CTSO cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTSO
Entrez Gene ID	1519
Full Name	cathepsin O
Synonyms	CTSO1
General protein information	Preferred Names cathepsin O Names cathepsin O
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q32.1
Summary	The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008].
Disorder MIM:	600550

mRNA and Protein(s)

mRNA	Protein	Name
NM_001334.2	NP_001325.1	cathepsin O preproprotein
NM_001334.3	NP_001325.1	cathepsin O preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CTSO	XP_002694471.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002720	XP_312205.5
Xenopus tropicalis (tropical clawed frog)	ctso	XP_002933519.1
Pan troglodytes (chimpanzee)	CTSO	XP_517502.2
Canis lupus familiaris (dog)	CTSO	XP_005629509.1
Danio rerio (zebrafish)	ctso	XP_695717.3
Homo sapiens (human)	CTSO	NP_001325.1
Mus musculus (house mouse)	Ctso	NP_808330.1
Gallus gallus (chicken)	CTSO	NP_001026300.1

Gene Ontology
Bibliography

Related articles in PubMed

SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ER?-positive breast cancer through regulation of BRCA1.
Cairns J, Ingle JN, Wickerham LD, Weinshilboum R, Liu M, Wang L
PLoS genetics13(10)e1007031(2017 Oct)

Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients.
Hato Y, Kondo N, Yoshimoto N, Endo Y, Asano T, Dong Y, Nishimoto M, Takahashi S, Fujii Y, Nakanishi R, Toyama T
International journal of clinical oncology21(3)539-47(2016 Jun)

Molecular insight into propeptide-protein interactions in cathepsins L and O.
Reif MM, Mach L, Oostenbrink C
Biochemistry51(43)8636-53(2012 Oct)

First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children.
Roeske D, Ludwig KU, Neuhoff N, Becker J, Bartling J, Bruder J, Brockschmidt FF, Warnke A, Remschmidt H, Hoffmann P, M?ller-Myhsok B, N?then MM, Schulte-K?rne G
Molecular psychiatry16(1)97-107(2011 Jan)

Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO).
Santamar?a I, Pend?s AM, Velasco G, L?pez-Ot?n C
Genomics53(2)231-4(1998 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We report that CTSO reduces the protein levels of BRCA1 and ZNF423 through cysteine proteinase-mediated degradation. We also have identified a series of transcription factors of BRCA1 that are regulated by CTSO at the protein level.
Title: SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ER?-positive breast cancer through regulation of BRCA1.

a single-nucleotide polymorphism near the CTSO gene is a poor prognostic factor in breast cancer although further research might help to reveal the factors linking this genotype and prognosis.
Title: Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients.

In this study, various molecular dynamics (MD) simulations of pro- and mature human cathepsins L and O were performed.
Title: Molecular insight into propeptide-protein interactions in cathepsins L and O.

The following CTSO gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTSO cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02884	NM_001334.3 Latest version!	Homo sapiens cathepsin O (CTSO), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu02884	NM_001334.2	Homo sapiens cathepsin O (CTSO), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTSO ( NM_001334.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001325.1 Homo sapiens cathepsin O (CTSO), mRNA.

Price & Availability↑

CloneID	OHu02884
Clone ID Related Accession (Same CDS sequence)	NM_001334.2 , NM_001334.3
Accession Version	NM_001334.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-23
Organism	Homo sapiens(human)
Product	cathepsin O preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI834113.1, X77383.1, BC049206.1, BG617165.1 and BQ006443.1. On Nov 14, 2003 this sequence version replaced NM_001334.1. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.90394.1, SRR1660805.122874.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGACGTGC GGGCGCTGCC GTGGCTGCCG TGGCTGCTGT GGCTGCTGTG CCGGGGCGGC 
GGCGATGCGG ACTCCCGCGC CCCCTTCACC CCGACCTGGC CGCGGAGCCG CGAGCGTGAA 
GCCGCCGCCT TCCGGGAAAG TCTTAATAGA CATCGATACT TGAATTCTTT ATTTCCCAGT 
GAAAACTCCA CCGCCTTCTA TGGAATAAAT CAGTTTTCCT ATTTGTTTCC TGAAGAGTTT 
AAAGCCATTT ATTTAAGAAG CAAACCTTCC AAGTTTCCCA GATACTCAGC AGAAGTACAT 
ATGTCCATCC CCAATGTGTC TTTGCCGTTA AGATTTGACT GGAGGGACAA GCAGGTTGTG 
ACACAAGTGA GAAACCAGCA GATGTGTGGA GGATGCTGGG CCTTCAGCGT GGTGGGGGCA 
GTGGAATCTG CTTATGCAAT AAAGGGGAAG CCCCTGGAAG ACCTAAGTGT CCAGCAGGTC 
ATTGACTGTT CGTATAATAA TTATGGCTGC AATGGAGGCT CTACTCTCAA TGCTTTGAAC 
TGGTTAAACA AGATGCAAGT AAAACTGGTG AAAGATTCAG AATATCCTTT TAAAGCACAA 
AATGGTCTGT GCCATTACTT TTCTGGTTCA CATTCTGGAT TTTCAATCAA AGGTTATTCT 
GCATATGACT TCAGTGACCA AGAAGATGAA ATGGCAAAAG CACTTCTTAC CTTTGGCCCT 
TTGGTAGTCA TAGTAGATGC AGTGAGCTGG CAAGATTATC TGGGAGGCAT TATACAGCAT 
CACTGCTCTA GTGGAGAAGC AAATCATGCA GTTCTCATAA CTGGGTTTGA TAAAACAGGA 
AGCACTCCAT ATTGGATTGT GCGGAATTCC TGGGGAAGTT CTTGGGGAGT AGATGGTTAT 
GCCCATGTCA AAATGGGAAG TAATGTTTGT GGTATTGCAG ATTCCGTTTC TTCTATATTT 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001325.1
CDS	50..1015
Translation	MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSSIFV

Target ORF information:

RefSeq Version	NM_001334.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin O (CTSO), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001334.2

ORF Insert Sequence:

ATGGACGTGC GGGCGCTGCC GTGGCTGCCG TGGCTGCTGT GGCTGCTGTG CCGGGGCGGC 
GGCGATGCGG ACTCCCGCGC CCCCTTCACC CCGACCTGGC CGCGGAGCCG CGAGCGTGAA 
GCCGCCGCCT TCCGGGAAAG TCTTAATAGA CATCGATACT TGAATTCTTT ATTTCCCAGT 
GAAAACTCCA CCGCCTTCTA TGGAATAAAT CAGTTTTCCT ATTTGTTTCC TGAAGAGTTT 
AAAGCCATTT ATTTAAGAAG CAAACCTTCC AAGTTTCCCA GATACTCAGC AGAAGTACAT 
ATGTCCATCC CCAATGTGTC TTTGCCGTTA AGATTTGACT GGAGGGACAA GCAGGTTGTG 
ACACAAGTGA GAAACCAGCA GATGTGTGGA GGATGCTGGG CCTTCAGCGT GGTGGGGGCA 
GTGGAATCTG CTTATGCAAT AAAGGGGAAG CCCCTGGAAG ACCTAAGTGT CCAGCAGGTC 
ATTGACTGTT CGTATAATAA TTATGGCTGC AATGGAGGCT CTACTCTCAA TGCTTTGAAC 
TGGTTAAACA AGATGCAAGT AAAACTGGTG AAAGATTCAG AATATCCTTT TAAAGCACAA 
AATGGTCTGT GCCATTACTT TTCTGGTTCA CATTCTGGAT TTTCAATCAA AGGTTATTCT 
GCATATGACT TCAGTGACCA AGAAGATGAA ATGGCAAAAG CACTTCTTAC CTTTGGCCCT 
TTGGTAGTCA TAGTAGATGC AGTGAGCTGG CAAGATTATC TGGGAGGCAT TATACAGCAT 
CACTGCTCTA GTGGAGAAGC AAATCATGCA GTTCTCATAA CTGGGTTTGA TAAAACAGGA 
AGCACTCCAT ATTGGATTGT GCGGAATTCC TGGGGAAGTT CTTGGGGAGT AGATGGTTAT 
GCCCATGTCA AAATGGGAAG TAATGTTTGT GGTATTGCAG ATTCCGTTTC TTCTATATTT 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSO ( NM_001334.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001325.1 Homo sapiens cathepsin O (CTSO), mRNA.

Price & Availability↑

CloneID	OHu02884
Clone ID Related Accession (Same CDS sequence)	NM_001334.2 , NM_001334.3
Accession Version	NM_001334.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cathepsin O preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X77383.1, BC049206.1, BG617165.1 and BQ006443.1. On Nov 23, 2018 this sequence version replaced NM_001334.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.171374.1, SRR1660805.122874.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000433477.4/ ENSP00000414904.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGTGC GGGCGCTGCC GTGGCTGCCG TGGCTGCTGT GGCTGCTGTG CCGGGGCGGC 
GGCGATGCGG ACTCCCGCGC CCCCTTCACC CCGACCTGGC CGCGGAGCCG CGAGCGTGAA 
GCCGCCGCCT TCCGGGAAAG TCTTAATAGA CATCGATACT TGAATTCTTT ATTTCCCAGT 
GAAAACTCCA CCGCCTTCTA TGGAATAAAT CAGTTTTCCT ATTTGTTTCC TGAAGAGTTT 
AAAGCCATTT ATTTAAGAAG CAAACCTTCC AAGTTTCCCA GATACTCAGC AGAAGTACAT 
ATGTCCATCC CCAATGTGTC TTTGCCGTTA AGATTTGACT GGAGGGACAA GCAGGTTGTG 
ACACAAGTGA GAAACCAGCA GATGTGTGGA GGATGCTGGG CCTTCAGCGT GGTGGGGGCA 
GTGGAATCTG CTTATGCAAT AAAGGGGAAG CCCCTGGAAG ACCTAAGTGT CCAGCAGGTC 
ATTGACTGTT CGTATAATAA TTATGGCTGC AATGGAGGCT CTACTCTCAA TGCTTTGAAC 
TGGTTAAACA AGATGCAAGT AAAACTGGTG AAAGATTCAG AATATCCTTT TAAAGCACAA 
AATGGTCTGT GCCATTACTT TTCTGGTTCA CATTCTGGAT TTTCAATCAA AGGTTATTCT 
GCATATGACT TCAGTGACCA AGAAGATGAA ATGGCAAAAG CACTTCTTAC CTTTGGCCCT 
TTGGTAGTCA TAGTAGATGC AGTGAGCTGG CAAGATTATC TGGGAGGCAT TATACAGCAT 
CACTGCTCTA GTGGAGAAGC AAATCATGCA GTTCTCATAA CTGGGTTTGA TAAAACAGGA 
AGCACTCCAT ATTGGATTGT GCGGAATTCC TGGGGAAGTT CTTGGGGAGT AGATGGTTAT 
GCCCATGTCA AAATGGGAAG TAATGTTTGT GGTATTGCAG ATTCCGTTTC TTCTATATTT 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001325.1
CDS	20..985
Translation	MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSSIFV

Target ORF information:

RefSeq Version	NM_001334.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin O (CTSO), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001334.3

ORF Insert Sequence:

ATGGACGTGC GGGCGCTGCC GTGGCTGCCG TGGCTGCTGT GGCTGCTGTG CCGGGGCGGC 
GGCGATGCGG ACTCCCGCGC CCCCTTCACC CCGACCTGGC CGCGGAGCCG CGAGCGTGAA 
GCCGCCGCCT TCCGGGAAAG TCTTAATAGA CATCGATACT TGAATTCTTT ATTTCCCAGT 
GAAAACTCCA CCGCCTTCTA TGGAATAAAT CAGTTTTCCT ATTTGTTTCC TGAAGAGTTT 
AAAGCCATTT ATTTAAGAAG CAAACCTTCC AAGTTTCCCA GATACTCAGC AGAAGTACAT 
ATGTCCATCC CCAATGTGTC TTTGCCGTTA AGATTTGACT GGAGGGACAA GCAGGTTGTG 
ACACAAGTGA GAAACCAGCA GATGTGTGGA GGATGCTGGG CCTTCAGCGT GGTGGGGGCA 
GTGGAATCTG CTTATGCAAT AAAGGGGAAG CCCCTGGAAG ACCTAAGTGT CCAGCAGGTC 
ATTGACTGTT CGTATAATAA TTATGGCTGC AATGGAGGCT CTACTCTCAA TGCTTTGAAC 
TGGTTAAACA AGATGCAAGT AAAACTGGTG AAAGATTCAG AATATCCTTT TAAAGCACAA 
AATGGTCTGT GCCATTACTT TTCTGGTTCA CATTCTGGAT TTTCAATCAA AGGTTATTCT 
GCATATGACT TCAGTGACCA AGAAGATGAA ATGGCAAAAG CACTTCTTAC CTTTGGCCCT 
TTGGTAGTCA TAGTAGATGC AGTGAGCTGG CAAGATTATC TGGGAGGCAT TATACAGCAT 
CACTGCTCTA GTGGAGAAGC AAATCATGCA GTTCTCATAA CTGGGTTTGA TAAAACAGGA 
AGCACTCCAT ATTGGATTGT GCGGAATTCC TGGGGAAGTT CTTGGGGAGT AGATGGTTAT 
GCCCATGTCA AAATGGGAAG TAATGTTTGT GGTATTGCAG ATTCCGTTTC TTCTATATTT 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ER?-positive breast cancer through regulation of BRCA1.
PLoS genetics13(10)e1007031(2017 Oct)
Cairns J,Ingle JN,Wickerham LD,Weinshilboum R,Liu M,Wang L

Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients.
International journal of clinical oncology21(3)539-47(2016 Jun)
Hato Y,Kondo N,Yoshimoto N,Endo Y,Asano T,Dong Y,Nishimoto M,Takahashi S,Fujii Y,Nakanishi R,Toyama T

Molecular insight into propeptide-protein interactions in cathepsins L and O.
Biochemistry51(43)8636-53(2012 Oct)
Reif MM,Mach L,Oostenbrink C

First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children.
Molecular psychiatry16(1)97-107(2011 Jan)
Roeske D,Ludwig KU,Neuhoff N,Becker J,Bartling J,Bruder J,Brockschmidt FF,Warnke A,Remschmidt H,Hoffmann P,M?ller-Myhsok B,N?then MM,Schulte-K?rne G

Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO).
Genomics53(2)231-4(1998 Oct)
Santamar?a I,Pend?s AM,Velasco G,L?pez-Ot?n C

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CTSO cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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