SCN2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCN2B
Entrez Gene ID	6327
Full Name	sodium voltage-gated channel beta subunit 2
Synonyms	ATFB14
General protein information	Preferred Names sodium voltage-gated channel beta subunit 2 Names sodium channel subunit beta-2 neuronal voltage-gated sodium channel beta 2 subunit sodium channel, voltage gated, type II beta subunit sodium channel, voltage-gated, type II, beta polypeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015].
Disorder MIM:	601327
Disorder Html:	Atrial fibrillation, familial, 14, 615378 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004588.5	NP_004579.1	sodium channel subunit beta-2 precursor
NM_004588.4	NP_004579.1	sodium channel subunit beta-2 precursor

Pathways from BioSystems

Homologies

	SCN2B	XP_001096430.2
Xenopus tropicalis (tropical clawed frog)	scn2b	NP_001116903.2
Homo sapiens (human)	SCN2B	NP_004579.1
Bos taurus (cattle)	SCN2B	NP_001179003.1
Rattus norvegicus (Norway rat)	Scn2b	NP_037009.1
Danio rerio (zebrafish)	scn2b	NP_001071097.1
Canis lupus familiaris (dog)	SCN2B	XP_005619771.1
Mus musculus (house mouse)	Scn2b	NP_001014761.1
Pan troglodytes (chimpanzee)	SCN2B	XP_522196.2
Gallus gallus (chicken)	SCN2B	XP_417914.3

Gene Ontology
Bibliography

Related articles in PubMed

Trafficking and localisation to the plasma membrane of Na
Dulsat G, Palomeras S, Cortada E, Riur? H, Brugada R, Verg?s M
Biology of the cell109(7)273-291(2017 Jul)

Binary architecture of the Nav1.2-?2 signaling complex.
Das S, Gilchrist J, Bosmans F, Van Petegem F
eLife5(2016 Feb)

The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.
Winkel BG, Yuan L, Olesen MS, Sadjadieh G, Wang Y, Risgaard B, Jabbari R, Hauns? S, Holst AG, Hollegaard MV, Tfelt-Hansen J, Jespersen T
Heart rhythm12(6)1241-9(2015 Jun)

Contribution of Cardiac Sodium Channel ?-Subunit Variants to Brugada Syndrome.
Peeters U, Scornik F, Riur? H, P?rez G, Komurcu-Bayrak E, Van Malderen S, Pappaert G, Tarradas A, Pagans S, Daneels D, Breckpot K, Brugada P, Bonduelle M, Brugada R, Van Dooren S
Circulation journal : official journal of the Japanese Circulation Society79(10)2118-29(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors identified a flexible loop formed by (72)Cys and (75)Cys, a unique feature among the four beta-subunit isoforms.
Title: Binary architecture of the Nav1.2-?2 signaling complex.

In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes.
Title: The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.

Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome.
Title: Contribution of Cardiac Sodium Channel ?-Subunit Variants to Brugada Syndrome.

sodium channel polymorphisms are associated with epilepsy
Title: Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

With increased beta-2 expression, prostate cancer cells display a trend of enhanced association with nerve axons.
Title: Identification of beta-2 as a key cell adhesion molecule in PCa cell neurotropic behavior: a novel ex vivo and biophysical approach.

The following SCN2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCN2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22615	NM_004588.5 Latest version!	Homo sapiens sodium voltage-gated channel beta subunit 2 (SCN2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu22615	NM_004588.4	Homo sapiens sodium voltage-gated channel beta subunit 2 (SCN2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCN2B ( NM_004588.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004579.1 Homo sapiens sodium voltage-gated channel beta subunit 2 (SCN2B), mRNA.

Price & Availability↑

CloneID	OHu22615
Clone ID Related Accession (Same CDS sequence)	NM_004588.5 , NM_004588.4
Accession Version	NM_004588.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Homo sapiens(human)
Product	sodium channel subunit beta-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP002800.4, DA290917.1 and BC036793.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_004588.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.258744.1, SRR3476690.817100.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000278947.6/ ENSP00000278947.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACAGAG ATGCCTGGCT ACCTCGCCCT GCCTTCAGCC TCACGGGGCT CAGTCTCTTT 
TTCTCTTTGG TGCCACCAGG ACGGAGCATG GAGGTCACAG TACCTGCCAC CCTCAACGTC 
CTCAATGGCT CTGACGCCCG CCTGCCCTGC ACCTTCAACT CCTGCTACAC AGTGAACCAC 
AAACAGTTCT CCCTGAACTG GACTTACCAG GAGTGCAACA ACTGCTCTGA GGAGATGTTC 
CTCCAGTTCC GCATGAAGAT CATTAACCTG AAGCTGGAGC GGTTTCAAGA CCGCGTGGAG 
TTCTCAGGGA ACCCCAGCAA GTACGATGTG TCGGTGATGC TGAGAAACGT GCAGCCGGAG 
GATGAGGGGA TTTACAACTG CTACATCATG AACCCCCCTG ACCGCCACCG TGGCCATGGC 
AAGATCCATC TGCAGGTCCT CATGGAAGAG CCCCCTGAGC GGGACTCCAC GGTGGCCGTG 
ATTGTGGGTG CCTCCGTCGG GGGCTTCCTG GCTGTGGTCA TCTTGGTGCT GATGGTGGTC 
AAGTGTGTGA GGAGAAAAAA AGAGCAGAAG CTGAGCACAG ATGACCTGAA GACCGAGGAG 
GAGGGCAAGA CGGACGGTGA AGGCAACCCG GATGATGGCG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004579.1
CDS	209..856
Translation	MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK

Target ORF information:

RefSeq Version	NM_004588.5
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium voltage-gated channel beta subunit 2 (SCN2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004588.5

ORF Insert Sequence:

ATGCACAGAG ATGCCTGGCT ACCTCGCCCT GCCTTCAGCC TCACGGGGCT CAGTCTCTTT 
TTCTCTTTGG TGCCACCAGG ACGGAGCATG GAGGTCACAG TACCTGCCAC CCTCAACGTC 
CTCAATGGCT CTGACGCCCG CCTGCCCTGC ACCTTCAACT CCTGCTACAC AGTGAACCAC 
AAACAGTTCT CCCTGAACTG GACTTACCAG GAGTGCAACA ACTGCTCTGA GGAGATGTTC 
CTCCAGTTCC GCATGAAGAT CATTAACCTG AAGCTGGAGC GGTTTCAAGA CCGCGTGGAG 
TTCTCAGGGA ACCCCAGCAA GTACGATGTG TCGGTGATGC TGAGAAACGT GCAGCCGGAG 
GATGAGGGGA TTTACAACTG CTACATCATG AACCCCCCTG ACCGCCACCG TGGCCATGGC 
AAGATCCATC TGCAGGTCCT CATGGAAGAG CCCCCTGAGC GGGACTCCAC GGTGGCCGTG 
ATTGTGGGTG CCTCCGTCGG GGGCTTCCTG GCTGTGGTCA TCTTGGTGCT GATGGTGGTC 
AAGTGTGTGA GGAGAAAAAA AGAGCAGAAG CTGAGCACAG ATGACCTGAA GACCGAGGAG 
GAGGGCAAGA CGGACGGTGA AGGCAACCCG GATGATGGCG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCN2B ( NM_004588.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004579.1 Homo sapiens sodium voltage-gated channel beta subunit 2 (SCN2B), mRNA.

Price & Availability↑

CloneID	OHu22615
Clone ID Related Accession (Same CDS sequence)	NM_004588.5 , NM_004588.4
Accession Version	NM_004588.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	sodium channel subunit beta-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA290917.1, BC036793.1 and AP002800.4. This sequence is a reference standard in the RefSeqGene project. On Apr 2, 2009 this sequence version replaced NM_004588.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036793.1, SRR1660803.108480.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACAGAG ATGCCTGGCT ACCTCGCCCT GCCTTCAGCC TCACGGGGCT CAGTCTCTTT 
TTCTCTTTGG TGCCACCAGG ACGGAGCATG GAGGTCACAG TACCTGCCAC CCTCAACGTC 
CTCAATGGCT CTGACGCCCG CCTGCCCTGC ACCTTCAACT CCTGCTACAC AGTGAACCAC 
AAACAGTTCT CCCTGAACTG GACTTACCAG GAGTGCAACA ACTGCTCTGA GGAGATGTTC 
CTCCAGTTCC GCATGAAGAT CATTAACCTG AAGCTGGAGC GGTTTCAAGA CCGCGTGGAG 
TTCTCAGGGA ACCCCAGCAA GTACGATGTG TCGGTGATGC TGAGAAACGT GCAGCCGGAG 
GATGAGGGGA TTTACAACTG CTACATCATG AACCCCCCTG ACCGCCACCG TGGCCATGGC 
AAGATCCATC TGCAGGTCCT CATGGAAGAG CCCCCTGAGC GGGACTCCAC GGTGGCCGTG 
ATTGTGGGTG CCTCCGTCGG GGGCTTCCTG GCTGTGGTCA TCTTGGTGCT GATGGTGGTC 
AAGTGTGTGA GGAGAAAAAA AGAGCAGAAG CTGAGCACAG ATGACCTGAA GACCGAGGAG 
GAGGGCAAGA CGGACGGTGA AGGCAACCCG GATGATGGCG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004579.1
CDS	192..839
Translation	MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK

Target ORF information:

RefSeq Version	NM_004588.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium voltage-gated channel beta subunit 2 (SCN2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004588.4

ORF Insert Sequence:

ATGCACAGAG ATGCCTGGCT ACCTCGCCCT GCCTTCAGCC TCACGGGGCT CAGTCTCTTT 
TTCTCTTTGG TGCCACCAGG ACGGAGCATG GAGGTCACAG TACCTGCCAC CCTCAACGTC 
CTCAATGGCT CTGACGCCCG CCTGCCCTGC ACCTTCAACT CCTGCTACAC AGTGAACCAC 
AAACAGTTCT CCCTGAACTG GACTTACCAG GAGTGCAACA ACTGCTCTGA GGAGATGTTC 
CTCCAGTTCC GCATGAAGAT CATTAACCTG AAGCTGGAGC GGTTTCAAGA CCGCGTGGAG 
TTCTCAGGGA ACCCCAGCAA GTACGATGTG TCGGTGATGC TGAGAAACGT GCAGCCGGAG 
GATGAGGGGA TTTACAACTG CTACATCATG AACCCCCCTG ACCGCCACCG TGGCCATGGC 
AAGATCCATC TGCAGGTCCT CATGGAAGAG CCCCCTGAGC GGGACTCCAC GGTGGCCGTG 
ATTGTGGGTG CCTCCGTCGG GGGCTTCCTG GCTGTGGTCA TCTTGGTGCT GATGGTGGTC 
AAGTGTGTGA GGAGAAAAAA AGAGCAGAAG CTGAGCACAG ATGACCTGAA GACCGAGGAG 
GAGGGCAAGA CGGACGGTGA AGGCAACCCG GATGATGGCG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Trafficking and localisation to the plasma membrane of Na
Biology of the cell109(7)273-291(2017 Jul)
Dulsat G,Palomeras S,Cortada E,Riur? H,Brugada R,Verg?s M

Binary architecture of the Nav1.2-?2 signaling complex.
eLife5(2016 Feb)
Das S,Gilchrist J,Bosmans F,Van Petegem F

The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.
Heart rhythm12(6)1241-9(2015 Jun)
Winkel BG,Yuan L,Olesen MS,Sadjadieh G,Wang Y,Risgaard B,Jabbari R,Hauns? S,Holst AG,Hollegaard MV,Tfelt-Hansen J,Jespersen T

Contribution of Cardiac Sodium Channel ?-Subunit Variants to Brugada Syndrome.
Circulation journal : official journal of the Japanese Circulation Society79(10)2118-29(2015)
Peeters U,Scornik F,Riur? H,P?rez G,Komurcu-Bayrak E,Van Malderen S,Pappaert G,Tarradas A,Pagans S,Daneels D,Breckpot K,Brugada P,Bonduelle M,Brugada R,Van Dooren S

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SCN2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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