CDC42EP5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDC42EP5
Entrez Gene ID	148170
Full Name	CDC42 effector protein 5
Synonyms	Borg3,CEP5
General protein information	Preferred Names CDC42 effector protein 5 Names cdc42 effector protein 5 CDC42 effector protein (Rho GTPase binding) 5 binder of Rho GTPases 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.42
Summary	Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013].
Disorder MIM:	609171

mRNA and Protein(s)

mRNA	Protein	Name
NM_145057.3	NP_659494.2	cdc42 effector protein 5
NM_145057.4	NP_659494.2	cdc42 effector protein 5

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CDC42EP5	XP_001174981.2
Canis lupus familiaris (dog)	CDC42EP5	XP_854183.1
Homo sapiens (human)	CDC42EP5	NP_659494.2
Bos taurus (cattle)	CDC42EP5	XP_005219798.1
Mus musculus (house mouse)	Cdc42ep5	NP_067429.1
Rattus norvegicus (Norway rat)	Cdc42ep5	NP_001101939.1

Gene Ontology
Bibliography

Related articles in PubMed

The Borg family of Cdc42 effector proteins Cdc42EP1-5.
Farrugia AJ, Calvo F
Biochemical Society transactions44(6)1709-1716(2016 12)

Borg proteins control septin organization and are negatively regulated by Cdc42.
Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, Macara IG
Nature cell biology3(10)861-6(2001 Oct)

A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes.
Hirsch DS, Pirone DM, Burbelo PD
The Journal of biological chemistry276(2)875-83(2001 Jan)

The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
Joberty G, Perlungher RR, Macara IG
Molecular and cellular biology19(10)6585-97(1999 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studies indicate some of the functional and mechanistic roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5), including cytoskeletal remodelling and signalling.
Title: The Borg family of Cdc42 effector proteins Cdc42EP1-5.

The following CDC42EP5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDC42EP5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06467	NM_145057.4 Latest version!	Homo sapiens CDC42 effector protein 5 (CDC42EP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu06467	NM_145057.3	Homo sapiens CDC42 effector protein 5 (CDC42EP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDC42EP5 ( NM_145057.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_659494.2 Homo sapiens CDC42 effector protein 5 (CDC42EP5), mRNA.

Price & Availability↑

CloneID	OHu06467
Clone ID Related Accession (Same CDS sequence)	NM_145057.3 , NM_145057.4
Accession Version	NM_145057.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	cdc42 effector protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA867588.1, BC024327.1, BC065910.1 and AI379873.1. On Aug 1, 2013 this sequence version replaced NM_145057.2. ##Evidence-Data-START## Transcript exon combination :: BC024327.1, ERR279841.5696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGTGC TGAAGCAGCT GGGCCCCGCG CAGCCCAAGA AGCGGCCTGA TCGCGGCGCC 
CTGTCCATCT CCGCGCCGCT CGGCGACTTC CGGCACACGC TGCACGTGGG GCGCGGCGGC 
GACGCCTTCG GGGACACCTC GTTCCTGAGC CGCCACGGCG GCGGGCCGCC CCCCGAGCCC 
CGGGCGCCCC CCGCGGGGGC CCCGCGCTCC CCGCCGCCGC CCGCCGTCCC GCAGTCCGCA 
GCGCCCTCGC CTGCCGACCC GCTGCTGTCC TTCCACCTGG ATCTGGGGCC CTCCATGCTG 
GACGCGGTGC TGGGCGTCAT GGACGCGGCG CGCCCGGAGG CGGCTGCCGC CAAGCCCGAC 
GCGGAACCCC GCCCCGGGAC GCAGCCCCCC CAGGCCCGCT GCCGCCCCAA CGCGGACCTC 
GAGCTGAACG ACGTCATCGG CCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659494.2
CDS	369..815
Translation	MPVLKQLGPAQPKKRPDRGALSISAPLGDFRHTLHVGRGGDAFGDTSFLSRHGGGPPPEPRAPPAGAPRSPPPPAVPQSAAPSPADPLLSFHLDLGPSMLDAVLGVMDAARPEAAAAKPDAEPRPGTQPPQARCRPNADLELNDVIGL

Target ORF information:

RefSeq Version	NM_145057.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CDC42 effector protein 5 (CDC42EP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145057.3

ORF Insert Sequence:

ATGCCCGTGC TGAAGCAGCT GGGCCCCGCG CAGCCCAAGA AGCGGCCTGA TCGCGGCGCC 
CTGTCCATCT CCGCGCCGCT CGGCGACTTC CGGCACACGC TGCACGTGGG GCGCGGCGGC 
GACGCCTTCG GGGACACCTC GTTCCTGAGC CGCCACGGCG GCGGGCCGCC CCCCGAGCCC 
CGGGCGCCCC CCGCGGGGGC CCCGCGCTCC CCGCCGCCGC CCGCCGTCCC GCAGTCCGCA 
GCGCCCTCGC CTGCCGACCC GCTGCTGTCC TTCCACCTGG ATCTGGGGCC CTCCATGCTG 
GACGCGGTGC TGGGCGTCAT GGACGCGGCG CGCCCGGAGG CGGCTGCCGC CAAGCCCGAC 
GCGGAACCCC GCCCCGGGAC GCAGCCCCCC CAGGCCCGCT GCCGCCCCAA CGCGGACCTC 
GAGCTGAACG ACGTCATCGG CCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDC42EP5 ( NM_145057.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_659494.2 Homo sapiens CDC42 effector protein 5 (CDC42EP5), mRNA.

Price & Availability↑

CloneID	OHu06467
Clone ID Related Accession (Same CDS sequence)	NM_145057.3 , NM_145057.4
Accession Version	NM_145057.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	cdc42 effector protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245884.3, DA867588.1, BC024327.1, BC065910.1 and AI379873.1. On Nov 22, 2018 this sequence version replaced NM_145057.3. ##Evidence-Data-START## Transcript exon combination :: BC024327.1, ERR279841.5696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301200.3/ ENSP00000301200.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCGTGC TGAAGCAGCT GGGCCCCGCG CAGCCCAAGA AGCGGCCTGA TCGCGGCGCC 
CTGTCCATCT CCGCGCCGCT CGGCGACTTC CGGCACACGC TGCACGTGGG GCGCGGCGGC 
GACGCCTTCG GGGACACCTC GTTCCTGAGC CGCCACGGCG GCGGGCCGCC CCCCGAGCCC 
CGGGCGCCCC CCGCGGGGGC CCCGCGCTCC CCGCCGCCGC CCGCCGTCCC GCAGTCCGCA 
GCGCCCTCGC CTGCCGACCC GCTGCTGTCC TTCCACCTGG ATCTGGGGCC CTCCATGCTG 
GACGCGGTGC TGGGCGTCAT GGACGCGGCG CGCCCGGAGG CGGCTGCCGC CAAGCCCGAC 
GCGGAACCCC GCCCCGGGAC GCAGCCCCCC CAGGCCCGCT GCCGCCCCAA CGCGGACCTC 
GAGCTGAACG ACGTCATCGG CCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659494.2
CDS	375..821
Translation	MPVLKQLGPAQPKKRPDRGALSISAPLGDFRHTLHVGRGGDAFGDTSFLSRHGGGPPPEPRAPPAGAPRSPPPPAVPQSAAPSPADPLLSFHLDLGPSMLDAVLGVMDAARPEAAAAKPDAEPRPGTQPPQARCRPNADLELNDVIGL

Target ORF information:

RefSeq Version	NM_145057.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CDC42 effector protein 5 (CDC42EP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145057.4

ORF Insert Sequence:

ATGCCCGTGC TGAAGCAGCT GGGCCCCGCG CAGCCCAAGA AGCGGCCTGA TCGCGGCGCC 
CTGTCCATCT CCGCGCCGCT CGGCGACTTC CGGCACACGC TGCACGTGGG GCGCGGCGGC 
GACGCCTTCG GGGACACCTC GTTCCTGAGC CGCCACGGCG GCGGGCCGCC CCCCGAGCCC 
CGGGCGCCCC CCGCGGGGGC CCCGCGCTCC CCGCCGCCGC CCGCCGTCCC GCAGTCCGCA 
GCGCCCTCGC CTGCCGACCC GCTGCTGTCC TTCCACCTGG ATCTGGGGCC CTCCATGCTG 
GACGCGGTGC TGGGCGTCAT GGACGCGGCG CGCCCGGAGG CGGCTGCCGC CAAGCCCGAC 
GCGGAACCCC GCCCCGGGAC GCAGCCCCCC CAGGCCCGCT GCCGCCCCAA CGCGGACCTC 
GAGCTGAACG ACGTCATCGG CCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Borg family of Cdc42 effector proteins Cdc42EP1-5.
Biochemical Society transactions44(6)1709-1716(2016 12)
Farrugia AJ,Calvo F

Borg proteins control septin organization and are negatively regulated by Cdc42.
Nature cell biology3(10)861-6(2001 Oct)
Joberty G,Perlungher RR,Sheffield PJ,Kinoshita M,Noda M,Haystead T,Macara IG

A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes.
The Journal of biological chemistry276(2)875-83(2001 Jan)
Hirsch DS,Pirone DM,Burbelo PD

The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
Molecular and cellular biology19(10)6585-97(1999 Oct)
Joberty G,Perlungher RR,Macara IG

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CDC42EP5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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