Lhr cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lhr
Entrez Gene ID	36957
Full Name	Lethal hybrid rescue
Synonyms	CG18468,Dmel\CG18468,HP3,LHR,LHR[[mel]],mel-Lhr
General protein information	Preferred Names Lethal hybrid rescue Names CG18468 gene product from transcript CG18468-RA CG18468-PA Lhr-PA lethal hybrid rescue
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 54B7-54B7

mRNA and Protein(s)

mRNA	Protein	Name
NM_137366.4	NP_611210.3	lethal hybrid rescue

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Using RNA-Seq analyses we discovered that Hmr and Lhr are required to repress transcripts from satellite DNAs and many families of transposable elements (TEs).
Title: The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats.

Results are consistent with the allelic asymmetry model of the Lhr gene expression in the hybrid.
Title: Allelic asymmetry of the Lethal hybrid rescue (Lhr) gene expression in the hybrid between Drosophila melanogaster and D. simulans: confirmation by using genetic variations of D. melanogaster.

LHR orthologs interact with HP1 and HP6, and can localize to heterochromatin when expressed in D. melanogaster.
Title: Functional conservation of the Drosophila hybrid incompatibility gene Lhr.

findings show Lhr has functionally diverged in D. simulans & interacts with Hybrid male rescue, which has functionally diverged in D. melanogaster, to cause lethality in F1 hybrid males; LHR has diverged in these species consistent with positive selection
Title: Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.

The following Lhr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lhr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa13031	NM_137366.4 Latest version!	Drosophila melanogaster lethal hybrid rescue (Lhr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lhr ( NM_137366.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_611210.3 Drosophila melanogaster lethal hybrid rescue (Lhr), mRNA.

Price & Availability↑

CloneID	OFa13031
Clone ID Related Accession (Same CDS sequence)	NM_137366.4
Accession Version	NM_137366.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	lethal hybrid rescue
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_137366.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTGTTGTA GAACGTTGGA GAAACACAGT GCGAAAAATA TTAAAATGAG TACCGACAGC 
GCCGAGGAAA CGGTGATCCA TTCCACTGTT CCCCATTTGG AGATTAACAT ATCAAACACC 
AACATCAGCG GCCAGATTGT TTTAAACGAC TTGCTGCTCA TGGAGATGCT CGCCCGGTAT 
CCCTTCCTTA TCATCCCGCA GGTGGAGCCC AAAATGGACG TTGACTACGA CTCCTGGGGT 
TGGGATCAGC TGGCCAAGTC CTTTAACCAA AGCTACGAGC ACGTTGAGCT GAGTACTCCG 
TTCTCCGTAA GTGAACTGAA GCTGCGTTGG GTGAAGCTGC GCCCGCTGGT CAGAGCCTTG 
GCCGGTTCCA AAGGGCAAAT CCCTGAACCT CTGTGGCGGG TGATGCACGA TGTGCACATT 
CGCATGCAAG CCCCGAATCC GGCGGATGTG CCGAAAACCA AGTGTCAGGA GTTTCTTCTC 
AGTCAGTTGC CTTTCGTGAA ATCTATGGCG CAAGCGGAAC GCCGGCATTT AGAAGTGGAG 
GTCCTCGCCC TCATCCTGGA GCAAGAGCGC CAAGAGAAAG CTACTCGAAA GCTGGGTCCT 
AAGGACCTGG AGACGGTTCA GAGCGAATAC GACGAATTTC TTAAAGCGAT ACGGGTGAAA 
GAGCTCCCAG CAGACAATTT ACTCAGTCCG GCCATGGACA GATTCGGCAT TAGCCCACAC 
AAAATAAGAC CCAATGTCGC AAGTGCCAAT AAAAGAATCA GATATAATAA TGCTTGCAAA 
GGATCAAATG ATGTCAAAAT CAAAATAGAA ACAGCTATTG AACCTAAAAT TAAAGATACA 
ACAAAATGTG ACGAACGACC GATAGAAACA CCACGCTTCG TTCCTCTTAA AAGCGCGAAA 
TACTACATTA AAAGGTGTCG CATCCGGCTG AAGCGAGTGG AAATTGATGA TTATTTACCC 
TTAGCTAGAA TACGGCGCTC AAGGCGGCCT ACGCTGAGAA CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_611210.3
CDS	129..1133
Translation	MCCRTLEKHSAKNIKMSTDSAEETVIHSTVPHLEINISNTNISGQIVLNDLLLMEMLARYPFLIIPQVEPKMDVDYDSWGWDQLAKSFNQSYEHVELSTPFSVSELKLRWVKLRPLVRALAGSKGQIPEPLWRVMHDVHIRMQAPNPADVPKTKCQEFLLSQLPFVKSMAQAERRHLEVEVLALILEQERQEKATRKLGPKDLETVQSEYDEFLKAIRVKELPADNLLSPAMDRFGISPHKIRPNVASANKRIRYNNACKGSNDVKIKIETAIEPKIKDTTKCDERPIETPRFVPLKSAKYYIKRCRIRLKRVEIDDYLPLARIRRSRRPTLRT

Target ORF information:

RefSeq Version	NM_137366.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster lethal hybrid rescue (Lhr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_137366.4

ORF Insert Sequence:

ATGTGTTGTA GAACGTTGGA GAAACACAGT GCGAAAAATA TTAAAATGAG TACCGACAGC 
GCCGAGGAAA CGGTGATCCA TTCCACTGTT CCCCATTTGG AGATTAACAT ATCAAACACC 
AACATCAGCG GCCAGATTGT TTTAAACGAC TTGCTGCTCA TGGAGATGCT CGCCCGGTAT 
CCCTTCCTTA TCATCCCGCA GGTGGAGCCC AAAATGGACG TTGACTACGA CTCCTGGGGT 
TGGGATCAGC TGGCCAAGTC CTTTAACCAA AGCTACGAGC ACGTTGAGCT GAGTACTCCG 
TTCTCCGTAA GTGAACTGAA GCTGCGTTGG GTGAAGCTGC GCCCGCTGGT CAGAGCCTTG 
GCCGGTTCCA AAGGGCAAAT CCCTGAACCT CTGTGGCGGG TGATGCACGA TGTGCACATT 
CGCATGCAAG CCCCGAATCC GGCGGATGTG CCGAAAACCA AGTGTCAGGA GTTTCTTCTC 
AGTCAGTTGC CTTTCGTGAA ATCTATGGCG CAAGCGGAAC GCCGGCATTT AGAAGTGGAG 
GTCCTCGCCC TCATCCTGGA GCAAGAGCGC CAAGAGAAAG CTACTCGAAA GCTGGGTCCT 
AAGGACCTGG AGACGGTTCA GAGCGAATAC GACGAATTTC TTAAAGCGAT ACGGGTGAAA 
GAGCTCCCAG CAGACAATTT ACTCAGTCCG GCCATGGACA GATTCGGCAT TAGCCCACAC 
AAAATAAGAC CCAATGTCGC AAGTGCCAAT AAAAGAATCA GATATAATAA TGCTTGCAAA 
GGATCAAATG ATGTCAAAAT CAAAATAGAA ACAGCTATTG AACCTAAAAT TAAAGATACA 
ACAAAATGTG ACGAACGACC GATAGAAACA CCACGCTTCG TTCCTCTTAA AAGCGCGAAA 
TACTACATTA AAAGGTGTCG CATCCGGCTG AAGCGAGTGG AAATTGATGA TTATTTACCC 
TTAGCTAGAA TACGGCGCTC AAGGCGGCCT ACGCTGAGAA CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Lhr cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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