STK11 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	STK11
Entrez Gene ID	420105
Full Name	serine/threonine kinase 11
Synonyms	LKB1
General protein information	Preferred Names serine/threonine kinase 11 Names serine/threonine-protein kinase STK11 liver kinase B1 homolog serine/threonine-protein kinase 11 serine/threonine-protein kinase LKB1
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001045833.1	NP_001039298.1	serine/threonine-protein kinase STK11
XM_015299932.2	XP_015155418.1	serine/threonine-protein kinase STK11 isoform X1
XM_015299932.1	XP_015155418.1	serine/threonine-protein kinase STK11 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	STK11	NP_000446.1
Pan troglodytes (chimpanzee)	STK11	XP_524028.2
Canis lupus familiaris (dog)	STK11	XP_542206.2
Mus musculus (house mouse)	Stk11	NP_035622.1
Gallus gallus (chicken)	STK11	NP_001039298.1
Xenopus tropicalis (tropical clawed frog)	stk11	NP_001016533.1
Danio rerio (zebrafish)	stk11	NP_001017839.1
Caenorhabditis elegans (roundworm)	par-4	NP_001256779.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003158	XP_312848.5
	STK11	XP_001093806.1
Rattus norvegicus (Norway rat)	Stk11	NP_001101539.1

Gene Ontology
Bibliography

Related articles in PubMed

LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development.
Creuzet SE, Viallet JP, Ghawitian M, Torch S, Th?lu J, Alrajeh M, Radu AG, Bouvard D, Costagliola F, Borgne ML, Buchet-Poyau K, Aznar N, Buschlen S, Hosoya H, Thibert C, Billaud M
Developmental biology418(2)283-96(2016 10)

Fasting alters protein expression of AMP-activated protein kinase in the hypothalamus of broiler chicks (Gallus gallus domesticus).
Song Z, Liu L, Yue Y, Jiao H, Lin H, Sheikhahmadi A, Everaert N, Decuypere E, Buyse J
General and comparative endocrinology178(3)546-55(2012 Sep)

In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase.
Bl?ttler SM, Rencurel F, Kaufmann MR, Meyer UA
Proceedings of the National Academy of Sciences of the United States of America104(3)1045-50(2007 Jan)

Characterization of the AMP-activated protein kinase pathway in chickens.
Proszkowiec-Weglarz M, Richards MP, Ramachandran R, McMurtry JP
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology143(1)92-106(2006 Jan)

Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.
Lin-Marq N, Borel C, Antonarakis SE
Molecular genetics and genomics : MGG273(2)184-96(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

silencing of the LKB1 tumor suppressor affects the delamination of pre-migratory cephalic neural crest cells from the neural primordium as well as their polarization and survival, thus resulting in severe facial and brain defects
Title: LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development.

The following STK11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STK11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OGa27295	NM_001045833.1 Latest version!	Gallus gallus serine/threonine kinase 11 (STK11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OGa47234	XM_015299932.2 Latest version!	Gallus gallus serine/threonine kinase 11 (STK11), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
View Old Accession Versions >>
OGa47234	XM_015299932.1	Gallus gallus serine/threonine kinase 11 (STK11), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

STK11 ( NM_001045833.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001039298.1 Gallus gallus serine/threonine kinase 11 (STK11), mRNA.

Price & Availability↑

CloneID	OGa27295
Clone ID Related Accession (Same CDS sequence)	NM_001045833.1
Accession Version	NM_001045833.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Gallus gallus(chicken)
Product	serine/threonine-protein kinase STK11
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ864976.1. On or before Sep 5, 2006 this sequence version replaced XM_418226.1, XM_418227.1. ##Evidence-Data-START## Transcript exon combination :: DQ864976.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATATGC AGGAGTCTCA GCAGCTGGGT ATGTTTGGAG AGAGCGAGCT GATGTCTGTG 
GGGATGGACA CTTTTATCCA TCGCATCGAC TCTACTGAAG TCATCTACCA GCCACGGCGG 
AAAAGGGCCA AGCTCATTGG CAAGTACTTG ATGGGAGACT TGCTTGGAGA AGGATCTTAT 
GGCAAAGTCA AGGAGATGCT GGACTCTGAA ACCCTCTGTA GGAGAGCTGT GAAGATTCTG 
AAGAAGAAGA AGCTACGCAG AATTCCCAAC GGGGAGGCAA ATGTGAAAAA GGAAATTCAG 
CTCCTGCGAC GACTGCGGCA CAAAAATGTT ATCCAGTTGG TAGATGTGTT ATACAATGAA 
GAGAAGCAGA AAATGTATAT GGTGATGGAG TACTGTGTGT GTGGGATGCA GGAGATGCTG 
GACAGTGTCC CAGAAAAGAG GTTTCCAGTT TTTCAGGCTC ATGGGTACTT CTGTCAGCTT 
ATAGATGGCT TAGAATACTT GCACAGCCAA GGGATTGTCC ACAAGGATAT AAAACCTGGG 
AACCTCCTGC TGACCACCAA TGGGACGCTG AAAATATCTG ATTTAGGGGT AGCAGAGGCA 
TTGCATCCAT TTGCAGAGGA TGACACGTGC CGAACGAGCC AAGGGTCGCC AGCATTCCAG 
CCACCAGAAA TTGCCAATGG CCTTGATACC TTTTCAGGCT TTAAAGTAGA CATCTGGTCC 
GCAGGGGTCA CACTATACAA CATTACAACG GGTCTATACC CCTTTGAAGG GGATAATATA 
TATAAGTTAT TTGAAAACAT CGGGAAAGGT GACTTCACAA TTCCAGAGGA TTGTGGTCCT 
CCACTCTCAG ACCTATTGAG AGGGATGCTT GAATACGACC CAGCCAAGAG ATTTTCAATA 
CAGCAGATAA GGCAGCACAA TTGGTTTCGT AAGAAACATG CTCAGGCAGA GACTCTGGTG 
CCCATACCTC CTAGCCCAGA AACAAAGGAC AAGTGGAGAA GTATGACGGC GGTGCCTTAT 
CTGGAAGATC TGCATGGCTA CAATGAGGAC GAAGATGATG ACTTGTATGA CATTGAAGAT 
GATATCATCT ACACTCAGGA CTTCACAGTA CCAGGACAGG TGCCTGAGGA GGAGGCAGGG 
CAGAACGGGC AGAGCCGTGG CCGGGGGCTG CCCAAGGCCA TCTGCATGAA CGGGACGGAG 
CCGGGACAGC TGAGCACCAA ATCCAAGGCG GAGCGCCGGG CCAGCGCCTC CTCCAACCCC 
TCGCGCAAGG CCTGCTCGGC CAGCAGCAAG ATCCGCAAGC TCTCCACCTG CAAGCAGCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001039298.1
CDS	318..1640
Translation	MDMQESQQLGMFGESELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEMLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVFQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAEDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDFTIPEDCGPPLSDLLRGMLEYDPAKRFSIQQIRQHNWFRKKHAQAETLVPIPPSPETKDKWRSMTAVPYLEDLHGYNEDEDDDLYDIEDDIIYTQDFTVPGQVPEEEAGQNGQSRGRGLPKAICMNGTEPGQLSTKSKAERRASASSNPSRKACSASSKIRKLSTCKQQ

Target ORF information:

RefSeq Version	NM_001045833.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus serine/threonine kinase 11 (STK11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001045833.1

ORF Insert Sequence:

ATGGATATGC AGGAGTCTCA GCAGCTGGGT ATGTTTGGAG AGAGCGAGCT GATGTCTGTG 
GGGATGGACA CTTTTATCCA TCGCATCGAC TCTACTGAAG TCATCTACCA GCCACGGCGG 
AAAAGGGCCA AGCTCATTGG CAAGTACTTG ATGGGAGACT TGCTTGGAGA AGGATCTTAT 
GGCAAAGTCA AGGAGATGCT GGACTCTGAA ACCCTCTGTA GGAGAGCTGT GAAGATTCTG 
AAGAAGAAGA AGCTACGCAG AATTCCCAAC GGGGAGGCAA ATGTGAAAAA GGAAATTCAG 
CTCCTGCGAC GACTGCGGCA CAAAAATGTT ATCCAGTTGG TAGATGTGTT ATACAATGAA 
GAGAAGCAGA AAATGTATAT GGTGATGGAG TACTGTGTGT GTGGGATGCA GGAGATGCTG 
GACAGTGTCC CAGAAAAGAG GTTTCCAGTT TTTCAGGCTC ATGGGTACTT CTGTCAGCTT 
ATAGATGGCT TAGAATACTT GCACAGCCAA GGGATTGTCC ACAAGGATAT AAAACCTGGG 
AACCTCCTGC TGACCACCAA TGGGACGCTG AAAATATCTG ATTTAGGGGT AGCAGAGGCA 
TTGCATCCAT TTGCAGAGGA TGACACGTGC CGAACGAGCC AAGGGTCGCC AGCATTCCAG 
CCACCAGAAA TTGCCAATGG CCTTGATACC TTTTCAGGCT TTAAAGTAGA CATCTGGTCC 
GCAGGGGTCA CACTATACAA CATTACAACG GGTCTATACC CCTTTGAAGG GGATAATATA 
TATAAGTTAT TTGAAAACAT CGGGAAAGGT GACTTCACAA TTCCAGAGGA TTGTGGTCCT 
CCACTCTCAG ACCTATTGAG AGGGATGCTT GAATACGACC CAGCCAAGAG ATTTTCAATA 
CAGCAGATAA GGCAGCACAA TTGGTTTCGT AAGAAACATG CTCAGGCAGA GACTCTGGTG 
CCCATACCTC CTAGCCCAGA AACAAAGGAC AAGTGGAGAA GTATGACGGC GGTGCCTTAT 
CTGGAAGATC TGCATGGCTA CAATGAGGAC GAAGATGATG ACTTGTATGA CATTGAAGAT 
GATATCATCT ACACTCAGGA CTTCACAGTA CCAGGACAGG TGCCTGAGGA GGAGGCAGGG 
CAGAACGGGC AGAGCCGTGG CCGGGGGCTG CCCAAGGCCA TCTGCATGAA CGGGACGGAG 
CCGGGACAGC TGAGCACCAA ATCCAAGGCG GAGCGCCGGG CCAGCGCCTC CTCCAACCCC 
TCGCGCAAGG CCTGCTCGGC CAGCAGCAAG ATCCGCAAGC TCTCCACCTG CAAGCAGCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STK11 ( XM_015299932.2 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015155418.1 Gallus gallus serine/threonine kinase 11 (STK11), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa47234
Clone ID Related Accession (Same CDS sequence)	XM_015299932.2 , XM_015299932.1
Accession Version	XM_015299932.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-16
Organism	Gallus gallus(chicken)
Product	serine/threonine-protein kinase STK11 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006115.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015299932.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATATGC AGGAGTCTCA GCAGCTGGGT ATGTTTGGAG AGAGCGAGCT GATGTCTGTG 
GGGATGGACA CTTTTATCCA TCGCATCGAC TCTACTGAAG TCATCTACCA GCCACGGCGG 
AAAAGGGCCA AGCTCATTGG CAAGTACTTG ATGGGAGACT TGCTTGGAGA AGGATCTTAT 
GGCAAAGTCA AGGAGATGCT GGACTCTGAA ACCCTCTGTA GGAGAGCTGT GAAGATTCTG 
AAGAAGAAGA AGCTACGCAG AATTCCCAAC GGGGAGGCAA ATGTGAAAAA GGAAATTCAG 
CTCCTGCGAC GACTGCGGCA CAAAAATGTT ATCCAGTTGG TAGATGTGTT ATACAATGAA 
GAGAAGCAGA AAATGTATAT GGTGATGGAG TACTGTGTGT GTGGGATGCA GGAGATGCTG 
GACAGTGTCC CAGAAAAGAG GTTTCCAGTT TTTCAGGCTC ATGGGTACTT CTGTCAGCTT 
ATAGATGGCT TAGAATACTT GCACAGCCAA GGGATTGTCC ACAAGGATAT AAAACCTGGG 
AACCTCCTGC TGACCACCAA TGGGACGCTG AAAATATCTG ATTTAGGGGT AGCAGAGGCA 
TTGCATCCAT TTGCAGAGGA TGACACGTGC CGAACGAGCC AAGGGTCGCC AGCATTCCAG 
CCACCAGAAA TTGCCAATGG CCTTGATACC TTTTCAGGCT TTAAAGTAGA CATCTGGTCC 
GCAGGGGTCA CACTATACAA CATTACAACG GGTCTATACC CCTTTGAAGG GGATAATATA 
TATAAGTTAT TTGAAAACAT CGGGAAAGGT GACTTCACAA TTCCAGAGGA TTGTGGTCCT 
CCACTCTCAG ACCTATTGAG AGGGATGCTT GAATACGACC CAGCCAAGAG ATTTTCAATA 
CAGCAGATAA GGCAGCACAA TTGGTTTCGT AAGAAACATG CTCAGGCAGA GACTCTGGTG 
CCCATACCTC CTAGCCCAGA AACAAAGGAC AAGTGGAGAA GTATGACGGC GGTGCCTTAT 
CTGGAAGATC TGCATGGCTA CAATGAGGAC GAAGATGATG ACTTGTATGA CATTGAAGAT 
GATATCATCT ACACTCAGGA CTTCACAGTA CCAGCTGCAG AGGAGGAAGC TGAGGCAGGG 
CGTAGAGGAG AGAGCGGAGC GCTGGGAAGC CGTGACAAGC TGTGTGCAGG AGGAAGCTGT 
GCTCCCATTG GAAAAAGGCA TAGAAGAGGA GTGAAGGTTA GCCTAGGCCC CGGAGCACTG 
CCCTCTCAGG CTCCCAGTGA CCTGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015155418.1
CDS	400..1689
Translation	MDMQESQQLGMFGESELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEMLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVFQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAEDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDFTIPEDCGPPLSDLLRGMLEYDPAKRFSIQQIRQHNWFRKKHAQAETLVPIPPSPETKDKWRSMTAVPYLEDLHGYNEDEDDDLYDIEDDIIYTQDFTVPAAEEEAEAGRRGESGALGSRDKLCAGGSCAPIGKRHRRGVKVSLGPGALPSQAPSDLT

Target ORF information:

RefSeq Version	XM_015299932.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus serine/threonine kinase 11 (STK11), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015299932.2

ORF Insert Sequence:

ATGGATATGC AGGAGTCTCA GCAGCTGGGT ATGTTTGGAG AGAGCGAGCT GATGTCTGTG 
GGGATGGACA CTTTTATCCA TCGCATCGAC TCTACTGAAG TCATCTACCA GCCACGGCGG 
AAAAGGGCCA AGCTCATTGG CAAGTACTTG ATGGGAGACT TGCTTGGAGA AGGATCTTAT 
GGCAAAGTCA AGGAGATGCT GGACTCTGAA ACCCTCTGTA GGAGAGCTGT GAAGATTCTG 
AAGAAGAAGA AGCTACGCAG AATTCCCAAC GGGGAGGCAA ATGTGAAAAA GGAAATTCAG 
CTCCTGCGAC GACTGCGGCA CAAAAATGTT ATCCAGTTGG TAGATGTGTT ATACAATGAA 
GAGAAGCAGA AAATGTATAT GGTGATGGAG TACTGTGTGT GTGGGATGCA GGAGATGCTG 
GACAGTGTCC CAGAAAAGAG GTTTCCAGTT TTTCAGGCTC ATGGGTACTT CTGTCAGCTT 
ATAGATGGCT TAGAATACTT GCACAGCCAA GGGATTGTCC ACAAGGATAT AAAACCTGGG 
AACCTCCTGC TGACCACCAA TGGGACGCTG AAAATATCTG ATTTAGGGGT AGCAGAGGCA 
TTGCATCCAT TTGCAGAGGA TGACACGTGC CGAACGAGCC AAGGGTCGCC AGCATTCCAG 
CCACCAGAAA TTGCCAATGG CCTTGATACC TTTTCAGGCT TTAAAGTAGA CATCTGGTCC 
GCAGGGGTCA CACTATACAA CATTACAACG GGTCTATACC CCTTTGAAGG GGATAATATA 
TATAAGTTAT TTGAAAACAT CGGGAAAGGT GACTTCACAA TTCCAGAGGA TTGTGGTCCT 
CCACTCTCAG ACCTATTGAG AGGGATGCTT GAATACGACC CAGCCAAGAG ATTTTCAATA 
CAGCAGATAA GGCAGCACAA TTGGTTTCGT AAGAAACATG CTCAGGCAGA GACTCTGGTG 
CCCATACCTC CTAGCCCAGA AACAAAGGAC AAGTGGAGAA GTATGACGGC GGTGCCTTAT 
CTGGAAGATC TGCATGGCTA CAATGAGGAC GAAGATGATG ACTTGTATGA CATTGAAGAT 
GATATCATCT ACACTCAGGA CTTCACAGTA CCAGCTGCAG AGGAGGAAGC TGAGGCAGGG 
CGTAGAGGAG AGAGCGGAGC GCTGGGAAGC CGTGACAAGC TGTGTGCAGG AGGAAGCTGT 
GCTCCCATTG GAAAAAGGCA TAGAAGAGGA GTGAAGGTTA GCCTAGGCCC CGGAGCACTG 
CCCTCTCAGG CTCCCAGTGA CCTGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STK11 ( XM_015299932.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015155418.1 Gallus gallus serine/threonine kinase 11 (STK11), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa47234
Clone ID Related Accession (Same CDS sequence)	XM_015299932.2 , XM_015299932.1
Accession Version	XM_015299932.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-03
Organism	Gallus gallus(chicken)
Product	serine/threonine-protein kinase STK11 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_456054.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATATGC AGGAGTCTCA GCAGCTGGGT ATGTTTGGAG AGAGCGAGCT GATGTCTGTG 
GGGATGGACA CTTTTATCCA TCGCATCGAC TCTACTGAAG TCATCTACCA GCCACGGCGG 
AAAAGGGCCA AGCTCATTGG CAAGTACTTG ATGGGAGACT TGCTTGGAGA AGGATCTTAT 
GGCAAAGTCA AGGAGATGCT GGACTCTGAA ACCCTCTGTA GGAGAGCTGT GAAGATTCTG 
AAGAAGAAGA AGCTACGCAG AATTCCCAAC GGGGAGGCAA ATGTGAAAAA GGAAATTCAG 
CTCCTGCGAC GACTGCGGCA CAAAAATGTT ATCCAGTTGG TAGATGTGTT ATACAATGAA 
GAGAAGCAGA AAATGTATAT GGTGATGGAG TACTGTGTGT GTGGGATGCA GGAGATGCTG 
GACAGTGTCC CAGAAAAGAG GTTTCCAGTT TTTCAGGCTC ATGGGTACTT CTGTCAGCTT 
ATAGATGGCT TAGAATACTT GCACAGCCAA GGGATTGTCC ACAAGGATAT AAAACCTGGG 
AACCTCCTGC TGACCACCAA TGGGACGCTG AAAATATCTG ATTTAGGGGT AGCAGAGGCA 
TTGCATCCAT TTGCAGAGGA TGACACGTGC CGAACGAGCC AAGGGTCGCC AGCATTCCAG 
CCACCAGAAA TTGCCAATGG CCTTGATACC TTTTCAGGCT TTAAAGTAGA CATCTGGTCC 
GCAGGGGTCA CACTATACAA CATTACAACG GGTCTATACC CCTTTGAAGG GGATAATATA 
TATAAGTTAT TTGAAAACAT CGGGAAAGGT GACTTCACAA TTCCAGAGGA TTGTGGTCCT 
CCACTCTCAG ACCTATTGAG AGGGATGCTT GAATACGACC CAGCCAAGAG ATTTTCAATA 
CAGCAGATAA GGCAGCACAA TTGGTTTCGT AAGAAACATG CTCAGGCAGA GACTCTGGTG 
CCCATACCTC CTAGCCCAGA AACAAAGGAC AAGTGGAGAA GTATGACGGC GGTGCCTTAT 
CTGGAAGATC TGCATGGCTA CAATGAGGAC GAAGATGATG ACTTGTATGA CATTGAAGAT 
GATATCATCT ACACTCAGGA CTTCACAGTA CCAGCTGCAG AGGAGGAAGC TGAGGCAGGG 
CGTAGAGGAG AGAGCGGAGC GCTGGGAAGC CGTGACAAGC TGTGTGCAGG AGGAAGCTGT 
GCTCCCATTG GAAAAAGGCA TAGAAGAGGA GTGAAGGTTA GCCTAGGCCC CGGAGCACTG 
CCCTCTCAGG CTCCCAGTGA CCTGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015155418.1
CDS	1318..2607
Translation	MDMQESQQLGMFGESELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEMLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVFQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAEDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDFTIPEDCGPPLSDLLRGMLEYDPAKRFSIQQIRQHNWFRKKHAQAETLVPIPPSPETKDKWRSMTAVPYLEDLHGYNEDEDDDLYDIEDDIIYTQDFTVPAAEEEAEAGRRGESGALGSRDKLCAGGSCAPIGKRHRRGVKVSLGPGALPSQAPSDLT

Target ORF information:

RefSeq Version	XM_015299932.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus serine/threonine kinase 11 (STK11), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015299932.1

ORF Insert Sequence:

ATGGATATGC AGGAGTCTCA GCAGCTGGGT ATGTTTGGAG AGAGCGAGCT GATGTCTGTG 
GGGATGGACA CTTTTATCCA TCGCATCGAC TCTACTGAAG TCATCTACCA GCCACGGCGG 
AAAAGGGCCA AGCTCATTGG CAAGTACTTG ATGGGAGACT TGCTTGGAGA AGGATCTTAT 
GGCAAAGTCA AGGAGATGCT GGACTCTGAA ACCCTCTGTA GGAGAGCTGT GAAGATTCTG 
AAGAAGAAGA AGCTACGCAG AATTCCCAAC GGGGAGGCAA ATGTGAAAAA GGAAATTCAG 
CTCCTGCGAC GACTGCGGCA CAAAAATGTT ATCCAGTTGG TAGATGTGTT ATACAATGAA 
GAGAAGCAGA AAATGTATAT GGTGATGGAG TACTGTGTGT GTGGGATGCA GGAGATGCTG 
GACAGTGTCC CAGAAAAGAG GTTTCCAGTT TTTCAGGCTC ATGGGTACTT CTGTCAGCTT 
ATAGATGGCT TAGAATACTT GCACAGCCAA GGGATTGTCC ACAAGGATAT AAAACCTGGG 
AACCTCCTGC TGACCACCAA TGGGACGCTG AAAATATCTG ATTTAGGGGT AGCAGAGGCA 
TTGCATCCAT TTGCAGAGGA TGACACGTGC CGAACGAGCC AAGGGTCGCC AGCATTCCAG 
CCACCAGAAA TTGCCAATGG CCTTGATACC TTTTCAGGCT TTAAAGTAGA CATCTGGTCC 
GCAGGGGTCA CACTATACAA CATTACAACG GGTCTATACC CCTTTGAAGG GGATAATATA 
TATAAGTTAT TTGAAAACAT CGGGAAAGGT GACTTCACAA TTCCAGAGGA TTGTGGTCCT 
CCACTCTCAG ACCTATTGAG AGGGATGCTT GAATACGACC CAGCCAAGAG ATTTTCAATA 
CAGCAGATAA GGCAGCACAA TTGGTTTCGT AAGAAACATG CTCAGGCAGA GACTCTGGTG 
CCCATACCTC CTAGCCCAGA AACAAAGGAC AAGTGGAGAA GTATGACGGC GGTGCCTTAT 
CTGGAAGATC TGCATGGCTA CAATGAGGAC GAAGATGATG ACTTGTATGA CATTGAAGAT 
GATATCATCT ACACTCAGGA CTTCACAGTA CCAGCTGCAG AGGAGGAAGC TGAGGCAGGG 
CGTAGAGGAG AGAGCGGAGC GCTGGGAAGC CGTGACAAGC TGTGTGCAGG AGGAAGCTGT 
GCTCCCATTG GAAAAAGGCA TAGAAGAGGA GTGAAGGTTA GCCTAGGCCC CGGAGCACTG 
CCCTCTCAGG CTCCCAGTGA CCTGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development.
Developmental biology418(2)283-96(2016 10)
Creuzet SE,Viallet JP,Ghawitian M,Torch S,Th?lu J,Alrajeh M,Radu AG,Bouvard D,Costagliola F,Borgne ML,Buchet-Poyau K,Aznar N,Buschlen S,Hosoya H,Thibert C,Billaud M

Fasting alters protein expression of AMP-activated protein kinase in the hypothalamus of broiler chicks (Gallus gallus domesticus).
General and comparative endocrinology178(3)546-55(2012 Sep)
Song Z,Liu L,Yue Y,Jiao H,Lin H,Sheikhahmadi A,Everaert N,Decuypere E,Buyse J

In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America104(3)1045-50(2007 Jan)
Bl?ttler SM,Rencurel F,Kaufmann MR,Meyer UA

Characterization of the AMP-activated protein kinase pathway in chickens.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology143(1)92-106(2006 Jan)
Proszkowiec-Weglarz M,Richards MP,Ramachandran R,McMurtry JP

Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.
Molecular genetics and genomics : MGG273(2)184-96(2005 Apr)
Lin-Marq N,Borel C,Antonarakis SE

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STK11 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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