scn2b cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	scn2b
Entrez Gene ID	777666
Full Name	sodium channel, voltage-gated, type II, beta
General protein information	Preferred Names sodium channel, voltage-gated, type II, beta Names sodium channel subunit beta-2 voltage-gated sodium channel beta 2 subunit
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001346412.1	NP_001333341.1	sodium channel subunit beta-2

Pathways from BioSystems

Homologies

	SCN2B	XP_001096430.2
Xenopus tropicalis (tropical clawed frog)	scn2b	NP_001116903.2
Homo sapiens (human)	SCN2B	NP_004579.1
Bos taurus (cattle)	SCN2B	NP_001179003.1
Rattus norvegicus (Norway rat)	Scn2b	NP_037009.1
Danio rerio (zebrafish)	scn2b	NP_001071097.1
Canis lupus familiaris (dog)	SCN2B	XP_005619771.1
Mus musculus (house mouse)	Scn2b	NP_001014761.1
Pan troglodytes (chimpanzee)	SCN2B	XP_522196.2
Gallus gallus (chicken)	SCN2B	XP_417914.3

Gene Ontology
Bibliography

Related articles in PubMed

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Baraban SC, Dinday MT, Hortopan GA
Nature communications42410(2013)

Identification and molecular characterization of the interleukin-10 receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius auratus L.).
Grayfer L, Belosevic M
Developmental and comparative immunology36(2)408-17(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following scn2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the scn2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa20266	NM_001346412.1 Latest version!	Danio rerio sodium channel, voltage-gated, type II, beta (scn2b), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

scn2b ( NM_001346412.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001333341.1 Danio rerio sodium channel, voltage-gated, type II, beta (scn2b), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ODa20266
Clone ID Related Accession (Same CDS sequence)	NM_001346412.1
Accession Version	NM_001346412.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-05
Organism	Danio rerio(zebrafish)
Product	sodium channel subunit beta-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU019627.6. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DQ489729.1, GFIL01034593.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGCTCATTT CATTGCATTC TGGGGAAACG CAATGGGCGT CCGCTTTGAA ATTATCCTGT 
GTTGCAATGG TGATGTTTCT GGCCTGTCCA GTGATGTCCA TGGATGTGCT GGTGCCGGCG 
CTGATCAACG CTCTCAACGG GAGTGACGTC AGAATCACAT GTACTTTCAC CTCATGCTAC 
AAGCTGGACC CCAGCAAGTT TGCAATGAAC TGGACATATC AGGAGACAAG CAACAGCACA 
GAGGAGATGT TCATGACCTA TAAGAACACC TATAAGATGA TACCCTTGAA GCCCAGTCGA 
TTTGGAGAGC GAGTCATGTT TACTGGAAAC CTGGATAAGA ACGACCTTTC CATCACCATC 
TCGGACGTGC AGCTGACAGA CGAGGGCATC TACAACTGCT ATGTGCGCAA CCCTCCAGAC 
CGCATTCAGG GCCATGGCAC CATCCAGTTT GCCGTCCTGA CTGAATTACC TCCACCAAGG 
GACTCGACCA TTGCTGTGGC CATCGGCGCA TCTGTGGGGG GCATCCTTGC TCTGCTCATT 
CTGTCCATGG TGGTGGTGAA GTGCATCCGC AGACATAAGA ACCAGGAGCT GATCTCAGAC 
GAGCAGAAGA TGGAAGAAGA GGGCAAAGTA GATGGTGAAG GAGGCACAGA AGAAGCAACA 
AAAAATTTAA GCCTCCTGCC TGAAGATATA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001333341.1
CDS	162..854
Translation	MLISLHSGETQWASALKLSCVAMVMFLACPVMSMDVLVPALINALNGSDVRITCTFTSCYKLDPSKFAMNWTYQETSNSTEEMFMTYKNTYKMIPLKPSRFGERVMFTGNLDKNDLSITISDVQLTDEGIYNCYVRNPPDRIQGHGTIQFAVLTELPPPRDSTIAVAIGASVGGILALLILSMVVVKCIRRHKNQELISDEQKMEEEGKVDGEGGTEEATKNLSLLPEDI

Target ORF information:

RefSeq Version	NM_001346412.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio sodium channel, voltage-gated, type II, beta (scn2b), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001346412.1

ORF Insert Sequence:

ATGCTCATTT CATTGCATTC TGGGGAAACG CAATGGGCGT CCGCTTTGAA ATTATCCTGT 
GTTGCAATGG TGATGTTTCT GGCCTGTCCA GTGATGTCCA TGGATGTGCT GGTGCCGGCG 
CTGATCAACG CTCTCAACGG GAGTGACGTC AGAATCACAT GTACTTTCAC CTCATGCTAC 
AAGCTGGACC CCAGCAAGTT TGCAATGAAC TGGACATATC AGGAGACAAG CAACAGCACA 
GAGGAGATGT TCATGACCTA TAAGAACACC TATAAGATGA TACCCTTGAA GCCCAGTCGA 
TTTGGAGAGC GAGTCATGTT TACTGGAAAC CTGGATAAGA ACGACCTTTC CATCACCATC 
TCGGACGTGC AGCTGACAGA CGAGGGCATC TACAACTGCT ATGTGCGCAA CCCTCCAGAC 
CGCATTCAGG GCCATGGCAC CATCCAGTTT GCCGTCCTGA CTGAATTACC TCCACCAAGG 
GACTCGACCA TTGCTGTGGC CATCGGCGCA TCTGTGGGGG GCATCCTTGC TCTGCTCATT 
CTGTCCATGG TGGTGGTGAA GTGCATCCGC AGACATAAGA ACCAGGAGCT GATCTCAGAC 
GAGCAGAAGA TGGAAGAAGA GGGCAAAGTA GATGGTGAAG GAGGCACAGA AGAAGCAACA 
AAAAATTTAA GCCTCCTGCC TGAAGATATA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Nature communications42410(2013)
Baraban SC,Dinday MT,Hortopan GA

Identification and molecular characterization of the interleukin-10 receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius auratus L.).
Developmental and comparative immunology36(2)408-17(2012 Feb)
Grayfer L,Belosevic M