SLC35A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC35A1
Entrez Gene ID	10559
Full Name	solute carrier family 35 member A1
Synonyms	CDG2F,CMPST,CST,hCST
General protein information	Preferred Names solute carrier family 35 member A1 Names CMP-sialic acid transporter CMP-SA-Tr CMP-Sia-Tr mutated CMP-sialic acid transporter A1 solute carrier family 35 (CMP-sialic acid transporter), member 1 solute carrier family 35 (CMP-sialic acid transporter), member A1 solute carrier family 35 (UDP-galactose transporter), member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q15
Summary	The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009].
Disorder MIM:	605634
Disorder Html:	Congenital disorder of glycosylation, type IIf, 603585 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006416.4	NP_006407.1	CMP-sialic acid transporter isoform a
NM_001168398.1	NP_001161870.1	CMP-sialic acid transporter isoform b
NM_006416.5	NP_006407.1	CMP-sialic acid transporter isoform a

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC35A1	NP_001003058.1
Gallus gallus (chicken)	SLC35A1	NP_989844.1
Bos taurus (cattle)	SLC35A1	NP_001029809.1
Pan troglodytes (chimpanzee)	SLC35A1	XP_001154966.1
Mus musculus (house mouse)	Slc35a1	NP_036025.2
Danio rerio (zebrafish)	slc35a1	NP_001122283.1
Caenorhabditis elegans (roundworm)	ugtp-1	NP_498930.1
	SLC35A1	XP_001092348.1
Rattus norvegicus (Norway rat)	Slc35a1	NP_001101394.1
Homo sapiens (human)	SLC35A1	NP_006407.1

Gene Ontology
Bibliography

Related articles in PubMed

Encephalopathy caused by novel mutations in the CMP-sialic acid transporter, SLC35A1.
Ng BG, Asteggiano CG, Kircher M, Buckingham KJ, Raymond K, Nickerson DA, Shendure J, Bamshad MJ, , Ensslen M, Freeze HH
American journal of medical genetics. Part A173(11)2906-2911(2017 Nov)

A functional splice variant of the human Golgi CMP-sialic acid transporter.
Salinas-Mar?n R, Mollicone R, Mart?nez-Duncker I
Glycoconjugate journal33(6)897-906(2016 Dec)

Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal ?-dystroglycan O-mannosylation, independent from sialic acid.
Riemersma M, Sandrock J, Boltje TJ, B?ll C, Heise T, Ashikov A, Adema GJ, van Bokhoven H, Lefeber DJ
Human molecular genetics24(8)2241-6(2015 Apr)

Intellectual disability and bleeding diathesis due to deficient CMP--sialic acid transport.
Mohamed M, Ashikov A, Guillard M, Robben JH, Schmidt S, van den Heuvel B, de Brouwer AP, Gerardy-Schahn R, Deen PM, Wevers RA, Lefeber DJ, Morava E
Neurology81(7)681-7(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the SLC35A1 generates additional isoforms through alternative splicing.
Title: A functional splice variant of the human Golgi CMP-sialic acid transporter.

SLC35A1-deficient cells lack of alpha-dystroglycan O-mannosylation, ligand binding and incorporation of sialic acids.
Title: Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal ?-dystroglycan O-mannosylation, independent from sialic acid.

We confirm an autosomal recessive, generalized sialylation defect due to mutations in SLC35A1
Title: Intellectual disability and bleeding diathesis due to deficient CMP--sialic acid transport.

CMP-sialic acid transporter is localized in the medial-trans Golgi
Title: The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail.

this study, we introduced two critical genes encoding human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter into tobacco suspension-cultured cell to pave a route for sialic biosynthetic pathway.
Title: Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell.

The following SLC35A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC35A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18218	NM_006416.5 Latest version!	Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16645	NM_001168398.1 Latest version!	Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu18218	NM_006416.4	Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC35A1 ( NM_006416.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006407.1 Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18218
Clone ID Related Accession (Same CDS sequence)	NM_006416.4 , NM_006416.5
Accession Version	NM_006416.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	CMP-sialic acid transporter isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB095595.1, BG699364.1, BC017807.1 and CB242593.1. This sequence is a reference standard in the RefSeqGene project. On Jul 29, 2008 this sequence version replaced NM_006416.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017807.1, SRR1803613.85745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCC CGAGAGACAA TGTCACTTTA TTATTCAAGT TATACTGCTT GGCAGTGATG 
ACCCTGATGG CTGCAGTCTA TACCATAGCT TTAAGATACA CAAGGACATC AGACAAAGAA 
CTCTACTTTT CAACCACAGC CGTGTGTATC ACAGAAGTTA TAAAGTTATT GCTAAGTGTG 
GGAATTTTAG CTAAAGAAAC TGGTAGTCTG GGTAGATTCA AAGCATCTTT AAGAGAAAAT 
GTCTTGGGGA GCCCCAAGGA ACTGTTGAAG TTAAGTGTGC CATCGTTAGT GTATGCTGTT 
CAGAACAACA TGGCTTTCCT AGCTCTTAGC AATCTGGATG CAGCAGTGTA CCAGGTGACC 
TACCAGTTGA AGATTCCGTG TACTGCTTTA TGCACTGTTT TAATGTTAAA CCGGACACTC 
AGCAAATTAC AGTGGGTTTC AGTTTTTATG CTGTGTGCTG GAGTTACGCT TGTACAGTGG 
AAACCAGCCC AAGCTACAAA AGTGGTGGTG GAACAAAATC CATTATTAGG GTTTGGCGCT 
ATAGCTATTG CTGTATTGTG CTCAGGATTT GCAGGAGTAT ATTTTGAAAA AGTTTTAAAG 
AGTTCAGATA CTTCTCTTTG GGTGAGAAAC ATTCAAATGT ATCTATCAGG GATTATTGTG 
ACATTAGCTG GCGTCTACTT GTCAGATGGA GCTGAAATTA AAGAAAAAGG ATTTTTCTAT 
GGTTACACAT ATTATGTCTG GTTTGTCATC TTTCTTGCAA GTGTTGGTGG CCTCTACACT 
TCTGTTGTGG TTAAGTACAC AGACAACATC ATGAAAGGCT TTTCTGCAGC AGCGGCCATT 
GTCCTTTCCA CCATTGCTTC AGTAATGCTG TTTGGATTAC AGATAACACT CACCTTTGCC 
CTGGGTACTC TTCTTGTATG TGTTTCCATA TATCTCTATG GATTACCCAG ACAAGACACT 
ACATCCATCC AACAAGGAGA AACAGCTTCA AAGGAGAGAG TTATTGGTGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006407.1
CDS	80..1093
Translation	MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV

Target ORF information:

RefSeq Version	NM_006416.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006416.4

ORF Insert Sequence:

ATGGCTGCCC CGAGAGACAA TGTCACTTTA TTATTCAAGT TATACTGCTT GGCAGTGATG 
ACCCTGATGG CTGCAGTCTA TACCATAGCT TTAAGATACA CAAGGACATC AGACAAAGAA 
CTCTACTTTT CAACCACAGC CGTGTGTATC ACAGAAGTTA TAAAGTTATT GCTAAGTGTG 
GGAATTTTAG CTAAAGAAAC TGGTAGTCTG GGTAGATTCA AAGCATCTTT AAGAGAAAAT 
GTCTTGGGGA GCCCCAAGGA ACTGTTGAAG TTAAGTGTGC CATCGTTAGT GTATGCTGTT 
CAGAACAACA TGGCTTTCCT AGCTCTTAGC AATCTGGATG CAGCAGTGTA CCAGGTGACC 
TACCAGTTGA AGATTCCGTG TACTGCTTTA TGCACTGTTT TAATGTTAAA CCGGACACTC 
AGCAAATTAC AGTGGGTTTC AGTTTTTATG CTGTGTGCTG GAGTTACGCT TGTACAGTGG 
AAACCAGCCC AAGCTACAAA AGTGGTGGTG GAACAAAATC CATTATTAGG GTTTGGCGCT 
ATAGCTATTG CTGTATTGTG CTCAGGATTT GCAGGAGTAT ATTTTGAAAA AGTTTTAAAG 
AGTTCAGATA CTTCTCTTTG GGTGAGAAAC ATTCAAATGT ATCTATCAGG GATTATTGTG 
ACATTAGCTG GCGTCTACTT GTCAGATGGA GCTGAAATTA AAGAAAAAGG ATTTTTCTAT 
GGTTACACAT ATTATGTCTG GTTTGTCATC TTTCTTGCAA GTGTTGGTGG CCTCTACACT 
TCTGTTGTGG TTAAGTACAC AGACAACATC ATGAAAGGCT TTTCTGCAGC AGCGGCCATT 
GTCCTTTCCA CCATTGCTTC AGTAATGCTG TTTGGATTAC AGATAACACT CACCTTTGCC 
CTGGGTACTC TTCTTGTATG TGTTTCCATA TATCTCTATG GATTACCCAG ACAAGACACT 
ACATCCATCC AACAAGGAGA AACAGCTTCA AAGGAGAGAG TTATTGGTGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC35A1 ( NM_006416.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006407.1 Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18218
Clone ID Related Accession (Same CDS sequence)	NM_006416.4 , NM_006416.5
Accession Version	NM_006416.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	CMP-sialic acid transporter isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB095595.1, BG699364.1, BC017807.1 and CB242593.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006416.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.59231.1, BC017807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369552.9/ ENSP00000358565.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCCC CGAGAGACAA TGTCACTTTA TTATTCAAGT TATACTGCTT GGCAGTGATG 
ACCCTGATGG CTGCAGTCTA TACCATAGCT TTAAGATACA CAAGGACATC AGACAAAGAA 
CTCTACTTTT CAACCACAGC CGTGTGTATC ACAGAAGTTA TAAAGTTATT GCTAAGTGTG 
GGAATTTTAG CTAAAGAAAC TGGTAGTCTG GGTAGATTCA AAGCATCTTT AAGAGAAAAT 
GTCTTGGGGA GCCCCAAGGA ACTGTTGAAG TTAAGTGTGC CATCGTTAGT GTATGCTGTT 
CAGAACAACA TGGCTTTCCT AGCTCTTAGC AATCTGGATG CAGCAGTGTA CCAGGTGACC 
TACCAGTTGA AGATTCCGTG TACTGCTTTA TGCACTGTTT TAATGTTAAA CCGGACACTC 
AGCAAATTAC AGTGGGTTTC AGTTTTTATG CTGTGTGCTG GAGTTACGCT TGTACAGTGG 
AAACCAGCCC AAGCTACAAA AGTGGTGGTG GAACAAAATC CATTATTAGG GTTTGGCGCT 
ATAGCTATTG CTGTATTGTG CTCAGGATTT GCAGGAGTAT ATTTTGAAAA AGTTTTAAAG 
AGTTCAGATA CTTCTCTTTG GGTGAGAAAC ATTCAAATGT ATCTATCAGG GATTATTGTG 
ACATTAGCTG GCGTCTACTT GTCAGATGGA GCTGAAATTA AAGAAAAAGG ATTTTTCTAT 
GGTTACACAT ATTATGTCTG GTTTGTCATC TTTCTTGCAA GTGTTGGTGG CCTCTACACT 
TCTGTTGTGG TTAAGTACAC AGACAACATC ATGAAAGGCT TTTCTGCAGC AGCGGCCATT 
GTCCTTTCCA CCATTGCTTC AGTAATGCTG TTTGGATTAC AGATAACACT CACCTTTGCC 
CTGGGTACTC TTCTTGTATG TGTTTCCATA TATCTCTATG GATTACCCAG ACAAGACACT 
ACATCCATCC AACAAGGAGA AACAGCTTCA AAGGAGAGAG TTATTGGTGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006407.1
CDS	31..1044
Translation	MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV

Target ORF information:

RefSeq Version	NM_006416.5
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006416.5

ORF Insert Sequence:

ATGGCTGCCC CGAGAGACAA TGTCACTTTA TTATTCAAGT TATACTGCTT GGCAGTGATG 
ACCCTGATGG CTGCAGTCTA TACCATAGCT TTAAGATACA CAAGGACATC AGACAAAGAA 
CTCTACTTTT CAACCACAGC CGTGTGTATC ACAGAAGTTA TAAAGTTATT GCTAAGTGTG 
GGAATTTTAG CTAAAGAAAC TGGTAGTCTG GGTAGATTCA AAGCATCTTT AAGAGAAAAT 
GTCTTGGGGA GCCCCAAGGA ACTGTTGAAG TTAAGTGTGC CATCGTTAGT GTATGCTGTT 
CAGAACAACA TGGCTTTCCT AGCTCTTAGC AATCTGGATG CAGCAGTGTA CCAGGTGACC 
TACCAGTTGA AGATTCCGTG TACTGCTTTA TGCACTGTTT TAATGTTAAA CCGGACACTC 
AGCAAATTAC AGTGGGTTTC AGTTTTTATG CTGTGTGCTG GAGTTACGCT TGTACAGTGG 
AAACCAGCCC AAGCTACAAA AGTGGTGGTG GAACAAAATC CATTATTAGG GTTTGGCGCT 
ATAGCTATTG CTGTATTGTG CTCAGGATTT GCAGGAGTAT ATTTTGAAAA AGTTTTAAAG 
AGTTCAGATA CTTCTCTTTG GGTGAGAAAC ATTCAAATGT ATCTATCAGG GATTATTGTG 
ACATTAGCTG GCGTCTACTT GTCAGATGGA GCTGAAATTA AAGAAAAAGG ATTTTTCTAT 
GGTTACACAT ATTATGTCTG GTTTGTCATC TTTCTTGCAA GTGTTGGTGG CCTCTACACT 
TCTGTTGTGG TTAAGTACAC AGACAACATC ATGAAAGGCT TTTCTGCAGC AGCGGCCATT 
GTCCTTTCCA CCATTGCTTC AGTAATGCTG TTTGGATTAC AGATAACACT CACCTTTGCC 
CTGGGTACTC TTCTTGTATG TGTTTCCATA TATCTCTATG GATTACCCAG ACAAGACACT 
ACATCCATCC AACAAGGAGA AACAGCTTCA AAGGAGAGAG TTATTGGTGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC35A1 ( NM_001168398.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161870.1 Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16645
Clone ID Related Accession (Same CDS sequence)	NM_001168398.1
Accession Version	NM_001168398.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	CMP-sialic acid transporter isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA210713.1, AJ851888.1, D87969.1 and CB242593.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.210175.1, SRR1803617.45418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCC CGAGAGACAA TGTCACTTTA TTATTCAAGT TATACTGCTT GGCAGTGATG 
ACCCTGATGG CTGCAGTCTA TACCATAGCT TTAAGATACA CAAGGACATC AGACAAAGAA 
CTCTACTTTT CAACCACAGC CGTGTGTATC ACAGAAGTTA TAAAGTTATT GCTAAGTGTG 
GGAATTTTAG CTAAAGAAAC TGGTAGTCTG GGTAGATTCA AAGCATCTTT AAGAGAAAAT 
GTCTTGGGGA GCCCCAAGGA ACTGTTGAAG TTAAGTGTGC CATCGTTAGT GTATGCTGTT 
CAGAACAACA TGGCTTTCCT AGCTCTTAGC AATCTGGATG CAGCAGTGTA CCAGGTGACC 
TACCAGTTGA AGATTCCGTG TACTGCTTTA TGCACTGTTT TAATGTTAAA CCGGACACTC 
AGCAAATTAC AGTGGGTTTC AGTTTTTATG CTGTGTGCTG GAGTTACGCT TGTACAGTGG 
AAACCAGCCC AAGCTACAAA AGTGGTGGTG GAACAAAATC CATTATTAGG GTTTGGCGCT 
ATAGCTATTG CTGTATTGTG CTCAGGATTT GCAGTTCTTG CAAGTGTTGG TGGCCTCTAC 
ACTTCTGTTG TGGTTAAGTA CACAGACAAC ATCATGAAAG GCTTTTCTGC AGCAGCGGCC 
ATTGTCCTTT CCACCATTGC TTCAGTAATG CTGTTTGGAT TACAGATAAC ACTCACCTTT 
GCCCTGGGTA CTCTTCTTGT ATGTGTTTCC ATATATCTCT ATGGATTACC CAGACAAGAC 
ACTACATCCA TCCAACAAGG AGAAACAGCT TCAAAGGAGA GAGTTATTGG TGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161870.1
CDS	80..916
Translation	MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSVGILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGAIAIAVLCSGFAVLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFALGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV

Target ORF information:

RefSeq Version	NM_001168398.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 35 member A1 (SLC35A1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168398.1

ORF Insert Sequence:

ATGGCTGCCC CGAGAGACAA TGTCACTTTA TTATTCAAGT TATACTGCTT GGCAGTGATG 
ACCCTGATGG CTGCAGTCTA TACCATAGCT TTAAGATACA CAAGGACATC AGACAAAGAA 
CTCTACTTTT CAACCACAGC CGTGTGTATC ACAGAAGTTA TAAAGTTATT GCTAAGTGTG 
GGAATTTTAG CTAAAGAAAC TGGTAGTCTG GGTAGATTCA AAGCATCTTT AAGAGAAAAT 
GTCTTGGGGA GCCCCAAGGA ACTGTTGAAG TTAAGTGTGC CATCGTTAGT GTATGCTGTT 
CAGAACAACA TGGCTTTCCT AGCTCTTAGC AATCTGGATG CAGCAGTGTA CCAGGTGACC 
TACCAGTTGA AGATTCCGTG TACTGCTTTA TGCACTGTTT TAATGTTAAA CCGGACACTC 
AGCAAATTAC AGTGGGTTTC AGTTTTTATG CTGTGTGCTG GAGTTACGCT TGTACAGTGG 
AAACCAGCCC AAGCTACAAA AGTGGTGGTG GAACAAAATC CATTATTAGG GTTTGGCGCT 
ATAGCTATTG CTGTATTGTG CTCAGGATTT GCAGTTCTTG CAAGTGTTGG TGGCCTCTAC 
ACTTCTGTTG TGGTTAAGTA CACAGACAAC ATCATGAAAG GCTTTTCTGC AGCAGCGGCC 
ATTGTCCTTT CCACCATTGC TTCAGTAATG CTGTTTGGAT TACAGATAAC ACTCACCTTT 
GCCCTGGGTA CTCTTCTTGT ATGTGTTTCC ATATATCTCT ATGGATTACC CAGACAAGAC 
ACTACATCCA TCCAACAAGG AGAAACAGCT TCAAAGGAGA GAGTTATTGG TGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Encephalopathy caused by novel mutations in the CMP-sialic acid transporter, SLC35A1.
American journal of medical genetics. Part A173(11)2906-2911(2017 Nov)
Ng BG,Asteggiano CG,Kircher M,Buckingham KJ,Raymond K,Nickerson DA,Shendure J,Bamshad MJ,,Ensslen M,Freeze HH

A functional splice variant of the human Golgi CMP-sialic acid transporter.
Glycoconjugate journal33(6)897-906(2016 Dec)
Salinas-Mar?n R,Mollicone R,Mart?nez-Duncker I

Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal ?-dystroglycan O-mannosylation, independent from sialic acid.
Human molecular genetics24(8)2241-6(2015 Apr)
Riemersma M,Sandrock J,Boltje TJ,B?ll C,Heise T,Ashikov A,Adema GJ,van Bokhoven H,Lefeber DJ

Intellectual disability and bleeding diathesis due to deficient CMP--sialic acid transport.
Neurology81(7)681-7(2013 Aug)
Mohamed M,Ashikov A,Guillard M,Robben JH,Schmidt S,van den Heuvel B,de Brouwer AP,Gerardy-Schahn R,Deen PM,Wevers RA,Lefeber DJ,Morava E

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SLC35A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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