DNAL4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNAL4
Entrez Gene ID	10126
Full Name	dynein axonemal light chain 4
Synonyms	MRMV3,PIG27
General protein information	Preferred Names dynein axonemal light chain 4 Names dynein light chain 4, axonemal dynein light chain, outer arm 4 dynein, axonemal, light polypeptide 4 proliferation-inducing gene 27 proliferation-inducing protein 27
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1
Summary	This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014].
Disorder MIM:	610565
Disorder Html:	?Mirror movements 3, 616059 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005740.3	NP_005731.1	dynein light chain 4, axonemal
NM_005740.2	NP_005731.1	dynein light chain 4, axonemal

Pathways from BioSystems

Homologies

	DNAL4	XP_001096055.1
Rattus norvegicus (Norway rat)	Dnal4	NP_001009666.1
Drosophila melanogaster (fruit fly)	CG8407	NP_001163124.1
Pan troglodytes (chimpanzee)	DNAL4	NP_001233287.1
Gallus gallus (chicken)	DNAL4	NP_001006242.1
Bos taurus (cattle)	DNAL4	NP_001074387.1
Xenopus tropicalis (tropical clawed frog)	dnal4	NP_001006784.1
Canis lupus familiaris (dog)	DNAL4	XP_849923.1
Mus musculus (house mouse)	Dnal4	NP_059498.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006887	XP_308872.2
Homo sapiens (human)	DNAL4	NP_005731.1
Danio rerio (zebrafish)	dnal4b	NP_001018338.1

Gene Ontology
Bibliography

Related articles in PubMed

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.
Ahmed I, Mittal K, Sheikh TI, Vasli N, Rafiq MA, Mikhailov A, Ohadi M, Mahmood H, Rouleau GA, Bhatti A, Ayub M, Srour M, John P, Vincent JB
Human genetics133(11)1419-29(2014 Nov)

Congenital mirror movements: no mutation in DNAL4 in 17 index cases.
M?neret A, Trouillard O, Vidailhet M, Depienne C, Roze E
Journal of neurology261(10)2030-1(2014 Oct)

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Lauc G, Huffman JE, Pu?i? M, Zgaga L, Adamczyk B, Mu?ini? A, Novokmet M, Pola?ek O, Gornik O, Kri?ti? J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kol?i? I, Luki? IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I
PLoS genetics9(1)e1003225(2013)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DNAL4 may play a role in the cytoplasmic dynein complex for netrin-1-directed retrograde transport, and in commissural neurons of the corpus callosum in particular. This could lead to faulty cross-brain wiring, resulting in Mirror movements (MRMV).
Title: Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.

No mutation in DNAL4 in Congenital mirror movements.
Title: Congenital mirror movements: no mutation in DNAL4 in 17 index cases.

The following DNAL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNAL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05013	NM_005740.3 Latest version!	Homo sapiens dynein axonemal light chain 4 (DNAL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05013	NM_005740.2	Homo sapiens dynein axonemal light chain 4 (DNAL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNAL4 ( NM_005740.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005731.1 Homo sapiens dynein axonemal light chain 4 (DNAL4), mRNA.

Price & Availability↑

CloneID	OHu05013
Clone ID Related Accession (Same CDS sequence)	NM_005740.3 , NM_005740.2
Accession Version	NM_005740.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	dynein light chain 4, axonemal
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035366.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005740.2. ##Evidence-Data-START## Transcript exon combination :: AL035366.1, SRR3476690.696320.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142586, SAMEA2145245 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216068.9/ ENSP00000216068.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAGAAA CAGAAGGGAA GAAAGATGAG GCTGATTATA AGCGACTGCA GACCTTCCCT 
CTGGTCAGGC ACTCGGACAT GCCAGAGGAG ATGCGCGTGG AGACCATGGA GCTATGTGTC 
ACAGCCTGTG AGAAATTCTC CAACAACAAC GAGAGCGCCG CCAAGATGAT CAAAGAGACA 
ATGGACAAGA AGTTCGGCTC CTCCTGGCAC GTGGTGATCG GCGAGGGCTT TGGGTTTGAG 
ATCACCCACG AGGTGAAGAA CCTCCTCTAC CTGTACTTCG GGGGCACCCT GGCTGTGTGC 
GTCTGGAAGT GCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005731.1
CDS	216..533
Translation	MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS

Target ORF information:

RefSeq Version	NM_005740.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein axonemal light chain 4 (DNAL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005740.3

ORF Insert Sequence:

ATGGGAGAAA CAGAAGGGAA GAAAGATGAG GCTGATTATA AGCGACTGCA GACCTTCCCT 
CTGGTCAGGC ACTCGGACAT GCCAGAGGAG ATGCGCGTGG AGACCATGGA GCTATGTGTC 
ACAGCCTGTG AGAAATTCTC CAACAACAAC GAGAGCGCCG CCAAGATGAT CAAAGAGACA 
ATGGACAAGA AGTTCGGCTC CTCCTGGCAC GTGGTGATCG GCGAGGGCTT TGGGTTTGAG 
ATCACCCACG AGGTGAAGAA CCTCCTCTAC CTGTACTTCG GGGGCACCCT GGCTGTGTGC 
GTCTGGAAGT GCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNAL4 ( NM_005740.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005731.1 Homo sapiens dynein axonemal light chain 4 (DNAL4), mRNA.

Price & Availability↑

CloneID	OHu05013
Clone ID Related Accession (Same CDS sequence)	NM_005740.3 , NM_005740.2
Accession Version	NM_005740.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	dynein light chain 4, axonemal
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX473356.1, AL035366.1 and BC002968.1. This sequence is a reference standard in the RefSeqGene project. On Aug 10, 2004 this sequence version replaced NM_005740.1. ##Evidence-Data-START## Transcript exon combination :: AL035366.1, SRR1163658.208930.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142586, SAMEA2145245 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGAAA CAGAAGGGAA GAAAGATGAG GCTGATTATA AGCGACTGCA GACCTTCCCT 
CTGGTCAGGC ACTCGGACAT GCCAGAGGAG ATGCGCGTGG AGACCATGGA GCTATGTGTC 
ACAGCCTGTG AGAAATTCTC CAACAACAAC GAGAGCGCCG CCAAGATGAT CAAAGAGACA 
ATGGACAAGA AGTTCGGCTC CTCCTGGCAC GTGGTGATCG GCGAGGGCTT TGGGTTTGAG 
ATCACCCACG AGGTGAAGAA CCTCCTCTAC CTGTACTTCG GGGGCACCCT GGCTGTGTGC 
GTCTGGAAGT GCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005731.1
CDS	229..546
Translation	MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS

Target ORF information:

RefSeq Version	NM_005740.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein axonemal light chain 4 (DNAL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005740.2

ORF Insert Sequence:

ATGGGAGAAA CAGAAGGGAA GAAAGATGAG GCTGATTATA AGCGACTGCA GACCTTCCCT 
CTGGTCAGGC ACTCGGACAT GCCAGAGGAG ATGCGCGTGG AGACCATGGA GCTATGTGTC 
ACAGCCTGTG AGAAATTCTC CAACAACAAC GAGAGCGCCG CCAAGATGAT CAAAGAGACA 
ATGGACAAGA AGTTCGGCTC CTCCTGGCAC GTGGTGATCG GCGAGGGCTT TGGGTTTGAG 
ATCACCCACG AGGTGAAGAA CCTCCTCTAC CTGTACTTCG GGGGCACCCT GGCTGTGTGC 
GTCTGGAAGT GCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.
Human genetics133(11)1419-29(2014 Nov)
Ahmed I,Mittal K,Sheikh TI,Vasli N,Rafiq MA,Mikhailov A,Ohadi M,Mahmood H,Rouleau GA,Bhatti A,Ayub M,Srour M,John P,Vincent JB

Congenital mirror movements: no mutation in DNAL4 in 17 index cases.
Journal of neurology261(10)2030-1(2014 Oct)
M?neret A,Trouillard O,Vidailhet M,Depienne C,Roze E

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
PLoS genetics9(1)e1003225(2013)
Lauc G,Huffman JE,Pu?i? M,Zgaga L,Adamczyk B,Mu?ini? A,Novokmet M,Pola?ek O,Gornik O,Kri?ti? J,Keser T,Vitart V,Scheijen B,Uh HW,Molokhia M,Patrick AL,McKeigue P,Kol?i? I,Luki? IK,Swann O,van Leeuwen FN,Ruhaak LR,Houwing-Duistermaat JJ,Slagboom PE,Beekman M,de Craen AJ,Deelder AM,Zeng Q,Wang W,Hastie ND,Gyllensten U,Wilson JF,Wuhrer M,Wright AF,Rudd PM,Hayward C,Aulchenko Y,Campbell H,Rudan I

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

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DNAL4 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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