Ilp2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ilp2
Entrez Gene ID	39150
Full Name	Insulin-like peptide 2
Synonyms	CG8167,DILP,DILP-2,DILP2,Dilp,Dilp 2,Dilp-2,Dilp2,Dmel\CG8167,ILP2,IRP,Ilp,Ilp-2,dILP-2,dILP2,dIlp2,dilp,dilp-2,dilp2,ilp2
General protein information	Preferred Names Insulin-like peptide 2 Names CG8167 gene product from transcript CG8167-RA CG8167-PA Ilp2-PA Insulin- related peptide 2 Insulin-related peptide drosophila insulin like peptide 2 drosophila insulin-like peptide 2 insulin-like 2 insulin-like peptide insulin-like peptide-2
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 67C8-67C8

mRNA and Protein(s)

mRNA	Protein	Name
NM_079288.3	NP_524012.1	Insulin-like peptide 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results found that virgin females with knockout mutations of Ilp2, Ilp3 and Ilp5 show high mating success rate with higher locomotion.
Title: Knockout mutations of insulin-like peptide genes enhance sexual receptivity in Drosophila virgin females.

Knockdown of the Drosophila orthologues of human T2DM risk genes, including GLIS3 and BCL11A, revealed roles of these Drosophila genes in Ilp2 production or secretion.
Title: A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion.

Under hypoxic conditions, Sima nuclear localization in the fat body is associated with lipid droplet aggregation and impaired lipid mobilization to oenocytes. The fat body in turn, perhaps through a secreted signal, inhibits Dilp2 secretion from the larval brain, associated with reduced insulin receptor signaling in peripheral tissues.
Title: Insulin- and warts-dependent regulation of tracheal plasticity modulates systemic larval growth during hypoxia in Drosophila melanogaster.

dMyc in fat body affects the release of DILP2 from the insulin producing cells.
Title: dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth.

These results indicate that adiponectin receptor in insulin producing cells regulates insulin secretion and controls glucose and lipid metabolism in Drosophila melanogaster.
Title: Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion.

The following Ilp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ilp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa18107	NM_079288.3 Latest version!	Drosophila melanogaster Insulin-like peptide 2 (Ilp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ilp2 ( NM_079288.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524012.1 Drosophila melanogaster Insulin-like peptide 2 (Ilp2), mRNA.

Price & Availability↑

CloneID	OFa18107
Clone ID Related Accession (Same CDS sequence)	NM_079288.3
Accession Version	NM_079288.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Insulin-like peptide 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_079288.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGAGCAAGC CTTTGTCCTT CATCTCGATG GTGGCCGTGA TTTTGCTGGC CAGCTCCACA 
GTGAAGTTGG CCCAAGGAAC GCTCTGCAGT GAAAAGCTCA ACGAGGTGCT GAGTATGGTG 
TGCGAGGAGT ATAATCCCGT GATTCCACAC AAGCGCGCCA TGCCCGGTGC CGACAGCGAT 
CTGGACGCCC TCAATCCCCT GCAGTTTGTC CAGGAGTTCG AGGAGGAGGA TAACTCGATA 
TCGGAACCGC TGCGAAGTGC CCTCTTTCCT GGGAGCTATC TTGGGGGTGT ACTCAATTCC 
CTGGCTGAAG TCCGGAGGCG AACTCGCCAA CGGCAAGGAA TCGTGGAGAG GTGCTGCAAA 
AAGTCCTGTG ATATGAAGGC TCTGCGGGAG TACTGCTCCG TGGTCAGAAA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524012.1
CDS	67..480
Translation	MSKPLSFISMVAVILLASSTVKLAQGTLCSEKLNEVLSMVCEEYNPVIPHKRAMPGADSDLDALNPLQFVQEFEEEDNSISEPLRSALFPGSYLGGVLNSLAEVRRRTRQRQGIVERCCKKSCDMKALREYCSVVRN

Target ORF information:

RefSeq Version	NM_079288.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Insulin-like peptide 2 (Ilp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079288.3

ORF Insert Sequence:

ATGAGCAAGC CTTTGTCCTT CATCTCGATG GTGGCCGTGA TTTTGCTGGC CAGCTCCACA 
GTGAAGTTGG CCCAAGGAAC GCTCTGCAGT GAAAAGCTCA ACGAGGTGCT GAGTATGGTG 
TGCGAGGAGT ATAATCCCGT GATTCCACAC AAGCGCGCCA TGCCCGGTGC CGACAGCGAT 
CTGGACGCCC TCAATCCCCT GCAGTTTGTC CAGGAGTTCG AGGAGGAGGA TAACTCGATA 
TCGGAACCGC TGCGAAGTGC CCTCTTTCCT GGGAGCTATC TTGGGGGTGT ACTCAATTCC 
CTGGCTGAAG TCCGGAGGCG AACTCGCCAA CGGCAAGGAA TCGTGGAGAG GTGCTGCAAA 
AAGTCCTGTG ATATGAAGGC TCTGCGGGAG TACTGCTCCG TGGTCAGAAA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Ilp2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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