BIRC8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BIRC8
Entrez Gene ID	112401
Full Name	baculoviral IAP repeat containing 8
Synonyms	ILP-2,ILP2,RNF136,hILP2
General protein information	Preferred Names baculoviral IAP repeat containing 8 Names baculoviral IAP repeat-containing protein 8 IAP-like protein 2 inhibitor of apoptosis-like protein 2 testis-specific inhibitor of apoptosis
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.42

mRNA and Protein(s)

mRNA	Protein	Name
NM_033341.4	NP_203127.3	baculoviral IAP repeat-containing protein 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	BIRC8	NP_203127.3
Pan troglodytes (chimpanzee)	BIRC8	NP_001009036.1

Gene Ontology
Bibliography

Related articles in PubMed

Fumonisin B? inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2.
Chuturgoon AA, Phulukdaree A, Moodley D
Toxicology letters235(2)67-74(2015 Jun)

Differential expression of BIRC family genes in chronic myeloid leukaemia--BIRC3 and BIRC8 as potential new candidates to identify disease progression.
Glodkowska-Mrowka E, Solarska I, Mrowka P, Bajorek K, Niesiobedzka-Krezel J, Seferynska I, Borg K, Stoklosa T
British journal of haematology164(5)740-2(2014 Mar)

Inhibitor of apoptosis protein-like protein-2 as a novel serological biomarker for breast cancer.
Xiang M, Zhou W, Gao D, Fang X, Liu Q
International journal of molecular sciences13(12)16737-50(2012 Dec)

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanch? H, Schreiber S, Nebel A
Mutation research694(1-2)13-9(2010 Dec)

The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.
Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS
The Biochemical journal385(Pt 1)1-10(2005 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fumonisin B1 caused dose-dependent increase in BIRC-8/ILP-2 mRNA and protein expression in HepG2 cells to inhibit apoptosis.
Title: Fumonisin B? inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2.

increased expression with progression of chronic myeloid leukaemia
Title: Differential expression of BIRC family genes in chronic myeloid leukaemia--BIRC3 and BIRC8 as potential new candidates to identify disease progression.

results indicate that ILP-2 is a novel breast cancer biomarker in the peripheral blood.
Title: Inhibitor of apoptosis protein-like protein-2 as a novel serological biomarker for breast cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

ILP2 is an unstable protein, and cannot inhibit caspase 9 in a physiological way on its own; possibly ILP2 requires assistance from unidentified cellular factors to be an effective inhibitor of apoptosis in vivo
Title: The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.

The following BIRC8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BIRC8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu55732	NM_033341.4 Latest version!	Homo sapiens baculoviral IAP repeat containing 8 (BIRC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BIRC8 ( NM_033341.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_203127.3 Homo sapiens baculoviral IAP repeat containing 8 (BIRC8), mRNA.

Price & Availability↑

CloneID	OHu55732
Clone ID Related Accession (Same CDS sequence)	NM_033341.4
Accession Version	NM_033341.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-16
Organism	Homo sapiens(human)
Product	baculoviral IAP repeat-containing protein 8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF420440.1, DB052483.1, BC056914.1 and BC039318.1. On Jan 22, 2011 this sequence version replaced NM_033341.3. ##Evidence-Data-START## Transcript is intronless :: AF420440.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGGGTT ATGAAGCCCG GCTCATTACT TTTGGGACAT GGATGTACTC CGTTAACAAA 
GAGCAGCTTG CAAGAGCTGG ATTTTATGCT ATAGGTCAAG AGGATAAAGT ACAGTGCTTT 
CACTGTGGAG GAGGGCTAGC CAACTGGAAG CCCAAGGAAG ATCCTTGGGA ACAGCATGCT 
AAATGGTATC CAGGTTGCAA ATATCTGCTA GAAGAGAAGG GACATGAATA TATAAACAAC 
ATTCATTTAA CCCGTTCACT TGAGGGAGCT CTGGTACAAA CTACCAAGAA AACACCATCA 
CTAACTAAAA GAATCAGTGA TACCATCTTC CCTAATCCTA TGCTACAAGA AGCTATACGA 
ATGGGATTTG ATTTCAAGGA CGTTAAGAAA ATAATGGAGG AAAGAATTCA AACATCTGGG 
AGCAACTATA AAACGCTTGA GGTTCTTGTT GCAGATCTAG TGAGCGCTCA GAAAGACACT 
ACAGAAAATG AATTGAATCA GACTTCATTG CAGAGAGAAA TCAGCCCTGA AGAGCCGCTA 
AGGCGTCTGC AAGAGGAGAA GCTTTGTAAA ATCTGCATGG ACAGACATAT CGCTGTTGTT 
TTTATTCCTT GTGGACATCT GGTCACTTGT AAACAATGTG CTGAAGCAGT TGACAGATGT 
CCCATGTGCA GCGCGGTTAT TGATTTCAAG CAAAGAGTTT TTATGTCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203127.3
CDS	1249..1959
Translation	MTGYEARLITFGTWMYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIRMGFDFKDVKKIMEERIQTSGSNYKTLEVLVADLVSAQKDTTENELNQTSLQREISPEEPLRRLQEEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCSAVIDFKQRVFMS

Target ORF information:

RefSeq Version	NM_033341.4
Organism	Homo sapiens(human)
Definition	Homo sapiens baculoviral IAP repeat containing 8 (BIRC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033341.4

ORF Insert Sequence:

ATGACGGGTT ATGAAGCCCG GCTCATTACT TTTGGGACAT GGATGTACTC CGTTAACAAA 
GAGCAGCTTG CAAGAGCTGG ATTTTATGCT ATAGGTCAAG AGGATAAAGT ACAGTGCTTT 
CACTGTGGAG GAGGGCTAGC CAACTGGAAG CCCAAGGAAG ATCCTTGGGA ACAGCATGCT 
AAATGGTATC CAGGTTGCAA ATATCTGCTA GAAGAGAAGG GACATGAATA TATAAACAAC 
ATTCATTTAA CCCGTTCACT TGAGGGAGCT CTGGTACAAA CTACCAAGAA AACACCATCA 
CTAACTAAAA GAATCAGTGA TACCATCTTC CCTAATCCTA TGCTACAAGA AGCTATACGA 
ATGGGATTTG ATTTCAAGGA CGTTAAGAAA ATAATGGAGG AAAGAATTCA AACATCTGGG 
AGCAACTATA AAACGCTTGA GGTTCTTGTT GCAGATCTAG TGAGCGCTCA GAAAGACACT 
ACAGAAAATG AATTGAATCA GACTTCATTG CAGAGAGAAA TCAGCCCTGA AGAGCCGCTA 
AGGCGTCTGC AAGAGGAGAA GCTTTGTAAA ATCTGCATGG ACAGACATAT CGCTGTTGTT 
TTTATTCCTT GTGGACATCT GGTCACTTGT AAACAATGTG CTGAAGCAGT TGACAGATGT 
CCCATGTGCA GCGCGGTTAT TGATTTCAAG CAAAGAGTTT TTATGTCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fumonisin B? inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2.
Toxicology letters235(2)67-74(2015 Jun)
Chuturgoon AA,Phulukdaree A,Moodley D

Differential expression of BIRC family genes in chronic myeloid leukaemia--BIRC3 and BIRC8 as potential new candidates to identify disease progression.
British journal of haematology164(5)740-2(2014 Mar)
Glodkowska-Mrowka E,Solarska I,Mrowka P,Bajorek K,Niesiobedzka-Krezel J,Seferynska I,Borg K,Stoklosa T

Inhibitor of apoptosis protein-like protein-2 as a novel serological biomarker for breast cancer.
International journal of molecular sciences13(12)16737-50(2012 Dec)
Xiang M,Zhou W,Gao D,Fang X,Liu Q

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Mutation research694(1-2)13-9(2010 Dec)
Flachsbart F,Franke A,Kleindorp R,Caliebe A,Blanch? H,Schreiber S,Nebel A

The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.
The Biochemical journal385(Pt 1)1-10(2005 Jan)
Shin H,Renatus M,Eckelman BP,Nunes VA,Sampaio CA,Salvesen GS

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BIRC8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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