OR2AG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OR2AG1
Entrez Gene ID	144125
Full Name	olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene)
Synonyms	OR11-79,OR2AG3
General protein information	Preferred Names olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene) Names olfactory receptor 2AG1 hT3 olfactory receptor olfactory receptor 2AG3 olfactory receptor OR11-79 olfactory receptor, family 2, subfamily AG, member 1 olfactory receptor, family 2, subfamily AG, member 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004489.2	NP_001004489.1	olfactory receptor 2AG1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC466417	XP_521816.1
Mus musculus (house mouse)	Olfr705	NP_667243.2
Homo sapiens (human)	OR2AG1	NP_001004489.1
	LOC711771	XP_001100626.2
Bos taurus (cattle)	LOC100125776	NP_001098519.1
Rattus norvegicus (Norway rat)	Olr217	NP_001000199.1

Gene Ontology
Bibliography

Related articles in PubMed

Personal receptor repertoires: olfaction as a model.
Olender T, Waszak SM, Viavant M, Khen M, Ben-Asher E, Reyes A, Nativ N, Wysocki CJ, Ge D, Lancet D
BMC genomics13414(2012 Aug)

Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1.
Dooley R, Baumgart S, Rasche S, Hatt H, Neuhaus EM
The FEBS journal276(24)7279-90(2009 Dec)

Beta-arrestin2-mediated internalization of mammalian odorant receptors.
Mashukova A, Spehr M, Hatt H, Neuhaus EM
The Journal of neuroscience : the official journal of the Society for Neuroscience26(39)9902-12(2006 Sep)

A probabilistic classifier for olfactory receptor pseudogenes.
Menashe I, Aloni R, Lancet D
BMC bioinformatics7393(2006 Aug)

A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins.
Neuhaus EM, Mashukova A, Zhang W, Barbour J, Hatt H
Chemical senses31(5)445-52(2006 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

OR2AG1 binds beta-arrestin2 with high affinity and is internalized via a clathrin-dependent mechanism.
Title: Beta-arrestin2-mediated internalization of mammalian odorant receptors.

The Hsc70t helps expression of OR2AG1 in heterologous cell systems and helped the characterization of an "orphan" human olfactory receptor.
Title: A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins.

The following OR2AG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OR2AG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu32275	NM_001004489.2 Latest version!	Homo sapiens olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene) (OR2AG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OR2AG1 ( NM_001004489.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001004489.1 Homo sapiens olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene) (OR2AG1), mRNA.

Price & Availability↑

CloneID	OHu32275
Clone ID Related Accession (Same CDS sequence)	NM_001004489.2
Accession Version	NM_001004489.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	olfactory receptor 2AG1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087280.11. On Jan 21, 2010 this sequence version replaced NM_001004489.1. Sequence Note: This gene is a segregating pseudogene. This RefSeq represents the protein encoded by the reference genome allele, which is predicted to be functional according to the Classifier for Olfactory Receptor Pseudogenes. This RefSeq was derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. ##Evidence-Data-START## Transcript is intronless :: BC151143.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 22908908 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGCTCT GGAACTTCAC CTTGGGAAGT GGCTTCATTT TGGTGGGGAT TCTGAATGAC 
AGTGGGTCTC CTGAACTGCT CTGTGCTACA ATTACAATCC TATACTTGTT GGCCCTGATC 
AGCAATGGCC TACTGCTCCT GGCTATCACC ATGGAAGCCC GGCTCCACAT GCCCATGTAC 
CTCCTGCTTG GGCAGCTCTC TCTCATGGAC CTCCTGTTCA CATCTGTTGT CACTCCCAAG 
GCCCTTGCGG ACTTTCTGCG CAGAGAAAAC ACCATCTCCT TTGGAGGCTG TGCCCTTCAG 
ATGTTCCTGG CACTGACAAT GGGTGGTGCT GAGGACCTCC TACTGGCCTT CATGGCCTAT 
GACAGGTATG TGGCCATTTG TCATCCTCTG ACATACATGA CCCTCATGAG CTCAAGAGCC 
TGCTGGCTCA TGGTGGCCAC GTCCTGGATC CTGGCATCCC TAAGTGCCCT AATATATACC 
GTGTATACCA TGCACTATCC CTTCTGCAGG GCCCAGGAGA TCAGGCATCT TCTCTGTGAG 
ATCCCACACT TGCTGAAGGT GGCCTGTGCT GATACCTCCA GATATGAGCT CATGGTATAT 
GTGATGGGTG TGACCTTCCT GATTCCCTCT CTTGCTGCTA TACTGGCCTC CTATACACAA 
ATTCTACTCA CTGTGCTCCA TATGCCATCA AATGAGGGGA GGAAGAAAGC CCTTGTCACC 
TGCTCTTCCC ACCTGACTGT GGTTGGGATG TTCTATGGAG CTGCCACATT CATGTATGTC 
TTGCCCAGTT CCTTCCACAG CACCAGACAA GACAACATCA TCTCTGTTTT CTACACAATT 
GTCACTCCAG CCCTGAATCC ACTCATCTAC AGCCTGAGGA ATAAGGAGGT CATGCGGGCC 
TTGAGGAGGG TCCTGGGAAA ATACATGCTG CCAGCACACT CCACGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004489.1
CDS	22..972
Translation	MELWNFTLGSGFILVGILNDSGSPELLCATITILYLLALISNGLLLLAITMEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGGAEDLLLAFMAYDRYVAICHPLTYMTLMSSRACWLMVATSWILASLSALIYTVYTMHYPFCRAQEIRHLLCEIPHLLKVACADTSRYELMVYVMGVTFLIPSLAAILASYTQILLTVLHMPSNEGRKKALVTCSSHLTVVGMFYGAATFMYVLPSSFHSTRQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVLGKYMLPAHSTL

Target ORF information:

RefSeq Version	NM_001004489.2
Organism	Homo sapiens(human)
Definition	Homo sapiens olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene) (OR2AG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004489.2

ORF Insert Sequence:

ATGGAGCTCT GGAACTTCAC CTTGGGAAGT GGCTTCATTT TGGTGGGGAT TCTGAATGAC 
AGTGGGTCTC CTGAACTGCT CTGTGCTACA ATTACAATCC TATACTTGTT GGCCCTGATC 
AGCAATGGCC TACTGCTCCT GGCTATCACC ATGGAAGCCC GGCTCCACAT GCCCATGTAC 
CTCCTGCTTG GGCAGCTCTC TCTCATGGAC CTCCTGTTCA CATCTGTTGT CACTCCCAAG 
GCCCTTGCGG ACTTTCTGCG CAGAGAAAAC ACCATCTCCT TTGGAGGCTG TGCCCTTCAG 
ATGTTCCTGG CACTGACAAT GGGTGGTGCT GAGGACCTCC TACTGGCCTT CATGGCCTAT 
GACAGGTATG TGGCCATTTG TCATCCTCTG ACATACATGA CCCTCATGAG CTCAAGAGCC 
TGCTGGCTCA TGGTGGCCAC GTCCTGGATC CTGGCATCCC TAAGTGCCCT AATATATACC 
GTGTATACCA TGCACTATCC CTTCTGCAGG GCCCAGGAGA TCAGGCATCT TCTCTGTGAG 
ATCCCACACT TGCTGAAGGT GGCCTGTGCT GATACCTCCA GATATGAGCT CATGGTATAT 
GTGATGGGTG TGACCTTCCT GATTCCCTCT CTTGCTGCTA TACTGGCCTC CTATACACAA 
ATTCTACTCA CTGTGCTCCA TATGCCATCA AATGAGGGGA GGAAGAAAGC CCTTGTCACC 
TGCTCTTCCC ACCTGACTGT GGTTGGGATG TTCTATGGAG CTGCCACATT CATGTATGTC 
TTGCCCAGTT CCTTCCACAG CACCAGACAA GACAACATCA TCTCTGTTTT CTACACAATT 
GTCACTCCAG CCCTGAATCC ACTCATCTAC AGCCTGAGGA ATAAGGAGGT CATGCGGGCC 
TTGAGGAGGG TCCTGGGAAA ATACATGCTG CCAGCACACT CCACGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Personal receptor repertoires: olfaction as a model.
BMC genomics13414(2012 Aug)
Olender T,Waszak SM,Viavant M,Khen M,Ben-Asher E,Reyes A,Nativ N,Wysocki CJ,Ge D,Lancet D

Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1.
The FEBS journal276(24)7279-90(2009 Dec)
Dooley R,Baumgart S,Rasche S,Hatt H,Neuhaus EM

Beta-arrestin2-mediated internalization of mammalian odorant receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience26(39)9902-12(2006 Sep)
Mashukova A,Spehr M,Hatt H,Neuhaus EM

A probabilistic classifier for olfactory receptor pseudogenes.
BMC bioinformatics7393(2006 Aug)
Menashe I,Aloni R,Lancet D

A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins.
Chemical senses31(5)445-52(2006 Jun)
Neuhaus EM,Mashukova A,Zhang W,Barbour J,Hatt H

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OR2AG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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