SIGLEC14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIGLEC14
Entrez Gene ID	100049587
Full Name	sialic acid binding Ig like lectin 14
General protein information	Preferred Names sialic acid binding Ig like lectin 14 Names sialic acid-binding Ig-like lectin 14 LLNLR-470E3.1 siglec-14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.41

mRNA and Protein(s)

mRNA	Protein	Name
XM_017026113.1	XP_016881602.1	sialic acid-binding Ig-like lectin 14 isoform X1
XM_017026113.2	XP_016881602.1	sialic acid-binding Ig-like lectin 14 isoform X1
NM_001098612.2	NP_001092082.1	sialic acid-binding Ig-like lectin 14 precursor
NM_001098612.1	NP_001092082.1	sialic acid-binding Ig-like lectin 14 precursor

Pathways from BioSystems

Homologies

	SIGLEC14	XP_001114886.1
Bos taurus (cattle)	LOC512863	XP_003587353.1
Pan troglodytes (chimpanzee)	SIGLEC5	XP_003316629.1
Bos taurus (cattle)	SIGLEC14	XP_002695284.3
Homo sapiens (human)	SIGLEC14	NP_001092082.1
Bos taurus (cattle)	LOC617909	XP_002683815.2

Gene Ontology
Bibliography

Related articles in PubMed

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.
Graustein AD, Horne DJ, Fong JJ, Schwarz F, Mefford HC, Peterson GJ, Wells RD, Musvosvi M, Shey M, Hanekom WA, Hatherill M, Scriba TJ, Thuong NTT, Mai NTH, Caws M, Bang ND, Dunstan SJ, Thwaites GE, Varki A, Angata T, Hawn TR
Tuberculosis (Edinburgh, Scotland)10438-45(2017 May)

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and?Siglec-14.
Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A
The EMBO journal34(22)2775-88(2015 Nov)

Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.
Ma Q, Ozel AB, Ramdas S, McGee B, Khoriaty R, Siemieniak D, Li HD, Guan Y, Brody LC, Mills JL, Molloy AM, Ginsburg D, Li JZ, Desch KC
Blood124(20)3155-64(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SIGLEC14 expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory.
Title: Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and?Siglec-14.

Genome-wide association analyses revealed common DNA variants in PLG, LPA, and near SIGLEC14 that contribute to plasma plasminogen level variation.
Title: Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.

Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.
Title: Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

Siglec-14 and its downstream signaling pathway facilitate the "infection-inflammation-exacerbation" axis of COPD disease progression
Title: Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.

The following SIGLEC14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIGLEC14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05856	NM_001098612.2 Latest version!	Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$169.50-$237.30 $339.00
OHu88096	XM_017026113.2 Latest version!	Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu88096	XM_017026113.1	Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu05856	NM_001098612.1	Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$169.50-$237.30 $339.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIGLEC14 ( NM_001098612.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001092082.1 Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), mRNA.

Price & Availability↑

CloneID	OHu05856
Clone ID Related Accession (Same CDS sequence)	NM_001098612.2 , NM_001098612.1
Accession Version	NM_001098612.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 14 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC018755.3. On Dec 4, 2019 this sequence version replaced NM_001098612.1. ##Evidence-Data-START## Transcript exon combination :: AY854038.1, AK298284.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGGTGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GAACCTCGCC 
ATCAGCATCT TCTTCAGAAA TGGCACAGGC ACAGCCCTGC GGATCCTGAG CAATGGCATG 
TCGGTGCCCA TCCAGGAGGG CCAGTCCCTG TTCCTCGCCT GCACAGTTGA CAGCAACCCC 
CCTGCCTCAC TGAGCTGGTT CCGGGAGGGA AAAGCCCTCA ATCCTTCCCA GACCTCAATG 
TCTGGGACCC TGGAGCTGCC TAACATAGGA GCTAGAGAGG GAGGGGAATT CACCTGCCGG 
GTTCAGCATC CGCTGGGCTC CCAGCACCTG TCCTTCATCC TTTCTGTGCA GAGAAGCTCC 
TCTTCCTGCA TATGTGTAAC TGAGAAACAG CAGGGCTCCT GGCCCCTCGT CCTCACCCTG 
ATCAGGGGGG CTCTCATGGG GGCTGGCTTC CTCCTCACCT ATGGCCTCAC CTGGATCTAC 
TATACCAGGT GTGGAGGCCC CCAGCAGAGC AGGGCTGAGA GGCCTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001092082.1
CDS	61..1251
Translation	MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQRSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRAERPG

Target ORF information:

RefSeq Version	NM_001098612.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098612.2

ORF Insert Sequence:

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGGTGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GAACCTCGCC 
ATCAGCATCT TCTTCAGAAA TGGCACAGGC ACAGCCCTGC GGATCCTGAG CAATGGCATG 
TCGGTGCCCA TCCAGGAGGG CCAGTCCCTG TTCCTCGCCT GCACAGTTGA CAGCAACCCC 
CCTGCCTCAC TGAGCTGGTT CCGGGAGGGA AAAGCCCTCA ATCCTTCCCA GACCTCAATG 
TCTGGGACCC TGGAGCTGCC TAACATAGGA GCTAGAGAGG GAGGGGAATT CACCTGCCGG 
GTTCAGCATC CGCTGGGCTC CCAGCACCTG TCCTTCATCC TTTCTGTGCA GAGAAGCTCC 
TCTTCCTGCA TATGTGTAAC TGAGAAACAG CAGGGCTCCT GGCCCCTCGT CCTCACCCTG 
ATCAGGGGGG CTCTCATGGG GGCTGGCTTC CTCCTCACCT ATGGCCTCAC CTGGATCTAC 
TATACCAGGT GTGGAGGCCC CCAGCAGAGC AGGGCTGAGA GGCCTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC14 ( NM_001098612.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001092082.1 Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), mRNA.

Price & Availability↑

CloneID	OHu05856
Clone ID Related Accession (Same CDS sequence)	NM_001098612.2 , NM_001098612.1
Accession Version	NM_001098612.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 14 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC428881.1, AY854038.1, AC018755.3 and CA439587.1. ##Evidence-Data-START## Transcript exon combination :: AY854038.1, AK298284.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGGTGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GAACCTCGCC 
ATCAGCATCT TCTTCAGAAA TGGCACAGGC ACAGCCCTGC GGATCCTGAG CAATGGCATG 
TCGGTGCCCA TCCAGGAGGG CCAGTCCCTG TTCCTCGCCT GCACAGTTGA CAGCAACCCC 
CCTGCCTCAC TGAGCTGGTT CCGGGAGGGA AAAGCCCTCA ATCCTTCCCA GACCTCAATG 
TCTGGGACCC TGGAGCTGCC TAACATAGGA GCTAGAGAGG GAGGGGAATT CACCTGCCGG 
GTTCAGCATC CGCTGGGCTC CCAGCACCTG TCCTTCATCC TTTCTGTGCA GAGAAGCTCC 
TCTTCCTGCA TATGTGTAAC TGAGAAACAG CAGGGCTCCT GGCCCCTCGT CCTCACCCTG 
ATCAGGGGGG CTCTCATGGG GGCTGGCTTC CTCCTCACCT ATGGCCTCAC CTGGATCTAC 
TATACCAGGT GTGGAGGCCC CCAGCAGAGC AGGGCTGAGA GGCCTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001092082.1
CDS	121..1311
Translation	MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQRSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRAERPG

Target ORF information:

RefSeq Version	NM_001098612.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098612.1

ORF Insert Sequence:

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGGTGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GAACCTCGCC 
ATCAGCATCT TCTTCAGAAA TGGCACAGGC ACAGCCCTGC GGATCCTGAG CAATGGCATG 
TCGGTGCCCA TCCAGGAGGG CCAGTCCCTG TTCCTCGCCT GCACAGTTGA CAGCAACCCC 
CCTGCCTCAC TGAGCTGGTT CCGGGAGGGA AAAGCCCTCA ATCCTTCCCA GACCTCAATG 
TCTGGGACCC TGGAGCTGCC TAACATAGGA GCTAGAGAGG GAGGGGAATT CACCTGCCGG 
GTTCAGCATC CGCTGGGCTC CCAGCACCTG TCCTTCATCC TTTCTGTGCA GAGAAGCTCC 
TCTTCCTGCA TATGTGTAAC TGAGAAACAG CAGGGCTCCT GGCCCCTCGT CCTCACCCTG 
ATCAGGGGGG CTCTCATGGG GGCTGGCTTC CTCCTCACCT ATGGCCTCAC CTGGATCTAC 
TATACCAGGT GTGGAGGCCC CCAGCAGAGC AGGGCTGAGA GGCCTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC14 ( XM_017026113.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881602.1 Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88096
Clone ID Related Accession (Same CDS sequence)	XM_017026113.1 , XM_017026113.2
Accession Version	XM_017026113.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGGTGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GAACCTCGCC 
ATCAGCATCT TCTTCAGAAA TGGCACAGGC ACAGGAAGCT CCTCTTCCTG CATATGTGTA 
ACTGAGAAAC AGCAGGGCTC CTGGCCCCTC GTCCTCACCC TGATCAGGGG GGCTCTCATG 
GGGGCTGGCT TCCTCCTCAC CTATGGCCTC ACCTGGATCT ACTATACCAG GTGTGGAGGC 
CCCCAGCAGA GCAGGGCTGA GAGGCCTGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881602.1
CDS	67..999
Translation	MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTGSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRAERPG

Target ORF information:

RefSeq Version	XM_017026113.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026113.1

ORF Insert Sequence:

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGGTGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GAACCTCGCC 
ATCAGCATCT TCTTCAGAAA TGGCACAGGC ACAGGAAGCT CCTCTTCCTG CATATGTGTA 
ACTGAGAAAC AGCAGGGCTC CTGGCCCCTC GTCCTCACCC TGATCAGGGG GGCTCTCATG 
GGGGCTGGCT TCCTCCTCAC CTATGGCCTC ACCTGGATCT ACTATACCAG GTGTGGAGGC 
CCCCAGCAGA GCAGGGCTGA GAGGCCTGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC14 ( XM_017026113.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881602.1 Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88096
Clone ID Related Accession (Same CDS sequence)	XM_017026113.1 , XM_017026113.2
Accession Version	XM_017026113.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017026113.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGGTGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GAACCTCGCC 
ATCAGCATCT TCTTCAGAAA TGGCACAGGC ACAGGAAGCT CCTCTTCCTG CATATGTGTA 
ACTGAGAAAC AGCAGGGCTC CTGGCCCCTC GTCCTCACCC TGATCAGGGG GGCTCTCATG 
GGGGCTGGCT TCCTCCTCAC CTATGGCCTC ACCTGGATCT ACTATACCAG GTGTGGAGGC 
CCCCAGCAGA GCAGGGCTGA GAGGCCTGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881602.1
CDS	94..1026
Translation	MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTGSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRAERPG

Target ORF information:

RefSeq Version	XM_017026113.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026113.2

ORF Insert Sequence:

ATGCTGCCCC TGCTGCTGCT GCCCCTGCTG TGGGGGGGGT CCCTGCAGGA GAAGCCAGTG 
TACGAGCTGC AAGTGCAGAA GTCGGTGACG GTGCAGGAGG GCCTGTGCGT CCTTGTGCCC 
TGCTCCTTCT CTTACCCCTG GAGATCCTGG TATTCCTCTC CCCCACTCTA CGTCTACTGG 
TTCCGGGACG GGGAGATCCC ATACTACGCT GAGGTTGTGG CCACAAACAA CCCAGACAGA 
AGAGTGAAGC CAGAGACCCA GGGCCGATTC CGCCTCCTTG GGGATGTCCA GAAGAAGAAC 
TGCTCCCTGA GCATCGGAGA TGCCAGAATG GAGGACACGG GAAGCTATTT CTTCCGCGTG 
GAGAGAGGAA GGGATGTAAA ATATAGCTAC CAACAGAATA AGCTGAACTT GGAGGTGACA 
GCCCTGATAG AGAAACCCGA CATCCACTTT CTGGAGCCTC TGGAGTCCGG CCGCCCCACA 
AGGCTGAGCT GCAGCCTTCC AGGATCCTGT GAAGCGGGAC CACCTCTCAC ATTCTCCTGG 
ACGGGGAATG CCCTCAGCCC CCTGGACCCC GAGACCACCC GCTCCTCGGA GCTCACCCTC 
ACCCCCAGGC CCGAGGACCA TGGCACCAAC CTCACCTGTC AGGTGAAACG CCAAGGAGCT 
CAGGTGACCA CGGAGAGAAC TGTCCAGCTC AATGTCTCCT ATGCTCCACA GAACCTCGCC 
ATCAGCATCT TCTTCAGAAA TGGCACAGGC ACAGGAAGCT CCTCTTCCTG CATATGTGTA 
ACTGAGAAAC AGCAGGGCTC CTGGCCCCTC GTCCTCACCC TGATCAGGGG GGCTCTCATG 
GGGGCTGGCT TCCTCCTCAC CTATGGCCTC ACCTGGATCT ACTATACCAG GTGTGGAGGC 
CCCCAGCAGA GCAGGGCTGA GAGGCCTGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.
Tuberculosis (Edinburgh, Scotland)10438-45(2017 May)
Graustein AD,Horne DJ,Fong JJ,Schwarz F,Mefford HC,Peterson GJ,Wells RD,Musvosvi M,Shey M,Hanekom WA,Hatherill M,Scriba TJ,Thuong NTT,Mai NTH,Caws M,Bang ND,Dunstan SJ,Thwaites GE,Varki A,Angata T,Hawn TR

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and?Siglec-14.
The EMBO journal34(22)2775-88(2015 Nov)
Fong JJ,Sreedhara K,Deng L,Varki NM,Angata T,Liu Q,Nizet V,Varki A

Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.
Blood124(20)3155-64(2014 Nov)
Ma Q,Ozel AB,Ramdas S,McGee B,Khoriaty R,Siemieniak D,Li HD,Guan Y,Brody LC,Mills JL,Molloy AM,Ginsburg D,Li JZ,Desch KC

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SIGLEC14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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