AvBD2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	AvBD2
Entrez Gene ID	395840
Full Name	avian beta-defensin 2
Synonyms	GAL 2,GAL2,gal-2
General protein information	Preferred Names avian beta-defensin 2 Names gallinacin-2 antimicrobial peptide 2 beta-defensin 2 antimicrobial peptide
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204992.2	NP_990323.2	gallinacin-2 precursor
NM_001201399.1	NP_001188328.1	gallinacin-2 precursor
XM_015285091.2	XP_015140577.1	gallinacin-2 isoform X1
XM_015285091.1	XP_015140577.1	gallinacin-2 isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Avian host defense peptides.
Cuperus T, Coorens M, van Dijk A, Haagsman HP
Developmental and comparative immunology41(3)352-69(2013 Nov)

Primary structure and antibacterial activity of chicken bone marrow-derived beta-defensins.
Derache C, Labas V, Aucagne V, Meudal H, Landon C, Delmas AF, Magallon T, Lalmanach AC
Antimicrobial agents and chemotherapy53(11)4647-55(2009 Nov)

Differential modulation of beta-defensin gene expression by Salmonella Enteritidis in intestinal epithelial cells from resistant and susceptible chicken inbred lines.
Derache C, Esnault E, Bonsergent C, Le Vern Y, Qu?r? P, Lalmanach AC
Developmental and comparative immunology33(9)959-66(2009 Sep)

Direct screening identifies mature beta-defensin 2 in avian heterophils.
Kannan L, Rath NC, Liyanage R, Lay JO Jr
Poultry science88(2)372-9(2009 Feb)

Non-coding RNAs revealed during identification of genes involved in chicken immune responses.
Ahanda ML, Ruby T, Wittzell H, Bed'Hom B, Chauss? AM, Morin V, Oudin A, Chevalier C, Young JR, Zoorob R
Immunogenetics61(1)55-70(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

intestinal epithelium express beta-defensin antimicrobial peptides that may play a role in immunoprotection against Salmonella Enteritidis.
Title: Differential modulation of beta-defensin gene expression by Salmonella Enteritidis in intestinal epithelial cells from resistant and susceptible chicken inbred lines.

peptides are 36 amino acids long including a highly conserved region with 6 invariant cysteines forming the 3 disulfide bonds characteristic of defensins
Title: Direct screening identifies mature beta-defensin 2 in avian heterophils.

mRNA expression of Gal-1, -2 and -3 in the vagina of laying hens increases with age but decreases in the regressed oviduct during the non-laying phase, and may increase in response to Salmonella enteritidis (SE) and lipopolysaccharide
Title: Effects of age, egg-laying activity, and Salmonella-inoculation on the expressions of gallinacin mRNA in the vagina of the hen oviduct.

Authors use expression of beta-defensins GAL1 and GLA2 to postulate in situ maturation of heterophils in hatchling gut tissue.
Title: Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick.

The chicken genome encodes only beta-defensins. The 13 chicken beta-defensin genes are clustered densely within a 86-Kb distance on the chromosome 3q3.5-q3.7. The deduced peptides share the characteristic defensin motif.
Title: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.

The following AvBD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AvBD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OGa28156	NM_001201399.1 Latest version!	Gallus gallus defensin beta 4A (DEFB4A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OGa28156	NM_204992.2 Latest version!	Gallus gallus defensin beta 4A (DEFB4A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OGa28156	XM_015285091.2 Latest version!	Gallus gallus avian beta-defensin 2 (AvBD2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OGa28156	XM_015285091.1	Gallus gallus avian beta-defensin 2 (AvBD2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AvBD2 ( NM_204992.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990323.2 Gallus gallus defensin beta 4A (DEFB4A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OGa28156
Clone ID Related Accession (Same CDS sequence)	NM_204992.2 , NM_001201399.1 , XM_015285091.2 , XM_015285091.1
Accession Version	NM_204992.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Gallus gallus(chicken)
Product	gallinacin-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF250963.1, AF033336.1, DQ858325.1 and BQ484799.1. On Jan 19, 2011 this sequence version replaced NM_204992.1. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcripts of different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ484799.1, BU449525.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGATTC TTTACCTGCT TTTCTCTCTC CTCTTCCTGG CACTCCAGGC TTCTCCAGGG 
TTGTCTTCGC CCCGGCGGGA CATGCTGTTC TGTAAAGGAG GGTCCTGCCA CTTTGGAGGG 
TGTCCCAGCC ATCTAATCAA AGTCGGAAGC TGCTTCGGGT TCCGTTCCTG CTGCAAATGG 
CCTTGGAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990323.2
CDS	88..282
Translation	MRILYLLFSLLFLALQASPGLSSPRRDMLFCKGGSCHFGGCPSHLIKVGSCFGFRSCCKWPWNA

Target ORF information:

RefSeq Version	NM_204992.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus defensin beta 4A (DEFB4A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204992.2

ORF Insert Sequence:

ATGAGGATTC TTTACCTGCT TTTCTCTCTC CTCTTCCTGG CACTCCAGGC TTCTCCAGGG 
TTGTCTTCGC CCCGGCGGGA CATGCTGTTC TGTAAAGGAG GGTCCTGCCA CTTTGGAGGG 
TGTCCCAGCC ATCTAATCAA AGTCGGAAGC TGCTTCGGGT TCCGTTCCTG CTGCAAATGG 
CCTTGGAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AvBD2 ( NM_001201399.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001188328.1 Gallus gallus defensin beta 4A (DEFB4A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OGa28156
Clone ID Related Accession (Same CDS sequence)	NM_204992.2 , NM_001201399.1 , XM_015285091.2 , XM_015285091.1
Accession Version	NM_001201399.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Gallus gallus(chicken)
Product	gallinacin-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF250963.1, AADN05001052.1, DQ858325.1 and AF033336.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcripts of different strains and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR2365563.198151.1, CF250963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2201383, SAMEA2812691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGATTC TTTACCTGCT TTTCTCTCTC CTCTTCCTGG CACTCCAGGC TTCTCCAGGG 
TTGTCTTCGC CCCGGCGGGA CATGCTGTTC TGTAAAGGAG GGTCCTGCCA CTTTGGAGGG 
TGTCCCAGCC ATCTAATCAA AGTCGGAAGC TGCTTCGGGT TCCGTTCCTG CTGCAAATGG 
CCTTGGAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001188328.1
CDS	152..346
Translation	MRILYLLFSLLFLALQASPGLSSPRRDMLFCKGGSCHFGGCPSHLIKVGSCFGFRSCCKWPWNA

Target ORF information:

RefSeq Version	NM_001201399.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus defensin beta 4A (DEFB4A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001201399.1

ORF Insert Sequence:

ATGAGGATTC TTTACCTGCT TTTCTCTCTC CTCTTCCTGG CACTCCAGGC TTCTCCAGGG 
TTGTCTTCGC CCCGGCGGGA CATGCTGTTC TGTAAAGGAG GGTCCTGCCA CTTTGGAGGG 
TGTCCCAGCC ATCTAATCAA AGTCGGAAGC TGCTTCGGGT TCCGTTCCTG CTGCAAATGG 
CCTTGGAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AvBD2 ( XM_015285091.2 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015140577.1 Gallus gallus avian beta-defensin 2 (AvBD2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa28156
Clone ID Related Accession (Same CDS sequence)	NM_204992.2 , NM_001201399.1 , XM_015285091.2 , XM_015285091.1
Accession Version	XM_015285091.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-16
Organism	Gallus gallus(chicken)
Product	gallinacin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006090.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015285091.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGATTC TTTACCTGCT TTTCTCTCTC CTCTTCCTGG CACTCCAGGC TTCTCCAGGG 
TTGTCTTCGC CCCGGCGGGA CATGCTGTTC TGTAAAGGAG GGTCCTGCCA CTTTGGAGGG 
TGTCCCAGCC ATCTAATCAA AGTCGGAAGC TGCTTCGGGT TCCGTTCCTG CTGCAAATGG 
CCTTGGAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015140577.1
CDS	105..299
Translation	MRILYLLFSLLFLALQASPGLSSPRRDMLFCKGGSCHFGGCPSHLIKVGSCFGFRSCCKWPWNA

Target ORF information:

RefSeq Version	XM_015285091.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus avian beta-defensin 2 (AvBD2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015285091.2

ORF Insert Sequence:

ATGAGGATTC TTTACCTGCT TTTCTCTCTC CTCTTCCTGG CACTCCAGGC TTCTCCAGGG 
TTGTCTTCGC CCCGGCGGGA CATGCTGTTC TGTAAAGGAG GGTCCTGCCA CTTTGGAGGG 
TGTCCCAGCC ATCTAATCAA AGTCGGAAGC TGCTTCGGGT TCCGTTCCTG CTGCAAATGG 
CCTTGGAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AvBD2 ( XM_015285091.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015140577.1 Gallus gallus avian beta-defensin 2 (AvBD2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa28156
Clone ID Related Accession (Same CDS sequence)	NM_204992.2 , NM_001201399.1 , XM_015285091.2 , XM_015285091.1
Accession Version	XM_015285091.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-03
Organism	Gallus gallus(chicken)
Product	gallinacin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_455847.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGATTC TTTACCTGCT TTTCTCTCTC CTCTTCCTGG CACTCCAGGC TTCTCCAGGG 
TTGTCTTCGC CCCGGCGGGA CATGCTGTTC TGTAAAGGAG GGTCCTGCCA CTTTGGAGGG 
TGTCCCAGCC ATCTAATCAA AGTCGGAAGC TGCTTCGGGT TCCGTTCCTG CTGCAAATGG 
CCTTGGAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015140577.1
CDS	109..303
Translation	MRILYLLFSLLFLALQASPGLSSPRRDMLFCKGGSCHFGGCPSHLIKVGSCFGFRSCCKWPWNA

Target ORF information:

RefSeq Version	XM_015285091.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus avian beta-defensin 2 (AvBD2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015285091.1

ORF Insert Sequence:

ATGAGGATTC TTTACCTGCT TTTCTCTCTC CTCTTCCTGG CACTCCAGGC TTCTCCAGGG 
TTGTCTTCGC CCCGGCGGGA CATGCTGTTC TGTAAAGGAG GGTCCTGCCA CTTTGGAGGG 
TGTCCCAGCC ATCTAATCAA AGTCGGAAGC TGCTTCGGGT TCCGTTCCTG CTGCAAATGG 
CCTTGGAATG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Avian host defense peptides.
Developmental and comparative immunology41(3)352-69(2013 Nov)
Cuperus T,Coorens M,van Dijk A,Haagsman HP

Primary structure and antibacterial activity of chicken bone marrow-derived beta-defensins.
Antimicrobial agents and chemotherapy53(11)4647-55(2009 Nov)
Derache C,Labas V,Aucagne V,Meudal H,Landon C,Delmas AF,Magallon T,Lalmanach AC

Differential modulation of beta-defensin gene expression by Salmonella Enteritidis in intestinal epithelial cells from resistant and susceptible chicken inbred lines.
Developmental and comparative immunology33(9)959-66(2009 Sep)
Derache C,Esnault E,Bonsergent C,Le Vern Y,Qu?r? P,Lalmanach AC

Direct screening identifies mature beta-defensin 2 in avian heterophils.
Poultry science88(2)372-9(2009 Feb)
Kannan L,Rath NC,Liyanage R,Lay JO Jr

Non-coding RNAs revealed during identification of genes involved in chicken immune responses.
Immunogenetics61(1)55-70(2009 Jan)
Ahanda ML,Ruby T,Wittzell H,Bed'Hom B,Chauss? AM,Morin V,Oudin A,Chevalier C,Young JR,Zoorob R

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AvBD2 cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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FAX

オンラインフォーム