ERVV-1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ERVV-1
Entrez Gene ID	147664
Full Name	endogenous retrovirus group V member 1, envelope
Synonyms	ENVV1,HERV-V1
General protein information	Preferred Names endogenous retrovirus group V member 1, envelope Names endogenous retrovirus group V member 1 Env polyprotein HERV-V_19q13.41 provirus ancestral Env polyprotein 1 endogenous retrovirus group V, member 1 endogenous retrovirus group V, member 2 envelope glycoprotein ENVV1 envelope protein ENVV1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.41
Summary	Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. The gene's envelope protein is expressed in the human placenta but is truncated at its C-terminus. [provided by RefSeq, Oct 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_152473.2	NP_689686.2	endogenous retrovirus group V member 1 Env polyprotein precursor

Pathways from BioSystems

Homologies

	ERVV-1	XP_002801433.1
Homo sapiens (human)	ERVV-1	NP_689686.2
Pan troglodytes (chimpanzee)	ERVV-1	XP_003316669.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.
Esnault C, Cornelis G, Heidmann O, Heidmann T
PLoS genetics9(3)e1003400(2013 Mar)

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.
Strissel PL, Ruebner M, Thiel F, Wachter D, Ekici AB, Wolf F, Thieme F, Ruprecht K, Beckmann MW, Strick R
Oncotarget3(10)1204-19(2012 Oct)

A revised nomenclature for transcribed human endogenous retroviral loci.
Mayer J, Blomberg J, Seal RL
Mobile DNA2(1)7(2011 May)

Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.
Kjeldbjerg AL, Villesen P, Aagaard L, Pedersen FS
BMC evolutionary biology8266(2008 Sep)

Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome research14(7)1324-32(2004 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the Old World monkeys, we show that envV is both specifically expressed at the level of the placental syncytiotrophoblast and fusogenic.
Title: Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.

The following ERVV-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ERVV-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu32192	NM_152473.2 Latest version!	Homo sapiens endogenous retrovirus group V member 1, envelope (ERVV-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ERVV-1 ( NM_152473.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_689686.2 Homo sapiens endogenous retrovirus group V member 1, envelope (ERVV-1), mRNA.

Price & Availability↑

CloneID	OHu32192
Clone ID Related Accession (Same CDS sequence)	NM_152473.2
Accession Version	NM_152473.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	endogenous retrovirus group V member 1 Env polyprotein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010328.4. On Jul 17, 2010 this sequence version replaced NM_152473.1. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from transcript alignments. ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 23555306 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGACAGAGA AATTCCTTTT CCTTTATCTT TCCCTCCTTC CCATGCCCCT ACTCTCACAG 
GCACAGTGGA ATGAAAATTC CCTTGTCAGT TTTTCCAAAA TAATTGCTTC GGGAAACCAT 
CTAAGCAACT GTTGGATCTG CCACAACTTC ATCACCAGGT CCTCATCTTA CCAATATATT 
TTGGTAAGAA ATTTTTCTTT AAACCTAACA TTTGGTTCAG GAATCCCTGA AGGCCAACAT 
AAATCTGTTC CGCTCCAGGT TTCGCTTGCT AACTCAGCGC ACCAAGTCCC CTGCCTGGAT 
CTCACTCCAC CTTTCAATCA AAGCTCTAAA ACTTCTTTCT ATTTCTACAA CTGCTCTTCT 
CTAAACCAAA CCTGTTGTCC ATGCCCTGAA GGACACTGTG ACAGGAAGAA CACCTCTGAG 
GAGGGATTCC CCAGTCCCAC CATCCATCCC ATGAGCTTCT CCCCAGCAGG CTGCCACCCT 
AACTTGACTC ACTGGTGTCC AGCTAAACAA ATGAACGATT ATCGAGACAA GTCACCCCAA 
AACCGCTGTG CAGCTTGGGA AGGAAAAGAG CTAATCACAT GGAGGGTTCT ATATTTGCTT 
CCCAAGGCAC ACACTGTCCC CACATGGCCA AAATCTACTG TTCCCCTGGG AGGGCCTCTA 
TCCCCTGCAT GCAATCAAAC TATTCCAGCA GGGTGGAAAT CGCAGTTACA CAAGTGGTTC 
GACAGCCACA TCCCCCGGTG GGCCTGTACC CCTCCTGGCT ATGTATTTTT ATGTGGGCCA 
CAAAAAAATA AACTGCCCTT TGATGGAAGT CCTAAGATAA CTTATTCAAC CCCCCCTGTG 
GCAAACCTCT ACACTTGCAT TAATAACATC CAACATACGG GAGAATGTGC TGTGGGACTT 
TTGGGACCAC GGGGGATAGG TGTGACCATT TATAACACCA CCCAACCCAG ACAGAAAAGA 
GCTCTGGGTC TAATACTGGC AGGGATGGGT GCGGCCATAG GAATGATCGC CCCATGGGGA 
GGGTTCACTT ATCATGATGT CACCCTCAGA AATCTCTCCA GACAAATAGA CAACATAGCT 
AAGAGTACCA GAGATAGCAT CTCTAAACTC AAGGCCTCCA TAGATTCTCT AGCAAATGTA 
GTCATGAACA ACAGATTGGC CTTAGATTAC CTCTTAGCAG AGCAGGGTGG AGTCTGTGCA 
GTGATCAGTA AATCCTGTTG CATTTATGTC AATAACAGTG GGGCGATAGA GGAGGATATA 
AAAAAGATCT ATGATGAGGT TACGTGGCTC CATAACTTTG GAAAAGGTGA TTCAGCAGGG 
TCCATTTGGG AGGCTGTGAA GTCTGCCCTC CCCTCCCTCA CATGGTTTGT CCCTTTACTG 
GGACCAGCTG CACTTAATAG CCTGCTTTCT CCTCTTTGGC CCTTGTCTCT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689686.2
CDS	1..1434
Translation	MTEKFLFLYLSLLPMPLLSQAQWNENSLVSFSKIIASGNHLSNCWICHNFITRSSSYQYILVRNFSLNLTFGSGIPEGQHKSVPLQVSLANSAHQVPCLDLTPPFNQSSKTSFYFYNCSSLNQTCCPCPEGHCDRKNTSEEGFPSPTIHPMSFSPAGCHPNLTHWCPAKQMNDYRDKSPQNRCAAWEGKELITWRVLYLLPKAHTVPTWPKSTVPLGGPLSPACNQTIPAGWKSQLHKWFDSHIPRWACTPPGYVFLCGPQKNKLPFDGSPKITYSTPPVANLYTCINNIQHTGECAVGLLGPRGIGVTIYNTTQPRQKRALGLILAGMGAAIGMIAPWGGFTYHDVTLRNLSRQIDNIAKSTRDSISKLKASIDSLANVVMNNRLALDYLLAEQGGVCAVISKSCCIYVNNSGAIEEDIKKIYDEVTWLHNFGKGDSAGSIWEAVKSALPSLTWFVPLLGPAALNSLLSPLWPLSL

Target ORF information:

RefSeq Version	NM_152473.2
Organism	Homo sapiens(human)
Definition	Homo sapiens endogenous retrovirus group V member 1, envelope (ERVV-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152473.2

ORF Insert Sequence:

ATGACAGAGA AATTCCTTTT CCTTTATCTT TCCCTCCTTC CCATGCCCCT ACTCTCACAG 
GCACAGTGGA ATGAAAATTC CCTTGTCAGT TTTTCCAAAA TAATTGCTTC GGGAAACCAT 
CTAAGCAACT GTTGGATCTG CCACAACTTC ATCACCAGGT CCTCATCTTA CCAATATATT 
TTGGTAAGAA ATTTTTCTTT AAACCTAACA TTTGGTTCAG GAATCCCTGA AGGCCAACAT 
AAATCTGTTC CGCTCCAGGT TTCGCTTGCT AACTCAGCGC ACCAAGTCCC CTGCCTGGAT 
CTCACTCCAC CTTTCAATCA AAGCTCTAAA ACTTCTTTCT ATTTCTACAA CTGCTCTTCT 
CTAAACCAAA CCTGTTGTCC ATGCCCTGAA GGACACTGTG ACAGGAAGAA CACCTCTGAG 
GAGGGATTCC CCAGTCCCAC CATCCATCCC ATGAGCTTCT CCCCAGCAGG CTGCCACCCT 
AACTTGACTC ACTGGTGTCC AGCTAAACAA ATGAACGATT ATCGAGACAA GTCACCCCAA 
AACCGCTGTG CAGCTTGGGA AGGAAAAGAG CTAATCACAT GGAGGGTTCT ATATTTGCTT 
CCCAAGGCAC ACACTGTCCC CACATGGCCA AAATCTACTG TTCCCCTGGG AGGGCCTCTA 
TCCCCTGCAT GCAATCAAAC TATTCCAGCA GGGTGGAAAT CGCAGTTACA CAAGTGGTTC 
GACAGCCACA TCCCCCGGTG GGCCTGTACC CCTCCTGGCT ATGTATTTTT ATGTGGGCCA 
CAAAAAAATA AACTGCCCTT TGATGGAAGT CCTAAGATAA CTTATTCAAC CCCCCCTGTG 
GCAAACCTCT ACACTTGCAT TAATAACATC CAACATACGG GAGAATGTGC TGTGGGACTT 
TTGGGACCAC GGGGGATAGG TGTGACCATT TATAACACCA CCCAACCCAG ACAGAAAAGA 
GCTCTGGGTC TAATACTGGC AGGGATGGGT GCGGCCATAG GAATGATCGC CCCATGGGGA 
GGGTTCACTT ATCATGATGT CACCCTCAGA AATCTCTCCA GACAAATAGA CAACATAGCT 
AAGAGTACCA GAGATAGCAT CTCTAAACTC AAGGCCTCCA TAGATTCTCT AGCAAATGTA 
GTCATGAACA ACAGATTGGC CTTAGATTAC CTCTTAGCAG AGCAGGGTGG AGTCTGTGCA 
GTGATCAGTA AATCCTGTTG CATTTATGTC AATAACAGTG GGGCGATAGA GGAGGATATA 
AAAAAGATCT ATGATGAGGT TACGTGGCTC CATAACTTTG GAAAAGGTGA TTCAGCAGGG 
TCCATTTGGG AGGCTGTGAA GTCTGCCCTC CCCTCCCTCA CATGGTTTGT CCCTTTACTG 
GGACCAGCTG CACTTAATAG CCTGCTTTCT CCTCTTTGGC CCTTGTCTCT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.
PLoS genetics9(3)e1003400(2013 Mar)
Esnault C,Cornelis G,Heidmann O,Heidmann T

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.
Oncotarget3(10)1204-19(2012 Oct)
Strissel PL,Ruebner M,Thiel F,Wachter D,Ekici AB,Wolf F,Thieme F,Ruprecht K,Beckmann MW,Strick R

A revised nomenclature for transcribed human endogenous retroviral loci.
Mobile DNA2(1)7(2011 May)
Mayer J,Blomberg J,Seal RL

Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.
BMC evolutionary biology8266(2008 Sep)
Kjeldbjerg AL,Villesen P,Aagaard L,Pedersen FS

Functional proteomics mapping of a human signaling pathway.
Genome research14(7)1324-32(2004 Jul)
Colland F,Jacq X,Trouplin V,Mougin C,Groizeleau C,Hamburger A,Meil A,Wojcik J,Legrain P,Gauthier JM

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ERVV-1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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