Gene Symbol | POU6F2 |
Entrez Gene ID | 11281 |
Full Name | POU class 6 homeobox 2 |
Synonyms | RPF-1,WT5,WTSL |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]. |
Disorder MIM: | |
Disorder Html: | {Wilms tumor susceptibility-5}, 601583 (3) |