TLR21 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	TLR21
Entrez Gene ID	415623
Full Name	Toll-like receptor 21
General protein information	Preferred Names Toll-like receptor 21 Names Toll-like receptor 21
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001030558.1	NP_001025729.1	Toll-like receptor 21 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100497009	XP_002936443.2
Danio rerio (zebrafish)	tlr21	NP_001186264.1
Gallus gallus (chicken)	TLR21	NP_001025729.1

Gene Ontology
Bibliography

Related articles in PubMed

TLR4 and TLR21 expression, MIF, IFN-?, MD-2, CD14 activation, and sIgA production in chickens administered with EFAL41 strain challenged with Campylobacter jejuni.
V K, E M, K B, R H, V R, D S, A K, M L, M L Jr, A L, Z ?, M L Sr
Folia microbiologica62(2)89-97(2017 Mar)

The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-? and IL-1?.
Chrz?stek K, Wieliczko A
Polish journal of veterinary sciences17(4)593-9(2014)

Polymorphisms of chicken Toll-like receptors 4, 15, and 21 in different breeds.
Ruan WK, Wu YH, An J, Zheng SJ
Poultry science91(10)2512-6(2012 Oct)

Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9.
Keestra AM, de Zoete MR, Bouwman LI, van Putten JP
Journal of immunology (Baltimore, Md. : 1950)185(1)460-7(2010 Jul)

Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides.
Brownlie R, Zhu J, Allan B, Mutwiri GK, Babiuk LA, Potter A, Griebel P
Molecular immunology46(15)3163-70(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Enterococcus faecium probiotic protects chickens from Campylobacter jejuni infection by modulating the expression of TKR4, TLR21, and immune response proteins.
Title: TLR4 and TLR21 expression, MIF, IFN-?, MD-2, CD14 activation, and sIgA production in chickens administered with EFAL41 strain challenged with Campylobacter jejuni.

The effect of class B CpG ODN administered by subcutaneous or intraocular injection on cytokine expression in chickens is reported.
Title: The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-? and IL-1?.

Nucleotide receptor TLR21 senses and responds to DNA, despite low sequence similarity with the functionally related mammalian TLR9.
Title: Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9.

TLR21 plays a similar role to that of mammalian TLR9 and enables recognition of microbial DNA as a danger signal resulting in downstream innate and adaptive immune responses.
Title: Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides.

The following TLR21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TLR21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa23787	NM_001030558.1 Latest version!	Gallus gallus Toll-like receptor 21 (TLR21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TLR21 ( NM_001030558.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001025729.1 Gallus gallus Toll-like receptor 21 (TLR21), mRNA.

Price & Availability↑

CloneID	OGa23787
Clone ID Related Accession (Same CDS sequence)	NM_001030558.1
Accession Version	NM_001030558.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2919bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	Toll-like receptor 21 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ720600.1. On Aug 8, 2005 this sequence version replaced XM_413989.1. ##Evidence-Data-START## Transcript exon combination :: AJ720600.1 [ECO:0000332] ##Evidence-Data-END##

ATGATGGAGA CAGCGGAGAA GGCATGGCCC AGCACCAGGA TGTGCCCCTC CCACTGCTGT 
CCACTCTGGC TGTTGCTGCT GGTGACAGTG ACACTGATGC CGATGGTGCA CCCGTATGGC 
TTTCGCAACT GCATTGAGGA TGTCAAGGCA CCTTTGTACT TCCGCTGCAT CCAGCGCTTC 
CTGCAGTCGC CGGCCCTGGC AGTGTCTGAC CTGCCACCAC ATGCCATCGC GCTCAATCTG 
TCATACAACA AAATGCGCTG CCTGCAGCCC TCTGCCTTTG CCCACCTGAC ACAGCTGCAT 
ACCCTGGACC TGACCTACAA CCTCCTGGAG ACCCTCTCCC CTGGTGCCTT CAATGGGCTG 
GGTGTGCTGG TGGTGCTGGA CCTGTCTCAC AACAAGCTGA CCACACTTGC TGAAGGGGTG 
TTCAACAGCT TGGGCAACCT GTCCTCGCTG CAGGTACAAC ATAACCCCCT CAGCACGGTG 
TCACCAAGTG CTCTGCTACC CCTGGTCAAC CTGCGCCGCC TGTCTCTACG GGGCGGGCGG 
CTGAATGGGT TGGGGGCAGT GGCAGTGGCA GTGCAGGGCT TGGCACAGCT GGAGCTGTTG 
GACCTATGTG AAAACAACCT GACAACGCTG GGGCCAGGCC CACCGCTACC CGCCTCGCTG 
CTCACCCTGC AGCTGTGCAA CAACTCGCTG AGGGAGTTAG CGGGGGGCAG CCCGGAGATG 
CTATGGCACG TGAAGATACT CGACCTCTCC TACAACAGTA TCTCACAGGC GGAGGTCTTC 
ACCCAGCTCC ACCTGCGCAA CATCAGCCTG CTCCACCTGA TCGGCAACCC CTTGGATGTC 
TTCCACCTGT TGGACATCTC TGACATCCAA CCTCGCAGCC TGGATTTCTC TGGGTTGGTG 
CTGGGGGCTC AGGGGCTGGA TAAGGTGTGC CTGAGGCTGC AGGGTCCCCA GGCCTTGCGG 
CGGCTGCAGC TACAACGCAA CGGGCTGAAG GTGCTGCATT GTAATGCACT GCAGTTGTGT 
CCTGTGCTGA GAGAGCTGGA CCTGTCCTGG AACCGGCTAC AGCACGTGGG CTGTGCCGGC 
CGGCTGCTGG GCAAGAAGCA GCGGGAGAAG CTGGAAGTGC TGACAGTGGA ACACAACCTG 
CTGAAGAAAC TGCCGTCTTG CCTGGGGGCC CAGGTGCTGC CTCGGCTGTA CAACGTTTCC 
TTCCGCTTTA ACCGCATCCT GACTGTTGGG CCCCAAGCCT TTGCCTACGC CCCGGCCCTG 
CAGGTGTTGT GGCTCAATAT TAACAGCCTG GTGTGGCTGG ACAGGCAGGC ACTGTGGAGG 
CTGCACAACC TGACAGAGCT GCGCCTGGAC AACAACCTGC TGACCGACCT CTATCACAAC 
TCCTTCATTG ACCTCCACAG ACTGCGCACC CTCAACCTGC GCAACAACCG TGTCTCCGTC 
CTCTTCTCTG GTGTCTTCCA GGGGCTGGCT GAGCTGCAGA CGCTGGATTT AGGGGGCAAC 
AACTTGCGCC ACCTGACTGC ACAGTCACTG CAGGGGCTGC CCAAACTGCG CAGGCTGTAC 
CTGGACCGCA ACAGACTGCT GGAGGTGAGC AGCACTGTGT TCGCCCCAGT GCAGGCTACC 
CTGGGGGTGC TGGACCTGCG GGCCAACAAC CTGCAGTACA TCTCACAGTG GCTGCGCAAG 
CCGCCACCCT TCCGCAACCT GAGCAGCCTG TACGACCTGA AGCTGCAGGC GCAGCAGCCC 
TATGGACTGA AGATGCTGCC TCACTACTTC TTCCAGGGCT TGGTGAGGCT GCAGCAGCTG 
TCGCTGTCAC AGAACATGCT GCGGTCCATC CCACCGGATG TCTTCGAGGA CTTGGGCCAG 
CTGCGCTCCC TGGCATTGGC TGACAGCAGC AATGGGCTGC ATGACCTGCC TGACGGCATC 
TTCAGAAACC TGGGCAACCT GCGGTTCCTG GACCTGGAGA ATGCAGGGCT GCACTCGCTC 
ACTCTGGAAG TCTTCGGCAA TCTCAGCCGG CTGCAGGTGC TGCACTTGGC CAGAAACGAG 
CTGAAGACCT TCAATGACAG CGTTGCCAGC CGGCTGTCCT CCTTGCGCTA CCTGGACCTG 
CGCAAGTGTC CGCTCAGCTG CACCTGTGAC AACATGTGGC TGCAGGGCTG GCTGAACAAC 
AGCCGTGTGC AGGTTGTCTA CCCCTACAAC TACACCTGTG GCTCACAGCA CAATGCCTAC 
ATCCACAGCT TTGACACACA CGTCTGCTTC CTGGACCTGG GGCTCTATCT CTTTGCTGGG 
ACTGCACCGG CAGTGCTGCT GCTGCTGGTG GTGCCGGTGG TGTACCACCG CGCCTACTGG 
AGGCTGAAGT ACCACTGGTA CCTTCTGCGG TGCTGGGTCA ACCAGCGGTG GCGGCGGGAG 
GAAAAGTGCT ACCTCTATGA CAGCTTTGTG TCCTACAATT CAGCTGATGA AAGTTGGGTG 
TTGCAGAAGC TGGTGCCTGA GCTGGAGCAC GGTGCCTTCC GCCTCTGCTT GCACCACCGC 
GACTTCCAGC CGGGCCGCAG CATCATTGAC AACATTGTGG ATGCTGTCTA CAACAGCCGG 
AAGACGGTGT GCGTGGTGAG CCGCAGCTAC CTGCGCAGCG AGTGGTGCTC TCTAGAGGTG 
CAGTTGGCCA GCTACCGGCT GTTGGATGAG CGGCGTGACA TCCTGGTACT GGTGCTGCTG 
GAGGACGTGG GTGATGCTGA GCTGTCTGCC TACCACCGCA TGCGGCGGGT GCTGCTGCGG 
CGCACCTACC TGCGCTGGCC TCTTGACCCC GCAGCTCAGC CGCTCTTTTG GGCACGGCTG 
AAGAGGGCAC TGAGGTGGGG AGAGGGAGGA GAGGAGGAGG AAGAAGAAGG TTTGGGTGGA 
GGGACGGGAA GGCCCAGGGA AGGAGACAAA CAGATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025729.1
CDS	23..2941
Translation	MMETAEKAWPSTRMCPSHCCPLWLLLLVTVTLMPMVHPYGFRNCIEDVKAPLYFRCIQRFLQSPALAVSDLPPHAIALNLSYNKMRCLQPSAFAHLTQLHTLDLTYNLLETLSPGAFNGLGVLVVLDLSHNKLTTLAEGVFNSLGNLSSLQVQHNPLSTVSPSALLPLVNLRRLSLRGGRLNGLGAVAVAVQGLAQLELLDLCENNLTTLGPGPPLPASLLTLQLCNNSLRELAGGSPEMLWHVKILDLSYNSISQAEVFTQLHLRNISLLHLIGNPLDVFHLLDISDIQPRSLDFSGLVLGAQGLDKVCLRLQGPQALRRLQLQRNGLKVLHCNALQLCPVLRELDLSWNRLQHVGCAGRLLGKKQREKLEVLTVEHNLLKKLPSCLGAQVLPRLYNVSFRFNRILTVGPQAFAYAPALQVLWLNINSLVWLDRQALWRLHNLTELRLDNNLLTDLYHNSFIDLHRLRTLNLRNNRVSVLFSGVFQGLAELQTLDLGGNNLRHLTAQSLQGLPKLRRLYLDRNRLLEVSSTVFAPVQATLGVLDLRANNLQYISQWLRKPPPFRNLSSLYDLKLQAQQPYGLKMLPHYFFQGLVRLQQLSLSQNMLRSIPPDVFEDLGQLRSLALADSSNGLHDLPDGIFRNLGNLRFLDLENAGLHSLTLEVFGNLSRLQVLHLARNELKTFNDSVASRLSSLRYLDLRKCPLSCTCDNMWLQGWLNNSRVQVVYPYNYTCGSQHNAYIHSFDTHVCFLDLGLYLFAGTAPAVLLLLVVPVVYHRAYWRLKYHWYLLRCWVNQRWRREEKCYLYDSFVSYNSADESWVLQKLVPELEHGAFRLCLHHRDFQPGRSIIDNIVDAVYNSRKTVCVVSRSYLRSEWCSLEVQLASYRLLDERRDILVLVLLEDVGDAELSAYHRMRRVLLRRTYLRWPLDPAAQPLFWARLKRALRWGEGGEEEEEEGLGGGTGRPREGDKQM

Target ORF information:

RefSeq Version	NM_001030558.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus Toll-like receptor 21 (TLR21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001030558.1

ORF Insert Sequence:

ATGATGGAGA CAGCGGAGAA GGCATGGCCC AGCACCAGGA TGTGCCCCTC CCACTGCTGT 
CCACTCTGGC TGTTGCTGCT GGTGACAGTG ACACTGATGC CGATGGTGCA CCCGTATGGC 
TTTCGCAACT GCATTGAGGA TGTCAAGGCA CCTTTGTACT TCCGCTGCAT CCAGCGCTTC 
CTGCAGTCGC CGGCCCTGGC AGTGTCTGAC CTGCCACCAC ATGCCATCGC GCTCAATCTG 
TCATACAACA AAATGCGCTG CCTGCAGCCC TCTGCCTTTG CCCACCTGAC ACAGCTGCAT 
ACCCTGGACC TGACCTACAA CCTCCTGGAG ACCCTCTCCC CTGGTGCCTT CAATGGGCTG 
GGTGTGCTGG TGGTGCTGGA CCTGTCTCAC AACAAGCTGA CCACACTTGC TGAAGGGGTG 
TTCAACAGCT TGGGCAACCT GTCCTCGCTG CAGGTACAAC ATAACCCCCT CAGCACGGTG 
TCACCAAGTG CTCTGCTACC CCTGGTCAAC CTGCGCCGCC TGTCTCTACG GGGCGGGCGG 
CTGAATGGGT TGGGGGCAGT GGCAGTGGCA GTGCAGGGCT TGGCACAGCT GGAGCTGTTG 
GACCTATGTG AAAACAACCT GACAACGCTG GGGCCAGGCC CACCGCTACC CGCCTCGCTG 
CTCACCCTGC AGCTGTGCAA CAACTCGCTG AGGGAGTTAG CGGGGGGCAG CCCGGAGATG 
CTATGGCACG TGAAGATACT CGACCTCTCC TACAACAGTA TCTCACAGGC GGAGGTCTTC 
ACCCAGCTCC ACCTGCGCAA CATCAGCCTG CTCCACCTGA TCGGCAACCC CTTGGATGTC 
TTCCACCTGT TGGACATCTC TGACATCCAA CCTCGCAGCC TGGATTTCTC TGGGTTGGTG 
CTGGGGGCTC AGGGGCTGGA TAAGGTGTGC CTGAGGCTGC AGGGTCCCCA GGCCTTGCGG 
CGGCTGCAGC TACAACGCAA CGGGCTGAAG GTGCTGCATT GTAATGCACT GCAGTTGTGT 
CCTGTGCTGA GAGAGCTGGA CCTGTCCTGG AACCGGCTAC AGCACGTGGG CTGTGCCGGC 
CGGCTGCTGG GCAAGAAGCA GCGGGAGAAG CTGGAAGTGC TGACAGTGGA ACACAACCTG 
CTGAAGAAAC TGCCGTCTTG CCTGGGGGCC CAGGTGCTGC CTCGGCTGTA CAACGTTTCC 
TTCCGCTTTA ACCGCATCCT GACTGTTGGG CCCCAAGCCT TTGCCTACGC CCCGGCCCTG 
CAGGTGTTGT GGCTCAATAT TAACAGCCTG GTGTGGCTGG ACAGGCAGGC ACTGTGGAGG 
CTGCACAACC TGACAGAGCT GCGCCTGGAC AACAACCTGC TGACCGACCT CTATCACAAC 
TCCTTCATTG ACCTCCACAG ACTGCGCACC CTCAACCTGC GCAACAACCG TGTCTCCGTC 
CTCTTCTCTG GTGTCTTCCA GGGGCTGGCT GAGCTGCAGA CGCTGGATTT AGGGGGCAAC 
AACTTGCGCC ACCTGACTGC ACAGTCACTG CAGGGGCTGC CCAAACTGCG CAGGCTGTAC 
CTGGACCGCA ACAGACTGCT GGAGGTGAGC AGCACTGTGT TCGCCCCAGT GCAGGCTACC 
CTGGGGGTGC TGGACCTGCG GGCCAACAAC CTGCAGTACA TCTCACAGTG GCTGCGCAAG 
CCGCCACCCT TCCGCAACCT GAGCAGCCTG TACGACCTGA AGCTGCAGGC GCAGCAGCCC 
TATGGACTGA AGATGCTGCC TCACTACTTC TTCCAGGGCT TGGTGAGGCT GCAGCAGCTG 
TCGCTGTCAC AGAACATGCT GCGGTCCATC CCACCGGATG TCTTCGAGGA CTTGGGCCAG 
CTGCGCTCCC TGGCATTGGC TGACAGCAGC AATGGGCTGC ATGACCTGCC TGACGGCATC 
TTCAGAAACC TGGGCAACCT GCGGTTCCTG GACCTGGAGA ATGCAGGGCT GCACTCGCTC 
ACTCTGGAAG TCTTCGGCAA TCTCAGCCGG CTGCAGGTGC TGCACTTGGC CAGAAACGAG 
CTGAAGACCT TCAATGACAG CGTTGCCAGC CGGCTGTCCT CCTTGCGCTA CCTGGACCTG 
CGCAAGTGTC CGCTCAGCTG CACCTGTGAC AACATGTGGC TGCAGGGCTG GCTGAACAAC 
AGCCGTGTGC AGGTTGTCTA CCCCTACAAC TACACCTGTG GCTCACAGCA CAATGCCTAC 
ATCCACAGCT TTGACACACA CGTCTGCTTC CTGGACCTGG GGCTCTATCT CTTTGCTGGG 
ACTGCACCGG CAGTGCTGCT GCTGCTGGTG GTGCCGGTGG TGTACCACCG CGCCTACTGG 
AGGCTGAAGT ACCACTGGTA CCTTCTGCGG TGCTGGGTCA ACCAGCGGTG GCGGCGGGAG 
GAAAAGTGCT ACCTCTATGA CAGCTTTGTG TCCTACAATT CAGCTGATGA AAGTTGGGTG 
TTGCAGAAGC TGGTGCCTGA GCTGGAGCAC GGTGCCTTCC GCCTCTGCTT GCACCACCGC 
GACTTCCAGC CGGGCCGCAG CATCATTGAC AACATTGTGG ATGCTGTCTA CAACAGCCGG 
AAGACGGTGT GCGTGGTGAG CCGCAGCTAC CTGCGCAGCG AGTGGTGCTC TCTAGAGGTG 
CAGTTGGCCA GCTACCGGCT GTTGGATGAG CGGCGTGACA TCCTGGTACT GGTGCTGCTG 
GAGGACGTGG GTGATGCTGA GCTGTCTGCC TACCACCGCA TGCGGCGGGT GCTGCTGCGG 
CGCACCTACC TGCGCTGGCC TCTTGACCCC GCAGCTCAGC CGCTCTTTTG GGCACGGCTG 
AAGAGGGCAC TGAGGTGGGG AGAGGGAGGA GAGGAGGAGG AAGAAGAAGG TTTGGGTGGA 
GGGACGGGAA GGCCCAGGGA AGGAGACAAA CAGATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TLR4 and TLR21 expression, MIF, IFN-?, MD-2, CD14 activation, and sIgA production in chickens administered with EFAL41 strain challenged with Campylobacter jejuni.
Folia microbiologica62(2)89-97(2017 Mar)
V K,E M,K B,R H,V R,D S,A K,M L,M L Jr,A L,Z ?,M L Sr

The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-? and IL-1?.
Polish journal of veterinary sciences17(4)593-9(2014)
Chrz?stek K,Wieliczko A

Polymorphisms of chicken Toll-like receptors 4, 15, and 21 in different breeds.
Poultry science91(10)2512-6(2012 Oct)
Ruan WK,Wu YH,An J,Zheng SJ

Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9.
Journal of immunology (Baltimore, Md. : 1950)185(1)460-7(2010 Jul)
Keestra AM,de Zoete MR,Bouwman LI,van Putten JP

Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides.
Molecular immunology46(15)3163-70(2009 Sep)
Brownlie R,Zhu J,Allan B,Mutwiri GK,Babiuk LA,Potter A,Griebel P

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TLR21 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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