FAM213A cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	FAM213A
Entrez Gene ID	423625
Full Name	selenoprotein U
Synonyms	C10ORF58,C6H10orf58,FAM213A,PAMM
General protein information	Preferred Names selenoprotein U Names selenoprotein U UPF0765 protein C10orf58 homolog family with sequence similarity 213 member A peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes peroxiredoxin-like 2 activated in M-CSF stimulated monocytes redox-regulatory protein FAM213A redox-regulatory protein PAMM
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	The protein encoded by this gene belongs to a subfamily of FAM213A/selenoprotein U (SelU), within a peroxiredoxin-like FAM213 superfamily. SelU is unusual in that it has restricted phylogenetic distribution in vertebrates, such as in chicken and fish. Other vertebrate members of this family, including mammals, contain cysteine-containing homologues. SelU proteins contain UxxC (U for selenocysteine and C for cysteine) motif in place of the catalytic CxxC motif found in cysteine-containing homologues. The latter function as redox regulatory proteins, suggesting a similar role for SelU proteins. Like majority of selenoproteins, SelU contains a single selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001193518.1	NP_001180447.1	selenoprotein U
NM_001193519.2	NP_001180448.1	selenoprotein U

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fam213a	NP_081740.2
Xenopus tropicalis (tropical clawed frog)	c10orf58	NP_001090691.1
Canis lupus familiaris (dog)	FAM213A	XP_005619151.1
Rattus norvegicus (Norway rat)	RGD1309676	NP_001014162.1
Gallus gallus (chicken)	C10ORF58	NP_001180447.1
Caenorhabditis elegans (roundworm)	R53.5	NP_496154.1
Pan troglodytes (chimpanzee)	FAM213A	XP_001153100.1
	LOC706244	XP_002805706.1
Danio rerio (zebrafish)	fam213aa	NP_001180454.1
Homo sapiens (human)	FAM213A	NP_115709.3
Bos taurus (cattle)	FAM213A	NP_001029771.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Carre W, Wang X, Porter TE, Nys Y, Tang J, Bernberg E, Morgan R, Burnside J, Aggrey SE, Simon J, Cogburn LA
Physiological genomics25(3)514-24(2006 May)

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM
Genome biology6(1)R6(2005)

Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution.
Castellano S, Novoselov SV, Kryukov GV, Lescure A, Blanco E, Krol A, Gladyshev VN, Guig? R
EMBO reports5(1)71-7(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FAM213A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FAM213A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00890	NM_001193518.1 Latest version!	Gallus gallus family with sequence similarity 213 member A (FAM213A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OGa00890	NM_001193519.2 Latest version!	Gallus gallus family with sequence similarity 213 member A (FAM213A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FAM213A ( NM_001193518.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001180447.1 Gallus gallus family with sequence similarity 213 member A (FAM213A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OGa00890
Clone ID Related Accession (Same CDS sequence)	NM_001193518.1 , NM_001193519.2
Accession Version	NM_001193518.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Gallus gallus(chicken)
Product	selenoprotein U
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU489653.1, BU119844.1, BU422656.1, BU320289.1, AADN05000334.1 and AJ727414.1. Transcript Variant: This variant (1) represents the longer transcript derived from an upstream promoter. Variants 1 and 2 encode the same selenoprotein. ##Evidence-Data-START## Transcript exon combination :: HAEL01003904.1, HAEK01110728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2201377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 14710190 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTTTCC TACCTGACTT TGGGATCTTC ACCATGGGCA TGTGGTCGGT TGGTCTCGGA 
GCCGTTGGCG CAGCCATAAC AGGGATTGTG CTTGCCAACA CTGACTTATT TTTGTCCAAG 
CCAGAAAAAG CAACGCTGGA ATTTTTGGAG GCGATAGAGC TAAAAACTTT GGGATCAGAA 
CCGAGAACAT TCAAAGCAAG TGAACTGTGG AAGAAGAATG GTGCAGTGAT CATGGCTGTG 
CGAAGACCTG GGTGATTTTT GTGCAGAGAG GAGGCTTCTG AGCTTTCCTC TCTGAAACCT 
CAGCTGTCCA AGCTGGGTGT TCCTCTCTAT GCTGTTGTGA AAGAGAAGAT AGGGACCGAA 
GTGGAGGATT TTCAGCATTA TTTCCAAGGA GAAATCTTTC TAGATGAAAA GAGAAGCTTC 
TATGGCCCAC GCAAGCGAAA AATGATGCTT TCAGGCTTCT TCCGCATTGG AGTCTGGCAA 
AATTTCTTCC GTGCTTGGAA AAATGGTTAT AGTGGCAACC TGGAAGGAGA AGGGTTCACC 
CTGGGAGGAG TGTATGTGAT TGGAGCAGGA AGACAGGGTG TTCTATTGGA GCATCGTGAG 
AAAGAATTTG GTGACAAAGT CAGCCTTCCA TCTGTCCTTG AAGCTGCCGA GAAGATAAAG 
CCACAGGCTT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001180447.1
CDS	131..805
Translation	MSFLPDFGIFTMGMWSVGLGAVGAAITGIVLANTDLFLSKPEKATLEFLEAIELKTLGSEPRTFKASELWKKNGAVIMAVRRPG*FLCREEASELSSLKPQLSKLGVPLYAVVKEKIGTEVEDFQHYFQGEIFLDEKRSFYGPRKRKMMLSGFFRIGVWQNFFRAWKNGYSGNLEGEGFTLGGVYVIGAGRQGVLLEHREKEFGDKVSLPSVLEAAEKIKPQAS

Target ORF information:

RefSeq Version	NM_001193518.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus family with sequence similarity 213 member A (FAM213A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001193518.1

ORF Insert Sequence:

ATGTCTTTCC TACCTGACTT TGGGATCTTC ACCATGGGCA TGTGGTCGGT TGGTCTCGGA 
GCCGTTGGCG CAGCCATAAC AGGGATTGTG CTTGCCAACA CTGACTTATT TTTGTCCAAG 
CCAGAAAAAG CAACGCTGGA ATTTTTGGAG GCGATAGAGC TAAAAACTTT GGGATCAGAA 
CCGAGAACAT TCAAAGCAAG TGAACTGTGG AAGAAGAATG GTGCAGTGAT CATGGCTGTG 
CGAAGACCTG GGTGATTTTT GTGCAGAGAG GAGGCTTCTG AGCTTTCCTC TCTGAAACCT 
CAGCTGTCCA AGCTGGGTGT TCCTCTCTAT GCTGTTGTGA AAGAGAAGAT AGGGACCGAA 
GTGGAGGATT TTCAGCATTA TTTCCAAGGA GAAATCTTTC TAGATGAAAA GAGAAGCTTC 
TATGGCCCAC GCAAGCGAAA AATGATGCTT TCAGGCTTCT TCCGCATTGG AGTCTGGCAA 
AATTTCTTCC GTGCTTGGAA AAATGGTTAT AGTGGCAACC TGGAAGGAGA AGGGTTCACC 
CTGGGAGGAG TGTATGTGAT TGGAGCAGGA AGACAGGGTG TTCTATTGGA GCATCGTGAG 
AAAGAATTTG GTGACAAAGT CAGCCTTCCA TCTGTCCTTG AAGCTGCCGA GAAGATAAAG 
CCACAGGCTT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM213A ( NM_001193519.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001180448.1 Gallus gallus family with sequence similarity 213 member A (FAM213A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OGa00890
Clone ID Related Accession (Same CDS sequence)	NM_001193518.1 , NM_001193519.2
Accession Version	NM_001193519.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Gallus gallus(chicken)
Product	selenoprotein U
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ720950.1, BM491988.1, BU119844.1, BU422656.1, BU320289.1, AADN05000334.1 and AJ727414.1. On Feb 10, 2016 this sequence version replaced NM_001193519.1. Transcript Variant: This variant (2) contains an alternate 5' non-coding exon derived from a downstream promoter, compared to variant 1. Variants 1 and 2 encode the same selenoprotein. ##Evidence-Data-START## Transcript exon combination :: AJ720950.1, ERR2365563.203314.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTTTCC TACCTGACTT TGGGATCTTC ACCATGGGCA TGTGGTCGGT TGGTCTCGGA 
GCCGTTGGCG CAGCCATAAC AGGGATTGTG CTTGCCAACA CTGACTTATT TTTGTCCAAG 
CCAGAAAAAG CAACGCTGGA ATTTTTGGAG GCGATAGAGC TAAAAACTTT GGGATCAGAA 
CCGAGAACAT TCAAAGCAAG TGAACTGTGG AAGAAGAATG GTGCAGTGAT CATGGCTGTG 
CGAAGACCTG GGTGATTTTT GTGCAGAGAG GAGGCTTCTG AGCTTTCCTC TCTGAAACCT 
CAGCTGTCCA AGCTGGGTGT TCCTCTCTAT GCTGTTGTGA AAGAGAAGAT AGGGACCGAA 
GTGGAGGATT TTCAGCATTA TTTCCAAGGA GAAATCTTTC TAGATGAAAA GAGAAGCTTC 
TATGGCCCAC GCAAGCGAAA AATGATGCTT TCAGGCTTCT TCCGCATTGG AGTCTGGCAA 
AATTTCTTCC GTGCTTGGAA AAATGGTTAT AGTGGCAACC TGGAAGGAGA AGGGTTCACC 
CTGGGAGGAG TGTATGTGAT TGGAGCAGGA AGACAGGGTG TTCTATTGGA GCATCGTGAG 
AAAGAATTTG GTGACAAAGT CAGCCTTCCA TCTGTCCTTG AAGCTGCCGA GAAGATAAAG 
CCACAGGCTT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001180448.1
CDS	122..796
Translation	MSFLPDFGIFTMGMWSVGLGAVGAAITGIVLANTDLFLSKPEKATLEFLEAIELKTLGSEPRTFKASELWKKNGAVIMAVRRPG*FLCREEASELSSLKPQLSKLGVPLYAVVKEKIGTEVEDFQHYFQGEIFLDEKRSFYGPRKRKMMLSGFFRIGVWQNFFRAWKNGYSGNLEGEGFTLGGVYVIGAGRQGVLLEHREKEFGDKVSLPSVLEAAEKIKPQAS

Target ORF information:

RefSeq Version	NM_001193519.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus family with sequence similarity 213 member A (FAM213A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001193519.2

ORF Insert Sequence:

ATGTCTTTCC TACCTGACTT TGGGATCTTC ACCATGGGCA TGTGGTCGGT TGGTCTCGGA 
GCCGTTGGCG CAGCCATAAC AGGGATTGTG CTTGCCAACA CTGACTTATT TTTGTCCAAG 
CCAGAAAAAG CAACGCTGGA ATTTTTGGAG GCGATAGAGC TAAAAACTTT GGGATCAGAA 
CCGAGAACAT TCAAAGCAAG TGAACTGTGG AAGAAGAATG GTGCAGTGAT CATGGCTGTG 
CGAAGACCTG GGTGATTTTT GTGCAGAGAG GAGGCTTCTG AGCTTTCCTC TCTGAAACCT 
CAGCTGTCCA AGCTGGGTGT TCCTCTCTAT GCTGTTGTGA AAGAGAAGAT AGGGACCGAA 
GTGGAGGATT TTCAGCATTA TTTCCAAGGA GAAATCTTTC TAGATGAAAA GAGAAGCTTC 
TATGGCCCAC GCAAGCGAAA AATGATGCTT TCAGGCTTCT TCCGCATTGG AGTCTGGCAA 
AATTTCTTCC GTGCTTGGAA AAATGGTTAT AGTGGCAACC TGGAAGGAGA AGGGTTCACC 
CTGGGAGGAG TGTATGTGAT TGGAGCAGGA AGACAGGGTG TTCTATTGGA GCATCGTGAG 
AAAGAATTTG GTGACAAAGT CAGCCTTCCA TCTGTCCTTG AAGCTGCCGA GAAGATAAAG 
CCACAGGCTT CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Physiological genomics25(3)514-24(2006 May)
Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Genome biology6(1)R6(2005)
Caldwell RB,Kierzek AM,Arakawa H,Bezzubov Y,Zaim J,Fiedler P,Kutter S,Blagodatski A,Kostovska D,Koter M,Plachy J,Carninci P,Hayashizaki Y,Buerstedde JM

Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution.
EMBO reports5(1)71-7(2004 Jan)
Castellano S,Novoselov SV,Kryukov GV,Lescure A,Blanco E,Krol A,Gladyshev VN,Guig? R

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FAM213A cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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