Pc cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pc
Entrez Gene ID	40358
Full Name	Polycomb
Synonyms	CG32443,CG7618,DmPc,Dmel\CG32443,PC,Pc-G,PcG,dPC,pc
General protein information	Preferred Names Polycomb Names CG32443 gene product from transcript CG32443-RA CG32443-PA Pc-PA polycomb
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 78C6-78C7

mRNA and Protein(s)

mRNA	Protein	Name
NM_079475.3	NP_524199.1	polycomb

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PRC1 components act as neoplastic tumor suppressors independently of PRC2 function
Title: Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development.

Stx facilitates Pc degradation in the proteasome, independent of ubiquitin modification.
Title: Stuxnet Facilitates the Degradation of Polycomb Protein during Development.

a Pc-mediated, Hisotne 3 lysine 27 trimethylation-dependent positive transcriptional regulation of Senseless (Sens), a key transcription factor required for development, is reported.
Title: A positive role for polycomb in transcriptional regulation via H4K20me1.

a novel activity of polycomb: inhibition of the histone acetylation activity of CREB-binding protein, is identified.
Title: Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.

transcription through the PRE is not sufficient for inducing an epigenetic switch in PRE activity.
Title: Transcriptional read-through is not sufficient to induce an epigenetic switch in the silencing activity of Polycomb response elements.

The following Pc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa20307	NM_079475.3 Latest version!	Drosophila melanogaster polycomb (Pc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pc ( NM_079475.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524199.1 Drosophila melanogaster polycomb (Pc), mRNA.

Price & Availability↑

CloneID	OFa20307
Clone ID Related Accession (Same CDS sequence)	NM_079475.3
Accession Version	NM_079475.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	polycomb
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_079475.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGACTGGTC GAGGCAAGGG GAGTAAGGGG AAGTTGGGGC GCGACAATGC GACCGACGAT 
CCAGTCGATC TAGTGTACGC GGCTGAGAAA ATCATCCAAA AGCGCGTTAA GAAGGGCGTC 
GTGGAGTACC GTGTCAAGTG GAAGGGCTGG AACCAGCGCT ACAACACCTG GGAACCGGAG 
GTAAACATCC TGGATCGCCG CCTCATCGAC ATCTACGAAC AAACGAACAA ATCCTCCGGA 
ACTCCCTCCA AGCGAGGCAT TAAGAAGAAG GAGAAAGAAC CCGATCCGGA GCCGGAATCC 
GAGGAGGATG AGTACACCTT CACCGAAAAC GATGTGGACA CGCATCAAGC CACCACCTCA 
TCGGCTACCC ACGATAAGGA GTCGAAGAAG GAGAAGAAGC ACCATCACCA CCACCACCAT 
CATCACCACA TCAAGTCCGA ACGCAACAGT GGACGGCGCT CGGAATCTCC GCTGACCCAC 
CATCATCATC ACCACCACCA CGAGTCCAAG CGTCAGCGCA TTGATCACAG CTCCTCCTCG 
AACAGCAGCT TCACGCACAA CTCATTTGTC CCCGAGCCGG ACAGCAACTC CTCCAGCTCC 
GAGGATCAGC CGCTGATCGG CACCAAACGC AAAGCCGAGG TGCTCAAGGA ATCGGGCAAG 
ATTGGAGTTA CGATTAAGAC CTCCCCAGAT GGCCCCACTA TTAAGCCTCA GCCGACCCAG 
CAGGTAACTC CCAGCCAGCA GCAGCCCTTC CAGGATCAGC AGCAAGCGGA AAAGATTGCC 
AGCGAGGCTG CAACGCAGCT GAAATCTGAG CAGCAGGCCA CCCCACTGGC CACAGAAGCC 
ATAAACACAA CGCCCGCAGA GTCCGGAGCT GAGGAAGAAG AAGTAGCCAA CGAGGAAGGC 
AACCAACAGG CGCCACAGGT TCCTTCCGAG AACAATAACA TACCAAAACC GTGCAACAAC 
CTGGCTATCA ACCAGAAACA GCCGCTTACT CCTCTTTCGC CGCGTGCCCT TCCGCCGCGC 
TTCTGGCTGC CGGCCAAATG CAACATATCC AACCGGGTGG TGATCACAGA CGTCACCGTA 
AACCTGGAGA CCGTTACCAT ACGCGAGTGC AAGACGGAGC GCGGGTTTTT TCGTGAGCGC 
GACATGAAAG GCGATTCGTC GCCAGTAGCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524199.1
CDS	111..1283
Translation	MTGRGKGSKGKLGRDNATDDPVDLVYAAEKIIQKRVKKGVVEYRVKWKGWNQRYNTWEPEVNILDRRLIDIYEQTNKSSGTPSKRGIKKKEKEPDPEPESEEDEYTFTENDVDTHQATTSSATHDKESKKEKKHHHHHHHHHHIKSERNSGRRSESPLTHHHHHHHHESKRQRIDHSSSSNSSFTHNSFVPEPDSNSSSSEDQPLIGTKRKAEVLKESGKIGVTIKTSPDGPTIKPQPTQQVTPSQQQPFQDQQQAEKIASEAATQLKSEQQATPLATEAINTTPAESGAEEEEVANEEGNQQAPQVPSENNNIPKPCNNLAINQKQPLTPLSPRALPPRFWLPAKCNISNRVVITDVTVNLETVTIRECKTERGFFRERDMKGDSSPVA

Target ORF information:

RefSeq Version	NM_079475.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster polycomb (Pc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079475.3

ORF Insert Sequence:

ATGACTGGTC GAGGCAAGGG GAGTAAGGGG AAGTTGGGGC GCGACAATGC GACCGACGAT 
CCAGTCGATC TAGTGTACGC GGCTGAGAAA ATCATCCAAA AGCGCGTTAA GAAGGGCGTC 
GTGGAGTACC GTGTCAAGTG GAAGGGCTGG AACCAGCGCT ACAACACCTG GGAACCGGAG 
GTAAACATCC TGGATCGCCG CCTCATCGAC ATCTACGAAC AAACGAACAA ATCCTCCGGA 
ACTCCCTCCA AGCGAGGCAT TAAGAAGAAG GAGAAAGAAC CCGATCCGGA GCCGGAATCC 
GAGGAGGATG AGTACACCTT CACCGAAAAC GATGTGGACA CGCATCAAGC CACCACCTCA 
TCGGCTACCC ACGATAAGGA GTCGAAGAAG GAGAAGAAGC ACCATCACCA CCACCACCAT 
CATCACCACA TCAAGTCCGA ACGCAACAGT GGACGGCGCT CGGAATCTCC GCTGACCCAC 
CATCATCATC ACCACCACCA CGAGTCCAAG CGTCAGCGCA TTGATCACAG CTCCTCCTCG 
AACAGCAGCT TCACGCACAA CTCATTTGTC CCCGAGCCGG ACAGCAACTC CTCCAGCTCC 
GAGGATCAGC CGCTGATCGG CACCAAACGC AAAGCCGAGG TGCTCAAGGA ATCGGGCAAG 
ATTGGAGTTA CGATTAAGAC CTCCCCAGAT GGCCCCACTA TTAAGCCTCA GCCGACCCAG 
CAGGTAACTC CCAGCCAGCA GCAGCCCTTC CAGGATCAGC AGCAAGCGGA AAAGATTGCC 
AGCGAGGCTG CAACGCAGCT GAAATCTGAG CAGCAGGCCA CCCCACTGGC CACAGAAGCC 
ATAAACACAA CGCCCGCAGA GTCCGGAGCT GAGGAAGAAG AAGTAGCCAA CGAGGAAGGC 
AACCAACAGG CGCCACAGGT TCCTTCCGAG AACAATAACA TACCAAAACC GTGCAACAAC 
CTGGCTATCA ACCAGAAACA GCCGCTTACT CCTCTTTCGC CGCGTGCCCT TCCGCCGCGC 
TTCTGGCTGC CGGCCAAATG CAACATATCC AACCGGGTGG TGATCACAGA CGTCACCGTA 
AACCTGGAGA CCGTTACCAT ACGCGAGTGC AAGACGGAGC GCGGGTTTTT TCGTGAGCGC 
GACATGAAAG GCGATTCGTC GCCAGTAGCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Pc cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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