IPO7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IPO7
Entrez Gene ID	10527
Full Name	importin 7
Synonyms	Imp7,RANBP7
General protein information	Preferred Names importin 7 Names importin-7 RAN-binding protein 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008].
Disorder MIM:	605586

mRNA and Protein(s)

mRNA	Protein	Name
NM_006391.3	NP_006382.1	importin-7
NM_006391.2	NP_006382.1	importin-7

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007299	XP_308523.4
Saccharomyces cerevisiae (baker's yeast)	NMD5	NP_012666.2
Magnaporthe oryzae (rice blast fungus)	MGG_02927	XP_003720790.1
Neurospora crassa	NCU01939	XP_964123.1
Arabidopsis thaliana (thale cress)	SAD2	NP_180724.2
Oryza sativa (rice)	Os02g0474700	NP_001046840.1
Gallus gallus (chicken)	IPO7	XP_003641442.2
Drosophila melanogaster (fruit fly)	msk	NP_524780.1
Kluyveromyces lactis	KLLA0B04202g	XP_451720.1
Schizosaccharomyces pombe (fission yeast)	SPCC550.11	NP_588103.1
Pan troglodytes (chimpanzee)	IPO7	XP_001169290.2
Homo sapiens (human)	IPO7	NP_006382.1
Canis lupus familiaris (dog)	IPO7	XP_542501.2
Bos taurus (cattle)	IPO7	NP_001179285.1
Mus musculus (house mouse)	Ipo7	NP_852658.2
Danio rerio (zebrafish)	ipo7	NP_957199.2
Rattus norvegicus (Norway rat)	Ipo7	NP_001101015.1
Eremothecium gossypii	AGOS_ABL068C	NP_982879.2
Arabidopsis thaliana (thale cress)	AT3G59020	NP_191461.2
Xenopus tropicalis (tropical clawed frog)	ipo7	NP_001128290.1

Gene Ontology
Bibliography

Related articles in PubMed

Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7.
Mohammad DK, Nore BF, Gustafsson MO, Mohamed AJ, Smith CIE
The international journal of biochemistry & cell biology7863-74(2016 09)

Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.
Soniat M, Ca?atay T, Chook YM
The Journal of biological chemistry291(40)21171-21183(2016 Sep)

Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome.
Braun DA, Sadowski CE, Kohl S, Lovric S, Astrinidis SA, Pabst WL, Gee HY, Ashraf S, Lawson JA, Shril S, Airik M, Tan W, Schapiro D, Rao J, Choi WI, Hermle T, Kemper MJ, Pohl M, Ozaltin F, Konrad M, Bogdanovic R, B?scher R, Helmchen U, Serdaroglu E, Lifton RP, Antonin W, Hildebrandt F
Nature genetics48(4)457-65(2016 Apr)

Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression.
Xue J, Zhou A, Tan C, Wu Y, Lee HT, Li W, Xie K, Huang S
The Journal of biological chemistry290(30)18662-70(2015 Jul)

Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.
Frohnert C, Hutten S, W?lde S, Nath A, Kehlenbach RH
PloS one9(2)e88887(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AKT and 14-3-3 proteins down-regulate the activity of several BCR-associated components, including BTK, BLNK and SYK and also inhibit SYK's interaction with Importin 7
Title: Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7.

Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
Title: Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.

Depletion of IPO7 by IPO7 siRNA reduced nuclear accumulation of GLI1. In addition, FOXM1 induced nuclear import of GLI1 by promoting IPO7 expression.
Title: Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression.

Importin 7 as a soluble nuclear transport factor that is required for efficient import of the protein component of human telomerase.
Title: Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.

Importin 7 contributes to the regulation of androgen receptor import by restraining import until androgen is detected in the cytoplasm.
Title: Androgen induces a switch from cytoplasmic retention to nuclear import of the androgen receptor.

The following IPO7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IPO7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu107353	NM_006391.3 Latest version!	Homo sapiens importin 7 (IPO7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
OHu11630	NM_006391.2 Latest version!	Homo sapiens importin 7 (IPO7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IPO7 ( NM_006391.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006382.1 Homo sapiens importin 7 (IPO7), mRNA.

Price & Availability↑

CloneID	OHu107353
Clone ID Related Accession (Same CDS sequence)	NM_006391.3
Accession Version	NM_006391.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3117bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-08
Organism	Homo sapiens(human)
Product	importin-7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC055845.15 and AC132192.3. On Nov 23, 2018 this sequence version replaced NM_006391.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.220723.1, SRR1660809.78558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000379719.8/ ENSP00000369042.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACCCCA ACACCATTAT CGAGGCCCTG CGGGGCACTA TGGACCCAGC CCTGCGTGAG 
GCCGCGGAGC GCCAGCTCAA TGAAGCACAC AAGTCTCTGA ATTTTGTCTC AACACTGCTC 
CAGATTACTA TGTCGGAACA GCTGGATTTA CCTGTGAGAC AGGCAGGTGT TATCTATCTG 
AAAAATATGA TAACACAGTA TTGGCCTGAT CGAGAAACAG CACCAGGGGA TATATCCCCT 
TATACTATTC CAGAAGAAGA TCGCCATTGT ATTCGAGAAA ATATTGTAGA AGCCATTATC 
CATTCTCCTG AGCTCATCAG GGTACAGCTT ACTACATGCA TTCATCACAT CATCAAACAT 
GATTATCCAA GCCGCTGGAC TGCCATTGTG GACAAAATTG GCTTTTATCT TCAGTCCGAT 
AACAGTGCTT GTTGGCTAGG AATTCTTCTT TGCCTTTATC AGCTTGTGAA AAATTATGAG 
TATAAAAAAC CAGAGGAGCG GAGTCCATTG GTAGCAGCAA TGCAGCATTT TCTGCCAGTT 
CTAAAGGATC GTTTTATCCA GCTTCTTTCT GACCAGTCTG ATCAGTCTGT CCTCATCCAG 
AAACAGATAT TCAAGATCTT CTATGCTCTT GTTCAGTATA CACTACCACT GGAACTGATA 
AACCAACAGA ACCTGACAGA ATGGATAGAA ATTTTAAAGA CTGTTGTGAA CAGGGATGTA 
CCTAATGAAA CACTTCAAGT TGAAGAAGAT GATCGACCTG AGTTACCATG GTGGAAATGC 
AAGAAGTGGG CCTTACATAT TTTAGCAAGA CTTTTTGAAA GATATGGAAG CCCTGGCAAT 
GTTTCCAAGG AGTATAATGA ATTTGCTGAA GTATTTCTGA AGGCATTTGC TGTTGGTGTC 
CAGCAAGTTT TATTGAAGGT GTTATATCAG TACAAGGAGA AGCAATATAT GGCTCCTCGA 
GTTTTACAAC AGACATTAAA TTATATTAAT CAAGGAGTTT CTCATGCTCT CACCTGGAAG 
AATCTGAAGC CCCATATACA AGGCATTATC CAAGATGTTA TTTTTCCATT GATGTGCTAT 
ACAGATGCTG ATGAGGAACT TTGGCAAGAA GACCCTTACG AATATATACG CATGAAGTTT 
GATGTGTTTG AAGATTTCAT TTCTCCTACC ACTGCTGCCC AGACACTTTT GTTTACAGCC 
TGTAGTAAGA GGAAAGAGGT ACTGCAAAAG ACTATGGGAT TTTGTTACCA GATTCTTACA 
GAACCAAATG CTGACCCTCG AAAAAAAGAT GGAGCCCTGC ATATGATTGG CTCTTTAGCT 
GAAATACTTC TGAAGAAAAA GATCTATAAA GATCAGATGG AATACATGTT GCAGAATCAT 
GTATTCCCTC TCTTCAGCAG TGAACTAGGC TACATGAGAG CAAGGGCTTG CTGGGTACTT 
CACTATTTTT GTGAAGTGAA GTTCAAAAGT GATCAGAACC TTCAAACAGC CTTAGAGCTA 
ACAAGAAGAT GTCTGATTGA TGATAGAGAA ATGCCTGTGA AAGTGGAAGC TGCCATTGCC 
CTTCAAGTAT TGATCAGCAA TCAAGAAAAA GCTAAAGAAT ATATCACACC ATTCATCAGA 
CCTGTAATGC AGGCTCTTCT TCACATTATA AGAGAAACAG AAAATGATGA CCTTACCAAT 
GTAATTCAGA AAATGATCTG TGAATATAGT GAAGAAGTTA CTCCTATTGC AGTAGAAATG 
ACACAACATT TGGCAATGAC ATTTAACCAA GTAATCCAGA CGGGGCCAGA TGAAGAAGGT 
AGTGATGACA AAGCAGTTAC TGCTATGGGA ATTCTGAATA CAATTGATAC ACTTCTTAGT 
GTAGTTGAAG ATCATAAAGA GATAACCCAA CAGCTTGAGG GAATCTGCTT ACAGGTCATT 
GGTACTGTTT TACAACAGCA TGTCTTAGAA TTCTATGAGG AGATCTTCTC TTTAGCGCAC 
AGTTTGACAT GTCAACAAGT GTCTCCACAG ATGTGGCAGC TACTACCCCT TGTATTTGAA 
GTCTTTCAGC AAGATGGCTT TGATTACTTT ACAGATATGA TGCCCCTCCT TCATAATTAT 
GTAACAGTTG ATACAGACAC ACTTCTGTCT GACACCAAGT ATCTTGAAAT GATATACAGT 
ATGTGCAAAA AGGTTCTTAC AGGAGTTGCA GGAGAAGATG CAGAGTGTCA TGCAGCAAAA 
TTGTTAGAGG TCATCATTCT GCAGTGCAAA GGGCGTGGCA TTGACCAGTG CATTCCCTTA 
TTCGTGGAAG CAGCCTTAGA AAGACTGACA AGAGAGGTTA AGACAAGTGA ACTTCGAACT 
ATGTGTCTGC AAGTTGCAAT TGCAGCTTTG TATTATAATC CACACCTACT ACTCAATACC 
TTAGAAAATC TTCGCTTCCC TAATAATGTT GAACCAGTTA CAAATCATTT TATTACACAG 
TGGCTTAATG ATGTTGACTG TTTCTTGGGG CTTCATGACA GAAAGATGTG TGTTCTCGGA 
CTCTGTGCTC TTATTGATAT GGAACAGATA CCCCAAGTTT TAAATCAGGT TTCTGGACAG 
ATTTTGCCGG CTTTTATCCT TTTATTTAAC GGATTGAAAA GAGCATATGC CTGCCATGCA 
GAACATGAGA ATGACAGTGA TGATGATGAT GAAGCTGAAG ATGATGATGA AACCGAGGAA 
CTGGGGAGTG ATGAAGATGA TATTGATGAA GATGGGCAAG AATATTTGGA GATTCTGGCT 
AAGCAGGCTG GTGAAGATGG AGATGATGAA GATTGGGAAG AAGATGATGC TGAAGAGACT 
GCTCTGGAAG GCTATTCCAC AATCATTGAT GATGAAGATA ACCCTGTTGA TGAGTATCAG 
ATATTTAAAG CTATCTTTCA AACTATTCAA AATCGTAATC CTGTGTGGTA TCAGGCACTG 
ACTCACGGTC TTAATGAAGA ACAAAGAAAA CAGTTACAGG ACATAGCAAC TCTGGCTGAT 
CAAAGAAGAG CAGCCCATGA ATCCAAAATG ATTGAGAAGC ATGGAGGATA CAAATTCAGT 
GCTCCAGTTG TGCCAAGTTC TTTCAATTTT GGAGGCCCAG CACCAGGGAT GAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006382.1
CDS	113..3229
Translation	MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIYLKNMITQYWPDRETAPGDISPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWIEILKTVVNRDVPNETLQVEEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVSHALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYKDQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKVLTGVAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYNPHLLLNTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLCALIDMEQIPQVLNQVSGQILPAFILLFNGLKRAYACHAEHENDSDDDDEAEDDDETEELGSDEDDIDEDGQEYLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQIFKAIFQTIQNRNPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFSAPVVPSSFNFGGPAPGMN

Target ORF information:

RefSeq Version	NM_006391.3
Organism	Homo sapiens(human)
Definition	Homo sapiens importin 7 (IPO7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006391.3

ORF Insert Sequence:

ATGGACCCCA ACACCATTAT CGAGGCCCTG CGGGGCACTA TGGACCCAGC CCTGCGTGAG 
GCCGCGGAGC GCCAGCTCAA TGAAGCACAC AAGTCTCTGA ATTTTGTCTC AACACTGCTC 
CAGATTACTA TGTCGGAACA GCTGGATTTA CCTGTGAGAC AGGCAGGTGT TATCTATCTG 
AAAAATATGA TAACACAGTA TTGGCCTGAT CGAGAAACAG CACCAGGGGA TATATCCCCT 
TATACTATTC CAGAAGAAGA TCGCCATTGT ATTCGAGAAA ATATTGTAGA AGCCATTATC 
CATTCTCCTG AGCTCATCAG GGTACAGCTT ACTACATGCA TTCATCACAT CATCAAACAT 
GATTATCCAA GCCGCTGGAC TGCCATTGTG GACAAAATTG GCTTTTATCT TCAGTCCGAT 
AACAGTGCTT GTTGGCTAGG AATTCTTCTT TGCCTTTATC AGCTTGTGAA AAATTATGAG 
TATAAAAAAC CAGAGGAGCG GAGTCCATTG GTAGCAGCAA TGCAGCATTT TCTGCCAGTT 
CTAAAGGATC GTTTTATCCA GCTTCTTTCT GACCAGTCTG ATCAGTCTGT CCTCATCCAG 
AAACAGATAT TCAAGATCTT CTATGCTCTT GTTCAGTATA CACTACCACT GGAACTGATA 
AACCAACAGA ACCTGACAGA ATGGATAGAA ATTTTAAAGA CTGTTGTGAA CAGGGATGTA 
CCTAATGAAA CACTTCAAGT TGAAGAAGAT GATCGACCTG AGTTACCATG GTGGAAATGC 
AAGAAGTGGG CCTTACATAT TTTAGCAAGA CTTTTTGAAA GATATGGAAG CCCTGGCAAT 
GTTTCCAAGG AGTATAATGA ATTTGCTGAA GTATTTCTGA AGGCATTTGC TGTTGGTGTC 
CAGCAAGTTT TATTGAAGGT GTTATATCAG TACAAGGAGA AGCAATATAT GGCTCCTCGA 
GTTTTACAAC AGACATTAAA TTATATTAAT CAAGGAGTTT CTCATGCTCT CACCTGGAAG 
AATCTGAAGC CCCATATACA AGGCATTATC CAAGATGTTA TTTTTCCATT GATGTGCTAT 
ACAGATGCTG ATGAGGAACT TTGGCAAGAA GACCCTTACG AATATATACG CATGAAGTTT 
GATGTGTTTG AAGATTTCAT TTCTCCTACC ACTGCTGCCC AGACACTTTT GTTTACAGCC 
TGTAGTAAGA GGAAAGAGGT ACTGCAAAAG ACTATGGGAT TTTGTTACCA GATTCTTACA 
GAACCAAATG CTGACCCTCG AAAAAAAGAT GGAGCCCTGC ATATGATTGG CTCTTTAGCT 
GAAATACTTC TGAAGAAAAA GATCTATAAA GATCAGATGG AATACATGTT GCAGAATCAT 
GTATTCCCTC TCTTCAGCAG TGAACTAGGC TACATGAGAG CAAGGGCTTG CTGGGTACTT 
CACTATTTTT GTGAAGTGAA GTTCAAAAGT GATCAGAACC TTCAAACAGC CTTAGAGCTA 
ACAAGAAGAT GTCTGATTGA TGATAGAGAA ATGCCTGTGA AAGTGGAAGC TGCCATTGCC 
CTTCAAGTAT TGATCAGCAA TCAAGAAAAA GCTAAAGAAT ATATCACACC ATTCATCAGA 
CCTGTAATGC AGGCTCTTCT TCACATTATA AGAGAAACAG AAAATGATGA CCTTACCAAT 
GTAATTCAGA AAATGATCTG TGAATATAGT GAAGAAGTTA CTCCTATTGC AGTAGAAATG 
ACACAACATT TGGCAATGAC ATTTAACCAA GTAATCCAGA CGGGGCCAGA TGAAGAAGGT 
AGTGATGACA AAGCAGTTAC TGCTATGGGA ATTCTGAATA CAATTGATAC ACTTCTTAGT 
GTAGTTGAAG ATCATAAAGA GATAACCCAA CAGCTTGAGG GAATCTGCTT ACAGGTCATT 
GGTACTGTTT TACAACAGCA TGTCTTAGAA TTCTATGAGG AGATCTTCTC TTTAGCGCAC 
AGTTTGACAT GTCAACAAGT GTCTCCACAG ATGTGGCAGC TACTACCCCT TGTATTTGAA 
GTCTTTCAGC AAGATGGCTT TGATTACTTT ACAGATATGA TGCCCCTCCT TCATAATTAT 
GTAACAGTTG ATACAGACAC ACTTCTGTCT GACACCAAGT ATCTTGAAAT GATATACAGT 
ATGTGCAAAA AGGTTCTTAC AGGAGTTGCA GGAGAAGATG CAGAGTGTCA TGCAGCAAAA 
TTGTTAGAGG TCATCATTCT GCAGTGCAAA GGGCGTGGCA TTGACCAGTG CATTCCCTTA 
TTCGTGGAAG CAGCCTTAGA AAGACTGACA AGAGAGGTTA AGACAAGTGA ACTTCGAACT 
ATGTGTCTGC AAGTTGCAAT TGCAGCTTTG TATTATAATC CACACCTACT ACTCAATACC 
TTAGAAAATC TTCGCTTCCC TAATAATGTT GAACCAGTTA CAAATCATTT TATTACACAG 
TGGCTTAATG ATGTTGACTG TTTCTTGGGG CTTCATGACA GAAAGATGTG TGTTCTCGGA 
CTCTGTGCTC TTATTGATAT GGAACAGATA CCCCAAGTTT TAAATCAGGT TTCTGGACAG 
ATTTTGCCGG CTTTTATCCT TTTATTTAAC GGATTGAAAA GAGCATATGC CTGCCATGCA 
GAACATGAGA ATGACAGTGA TGATGATGAT GAAGCTGAAG ATGATGATGA AACCGAGGAA 
CTGGGGAGTG ATGAAGATGA TATTGATGAA GATGGGCAAG AATATTTGGA GATTCTGGCT 
AAGCAGGCTG GTGAAGATGG AGATGATGAA GATTGGGAAG AAGATGATGC TGAAGAGACT 
GCTCTGGAAG GCTATTCCAC AATCATTGAT GATGAAGATA ACCCTGTTGA TGAGTATCAG 
ATATTTAAAG CTATCTTTCA AACTATTCAA AATCGTAATC CTGTGTGGTA TCAGGCACTG 
ACTCACGGTC TTAATGAAGA ACAAAGAAAA CAGTTACAGG ACATAGCAAC TCTGGCTGAT 
CAAAGAAGAG CAGCCCATGA ATCCAAAATG ATTGAGAAGC ATGGAGGATA CAAATTCAGT 
GCTCCAGTTG TGCCAAGTTC TTTCAATTTT GGAGGCCCAG CACCAGGGAT GAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IPO7 ( NM_006391.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006382.1 Homo sapiens importin 7 (IPO7), mRNA.

Price & Availability↑

CloneID	OHu11630
Clone ID Related Accession (Same CDS sequence)	NM_006391.2
Accession Version	NM_006391.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3117bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	importin-7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA780921.1, BC114929.1, BX342418.2, AK027892.1, AC132192.3, AL117596.1 and BM980653.1. On Jan 24, 2009 this sequence version replaced NM_006391.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.78558.1, SRR1803612.230578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCCA ACACCATTAT CGAGGCCCTG CGGGGCACCA TGGACCCAGC CCTGCGTGAG 
GCCGCGGAGC GCCAGCTCAA TGAAGCACAC AAGTCTCTGA ATTTTGTCTC AACACTGCTC 
CAGATTACTA TGTCGGAACA GCTGGATTTA CCTGTGAGAC AGGCAGGTGT TATCTATCTG 
AAAAATATGA TAACACAGTA TTGGCCTGAT CGAGAAACAG CACCAGGGGA TATATCCCCT 
TATACTATTC CAGAAGAAGA TCGCCATTGT ATTCGAGAAA ATATTGTAGA AGCCATTATC 
CATTCTCCTG AGCTCATCAG GGTACAGCTT ACTACATGCA TTCATCACAT CATCAAACAT 
GATTATCCAA GCCGCTGGAC TGCCATTGTG GACAAAATTG GCTTTTATCT TCAGTCCGAT 
AACAGTGCTT GTTGGCTAGG AATTCTTCTT TGCCTTTATC AGCTTGTGAA AAATTATGAG 
TATAAAAAAC CAGAGGAGCG GAGTCCATTG GTAGCAGCAA TGCAGCATTT TCTGCCAGTT 
CTAAAGGATC GTTTTATCCA GCTTCTTTCT GACCAGTCTG ATCAGTCTGT CCTCATCCAG 
AAACAGATAT TCAAGATCTT CTATGCTCTT GTTCAGTATA CACTACCACT GGAACTGATA 
AACCAACAGA ACCTGACAGA ATGGATAGAA ATTTTAAAGA CTGTTGTGAA CAGGGATGTA 
CCTAATGAAA CACTTCAAGT TGAAGAAGAT GATCGACCTG AGTTACCATG GTGGAAATGC 
AAGAAGTGGG CCTTACATAT TTTAGCAAGA CTTTTTGAAA GATATGGAAG CCCTGGCAAT 
GTTTCCAAGG AGTATAATGA ATTTGCTGAA GTATTTCTGA AGGCATTTGC TGTTGGTGTC 
CAGCAAGTTT TATTGAAGGT GTTATATCAG TACAAGGAGA AGCAATATAT GGCTCCTCGA 
GTTTTACAAC AGACATTAAA TTATATTAAT CAAGGAGTTT CTCATGCTCT CACCTGGAAG 
AATCTGAAGC CCCATATACA AGGCATTATC CAAGATGTTA TTTTTCCATT GATGTGCTAT 
ACAGATGCTG ATGAGGAACT TTGGCAAGAA GACCCTTACG AATATATACG CATGAAGTTT 
GATGTGTTTG AAGATTTCAT TTCTCCTACC ACTGCTGCCC AGACACTTTT GTTTACAGCC 
TGTAGTAAGA GGAAAGAGGT ACTGCAAAAG ACTATGGGAT TTTGTTACCA GATTCTTACA 
GAACCAAATG CTGACCCTCG AAAAAAAGAT GGAGCCCTGC ATATGATTGG CTCTTTAGCT 
GAAATACTTC TGAAGAAAAA GATCTATAAA GATCAGATGG AATACATGTT GCAGAATCAT 
GTATTCCCTC TCTTCAGCAG TGAACTAGGC TACATGAGAG CAAGGGCTTG CTGGGTACTT 
CACTATTTTT GTGAAGTGAA GTTCAAAAGT GATCAGAACC TTCAAACAGC CTTAGAGCTA 
ACAAGAAGAT GTCTGATTGA TGATAGAGAA ATGCCTGTGA AAGTGGAAGC TGCCATTGCC 
CTTCAAGTAT TGATCAGCAA TCAAGAAAAA GCTAAAGAAT ATATCACACC ATTCATCAGA 
CCTGTAATGC AGGCTCTTCT TCACATTATA AGAGAAACAG AAAATGATGA CCTTACCAAT 
GTAATTCAGA AAATGATCTG TGAATATAGT GAAGAAGTTA CTCCTATTGC AGTAGAAATG 
ACACAACATT TGGCAATGAC ATTTAACCAA GTAATCCAGA CGGGGCCAGA TGAAGAAGGT 
AGTGATGACA AAGCAGTTAC TGCTATGGGA ATTCTGAATA CAATTGATAC ACTTCTTAGT 
GTAGTTGAAG ATCATAAAGA GATAACCCAA CAGCTTGAGG GAATCTGCTT ACAGGTCATT 
GGTACTGTTT TACAACAGCA TGTCTTAGAA TTCTATGAGG AGATCTTCTC TTTAGCGCAC 
AGTTTGACAT GTCAACAAGT GTCTCCACAG ATGTGGCAGC TACTACCCCT TGTATTTGAA 
GTCTTTCAGC AAGATGGCTT TGATTACTTT ACAGATATGA TGCCCCTCCT TCATAATTAT 
GTAACAGTTG ATACAGACAC ACTTCTGTCT GACACCAAGT ATCTTGAAAT GATATACAGT 
ATGTGCAAAA AGGTTCTTAC AGGAGTTGCA GGAGAAGATG CAGAGTGTCA TGCAGCAAAA 
TTGTTAGAGG TCATCATTCT GCAGTGCAAA GGGCGTGGCA TTGACCAGTG CATTCCCTTA 
TTCGTGGAAG CAGCCTTAGA AAGACTGACA AGAGAGGTTA AGACAAGTGA ACTTCGAACT 
ATGTGTCTGC AAGTTGCAAT TGCAGCTTTG TATTATAATC CACACCTACT ACTCAATACC 
TTAGAAAATC TTCGCTTCCC TAATAATGTT GAACCAGTTA CAAATCATTT TATTACACAG 
TGGCTTAATG ATGTTGACTG TTTCTTGGGG CTTCATGACA GAAAGATGTG TGTTCTCGGA 
CTCTGTGCTC TTATTGATAT GGAACAGATA CCCCAAGTTT TAAATCAGGT TTCTGGACAG 
ATTTTGCCGG CTTTTATCCT TTTATTTAAC GGATTGAAAA GAGCATATGC CTGCCATGCA 
GAACATGAGA ATGACAGTGA TGATGATGAT GAAGCTGAAG ATGATGATGA AACCGAGGAA 
CTGGGGAGTG ATGAAGATGA TATTGATGAA GATGGGCAAG AATATTTGGA GATTCTGGCT 
AAGCAGGCTG GTGAAGATGG AGATGATGAA GATTGGGAAG AAGATGATGC TGAAGAGACT 
GCTCTGGAAG GCTATTCCAC AATCATTGAT GATGAAGATA ACCCTGTTGA TGAGTATCAG 
ATATTTAAAG CTATCTTTCA AACTATTCAA AATCGTAATC CTGTGTGGTA TCAGGCACTG 
ACTCACGGTC TTAATGAAGA ACAAAGAAAA CAGTTACAGG ACATAGCAAC TCTGGCTGAT 
CAAAGAAGAG CAGCCCATGA ATCCAAAATG ATTGAGAAGC ATGGAGGATA CAAATTCAGT 
GCTCCAGTTG TGCCAAGTTC TTTCAATTTT GGAGGCCCAG CACCAGGGAT GAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006382.1
CDS	143..3259
Translation	MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIYLKNMITQYWPDRETAPGDISPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWIEILKTVVNRDVPNETLQVEEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVSHALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYKDQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKVLTGVAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYNPHLLLNTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLCALIDMEQIPQVLNQVSGQILPAFILLFNGLKRAYACHAEHENDSDDDDEAEDDDETEELGSDEDDIDEDGQEYLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQIFKAIFQTIQNRNPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFSAPVVPSSFNFGGPAPGMN

Target ORF information:

RefSeq Version	NM_006391.2
Organism	Homo sapiens(human)
Definition	Homo sapiens importin 7 (IPO7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006391.2

ORF Insert Sequence:

ATGGACCCCA ACACCATTAT CGAGGCCCTG CGGGGCACCA TGGACCCAGC CCTGCGTGAG 
GCCGCGGAGC GCCAGCTCAA TGAAGCACAC AAGTCTCTGA ATTTTGTCTC AACACTGCTC 
CAGATTACTA TGTCGGAACA GCTGGATTTA CCTGTGAGAC AGGCAGGTGT TATCTATCTG 
AAAAATATGA TAACACAGTA TTGGCCTGAT CGAGAAACAG CACCAGGGGA TATATCCCCT 
TATACTATTC CAGAAGAAGA TCGCCATTGT ATTCGAGAAA ATATTGTAGA AGCCATTATC 
CATTCTCCTG AGCTCATCAG GGTACAGCTT ACTACATGCA TTCATCACAT CATCAAACAT 
GATTATCCAA GCCGCTGGAC TGCCATTGTG GACAAAATTG GCTTTTATCT TCAGTCCGAT 
AACAGTGCTT GTTGGCTAGG AATTCTTCTT TGCCTTTATC AGCTTGTGAA AAATTATGAG 
TATAAAAAAC CAGAGGAGCG GAGTCCATTG GTAGCAGCAA TGCAGCATTT TCTGCCAGTT 
CTAAAGGATC GTTTTATCCA GCTTCTTTCT GACCAGTCTG ATCAGTCTGT CCTCATCCAG 
AAACAGATAT TCAAGATCTT CTATGCTCTT GTTCAGTATA CACTACCACT GGAACTGATA 
AACCAACAGA ACCTGACAGA ATGGATAGAA ATTTTAAAGA CTGTTGTGAA CAGGGATGTA 
CCTAATGAAA CACTTCAAGT TGAAGAAGAT GATCGACCTG AGTTACCATG GTGGAAATGC 
AAGAAGTGGG CCTTACATAT TTTAGCAAGA CTTTTTGAAA GATATGGAAG CCCTGGCAAT 
GTTTCCAAGG AGTATAATGA ATTTGCTGAA GTATTTCTGA AGGCATTTGC TGTTGGTGTC 
CAGCAAGTTT TATTGAAGGT GTTATATCAG TACAAGGAGA AGCAATATAT GGCTCCTCGA 
GTTTTACAAC AGACATTAAA TTATATTAAT CAAGGAGTTT CTCATGCTCT CACCTGGAAG 
AATCTGAAGC CCCATATACA AGGCATTATC CAAGATGTTA TTTTTCCATT GATGTGCTAT 
ACAGATGCTG ATGAGGAACT TTGGCAAGAA GACCCTTACG AATATATACG CATGAAGTTT 
GATGTGTTTG AAGATTTCAT TTCTCCTACC ACTGCTGCCC AGACACTTTT GTTTACAGCC 
TGTAGTAAGA GGAAAGAGGT ACTGCAAAAG ACTATGGGAT TTTGTTACCA GATTCTTACA 
GAACCAAATG CTGACCCTCG AAAAAAAGAT GGAGCCCTGC ATATGATTGG CTCTTTAGCT 
GAAATACTTC TGAAGAAAAA GATCTATAAA GATCAGATGG AATACATGTT GCAGAATCAT 
GTATTCCCTC TCTTCAGCAG TGAACTAGGC TACATGAGAG CAAGGGCTTG CTGGGTACTT 
CACTATTTTT GTGAAGTGAA GTTCAAAAGT GATCAGAACC TTCAAACAGC CTTAGAGCTA 
ACAAGAAGAT GTCTGATTGA TGATAGAGAA ATGCCTGTGA AAGTGGAAGC TGCCATTGCC 
CTTCAAGTAT TGATCAGCAA TCAAGAAAAA GCTAAAGAAT ATATCACACC ATTCATCAGA 
CCTGTAATGC AGGCTCTTCT TCACATTATA AGAGAAACAG AAAATGATGA CCTTACCAAT 
GTAATTCAGA AAATGATCTG TGAATATAGT GAAGAAGTTA CTCCTATTGC AGTAGAAATG 
ACACAACATT TGGCAATGAC ATTTAACCAA GTAATCCAGA CGGGGCCAGA TGAAGAAGGT 
AGTGATGACA AAGCAGTTAC TGCTATGGGA ATTCTGAATA CAATTGATAC ACTTCTTAGT 
GTAGTTGAAG ATCATAAAGA GATAACCCAA CAGCTTGAGG GAATCTGCTT ACAGGTCATT 
GGTACTGTTT TACAACAGCA TGTCTTAGAA TTCTATGAGG AGATCTTCTC TTTAGCGCAC 
AGTTTGACAT GTCAACAAGT GTCTCCACAG ATGTGGCAGC TACTACCCCT TGTATTTGAA 
GTCTTTCAGC AAGATGGCTT TGATTACTTT ACAGATATGA TGCCCCTCCT TCATAATTAT 
GTAACAGTTG ATACAGACAC ACTTCTGTCT GACACCAAGT ATCTTGAAAT GATATACAGT 
ATGTGCAAAA AGGTTCTTAC AGGAGTTGCA GGAGAAGATG CAGAGTGTCA TGCAGCAAAA 
TTGTTAGAGG TCATCATTCT GCAGTGCAAA GGGCGTGGCA TTGACCAGTG CATTCCCTTA 
TTCGTGGAAG CAGCCTTAGA AAGACTGACA AGAGAGGTTA AGACAAGTGA ACTTCGAACT 
ATGTGTCTGC AAGTTGCAAT TGCAGCTTTG TATTATAATC CACACCTACT ACTCAATACC 
TTAGAAAATC TTCGCTTCCC TAATAATGTT GAACCAGTTA CAAATCATTT TATTACACAG 
TGGCTTAATG ATGTTGACTG TTTCTTGGGG CTTCATGACA GAAAGATGTG TGTTCTCGGA 
CTCTGTGCTC TTATTGATAT GGAACAGATA CCCCAAGTTT TAAATCAGGT TTCTGGACAG 
ATTTTGCCGG CTTTTATCCT TTTATTTAAC GGATTGAAAA GAGCATATGC CTGCCATGCA 
GAACATGAGA ATGACAGTGA TGATGATGAT GAAGCTGAAG ATGATGATGA AACCGAGGAA 
CTGGGGAGTG ATGAAGATGA TATTGATGAA GATGGGCAAG AATATTTGGA GATTCTGGCT 
AAGCAGGCTG GTGAAGATGG AGATGATGAA GATTGGGAAG AAGATGATGC TGAAGAGACT 
GCTCTGGAAG GCTATTCCAC AATCATTGAT GATGAAGATA ACCCTGTTGA TGAGTATCAG 
ATATTTAAAG CTATCTTTCA AACTATTCAA AATCGTAATC CTGTGTGGTA TCAGGCACTG 
ACTCACGGTC TTAATGAAGA ACAAAGAAAA CAGTTACAGG ACATAGCAAC TCTGGCTGAT 
CAAAGAAGAG CAGCCCATGA ATCCAAAATG ATTGAGAAGC ATGGAGGATA CAAATTCAGT 
GCTCCAGTTG TGCCAAGTTC TTTCAATTTT GGAGGCCCAG CACCAGGGAT GAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7.
The international journal of biochemistry & cell biology7863-74(2016 09)
Mohammad DK,Nore BF,Gustafsson MO,Mohamed AJ,Smith CIE

Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.
The Journal of biological chemistry291(40)21171-21183(2016 Sep)
Soniat M,Ca?atay T,Chook YM

Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome.
Nature genetics48(4)457-65(2016 Apr)
Braun DA,Sadowski CE,Kohl S,Lovric S,Astrinidis SA,Pabst WL,Gee HY,Ashraf S,Lawson JA,Shril S,Airik M,Tan W,Schapiro D,Rao J,Choi WI,Hermle T,Kemper MJ,Pohl M,Ozaltin F,Konrad M,Bogdanovic R,B?scher R,Helmchen U,Serdaroglu E,Lifton RP,Antonin W,Hildebrandt F

Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression.
The Journal of biological chemistry290(30)18662-70(2015 Jul)
Xue J,Zhou A,Tan C,Wu Y,Lee HT,Li W,Xie K,Huang S

Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.
PloS one9(2)e88887(2014)
Frohnert C,Hutten S,W?lde S,Nath A,Kehlenbach RH

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IPO7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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