egr cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	egr
Entrez Gene ID	36054
Full Name	eiger
Synonyms	BcDNA:RH51659,CG12919,Dmel\CG12919,Ect1,Egr,Regg1,TNF,TNF-alpha,TNFalpha,darth,dt1,regg1
General protein information	Preferred Names eiger Names CG12919 gene product from transcript CG12919-RA CG12919-PA CG12919-PB TNF-alpha drosophila aspartate rich TNF homolog egr-PA egr-PB tumor necrosis factor family member DT1 wengen
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 46E1-46E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_206069.3	NP_995791.1	eiger, isoform B
NM_165735.4	NP_724878.2	eiger, isoform A

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rac1-dependent production of an Eiger signaling endosome is a crucial element required for activation of the cell death pathway in fly.
Title: Eiger-induced cell death relies on Rac1-dependent endocytosis.

This study shows that Eiger, the Drosophila TNF-alpha, is a metabolic hormone that mediates nutrient response by remotely acting on insulin-producing cells.
Title: The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response.

Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth
Title: The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth.

a new requirement for Eiger in eliminating damaged cells during development
Title: The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis.

Data indicate that dysfunction of Rab5 leads to cell-autonomous accumulation of a TNF homolog Eiger, and causes activation of Ras signaling.
Title: Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila.

The following egr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the egr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa09456	NM_206069.3 Latest version!	Drosophila melanogaster eiger (egr), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OFa09457	NM_165735.4 Latest version!	Drosophila melanogaster eiger (egr), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

egr ( NM_206069.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_995791.1 Drosophila melanogaster eiger (egr), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa09456
Clone ID Related Accession (Same CDS sequence)	NM_206069.3
Accession Version	NM_206069.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	eiger, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_206069.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGACTGCCG AGACCCTCAA GCCGTTTATA ACGCCAACGA GTGCCAACGA TGATGGTTTT 
CCGGCCAAAG CGACCAGCAC GGCGACCGCC CAGCGACGCA CCCGCCAGCT GATCCCCCTG 
GTTTTGGGGT TCATCGGTCT GGGGCTGGTC GTTGCCATTC TCGCACTAAC GATCTGGCAG 
ACAACGCGTG TATCGCATCT GGACAAGGAG CTGAAGAGCC TGAAGCGAGT CGTCGATAAT 
CTCCAGCAGC GTTTGGGCAT AAACTATCTG GACGAGTTCG ACGAGTTCCA AAAGGAGTAC 
GAGAATGCCC TCATCGACTA TCCAAAAAAG GTGGATGGCC TCACGGATGA GGAGGACGAC 
GACGATGGCG ATGGTCTGGA TTCCATTGCG GACGACGAGG ACGACGACGT TAGCTATAGC 
TCTGTGGATG ATGTTGGCGC AGACTACGAG GACTACACCG ATATGTTAAA TAAACTCAAC 
AATGCACATA CCGGCACCAC GCCCACATCT GAGACCACTG CTGAGGGCGA GGGCGAGACG 
GACAGTGCAT CCTCAGCCTC AAATGATGAC AATGTGTTCG ATGACTTTAC CAGCTACAAT 
GCCCACAAAA AGAAGCAGGA GAGAAAATCT CGCTCGATTG CCGATGTACG CAATGAGGAG 
CAGAATATTC AAGGAAATCA CACAGAGCTT CAGGAAAAGT CATCCAATGA GGCAACTTCC 
AAAGAGAGCC CTGCACCACT TCACCACCGT CGCAGAATGC ATTCCCGCCA TCGCCACCTC 
CTAGTCCGCA AAGCCAGATC CGAGGACTCG AGGCCAGCAG CCCATTTCCA CTTGAGCAGC 
AGGCGGCGTC ACCAAGGAAG TATGGGCTAC CATGGAGATA TGTACATAGG AAATGATAAC 
GAGAGAAACT CTTATCAGGG ACACTTTCAA ACGCGCGATG GCGTCTTGAC GGTGACCAAT 
ACAGGCCTAT ATTACGTATA CGCCCAGATA TGCTACAACA ACTCGCACGA CCAGAACGGA 
TTTATCGTCT TTCAAGGAGA CACTCCATTC CTGCAGTGCT TGAACACGGT GCCCACCAAC 
ATGCCACATA AGGTGCACAC CTGCCACACG AGTGGTCTGA TCCACCTGGA ACGAAACGAG 
AGGATCCATC TGAAGGACAT TCACAACGAT CGCAATGCAG TTCTGCGGGA GGGAAACAAC 
CGAAGCTACT TTGGCATCTT CAAGGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_995791.1
CDS	647..1876
Translation	MTAETLKPFITPTSANDDGFPAKATSTATAQRRTRQLIPLVLGFIGLGLVVAILALTIWQTTRVSHLDKELKSLKRVVDNLQQRLGINYLDEFDEFQKEYENALIDYPKKVDGLTDEEDDDDGDGLDSIADDEDDDVSYSSVDDVGADYEDYTDMLNKLNNAHTGTTPTSETTAEGEGETDSASSASNDDNVFDDFTSYNAHKKKQERKSRSIADVRNEEQNIQGNHTELQEKSSNEATSKESPAPLHHRRRMHSRHRHLLVRKARSEDSRPAAHFHLSSRRRHQGSMGYHGDMYIGNDNERNSYQGHFQTRDGVLTVTNTGLYYVYAQICYNNSHDQNGFIVFQGDTPFLQCLNTVPTNMPHKVHTCHTSGLIHLERNERIHLKDIHNDRNAVLREGNNRSYFGIFKV

Target ORF information:

RefSeq Version	NM_206069.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster eiger (egr), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206069.3

ORF Insert Sequence:

ATGACTGCCG AGACCCTCAA GCCGTTTATA ACGCCAACGA GTGCCAACGA TGATGGTTTT 
CCGGCCAAAG CGACCAGCAC GGCGACCGCC CAGCGACGCA CCCGCCAGCT GATCCCCCTG 
GTTTTGGGGT TCATCGGTCT GGGGCTGGTC GTTGCCATTC TCGCACTAAC GATCTGGCAG 
ACAACGCGTG TATCGCATCT GGACAAGGAG CTGAAGAGCC TGAAGCGAGT CGTCGATAAT 
CTCCAGCAGC GTTTGGGCAT AAACTATCTG GACGAGTTCG ACGAGTTCCA AAAGGAGTAC 
GAGAATGCCC TCATCGACTA TCCAAAAAAG GTGGATGGCC TCACGGATGA GGAGGACGAC 
GACGATGGCG ATGGTCTGGA TTCCATTGCG GACGACGAGG ACGACGACGT TAGCTATAGC 
TCTGTGGATG ATGTTGGCGC AGACTACGAG GACTACACCG ATATGTTAAA TAAACTCAAC 
AATGCACATA CCGGCACCAC GCCCACATCT GAGACCACTG CTGAGGGCGA GGGCGAGACG 
GACAGTGCAT CCTCAGCCTC AAATGATGAC AATGTGTTCG ATGACTTTAC CAGCTACAAT 
GCCCACAAAA AGAAGCAGGA GAGAAAATCT CGCTCGATTG CCGATGTACG CAATGAGGAG 
CAGAATATTC AAGGAAATCA CACAGAGCTT CAGGAAAAGT CATCCAATGA GGCAACTTCC 
AAAGAGAGCC CTGCACCACT TCACCACCGT CGCAGAATGC ATTCCCGCCA TCGCCACCTC 
CTAGTCCGCA AAGCCAGATC CGAGGACTCG AGGCCAGCAG CCCATTTCCA CTTGAGCAGC 
AGGCGGCGTC ACCAAGGAAG TATGGGCTAC CATGGAGATA TGTACATAGG AAATGATAAC 
GAGAGAAACT CTTATCAGGG ACACTTTCAA ACGCGCGATG GCGTCTTGAC GGTGACCAAT 
ACAGGCCTAT ATTACGTATA CGCCCAGATA TGCTACAACA ACTCGCACGA CCAGAACGGA 
TTTATCGTCT TTCAAGGAGA CACTCCATTC CTGCAGTGCT TGAACACGGT GCCCACCAAC 
ATGCCACATA AGGTGCACAC CTGCCACACG AGTGGTCTGA TCCACCTGGA ACGAAACGAG 
AGGATCCATC TGAAGGACAT TCACAACGAT CGCAATGCAG TTCTGCGGGA GGGAAACAAC 
CGAAGCTACT TTGGCATCTT CAAGGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

egr ( NM_165735.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_724878.2 Drosophila melanogaster eiger (egr), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa09457
Clone ID Related Accession (Same CDS sequence)	NM_165735.4
Accession Version	NM_165735.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	eiger, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_165735.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGACTGCCG AGACCCTCAA GCCGTTTATA ACGCCAACGA GTGCCAACGA TGATGGTTTT 
CCGGCCAAAG CGACCAGCAC GGCGACCGCC CAGCGACGCA CCCGCCAGCT GATCCCCCTG 
GTTTTGGGGT TCATCGGTCT GGGGCTGGTC GTTGCCATTC TCGCACTAAC GATCTGGCAG 
ACAACGCGTG TATCGCATCT GGACAAGGAG CTGAAGAGCC TGAAGCGAGT CGTCGATAAT 
CTCCAGCAGC GTTTGGGCAT AAACTATCTG GACGAGTTCG ACGAGTTCCA AAAGGAGTAC 
GAGAATGCCC TCATCGACTA TCCAAAAAAG GTGGATGGCC TCACGGATGA GGAGGACGAC 
GACGATGGCG ATGGTCTGGA TTCCATTGCG GACGACGAGG ACGACGACGT TAGCTATAGC 
TCTGTGGATG ATGTTGGCGC AGACTACGAG GACTACACCG ATATGTTAAA TAAACTCAAC 
AATGCACATA CCGGCACCAC GCCCACATCT GAGACCACTG CTGAGGGCGA GGGCGAGACG 
GACAGTGCAT CCTCAGCCTC AAATGATGAC AATGTGTTCG ATGACTTTAC CAGCTACAAT 
GCCCACAAAA AGAAGCAGGA GAGAAAATCT CGCTCGATTG CCGATGTACG CAATGAGGAG 
CAGAATATTC AAGGAAATCA CACAGAGCTT CAGGAAAAGT CATCCAATGA GGCAACTTCC 
AAAGAGAGCC CTGCACCACT TCACCACCGT CGCAGAATGC ATTCCCGCCA TCGCCACCTC 
CTAGTCCGCA AAGGTGAATC TCTTCTTTCA GCCAGATCCG AGGACTCGAG GCCAGCAGCC 
CATTTCCACT TGAGCAGCAG GCGGCGTCAC CAAGGAAGTA TGGGCTACCA TGGAGATATG 
TACATAGGAA ATGATAACGA GAGAAACTCT TATCAGGGAC ACTTTCAAAC GCGCGATGGC 
GTCTTGACGG TGACCAATAC AGGCCTATAT TACGTATACG CCCAGATATG CTACAACAAC 
TCGCACGACC AGAACGGATT TATCGTCTTT CAAGGAGACA CTCCATTCCT GCAGTGCTTG 
AACACGGTGC CCACCAACAT GCCACATAAG GTGCACACCT GCCACACGAG TGGTCTGATC 
CACCTGGAAC GAAACGAGAG GATCCATCTG AAGGACATTC ACAACGATCG CAATGCAGTT 
CTGCGGGAGG GAAACAACCG AAGCTACTTT GGCATCTTCA AGGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_724878.2
CDS	647..1894
Translation	MTAETLKPFITPTSANDDGFPAKATSTATAQRRTRQLIPLVLGFIGLGLVVAILALTIWQTTRVSHLDKELKSLKRVVDNLQQRLGINYLDEFDEFQKEYENALIDYPKKVDGLTDEEDDDDGDGLDSIADDEDDDVSYSSVDDVGADYEDYTDMLNKLNNAHTGTTPTSETTAEGEGETDSASSASNDDNVFDDFTSYNAHKKKQERKSRSIADVRNEEQNIQGNHTELQEKSSNEATSKESPAPLHHRRRMHSRHRHLLVRKGESLLSARSEDSRPAAHFHLSSRRRHQGSMGYHGDMYIGNDNERNSYQGHFQTRDGVLTVTNTGLYYVYAQICYNNSHDQNGFIVFQGDTPFLQCLNTVPTNMPHKVHTCHTSGLIHLERNERIHLKDIHNDRNAVLREGNNRSYFGIFKV

Target ORF information:

RefSeq Version	NM_165735.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster eiger (egr), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_165735.4

ORF Insert Sequence:

ATGACTGCCG AGACCCTCAA GCCGTTTATA ACGCCAACGA GTGCCAACGA TGATGGTTTT 
CCGGCCAAAG CGACCAGCAC GGCGACCGCC CAGCGACGCA CCCGCCAGCT GATCCCCCTG 
GTTTTGGGGT TCATCGGTCT GGGGCTGGTC GTTGCCATTC TCGCACTAAC GATCTGGCAG 
ACAACGCGTG TATCGCATCT GGACAAGGAG CTGAAGAGCC TGAAGCGAGT CGTCGATAAT 
CTCCAGCAGC GTTTGGGCAT AAACTATCTG GACGAGTTCG ACGAGTTCCA AAAGGAGTAC 
GAGAATGCCC TCATCGACTA TCCAAAAAAG GTGGATGGCC TCACGGATGA GGAGGACGAC 
GACGATGGCG ATGGTCTGGA TTCCATTGCG GACGACGAGG ACGACGACGT TAGCTATAGC 
TCTGTGGATG ATGTTGGCGC AGACTACGAG GACTACACCG ATATGTTAAA TAAACTCAAC 
AATGCACATA CCGGCACCAC GCCCACATCT GAGACCACTG CTGAGGGCGA GGGCGAGACG 
GACAGTGCAT CCTCAGCCTC AAATGATGAC AATGTGTTCG ATGACTTTAC CAGCTACAAT 
GCCCACAAAA AGAAGCAGGA GAGAAAATCT CGCTCGATTG CCGATGTACG CAATGAGGAG 
CAGAATATTC AAGGAAATCA CACAGAGCTT CAGGAAAAGT CATCCAATGA GGCAACTTCC 
AAAGAGAGCC CTGCACCACT TCACCACCGT CGCAGAATGC ATTCCCGCCA TCGCCACCTC 
CTAGTCCGCA AAGGTGAATC TCTTCTTTCA GCCAGATCCG AGGACTCGAG GCCAGCAGCC 
CATTTCCACT TGAGCAGCAG GCGGCGTCAC CAAGGAAGTA TGGGCTACCA TGGAGATATG 
TACATAGGAA ATGATAACGA GAGAAACTCT TATCAGGGAC ACTTTCAAAC GCGCGATGGC 
GTCTTGACGG TGACCAATAC AGGCCTATAT TACGTATACG CCCAGATATG CTACAACAAC 
TCGCACGACC AGAACGGATT TATCGTCTTT CAAGGAGACA CTCCATTCCT GCAGTGCTTG 
AACACGGTGC CCACCAACAT GCCACATAAG GTGCACACCT GCCACACGAG TGGTCTGATC 
CACCTGGAAC GAAACGAGAG GATCCATCTG AAGGACATTC ACAACGATCG CAATGCAGTT 
CTGCGGGAGG GAAACAACCG AAGCTACTTT GGCATCTTCA AGGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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egr cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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