| Gene Symbol | selenoj |
| Entrez Gene ID | 572182 |
| Full Name | selenoprotein J |
| Synonyms | fb98a02,im:6797427,selj,si:dkey-74f15.2,wu:fb26a06,wu:fb98a02,wu:fc76f01 |
| General protein information |
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| Gene Type | protein-coding |
| Organism | Danio rerio(zebrafish) |
| Summary | The protein encoded by this gene belongs to a subfamily of selenoprotein J (SelJ) and J1-crystallins, within a superfamily of ADP-ribosylglycohydrolase. SelJ is unusual in that it has a highly restricted phylogenetic distribution; being found only in actinopterygian fishes and sea urchin, but not in other vertebrates, including mammals, birds and amphibians. SelJ is preferentially expressed in the eye lens in early embryogenesis, and shares significant similarity with jellyfish crystallins, which act to maintain transparency and proper light diffraction in the eye lens. The potential role for SelJ as a structural crystallin is unlike majority of selenoproteins, which are believed to have enzymatic function. Like all selenoproteins, SelJ contains the rare amino acid selenocysteine (Sec), which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017]. |
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