTC TACATACTTC AATTAGCCTA TGATTCTACC 
AGCTATTATT CAGCAAACAA TCTCAATGTG TTCCTGATGG GAGAGAGAGC ATCTGGAAAA 
ACTATTGTTA TAAATCTGGC TGTGTTGAGG TGGATCAAGG GTGAGATGTG GCAGAACATG 
ATCTCGTACG TCGTTCACCT CACTGCTCAC GAAATAAACC AGATGACCAA CAGCAGCTTG 
GCTGAGCTAA TCGCCAAGGA CTGGCCTGAC GGCCAGGCTC CCATTGCAGA CATCCTGTCT 
GATCCCAAGA AACTCCTTTT CATCCTCGAG GACTTGGACA ACATAAGATT CGAGTTAAAT 
GTCAATGAAA GTGCTTTGTG TAGTAACAGC ACCCAGAAAG TTCCCATTCC AGTTCTCCTG 
GTCAGTTTGC TGAAGAGAAA AATGGCTCCA GGCTGCTGGT TCCTCATCTC CTCAAGGCCC 
ACACGTGGGA ATAATGTAAA AACGTTCTTG AAAGAGGTAG ATTGCTGCAC GACCTTGCAG 
CTGTCGAATG GGAAGAGGGA GATATATTTT AACTCTTTCT TTAAAGACCG CCAGAGGGCG 
TCGGCAGCCC TCCAGCTTGT ACATGAGGAT GAAATACTCG TGGGTCTGTG CCGAGTCGCC 
ATCTTATGCT GGATCACGTG TACTGTCCTG AAGCGGCAGA TGGACAAGGG GCGTGACTTC 
CAGCTCTGCT GCCAAACACC CACTGATCTA CATGCCCACT TTCTTGCTGA TGCGTTGACA 
TCAGAGGCTG GACTTACTGC CAATCAGTAT CACCTAGGTC TCCTAAAACG TCTGTGTTTG 
CTGGCTGCAG GAGGACTGTT TCTGAGCACC CTGAATTTCA GTGGTGAAGA CCTCAGATGT 
GTTGGGTTTA CTGAGGCTGA TGTCTCTGTG TTGCAGGCCG CGAATATTCT TTTGCCGAGC 
AACACTCATA AAGACCGTTA CAAGTTCATA CACTTGAACG TCCAGGAGTT TTGTACAGCC 
ATTGCATTTC TGATGGCAGT ACCCAACTAT CTGATCCCCT CAGGCAGCAG AGAGTATAAA 
GAGAAGAGAG AACAATACTC TGACTTTAAT CAAGTGTTTA CTTTCATTTT TGGTCTTCTA 
AATGCAAACA GGAGAAAGAT TCTTGAGACA TCCTTTGGAT ACCAGCTACC GATGGTAGAC 
AGCTTCAAGT GGTACTCGGT GGGATACATG AAACATTTGG ACCGTGACCC GGAAAAGTTG 
ACGCACCATA TGCCTTTGTT TTACTGTCTC TATGAGAATC GGGAAGAAGA ATTTGTGAAG 
ACGATTGTGG ATGCTCTCAT GGAGGTTACA GTTTACCTTC AATCAGACAA GGATATGATG 
GTCTCATTAT ACTGTCTGGA TTACTGCTGT CACCTGAGGA CACTTAAGTT GAGTGTTCAG 
CGCATCTTTC AAAACAAAGA GCCACTTATA AGGCCAACTG CTAGTCAAAT GAAGAGCCTT 
GTCTACTGGA GAGAGATCTG CTCTCTTTTT TATACAATGG AGAGCCTCCG GGAGCTGCAT 
ATCTTTGACA ATGACCTTAA TGGTATTTCA GAAAGGATTC TGTCTAAAGC CCTGGAGCAT 
TCTAGCTGTA AACTTCGCAC ACTCAAGTTG TCCTATGTCT CGACTGCTTC TGGTTTTGAA 
GACTTACTCA AGGCTTTGGC TCGTAATCGG AGCCTGACAT ACCTGAGTAT CAACTGTACG 
TCCATTTCCC TAAATATGTT TTCACTTCTG CATGACATCC TGCACGAGCC CACATGCCAA 
ATAAGTCATC TGAGCTTGAT GAAATGTGAT TTGCGAGCCA GCGAATGTGA AGAAATCGCC 
TCTCTCCTCA TCAGTGGCGG GAGTCTGAGA AAACTGACCT TATCCAGCAA TCCGCTGAGG 
AGCGACGGGA TGAACATACT GTGTGATGCC TTGCTTCATC CCAACTGCAC TCTTATATCA 
CTGGTGTTAG TCTTCTGCTG TCTCACTGAA AATTGCTGCA GCGCCCTTGG AAGAGTGCTT 
CTGTTCAGCC CAACTCTAAG ACAACTAGAC CTGTGTGTGA ATCGCTTAAA AAATTACGGA 
GTGTTGCATG TGACGTTTCC CTTGCTGTTT CCAACCTGTC AGTTAGAGGA GCTTCATCTG 
TCTGGCTGTT TCTTTAGCAG CGATATCTGT CAATATATTG CCATAGTTAT TGCTACTAAT 
GAAAAACTGA GGAGCCTGGA GATTGGGAGC AACAAAATAG AAGATGCAGG AATGCAGCTG 
CTATGTGGTG GTTTGAGACA TCCCAACTGC ATGTTGGTGA ATATTGGGCT AGAAGAGTGC 
ATGTTAACCA GTGCCTGCTG TCGATCTCTT GCCTCTGTTC TTACCACCAA CAAAACACTA 
GAAAGACTCA ACTTGCTTCA AAATCACTTG GGCAATGATG GAGTTGCAAA ACTTCTTGAG 
AGCTTGATCA GCCCAGATTG TGTACTTAAG GTAGTTGGGC TTCCATTAAC TGGCCTGAAC 
ACACAAACCC AGCAGTTGCT GATGACTGTA AAGGAAAGAA AACCCAGTTT GATCTTTCTG 
TCTGAAACTT GGTCTTTAAA GGAAGGCAGA GAAATTGGTG TGACACCTGC TTCTCAGCCA 
GGTTCAATAA TACCTAATTC TAATTTGGAT TACATGTTTT TCAAATTTCC CAGAATGTCT 
GCAGCCATGA GAACGTCAAA TACAGCATCT AGGCAACCCC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284672.1
CDS	159..2963
Translation	MRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKEKREQYSDFNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAAMRTSNTASRQPL

Target ORF information:

RefSeq Version	NM_001297743.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 11 (NLRP11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297743.1

ORF Insert Sequence:

ATGAGGAGAA AATTCATGCT GCAATGGGAA AGTCACACTT TTGGAAAATT TCATTATAAA 
TTTTTTCGTG ACGTTTCGTC AGATGTGTTC TACATACTTC AATTAGCCTA TGATTCTACC 
AGCTATTATT CAGCAAACAA TCTCAATGTG TTCCTGATGG GAGAGAGAGC ATCTGGAAAA 
ACTATTGTTA TAAATCTGGC TGTGTTGAGG TGGATCAAGG GTGAGATGTG GCAGAACATG 
ATCTCGTACG TCGTTCACCT CACTGCTCAC GAAATAAACC AGATGACCAA CAGCAGCTTG 
GCTGAGCTAA TCGCCAAGGA CTGGCCTGAC GGCCAGGCTC CCATTGCAGA CATCCTGTCT 
GATCCCAAGA AACTCCTTTT CATCCTCGAG GACTTGGACA ACATAAGATT CGAGTTAAAT 
GTCAATGAAA GTGCTTTGTG TAGTAACAGC ACCCAGAAAG TTCCCATTCC AGTTCTCCTG 
GTCAGTTTGC TGAAGAGAAA AATGGCTCCA GGCTGCTGGT TCCTCATCTC CTCAAGGCCC 
ACACGTGGGA ATAATGTAAA AACGTTCTTG AAAGAGGTAG ATTGCTGCAC GACCTTGCAG 
CTGTCGAATG GGAAGAGGGA GATATATTTT AACTCTTTCT TTAAAGACCG CCAGAGGGCG 
TCGGCAGCCC TCCAGCTTGT ACATGAGGAT GAAATACTCG TGGGTCTGTG CCGAGTCGCC 
ATCTTATGCT GGATCACGTG TACTGTCCTG AAGCGGCAGA TGGACAAGGG GCGTGACTTC 
CAGCTCTGCT GCCAAACACC CACTGATCTA CATGCCCACT TTCTTGCTGA TGCGTTGACA 
TCAGAGGCTG GACTTACTGC CAATCAGTAT CACCTAGGTC TCCTAAAACG TCTGTGTTTG 
CTGGCTGCAG GAGGACTGTT TCTGAGCACC CTGAATTTCA GTGGTGAAGA CCTCAGATGT 
GTTGGGTTTA CTGAGGCTGA TGTCTCTGTG TTGCAGGCCG CGAATATTCT TTTGCCGAGC 
AACACTCATA AAGACCGTTA CAAGTTCATA CACTTGAACG TCCAGGAGTT TTGTACAGCC 
ATTGCATTTC TGATGGCAGT ACCCAACTAT CTGATCCCCT CAGGCAGCAG AGAGTATAAA 
GAGAAGAGAG AACAATACTC TGACTTTAAT CAAGTGTTTA CTTTCATTTT TGGTCTTCTA 
AATGCAAACA GGAGAAAGAT TCTTGAGACA TCCTTTGGAT ACCAGCTACC GATGGTAGAC 
AGCTTCAAGT GGTACTCGGT GGGATACATG AAACATTTGG ACCGTGACCC GGAAAAGTTG 
ACGCACCATA TGCCTTTGTT TTACTGTCTC TATGAGAATC GGGAAGAAGA ATTTGTGAAG 
ACGATTGTGG ATGCTCTCAT GGAGGTTACA GTTTACCTTC AATCAGACAA GGATATGATG 
GTCTCATTAT ACTGTCTGGA TTACTGCTGT CACCTGAGGA CACTTAAGTT GAGTGTTCAG 
CGCATCTTTC AAAACAAAGA GCCACTTATA AGGCCAACTG CTAGTCAAAT GAAGAGCCTT 
GTCTACTGGA GAGAGATCTG CTCTCTTTTT TATACAATGG AGAGCCTCCG GGAGCTGCAT 
ATCTTTGACA ATGACCTTAA TGGTATTTCA GAAAGGATTC TGTCTAAAGC CCTGGAGCAT 
TCTAGCTGTA AACTTCGCAC ACTCAAGTTG TCCTATGTCT CGACTGCTTC TGGTTTTGAA 
GACTTACTCA AGGCTTTGGC TCGTAATCGG AGCCTGACAT ACCTGAGTAT CAACTGTACG 
TCCATTTCCC TAAATATGTT TTCACTTCTG CATGACATCC TGCACGAGCC CACATGCCAA 
ATAAGTCATC TGAGCTTGAT GAAATGTGAT TTGCGAGCCA GCGAATGTGA AGAAATCGCC 
TCTCTCCTCA TCAGTGGCGG GAGTCTGAGA AAACTGACCT TATCCAGCAA TCCGCTGAGG 
AGCGACGGGA TGAACATACT GTGTGATGCC TTGCTTCATC CCAACTGCAC TCTTATATCA 
CTGGTGTTAG TCTTCTGCTG TCTCACTGAA AATTGCTGCA GCGCCCTTGG AAGAGTGCTT 
CTGTTCAGCC CAACTCTAAG ACAACTAGAC CTGTGTGTGA ATCGCTTAAA AAATTACGGA 
GTGTTGCATG TGACGTTTCC CTTGCTGTTT CCAACCTGTC AGTTAGAGGA GCTTCATCTG 
TCTGGCTGTT TCTTTAGCAG CGATATCTGT CAATATATTG CCATAGTTAT TGCTACTAAT 
GAAAAACTGA GGAGCCTGGA GATTGGGAGC AACAAAATAG AAGATGCAGG AATGCAGCTG 
CTATGTGGTG GTTTGAGACA TCCCAACTGC ATGTTGGTGA ATATTGGGCT AGAAGAGTGC 
ATGTTAACCA GTGCCTGCTG TCGATCTCTT GCCTCTGTTC TTACCACCAA CAAAACACTA 
GAAAGACTCA ACTTGCTTCA AAATCACTTG GGCAATGATG GAGTTGCAAA ACTTCTTGAG 
AGCTTGATCA GCCCAGATTG TGTACTTAAG GTAGTTGGGC TTCCATTAAC TGGCCTGAAC 
ACACAAACCC AGCAGTTGCT GATGACTGTA AAGGAAAGAA AACCCAGTTT GATCTTTCTG 
TCTGAAACTT GGTCTTTAAA GGAAGGCAGA GAAATTGGTG TGACACCTGC TTCTCAGCCA 
GGTTCAATAA TACCTAATTC TAATTTGGAT TACATGTTTT TCAAATTTCC CAGAATGTCT 
GCAGCCATGA GAACGTCAAA TACAGCATCT AGGCAACCCC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NLRP11 ( NM_145007.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_659444.2 Homo sapiens NLR family pyrin domain containing 11 (NLRP11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06437
Clone ID Related Accession (Same CDS sequence)	NM_145007.3
Accession Version	NM_145007.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3102bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 11 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC036506.1, AK310394.1, AY095145.1, AC012310.5, AK129784.1 and BU622142.1. This sequence is a reference standard in the RefSeqGene project. On Jul 10, 2008 this sequence version replaced NM_145007.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AY095145.1, AY154466.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAAT CGGATTCTAC TGACTTTGAC CTGCTGTGGT ATCTAGAGAA TCTCAGTGAC 
AAGGAATTTC AGAGTTTTAA GAAGTATCTG GCACGCAAGA TTCTTGATTT CAAACTGCCA 
CAGTTTCCAC TGATACAGAT GACAAAAGAA GAACTGGCTA ACGTGTTGCC AATCTCTTAT 
GAGGGACAGT ATATATGGAA TATGCTCTTC AGCATATTTT CAATGATGCG TAAGGAAGAT 
CTTTGTAGGA AGATCATTGG CAGACGAAAC CGCAATCAGG AGGCATGCAA AGCTGTCATG 
AGGAGAAAAT TCATGCTGCA ATGGGAAAGT CACACTTTTG GAAAATTTCA TTATAAATTT 
TTTCGTGACG TTTCGTCAGA TGTGTTCTAC ATACTTCAAT TAGCCTATGA TTCTACCAGC 
TATTATTCAG CAAACAATCT CAATGTGTTC CTGATGGGAG AGAGAGCATC TGGAAAAACT 
ATTGTTATAA ATCTGGCTGT GTTGAGGTGG ATCAAGGGTG AGATGTGGCA GAACATGATC 
TCGTACGTCG TTCACCTCAC TGCTCACGAA ATAAACCAGA TGACCAACAG CAGCTTGGCT 
GAGCTAATCG CCAAGGACTG GCCTGACGGC CAGGCTCCCA TTGCAGACAT CCTGTCTGAT 
CCCAAGAAAC TCCTTTTCAT CCTCGAGGAC TTGGACAACA TAAGATTCGA GTTAAATGTC 
AATGAAAGTG CTTTGTGTAG TAACAGCACC CAGAAAGTTC CCATTCCAGT TCTCCTGGTC 
AGTTTGCTGA AGAGAAAAAT GGCTCCAGGC TGCTGGTTCC TCATCTCCTC AAGGCCCACA 
CGTGGGAATA ATGTAAAAAC GTTCTTGAAA GAGGTAGATT GCTGCACGAC CTTGCAGCTG 
TCGAATGGGA AGAGGGAGAT ATATTTTAAC TCTTTCTTTA AAGACCGCCA GAGGGCGTCG 
GCAGCCCTCC AGCTTGTACA TGAGGATGAA ATACTCGTGG GTCTGTGCCG AGTCGCCATC 
TTATGCTGGA TCACGTGTAC TGTCCTGAAG CGGCAGATGG ACAAGGGGCG TGACTTCCAG 
CTCTGCTGCC AAACACCCAC TGATCTACAT GCCCACTTTC TTGCTGATGC GTTGACATCA 
GAGGCTGGAC TTACTGCCAA TCAGTATCAC CTAGGTCTCC TAAAACGTCT GTGTTTGCTG 
GCTGCAGGAG GACTGTTTCT GAGCACCCTG AATTTCAGTG GTGAAGACCT CAGATGTGTT 
GGGTTTACTG AGGCTGATGT CTCTGTGTTG CAGGCCGCGA ATATTCTTTT GCCGAGCAAC 
ACTCATAAAG ACCGTTACAA GTTCATACAC TTGAACGTCC AGGAGTTTTG TACAGCCATT 
GCATTTCTGA TGGCAGTACC CAACTATCTG ATCCCCTCAG GCAGCAGAGA GTATAAAGAG 
AAGAGAGAAC AATACTCTGA CTTTAATCAA GTGTTTACTT TCATTTTTGG TCTTCTAAAT 
GCAAACAGGA GAAAGATTCT TGAGACATCC TTTGGATACC AGCTACCGAT GGTAGACAGC 
TTCAAGTGGT ACTCGGTGGG ATACATGAAA CATTTGGACC GTGACCCGGA AAAGTTGACG 
CACCATATGC CTTTGTTTTA CTGTCTCTAT GAGAATCGGG AAGAAGAATT TGTGAAGACG 
ATTGTGGATG CTCTCATGGA GGTTACAGTT TACCTTCAAT CAGACAAGGA TATGATGGTC 
TCATTATACT GTCTGGATTA CTGCTGTCAC CTGAGGACAC TTAAGTTGAG TGTTCAGCGC 
ATCTTTCAAA ACAAAGAGCC ACTTATAAGG CCAACTGCTA GTCAAATGAA GAGCCTTGTC 
TACTGGAGAG AGATCTGCTC TCTTTTTTAT ACAATGGAGA GCCTCCGGGA GCTGCATATC 
TTTGACAATG ACCTTAATGG TATTTCAGAA AGGATTCTGT CTAAAGCCCT GGAGCATTCT 
AGCTGTAAAC TTCGCACACT CAAGTTGTCC TATGTCTCGA CTGCTTCTGG TTTTGAAGAC 
TTACTCAAGG CTTTGGCTCG TAATCGGAGC CTGACATACC TGAGTATCAA CTGTACGTCC 
ATTTCCCTAA ATATGTTTTC ACTTCTGCAT GACATCCTGC ACGAGCCCAC ATGCCAAATA 
AGTCATCTGA GCTTGATGAA ATGTGATTTG CGAGCCAGCG AATGTGAAGA AATCGCCTCT 
CTCCTCATCA GTGGCGGGAG TCTGAGAAAA CTGACCTTAT CCAGCAATCC GCTGAGGAGC 
GACGGGATGA ACATACTGTG TGATGCCTTG CTTCATCCCA ACTGCACTCT TATATCACTG 
GTGTTAGTCT TCTGCTGTCT CACTGAAAAT TGCTGCAGCG CCCTTGGAAG AGTGCTTCTG 
TTCAGCCCAA CTCTAAGACA ACTAGACCTG TGTGTGAATC GCTTAAAAAA TTACGGAGTG 
TTGCATGTGA CGTTTCCCTT GCTGTTTCCA ACCTGTCAGT TAGAGGAGCT TCATCTGTCT 
GGCTGTTTCT TTAGCAGCGA TATCTGTCAA TATATTGCCA TAGTTATTGC TACTAATGAA 
AAACTGAGGA GCCTGGAGAT TGGGAGCAAC AAAATAGAAG ATGCAGGAAT GCAGCTGCTA 
TGTGGTGGTT TGAGACATCC CAACTGCATG TTGGTGAATA TTGGGCTAGA AGAGTGCATG 
TTAACCAGTG CCTGCTGTCG ATCTCTTGCC TCTGTTCTTA CCACCAACAA AACACTAGAA 
AGACTCAACT TGCTTCAAAA TCACTTGGGC AATGATGGAG TTGCAAAACT TCTTGAGAGC 
TTGATCAGCC CAGATTGTGT ACTTAAGGTA GTTGGGCTTC CATTAACTGG CCTGAACACA 
CAAACCCAGC AGTTGCTGAT GACTGTAAAG GAAAGAAAAC CCAGTTTGAT CTTTCTGTCT 
GAAACTTGGT CTTTAAAGGA AGGCAGAGAA ATTGGTGTGA CACCTGCTTC TCAGCCAGGT 
TCAATAATAC CTAATTCTAA TTTGGATTAC ATGTTTTTCA AATTTCCCAG AATGTCTGCA 
GCCATGAGAA CGTCAAATAC AGCATCTAGG CAACCCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659444.2
CDS	712..3813
Translation	MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTKEELANVLPISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKEKREQYSDFNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAAMRTSNTASRQPL

Target ORF information:

RefSeq Version	NM_145007.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 11 (NLRP11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145007.3

ORF Insert Sequence:

ATGGCAGAAT CGGATTCTAC TGACTTTGAC CTGCTGTGGT ATCTAGAGAA TCTCAGTGAC 
AAGGAATTTC AGAGTTTTAA GAAGTATCTG GCACGCAAGA TTCTTGATTT CAAACTGCCA 
CAGTTTCCAC TGATACAGAT GACAAAAGAA GAACTGGCTA ACGTGTTGCC AATCTCTTAT 
GAGGGACAGT ATATATGGAA TATGCTCTTC AGCATATTTT CAATGATGCG TAAGGAAGAT 
CTTTGTAGGA AGATCATTGG CAGACGAAAC CGCAATCAGG AGGCATGCAA AGCTGTCATG 
AGGAGAAAAT TCATGCTGCA ATGGGAAAGT CACACTTTTG GAAAATTTCA TTATAAATTT 
TTTCGTGACG TTTCGTCAGA TGTGTTCTAC ATACTTCAAT TAGCCTATGA TTCTACCAGC 
TATTATTCAG CAAACAATCT CAATGTGTTC CTGATGGGAG AGAGAGCATC TGGAAAAACT 
ATTGTTATAA ATCTGGCTGT GTTGAGGTGG ATCAAGGGTG AGATGTGGCA GAACATGATC 
TCGTACGTCG TTCACCTCAC TGCTCACGAA ATAAACCAGA TGACCAACAG CAGCTTGGCT 
GAGCTAATCG CCAAGGACTG GCCTGACGGC CAGGCTCCCA TTGCAGACAT CCTGTCTGAT 
CCCAAGAAAC TCCTTTTCAT CCTCGAGGAC TTGGACAACA TAAGATTCGA GTTAAATGTC 
AATGAAAGTG CTTTGTGTAG TAACAGCACC CAGAAAGTTC CCATTCCAGT TCTCCTGGTC 
AGTTTGCTGA AGAGAAAAAT GGCTCCAGGC TGCTGGTTCC TCATCTCCTC AAGGCCCACA 
CGTGGGAATA ATGTAAAAAC GTTCTTGAAA GAGGTAGATT GCTGCACGAC CTTGCAGCTG 
TCGAATGGGA AGAGGGAGAT ATATTTTAAC TCTTTCTTTA AAGACCGCCA GAGGGCGTCG 
GCAGCCCTCC AGCTTGTACA TGAGGATGAA ATACTCGTGG GTCTGTGCCG AGTCGCCATC 
TTATGCTGGA TCACGTGTAC TGTCCTGAAG CGGCAGATGG ACAAGGGGCG TGACTTCCAG 
CTCTGCTGCC AAACACCCAC TGATCTACAT GCCCACTTTC TTGCTGATGC GTTGACATCA 
GAGGCTGGAC TTACTGCCAA TCAGTATCAC CTAGGTCTCC TAAAACGTCT GTGTTTGCTG 
GCTGCAGGAG GACTGTTTCT GAGCACCCTG AATTTCAGTG GTGAAGACCT CAGATGTGTT 
GGGTTTACTG AGGCTGATGT CTCTGTGTTG CAGGCCGCGA ATATTCTTTT GCCGAGCAAC 
ACTCATAAAG ACCGTTACAA GTTCATACAC TTGAACGTCC AGGAGTTTTG TACAGCCATT 
GCATTTCTGA TGGCAGTACC CAACTATCTG ATCCCCTCAG GCAGCAGAGA GTATAAAGAG 
AAGAGAGAAC AATACTCTGA CTTTAATCAA GTGTTTACTT TCATTTTTGG TCTTCTAAAT 
GCAAACAGGA GAAAGATTCT TGAGACATCC TTTGGATACC AGCTACCGAT GGTAGACAGC 
TTCAAGTGGT ACTCGGTGGG ATACATGAAA CATTTGGACC GTGACCCGGA AAAGTTGACG 
CACCATATGC CTTTGTTTTA CTGTCTCTAT GAGAATCGGG AAGAAGAATT TGTGAAGACG 
ATTGTGGATG CTCTCATGGA GGTTACAGTT TACCTTCAAT CAGACAAGGA TATGATGGTC 
TCATTATACT GTCTGGATTA CTGCTGTCAC CTGAGGACAC TTAAGTTGAG TGTTCAGCGC 
ATCTTTCAAA ACAAAGAGCC ACTTATAAGG CCAACTGCTA GTCAAATGAA GAGCCTTGTC 
TACTGGAGAG AGATCTGCTC TCTTTTTTAT ACAATGGAGA GCCTCCGGGA GCTGCATATC 
TTTGACAATG ACCTTAATGG TATTTCAGAA AGGATTCTGT CTAAAGCCCT GGAGCATTCT 
AGCTGTAAAC TTCGCACACT CAAGTTGTCC TATGTCTCGA CTGCTTCTGG TTTTGAAGAC 
TTACTCAAGG CTTTGGCTCG TAATCGGAGC CTGACATACC TGAGTATCAA CTGTACGTCC 
ATTTCCCTAA ATATGTTTTC ACTTCTGCAT GACATCCTGC ACGAGCCCAC ATGCCAAATA 
AGTCATCTGA GCTTGATGAA ATGTGATTTG CGAGCCAGCG AATGTGAAGA AATCGCCTCT 
CTCCTCATCA GTGGCGGGAG TCTGAGAAAA CTGACCTTAT CCAGCAATCC GCTGAGGAGC 
GACGGGATGA ACATACTGTG TGATGCCTTG CTTCATCCCA ACTGCACTCT TATATCACTG 
GTGTTAGTCT TCTGCTGTCT CACTGAAAAT TGCTGCAGCG CCCTTGGAAG AGTGCTTCTG 
TTCAGCCCAA CTCTAAGACA ACTAGACCTG TGTGTGAATC GCTTAAAAAA TTACGGAGTG 
TTGCATGTGA CGTTTCCCTT GCTGTTTCCA ACCTGTCAGT TAGAGGAGCT TCATCTGTCT 
GGCTGTTTCT TTAGCAGCGA TATCTGTCAA TATATTGCCA TAGTTATTGC TACTAATGAA 
AAACTGAGGA GCCTGGAGAT TGGGAGCAAC AAAATAGAAG ATGCAGGAAT GCAGCTGCTA 
TGTGGTGGTT TGAGACATCC CAACTGCATG TTGGTGAATA TTGGGCTAGA AGAGTGCATG 
TTAACCAGTG CCTGCTGTCG ATCTCTTGCC TCTGTTCTTA CCACCAACAA AACACTAGAA 
AGACTCAACT TGCTTCAAAA TCACTTGGGC AATGATGGAG TTGCAAAACT TCTTGAGAGC 
TTGATCAGCC CAGATTGTGT ACTTAAGGTA GTTGGGCTTC CATTAACTGG CCTGAACACA 
CAAACCCAGC AGTTGCTGAT GACTGTAAAG GAAAGAAAAC CCAGTTTGAT CTTTCTGTCT 
GAAACTTGGT CTTTAAAGGA AGGCAGAGAA ATTGGTGTGA CACCTGCTTC TCAGCCAGGT 
TCAATAATAC CTAATTCTAA TTTGGATTAC ATGTTTTTCA AATTTCCCAG AATGTCTGCA 
GCCATGAGAA CGTCAAATAC AGCATCTAGG CAACCCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Journal of biological chemistry(2018 Jan)
Ellwanger K,Becker E,Kienes I,Sowa A,Postma Y,Gloria YC,Weber ANR,Kufer TA

NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis.
EMBO reports18(12)2160-2171(2017 Dec)
Qin Y,Su Z,Wu Y,Wu C,Jin S,Xie W,Jiang W,Zhou R,Cui J

A genome-wide association study of early menopause and the combined impact of identified variants.
Human molecular genetics22(7)1465-72(2013 Apr)
Perry JR,Corre T,Esko T,Chasman DI,Fischer K,Franceschini N,He C,Kutalik Z,Mangino M,Rose LM,Vernon Smith A,Stolk L,Sulem P,Weedon MN,Zhuang WV,Arnold A,Ashworth A,Bergmann S,Buring JE,Burri A,Chen C,Cornelis MC,Couper DJ,Goodarzi MO,Gudnason V,Harris T,Hofman A,Jones M,Kraft P,Launer L,Laven JS,Li G,McKnight B,Masciullo C,Milani L,Orr N,Psaty BM,,Ridker PM,Rivadeneira F,Sala C,Salumets A,Schoemaker M,Traglia M,Waeber G,Chanock SJ,Demerath EW,Garcia M,Hankinson SE,Hu FB,Hunter DJ,Lunetta KL,Metspalu A,Montgomery GW,Murabito JM,Newman AB,Ong KK,Spector TD,Stefansson K,Swerdlow AJ,Thorsteinsdottir U,Van Dam RM,Uitterlinden AG,Visser JA,Vollenweider P,Toniolo D,Murray A

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
The American journal of psychiatry170(2)207-17(2013 Feb)
,,

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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NLRP11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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