CST11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CST11
Entrez Gene ID	140880
Full Name	cystatin 11
Synonyms	CST8L,CTES2,SC13,dJ322G13.6
General protein information	Preferred Names cystatin 11 Names cystatin-11 SC13delta cystatin-related epididymal-specific protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p11.21
Summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014].
Disorder MIM:	609731

mRNA and Protein(s)

mRNA	Protein	Name
NM_130794.2	NP_570612.1	cystatin-11 isoform 1 precursor
NM_080830.3	NP_543020.2	cystatin-11 isoform 2 precursor
NM_080830.2	NP_543020.2	cystatin-11 isoform 2 precursor
NM_130794.1	NP_570612.1	cystatin-11 isoform 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CST11	XP_848363.2
Bos taurus (cattle)	CST11	NP_001179502.1
Rattus norvegicus (Norway rat)	Cst11	NP_620785.1
Mus musculus (house mouse)	Cst11	NP_084335.1
Homo sapiens (human)	CST11	NP_570612.1
Pan troglodytes (chimpanzee)	CST11	XP_525284.3
	CST11	NP_001033750.1

Gene Ontology
Bibliography

Related articles in PubMed

Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.
Frygelius J, Arvestad L, Wedell A, T?h?nen V
Evolution & development12(3)329-42(2010 May-Jun)

Cystatin 11: a new member of the cystatin type 2 family.
Hamil KG, Liu Q, Sivashanmugam P, Yenugu S, Soundararajan R, Grossman G, Richardson RT, Zhang YL, O'Rand MG, Petrusz P, French FS, Hall SH
Endocrinology143(7)2787-96(2002 Jul)

Friends and relations of the cystatin superfamily--new members and their evolution.
Brown WM, Dziegielewska KM
Protein science : a publication of the Protein Society6(1)5-12(1997 Jan)

Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2.
Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ
Genomics24(1)172-5(1994 Nov)

The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20.
Thiesse M, Millar SJ, Dickinson DP
DNA and cell biology13(2)97-116(1994 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CST11 is an antimicrobial peptide that has shown to be effective against E. coli.
Title: Cystatin 11: a new member of the cystatin type 2 family.

The following CST11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CST11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29244	NM_080830.3 Latest version!	Homo sapiens cystatin 11 (CST11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29349	NM_130794.2 Latest version!	Homo sapiens cystatin 11 (CST11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29244	NM_080830.2	Homo sapiens cystatin 11 (CST11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29349	NM_130794.1	Homo sapiens cystatin 11 (CST11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CST11 ( NM_080830.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_543020.2 Homo sapiens cystatin 11 (CST11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29244
Clone ID Related Accession (Same CDS sequence)	NM_080830.3 , NM_080830.2
Accession Version	NM_080830.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	cystatin-11 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL096677.21 and AF335481.1. On May 31, 2019 this sequence version replaced NM_080830.2. Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. The encoded isoform (2) is missing an internal segment, which results in a C-terminal truncation of the cystatin domain compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BX103081.1, AF335481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12072414 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGGCTG AGCCCTGGCA GGCCCTACAG CTCCTGTTGG CCATTCTATT GACTCTGATG 
GCCCTCCCCT ACCAAGCAAG GAAGAAAACC TTTCTAAGCG TCCATGAAGT GATGGCAGTA 
GAAAACTATG CGAAGGACAG CTTGCAGTGG ATCACCGACC AGTATAACAA GGAAAGTGAT 
GACAAGTACC ACTTCAGGAT CTTCCGAGTC CTTAAAGTCC AGAGGCAGCA AGTCAACTGC 
TTCTTCTCAG TGTTTGCTGT ACCCTGGTTT GAACAGTACA AAATTTTGAA CAAAAGCTGC 
AGCAGTGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543020.2
CDS	66..377
Translation	MMAEPWQALQLLLAILLTLMALPYQARKKTFLSVHEVMAVENYAKDSLQWITDQYNKESDDKYHFRIFRVLKVQRQQVNCFFSVFAVPWFEQYKILNKSCSSD

Target ORF information:

RefSeq Version	NM_080830.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin 11 (CST11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080830.3

ORF Insert Sequence:

ATGATGGCTG AGCCCTGGCA GGCCCTACAG CTCCTGTTGG CCATTCTATT GACTCTGATG 
GCCCTCCCCT ACCAAGCAAG GAAGAAAACC TTTCTAAGCG TCCATGAAGT GATGGCAGTA 
GAAAACTATG CGAAGGACAG CTTGCAGTGG ATCACCGACC AGTATAACAA GGAAAGTGAT 
GACAAGTACC ACTTCAGGAT CTTCCGAGTC CTTAAAGTCC AGAGGCAGCA AGTCAACTGC 
TTCTTCTCAG TGTTTGCTGT ACCCTGGTTT GAACAGTACA AAATTTTGAA CAAAAGCTGC 
AGCAGTGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CST11 ( NM_080830.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_543020.2 Homo sapiens cystatin 11 (CST11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29244
Clone ID Related Accession (Same CDS sequence)	NM_080830.3 , NM_080830.2
Accession Version	NM_080830.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-08
Organism	Homo sapiens(human)
Product	cystatin-11 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF335481.1. On Feb 11, 2002 this sequence version replaced NM_080830.1. Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. The encoded isoform (2) is missing an internal segment, which results in a C-terminal truncation of the cystatin domain compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AF335481.1, BX103081.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12072414 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGGCTG AGCCCTGGCA GGCCCTACAG CTCCTGTTGG CCATTCTATT GACTCTGATG 
GCCCTCCCCT ACCAAGCAAG GAAGAAAACC TTTCTAAGCG TCCATGAAGT GATGGCAGTA 
GAAAACTATG CGAAGGACAG CTTGCAGTGG ATCACCGACC AGTATAACAA GGAAAGTGAT 
GACAAGTACC ACTTCAGGAT CTTCCGAGTC CTTAAAGTCC AGAGGCAGCA AGTCAACTGC 
TTCTTCTCAG TGTTTGCTGT ACCCTGGTTT GAACAGTACA AAATTTTGAA CAAAAGCTGC 
AGCAGTGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543020.2
CDS	35..346
Translation	MMAEPWQALQLLLAILLTLMALPYQARKKTFLSVHEVMAVENYAKDSLQWITDQYNKESDDKYHFRIFRVLKVQRQQVNCFFSVFAVPWFEQYKILNKSCSSD

Target ORF information:

RefSeq Version	NM_080830.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin 11 (CST11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080830.2

ORF Insert Sequence:

ATGATGGCTG AGCCCTGGCA GGCCCTACAG CTCCTGTTGG CCATTCTATT GACTCTGATG 
GCCCTCCCCT ACCAAGCAAG GAAGAAAACC TTTCTAAGCG TCCATGAAGT GATGGCAGTA 
GAAAACTATG CGAAGGACAG CTTGCAGTGG ATCACCGACC AGTATAACAA GGAAAGTGAT 
GACAAGTACC ACTTCAGGAT CTTCCGAGTC CTTAAAGTCC AGAGGCAGCA AGTCAACTGC 
TTCTTCTCAG TGTTTGCTGT ACCCTGGTTT GAACAGTACA AAATTTTGAA CAAAAGCTGC 
AGCAGTGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CST11 ( NM_130794.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_570612.1 Homo sapiens cystatin 11 (CST11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29349
Clone ID Related Accession (Same CDS sequence)	NM_130794.2 , NM_130794.1
Accession Version	NM_130794.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	cystatin-11 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL096677.21 and AF335480.1. On Nov 22, 2018 this sequence version replaced NM_130794.1. Transcript Variant: This variant (1) is the longest transcript, encoding the full-length isoform (1). ##Evidence-Data-START## Transcript exon combination :: AF335480.1, BC121080.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142853, SAMEA2148874 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000377009.8/ ENSP00000366208.3 Protein has antimicrobial activity :: PMID: 12072414 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGGCTG AGCCCTGGCA GGCCCTACAG CTCCTGTTGG CCATTCTATT GACTCTGATG 
GCCCTCCCCT ACCAAGCAAG GAAGAAAACC TTTCTAAGCG TCCATGAAGT GATGGCAGTA 
GAAAACTATG CGAAGGACAG CTTGCAGTGG ATCACCGACC AGTATAACAA GGAAAGTGAT 
GACAAGTACC ACTTCAGGAT CTTCCGAGTC CTTAAAGTCC AGAGGCAGGT CACTGACCAC 
CTGGAGTATC ACCTGAATGT GGAAATGCAG TGGACCACCT GCCAAAAGCC AGAGACCACG 
AACTGTGTCC CCCAGGAAAG GGAGCTTCAC AAGCAAGTCA ACTGCTTCTT CTCAGTGTTT 
GCTGTACCCT GGTTTGAACA GTACAAAATT TTGAACAAAA GCTGCAGCAG TGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570612.1
CDS	66..482
Translation	MMAEPWQALQLLLAILLTLMALPYQARKKTFLSVHEVMAVENYAKDSLQWITDQYNKESDDKYHFRIFRVLKVQRQVTDHLEYHLNVEMQWTTCQKPETTNCVPQERELHKQVNCFFSVFAVPWFEQYKILNKSCSSD

Target ORF information:

RefSeq Version	NM_130794.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin 11 (CST11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130794.2

ORF Insert Sequence:

ATGATGGCTG AGCCCTGGCA GGCCCTACAG CTCCTGTTGG CCATTCTATT GACTCTGATG 
GCCCTCCCCT ACCAAGCAAG GAAGAAAACC TTTCTAAGCG TCCATGAAGT GATGGCAGTA 
GAAAACTATG CGAAGGACAG CTTGCAGTGG ATCACCGACC AGTATAACAA GGAAAGTGAT 
GACAAGTACC ACTTCAGGAT CTTCCGAGTC CTTAAAGTCC AGAGGCAGGT CACTGACCAC 
CTGGAGTATC ACCTGAATGT GGAAATGCAG TGGACCACCT GCCAAAAGCC AGAGACCACG 
AACTGTGTCC CCCAGGAAAG GGAGCTTCAC AAGCAAGTCA ACTGCTTCTT CTCAGTGTTT 
GCTGTACCCT GGTTTGAACA GTACAAAATT TTGAACAAAA GCTGCAGCAG TGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CST11 ( NM_130794.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_570612.1 Homo sapiens cystatin 11 (CST11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29349
Clone ID Related Accession (Same CDS sequence)	NM_130794.2 , NM_130794.1
Accession Version	NM_130794.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-24
Organism	Homo sapiens(human)
Product	cystatin-11 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF335480.1. Transcript Variant: This variant (1) is the longest transcript, encoding the full-length isoform (1). ##Evidence-Data-START## Transcript exon combination :: AF335480.1, BC121080.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142853, SAMEA2148874 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12072414 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGGCTG AGCCCTGGCA GGCCCTACAG CTCCTGTTGG CCATTCTATT GACTCTGATG 
GCCCTCCCCT ACCAAGCAAG GAAGAAAACC TTTCTAAGCG TCCATGAAGT GATGGCAGTA 
GAAAACTATG CGAAGGACAG CTTGCAGTGG ATCACCGACC AGTATAACAA GGAAAGTGAT 
GACAAGTACC ACTTCAGGAT CTTCCGAGTC CTTAAAGTCC AGAGGCAGGT CACTGACCAC 
CTGGAGTATC ACCTGAATGT GGAAATGCAG TGGACCACCT GCCAAAAGCC AGAGACCACG 
AACTGTGTCC CCCAGGAAAG GGAGCTTCAC AAGCAAGTCA ACTGCTTCTT CTCAGTGTTT 
GCTGTACCCT GGTTTGAACA GTACAAAATT TTGAACAAAA GCTGCAGCAG TGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570612.1
CDS	35..451
Translation	MMAEPWQALQLLLAILLTLMALPYQARKKTFLSVHEVMAVENYAKDSLQWITDQYNKESDDKYHFRIFRVLKVQRQVTDHLEYHLNVEMQWTTCQKPETTNCVPQERELHKQVNCFFSVFAVPWFEQYKILNKSCSSD

Target ORF information:

RefSeq Version	NM_130794.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin 11 (CST11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130794.1

ORF Insert Sequence:

ATGATGGCTG AGCCCTGGCA GGCCCTACAG CTCCTGTTGG CCATTCTATT GACTCTGATG 
GCCCTCCCCT ACCAAGCAAG GAAGAAAACC TTTCTAAGCG TCCATGAAGT GATGGCAGTA 
GAAAACTATG CGAAGGACAG CTTGCAGTGG ATCACCGACC AGTATAACAA GGAAAGTGAT 
GACAAGTACC ACTTCAGGAT CTTCCGAGTC CTTAAAGTCC AGAGGCAGGT CACTGACCAC 
CTGGAGTATC ACCTGAATGT GGAAATGCAG TGGACCACCT GCCAAAAGCC AGAGACCACG 
AACTGTGTCC CCCAGGAAAG GGAGCTTCAC AAGCAAGTCA ACTGCTTCTT CTCAGTGTTT 
GCTGTACCCT GGTTTGAACA GTACAAAATT TTGAACAAAA GCTGCAGCAG TGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.
Evolution & development12(3)329-42(2010 May-Jun)
Frygelius J,Arvestad L,Wedell A,T?h?nen V

Cystatin 11: a new member of the cystatin type 2 family.
Endocrinology143(7)2787-96(2002 Jul)
Hamil KG,Liu Q,Sivashanmugam P,Yenugu S,Soundararajan R,Grossman G,Richardson RT,Zhang YL,O'Rand MG,Petrusz P,French FS,Hall SH

Friends and relations of the cystatin superfamily--new members and their evolution.
Protein science : a publication of the Protein Society6(1)5-12(1997 Jan)
Brown WM,Dziegielewska KM

Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2.
Genomics24(1)172-5(1994 Nov)
Dickinson DP,Zhao Y,Thiesse M,Siciliano MJ

The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20.
DNA and cell biology13(2)97-116(1994 Feb)
Thiesse M,Millar SJ,Dickinson DP

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CST11 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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