Su(fu) cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Su(fu)
Entrez Gene ID	41565
Full Name	Suppressor of fused
Synonyms	CG6054,Dmel\CG6054,SU(FU),SUFU,Su(Fu),SuFu,Sufu,dSufu,su(fu),sufu
General protein information	Preferred Names Suppressor of fused Names CG6054 gene product from transcript CG6054-RA CG6054-PA Su(fu)-PA suppressor of fused
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 87C5-87C5

mRNA and Protein(s)

mRNA	Protein	Name
NM_080502.5	NP_536750.2	suppressor of fused

Pathways from BioSystems

Homologies

Homo sapiens (human)	SUFU	NP_057253.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001948	XP_321114.1
Pan troglodytes (chimpanzee)	SUFU	XP_001171637.1
Bos taurus (cattle)	SUFU	NP_001091552.1
Rattus norvegicus (Norway rat)	Sufu	NP_001020070.1
Danio rerio (zebrafish)	sufu	NP_958466.1
Mus musculus (house mouse)	Sufu	NP_056567.2
Gallus gallus (chicken)	SUFU	NP_989595.1
	SUFU	XP_001113024.1
Canis lupus familiaris (dog)	SUFU	XP_005637731.1
Drosophila melanogaster (fruit fly)	Su(fu)	NP_536750.2
Xenopus tropicalis (tropical clawed frog)	sufu	NP_001123387.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sufu can sequester Ci/Gli in the cytoplasm through binding to an N-terminal site while inhibiting Ci/Gli activity in the nucleus depending on a C-terminal Sufu-interacting site.
Title: Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction.

A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response
Title: A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.

Drosophila Hedgehog signaling promotes downregulation of Su(fu) through its target protein HIB (Hh-induced BTB protein).
Title: Hedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila.

Suppressor of fused (Sufu) opposes Trn-mediated Ci nuclear import by masking its PY-nuclear localization sequence.
Title: Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kap?2 in Hedgehog signaling.

The 'closed' form of Sufu is stabilized by Gli binding and inhibited by Hh treatment, whereas the 'open' state of Sufu is promoted by Gli-dissociation and Hh signaling.
Title: Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.

The following Su(fu) gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Su(fu) cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa04714	NM_080502.5 Latest version!	Drosophila melanogaster suppressor of fused (Su(fu)), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Su(fu) ( NM_080502.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_536750.2 Drosophila melanogaster suppressor of fused (Su(fu)), mRNA.

Price & Availability↑

CloneID	OFa04714
Clone ID Related Accession (Same CDS sequence)	NM_080502.5
Accession Version	NM_080502.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	suppressor of fused
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_080502.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCCGAGG CGAATTTGGA CAAAAAACCT GAGGTGAAGC CTCCGCCGGG CCTTAAGGCC 
ATCATAGACC ACCTCGGGCA GGTGTACCCC AACCAGCCGA ACCCGCTGCA GGTGACCACA 
CTGCTCAAGT ACTGGCTGGG CGGTCAGGAT CCGTTGGACT ACATTAGCAT GTACAACTAT 
CCCGGAGATG TGGATAGGAA CGTTCCGCCG CACTGGCACT ACATTAGTTT CGGACTCAGC 
GACCTACACG GGGACGAGCG AGTCCACTTG CGCGAGGAGG GCGTCACTCG GTCTGGCATG 
GGGTTCGAGT TGACCTTTCG CTTGGCCAAA ACAGAAATAG AGCTAAAGCA GCAGATTGAG 
AACCCGGAAA AGCCCCAAAG ACCGCCCACC TGGCCGGCGA ACCTGTTGCA GGCCATCGGA 
CGCTATTGTT TTCAAACAGG CAACGGGTTG TGCTTCGGAG ACAACATCCC GTGGCGCAAG 
AGTCTGGATG GCAGTACCAC TTCCAAGCTA CAGAACCTGC TCGTCGCCCA GGACCCGCAG 
TTGGGCTGCA TCGACACTCC CACGGGCACG GTGGACTTCT GCCAGATCGT CGGCGTCTTT 
GACGACGAAC TTGAGCAGGC ATCGCGTTGG AACGGGCGCG GTGTGCTCAA CTTCCTTCGC 
CAAGATATGC AAACTGGCGG TGATTGGCTG GTGACTAACA TGGATCGCCA GATGAGCGTC 
TTCGAACTGT TTCCCGAAAC GCTGCTAAAC CTACAGGACG ATCTGGAGAA GCAGGGTTCC 
GATCTGGCCG GCGTTAATGC AGATTTTACG TTCCGTGAGC TGAAACCTAC CAAGGAGGTG 
AAGGAGGAGG TGGATTTCCA GGCGCTGAGC GAGAAGTGCG CCAACGACGA AAACAATCGG 
CAGCTGACGG ATACGCAAAT GAAACGCGAG GAACCAAGCT TTCCACAATC CATGTCGATG 
AGCAGCAATT CGCTGCACAA GTCCTGTCCC CTGGACTTTC AAGCGCAGGC ACCAAACTGC 
ATTTCACTGG ACGGTATTGA GATTACCCTC GCACCTGGTG TGGCCAAGTA CCTCCTACTG 
GCCATCAAGG ATCGCATCCG ACATGGGCGC CACTTCACCT TCAAGGCTCA GCATCTGGCG 
CTCACTTTGG TGGCGGAATC CGTCACCGGC TCGGCGGTGA CAGTGAACGA ACCGTACGGC 
GTGCTGGGCT ACTGGATTCA GGTCCTGATT CCCGATGAAC TGGTGCCGCG CCTGATGGAA 
GACTTCCGCA GCGCGGGCCT AGACGAGAAA TGCGAGCCCA AGGAGCGACT GGAGCTCGAG 
TGGCCCGACA AGAATCTGAA GCTGATCATC GACCAGCCGG AACCTGTGCT GCCCATGTCG 
CTCGACGCTG CTCCTCTGAA AATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536750.2
CDS	31..1437
Translation	MAEANLDKKPEVKPPPGLKAIIDHLGQVYPNQPNPLQVTTLLKYWLGGQDPLDYISMYNYPGDVDRNVPPHWHYISFGLSDLHGDERVHLREEGVTRSGMGFELTFRLAKTEIELKQQIENPEKPQRPPTWPANLLQAIGRYCFQTGNGLCFGDNIPWRKSLDGSTTSKLQNLLVAQDPQLGCIDTPTGTVDFCQIVGVFDDELEQASRWNGRGVLNFLRQDMQTGGDWLVTNMDRQMSVFELFPETLLNLQDDLEKQGSDLAGVNADFTFRELKPTKEVKEEVDFQALSEKCANDENNRQLTDTQMKREEPSFPQSMSMSSNSLHKSCPLDFQAQAPNCISLDGIEITLAPGVAKYLLLAIKDRIRHGRHFTFKAQHLALTLVAESVTGSAVTVNEPYGVLGYWIQVLIPDELVPRLMEDFRSAGLDEKCEPKERLELEWPDKNLKLIIDQPEPVLPMSLDAAPLKM

Target ORF information:

RefSeq Version	NM_080502.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster suppressor of fused (Su(fu)), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080502.5

ORF Insert Sequence:

ATGGCCGAGG CGAATTTGGA CAAAAAACCT GAGGTGAAGC CTCCGCCGGG CCTTAAGGCC 
ATCATAGACC ACCTCGGGCA GGTGTACCCC AACCAGCCGA ACCCGCTGCA GGTGACCACA 
CTGCTCAAGT ACTGGCTGGG CGGTCAGGAT CCGTTGGACT ACATTAGCAT GTACAACTAT 
CCCGGAGATG TGGATAGGAA CGTTCCGCCG CACTGGCACT ACATTAGTTT CGGACTCAGC 
GACCTACACG GGGACGAGCG AGTCCACTTG CGCGAGGAGG GCGTCACTCG GTCTGGCATG 
GGGTTCGAGT TGACCTTTCG CTTGGCCAAA ACAGAAATAG AGCTAAAGCA GCAGATTGAG 
AACCCGGAAA AGCCCCAAAG ACCGCCCACC TGGCCGGCGA ACCTGTTGCA GGCCATCGGA 
CGCTATTGTT TTCAAACAGG CAACGGGTTG TGCTTCGGAG ACAACATCCC GTGGCGCAAG 
AGTCTGGATG GCAGTACCAC TTCCAAGCTA CAGAACCTGC TCGTCGCCCA GGACCCGCAG 
TTGGGCTGCA TCGACACTCC CACGGGCACG GTGGACTTCT GCCAGATCGT CGGCGTCTTT 
GACGACGAAC TTGAGCAGGC ATCGCGTTGG AACGGGCGCG GTGTGCTCAA CTTCCTTCGC 
CAAGATATGC AAACTGGCGG TGATTGGCTG GTGACTAACA TGGATCGCCA GATGAGCGTC 
TTCGAACTGT TTCCCGAAAC GCTGCTAAAC CTACAGGACG ATCTGGAGAA GCAGGGTTCC 
GATCTGGCCG GCGTTAATGC AGATTTTACG TTCCGTGAGC TGAAACCTAC CAAGGAGGTG 
AAGGAGGAGG TGGATTTCCA GGCGCTGAGC GAGAAGTGCG CCAACGACGA AAACAATCGG 
CAGCTGACGG ATACGCAAAT GAAACGCGAG GAACCAAGCT TTCCACAATC CATGTCGATG 
AGCAGCAATT CGCTGCACAA GTCCTGTCCC CTGGACTTTC AAGCGCAGGC ACCAAACTGC 
ATTTCACTGG ACGGTATTGA GATTACCCTC GCACCTGGTG TGGCCAAGTA CCTCCTACTG 
GCCATCAAGG ATCGCATCCG ACATGGGCGC CACTTCACCT TCAAGGCTCA GCATCTGGCG 
CTCACTTTGG TGGCGGAATC CGTCACCGGC TCGGCGGTGA CAGTGAACGA ACCGTACGGC 
GTGCTGGGCT ACTGGATTCA GGTCCTGATT CCCGATGAAC TGGTGCCGCG CCTGATGGAA 
GACTTCCGCA GCGCGGGCCT AGACGAGAAA TGCGAGCCCA AGGAGCGACT GGAGCTCGAG 
TGGCCCGACA AGAATCTGAA GCTGATCATC GACCAGCCGG AACCTGTGCT GCCCATGTCG 
CTCGACGCTG CTCCTCTGAA AATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Su(fu) cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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