PRR4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRR4
Entrez Gene ID	11272
Full Name	proline rich 4 (lacrimal)
Synonyms	LPRP,PROL4
General protein information	Preferred Names proline rich 4 (lacrimal) Names proline-rich protein 4 lacrimal proline-rich protein nasopharyngeal carcinoma-associated proline-rich protein 4 proline-rich polypeptide 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011].
Disorder MIM:	605359

mRNA and Protein(s)

mRNA	Protein	Name
NM_007244.3	NP_009175.2	proline-rich protein 4 isoform 2 precursor
NM_001098538.3	NP_001092008.2	proline-rich protein 4 isoform 1 precursor
NM_007244.2	NP_009175.2	proline-rich protein 4 isoform 2 precursor
NM_001098538.2	NP_001092008.2	proline-rich protein 4 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PRR4	XP_001150806.2
Homo sapiens (human)	PRR4	NP_009175.2
	LOC717988	XP_001115500.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4).
Perumal N, Funke S, Wolters D, Pfeiffer N, Grus FH
Proteomics15(19)3370-81(2015 Oct)

Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome.
Perumal N, Funke S, Pfeiffer N, Grus FH
Proteomics14(13-14)1698-709(2014 Jul)

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Pieragostino D, Agnifili L, Fasanella V, D'Aguanno S, Mastropasqua R, Di Ilio C, Sacchetta P, Urbani A, Del Boccio P
Molecular bioSystems9(6)1108-16(2013 Jun)

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
B?hm D, Keller K, Pieter J, Boehm N, Wolters D, Siggelkow W, Lebrecht A, Schmidt M, K?lbl H, Pfeiffer N, Grus FH
Oncology reports28(2)429-38(2012 Aug)

Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
Aluru SV, Agarwal S, Srinivasan B, Iyer GK, Rajappa SM, Tatu U, Padmanabhan P, Subramanian N, Narayanasamy A
PloS one7(12)e51979(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High expression of lacrimal proline-rich protein 4 (PRR4) was found in reflex tears.
Title: Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4).

A new PRR4 isoform designated as PRR4-N3 in addition to PRR4 (gi154448886) and pHL E1F1 (gi1050983) was identified in human tear proteome.
Title: Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome.

Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
Title: Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following PRR4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRR4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15631	NM_007244.3 Latest version!	Homo sapiens proline rich 4 (PRR4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15616	NM_001098538.3 Latest version!	Homo sapiens proline rich 4 (PRR4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu15631	NM_007244.2	Homo sapiens proline rich 4 (lacrimal) (PRR4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15616	NM_001098538.2	Homo sapiens proline rich 4 (PRR4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRR4 ( NM_007244.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009175.2 Homo sapiens proline rich 4 (PRR4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15631
Clone ID Related Accession (Same CDS sequence)	NM_007244.3 , NM_007244.2
Accession Version	NM_007244.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	proline-rich protein 4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB229285.1 and AF530472.1. On Nov 23, 2018 this sequence version replaced NM_007244.2. Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2). ##Evidence-Data-START## Transcript exon combination :: BP343443.1, BP343614.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000228811.8/ ENSP00000228811.4 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCTGG TCCTGCTCTC AGTGGTCCTT CTGGCTCTGA GCTCAGCTCA GAGCACAGAT 
AATGATGTGA ACTATGAAGA CTTTACTTTC ACCATACCAG ATGTAGAGGA CTCAAGTCAG 
AGACCAGATC AGGGACCCCA GAGACCTCCT CCTGAAGGAC TCCTACCTAG ACCCCCTGGT 
GATAGTGGTA ACCAAGATGA TGGTCCTCAG CAGAGACCAC CAAAACCAGG AGGCCATCAC 
CGCCATCCTC CCCCACCTCC TTTTCAAAAT CAGCAACGAC CACCCCGACG AGGACACCGT 
CAACTCTCTC TACCCCGATT TCCTTCTGTC AGCCTGCAGG AAGCATCATC ATTCTTCCAG 
AGGGACAGAC CAGCAAGACA TCCCCAGGAG CAACCACTCT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009175.2
CDS	39..443
Translation	MLLVLLSVVLLALSSAQSTDNDVNYEDFTFTIPDVEDSSQRPDQGPQRPPPEGLLPRPPGDSGNQDDGPQQRPPKPGGHHRHPPPPPFQNQQRPPRRGHRQLSLPRFPSVSLQEASSFFQRDRPARHPQEQPLW

Target ORF information:

RefSeq Version	NM_007244.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich 4 (PRR4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007244.3

ORF Insert Sequence:

ATGCTGCTGG TCCTGCTCTC AGTGGTCCTT CTGGCTCTGA GCTCAGCTCA GAGCACAGAT 
AATGATGTGA ACTATGAAGA CTTTACTTTC ACCATACCAG ATGTAGAGGA CTCAAGTCAG 
AGACCAGATC AGGGACCCCA GAGACCTCCT CCTGAAGGAC TCCTACCTAG ACCCCCTGGT 
GATAGTGGTA ACCAAGATGA TGGTCCTCAG CAGAGACCAC CAAAACCAGG AGGCCATCAC 
CGCCATCCTC CCCCACCTCC TTTTCAAAAT CAGCAACGAC CACCCCGACG AGGACACCGT 
CAACTCTCTC TACCCCGATT TCCTTCTGTC AGCCTGCAGG AAGCATCATC ATTCTTCCAG 
AGGGACAGAC CAGCAAGACA TCCCCAGGAG CAACCACTCT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRR4 ( NM_007244.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_009175.2 Homo sapiens proline rich 4 (lacrimal) (PRR4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15631
Clone ID Related Accession (Same CDS sequence)	NM_007244.3 , NM_007244.2
Accession Version	NM_007244.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	proline-rich protein 4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB229285.1 and AF530472.1. On Aug 2, 2007 this sequence version replaced NM_007244.1. Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2). ##Evidence-Data-START## Transcript exon combination :: DB201880.1, BX502454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGG TCCTGCTCTC AGTGGTCCTT CTGGCTCTGA GCTCAGCTCA GAGCACAGAT 
AATGATGTGA ACTATGAAGA CTTTACTTTC ACCATACCAG ATGTAGAGGA CTCAAGTCAG 
AGACCAGATC AGGGACCCCA GAGACCTCCT CCTGAAGGAC TCCTACCTAG ACCCCCTGGT 
GATAGTGGTA ACCAAGATGA TGGTCCTCAG CAGAGACCAC CAAAACCAGG AGGCCATCAC 
CGCCATCCTC CCCCACCTCC TTTTCAAAAT CAGCAACGAC CACCCCGACG AGGACACCGT 
CAACTCTCTC TACCCCGATT TCCTTCTGTC AGCCTGCAGG AAGCATCATC ATTCTTCCAG 
AGGGACAGAC CAGCAAGACA TCCCCAGGAG CAACCACTCT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009175.2
CDS	40..444
Translation	MLLVLLSVVLLALSSAQSTDNDVNYEDFTFTIPDVEDSSQRPDQGPQRPPPEGLLPRPPGDSGNQDDGPQQRPPKPGGHHRHPPPPPFQNQQRPPRRGHRQLSLPRFPSVSLQEASSFFQRDRPARHPQEQPLW

Target ORF information:

RefSeq Version	NM_007244.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich 4 (lacrimal) (PRR4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007244.2

ORF Insert Sequence:

ATGCTGCTGG TCCTGCTCTC AGTGGTCCTT CTGGCTCTGA GCTCAGCTCA GAGCACAGAT 
AATGATGTGA ACTATGAAGA CTTTACTTTC ACCATACCAG ATGTAGAGGA CTCAAGTCAG 
AGACCAGATC AGGGACCCCA GAGACCTCCT CCTGAAGGAC TCCTACCTAG ACCCCCTGGT 
GATAGTGGTA ACCAAGATGA TGGTCCTCAG CAGAGACCAC CAAAACCAGG AGGCCATCAC 
CGCCATCCTC CCCCACCTCC TTTTCAAAAT CAGCAACGAC CACCCCGACG AGGACACCGT 
CAACTCTCTC TACCCCGATT TCCTTCTGTC AGCCTGCAGG AAGCATCATC ATTCTTCCAG 
AGGGACAGAC CAGCAAGACA TCCCCAGGAG CAACCACTCT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRR4 ( NM_001098538.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001092008.2 Homo sapiens proline rich 4 (PRR4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15616
Clone ID Related Accession (Same CDS sequence)	NM_001098538.3 , NM_001098538.2
Accession Version	NM_001098538.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	proline-rich protein 4 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292934.1, BX537839.1 and AF530472.1. On May 31, 2019 this sequence version replaced NM_001098538.2. Transcript Variant: This variant (1) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 2. The resulting isoform (1) has a distinct and shorter C-terminus, compared to isoform 2. ##Evidence-Data-START## Transcript exon combination :: DB198298.1, BX500395.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGG TCCTGCTCTC AGTGGTCCTT CTGGCTCTGA GCTCAGCTCA GAGCACAGAT 
AATGATGTGA ACTATGAAGA CTTTACTTTC ACCATACCAG CCTGCAGGAA GCATCATCAT 
TCTTCCAGAG GGACAGACCA GCAAGACATC CCCAGGAGCA ACCACTCTGG TAATCTAGAA 
TTCAGTGGCA GAAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001092008.2
CDS	39..236
Translation	MLLVLLSVVLLALSSAQSTDNDVNYEDFTFTIPACRKHHHSSRGTDQQDIPRSNHSGNLEFSGRK

Target ORF information:

RefSeq Version	NM_001098538.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich 4 (PRR4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098538.3

ORF Insert Sequence:

ATGCTGCTGG TCCTGCTCTC AGTGGTCCTT CTGGCTCTGA GCTCAGCTCA GAGCACAGAT 
AATGATGTGA ACTATGAAGA CTTTACTTTC ACCATACCAG CCTGCAGGAA GCATCATCAT 
TCTTCCAGAG GGACAGACCA GCAAGACATC CCCAGGAGCA ACCACTCTGG TAATCTAGAA 
TTCAGTGGCA GAAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRR4 ( NM_001098538.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001092008.2 Homo sapiens proline rich 4 (PRR4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15616
Clone ID Related Accession (Same CDS sequence)	NM_001098538.3 , NM_001098538.2
Accession Version	NM_001098538.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	proline-rich protein 4 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292934.1, BX537839.1 and AF530472.1. On Mar 1, 2011 this sequence version replaced NM_001098538.1. Transcript Variant: This variant (1) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 2. The resulting isoform (1) has a distinct and shorter C-terminus, compared to isoform 2. ##Evidence-Data-START## Transcript exon combination :: DB198298.1, CB986400.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2150585 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGG TCCTGCTCTC AGTGGTCCTT CTGGCTCTGA GCTCAGCTCA GAGCACAGAT 
AATGATGTGA ACTATGAAGA CTTTACTTTC ACCATACCAG CCTGCAGGAA GCATCATCAT 
TCTTCCAGAG GGACAGACCA GCAAGACATC CCCAGGAGCA ACCACTCTGG TAATCTAGAA 
TTCAGTGGCA GAAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001092008.2
CDS	40..237
Translation	MLLVLLSVVLLALSSAQSTDNDVNYEDFTFTIPACRKHHHSSRGTDQQDIPRSNHSGNLEFSGRK

Target ORF information:

RefSeq Version	NM_001098538.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich 4 (PRR4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098538.2

ORF Insert Sequence:

ATGCTGCTGG TCCTGCTCTC AGTGGTCCTT CTGGCTCTGA GCTCAGCTCA GAGCACAGAT 
AATGATGTGA ACTATGAAGA CTTTACTTTC ACCATACCAG CCTGCAGGAA GCATCATCAT 
TCTTCCAGAG GGACAGACCA GCAAGACATC CCCAGGAGCA ACCACTCTGG TAATCTAGAA 
TTCAGTGGCA GAAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4).
Proteomics15(19)3370-81(2015 Oct)
Perumal N,Funke S,Wolters D,Pfeiffer N,Grus FH

Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome.
Proteomics14(13-14)1698-709(2014 Jul)
Perumal N,Funke S,Pfeiffer N,Grus FH

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Molecular bioSystems9(6)1108-16(2013 Jun)
Pieragostino D,Agnifili L,Fasanella V,D'Aguanno S,Mastropasqua R,Di Ilio C,Sacchetta P,Urbani A,Del Boccio P

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Oncology reports28(2)429-38(2012 Aug)
B?hm D,Keller K,Pieter J,Boehm N,Wolters D,Siggelkow W,Lebrecht A,Schmidt M,K?lbl H,Pfeiffer N,Grus FH

Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
PloS one7(12)e51979(2012)
Aluru SV,Agarwal S,Srinivasan B,Iyer GK,Rajappa SM,Tatu U,Padmanabhan P,Subramanian N,Narayanasamy A

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PRR4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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