lypd6 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	lypd6
Entrez Gene ID	447932
Full Name	LY6/PLAUR domain containing 6
Synonyms	zgc:101899
General protein information	Preferred Names LY6/PLAUR domain containing 6 Names ly6/PLAUR domain-containing protein 6
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_021478643.1	XP_021334318.1	ly6/PLAUR domain-containing protein 6 isoform X1
NM_001004670.1	NP_001004670.1	ly6/PLAUR domain-containing protein 6 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LYPD6	XP_002685433.1
Canis lupus familiaris (dog)	LYPD6	XP_850653.1
Homo sapiens (human)	LYPD6	NP_001182614.1
Gallus gallus (chicken)	LYPD6	XP_001234906.1
Pan troglodytes (chimpanzee)	LYPD6	XP_001134811.1
	LYPD6	XP_002798923.1
Mus musculus (house mouse)	Lypd6	NP_796113.1
Rattus norvegicus (Norway rat)	Lypd6	XP_001053512.3
Danio rerio (zebrafish)	lypd6	NP_001004670.1
Xenopus tropicalis (tropical clawed frog)	lypd6	NP_001106503.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Identification of a Ly-6 superfamily gene expressed in lateral line neuromasts in zebrafish.
Ji D, Li L, Zhang S, Li H
Development genes and evolution225(1)47-53(2015 Jan)

Lypd6 enhances Wnt/?-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.
?zhan G, Sezgin E, Wehner D, Pfister AS, K?hl SJ, Kagermeier-Schenk B, K?hl M, Schwille P, Weidinger G
Developmental cell26(4)331-45(2013 Aug)

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Baraban SC, Dinday MT, Hortopan GA
Nature communications42410(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling.
Title: Lypd6 enhances Wnt/?-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.

The following lypd6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the lypd6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa00685	NM_001004670.1 Latest version!	Danio rerio LY6/PLAUR domain containing 6 (lypd6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
ODa143904	XM_021478643.1 Latest version!	Danio rerio LY6/PLAUR domain containing 6 (lypd6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

lypd6 ( NM_001004670.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001004670.1 Danio rerio LY6/PLAUR domain containing 6 (lypd6), mRNA.

Price & Availability↑

CloneID	ODa00685
Clone ID Related Accession (Same CDS sequence)	NM_001004670.1
Accession Version	NM_001004670.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Danio rerio(zebrafish)
Product	ly6/PLAUR domain-containing protein 6 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081426.1. ##Evidence-Data-START## Transcript exon combination :: BC081426.1, EH580181.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCCCT GGCCTCTCAT GGCCTGGGGT CTGATGCTGA CCGCCATTAC CGGCTGGATC 
AAAGCCGTTC AATCACGCGA CTTCACCGAA AAAGACATCA TTTTCCTCCA TCCTTCAACA 
ACTCCATATC CAGGAGGATT TAAATGTTTT ACCTGTGAAG ACGCACCTGA CAACTATGAA 
TGCAACCGCT GGGCTCCAGA TCTCTACTGT CCACGAGAAA GCAGATATTG CTATACGCAT 
CATAAGATGA GCTGGGATGG AAACACGGTG TCAGTGACGA AGCGTTGTGT GCCGCTGGAG 
GACTGTCTCC AAACAGGCTG CTCTGACATT GACCATGAAG GAAACAGGGT TTGTACTGCC 
TGTTGTGAGG GGAACATCTG TAACCTGCCT CTCCCACGAA ACGAAACTGA TGCCATCTTT 
TCCACCACAT CACCCATTAA CAGGAGCGCA CAATCCACAC AGACTCTCCC ACTGCTGCTG 
CTTTCCGTCT CCATCACCAG CCTGATGCTC CACAGTATTA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004670.1
CDS	200..724
Translation	MEPWPLMAWGLMLTAITGWIKAVQSRDFTEKDIIFLHPSTTPYPGGFKCFTCEDAPDNYECNRWAPDLYCPRESRYCYTHHKMSWDGNTVSVTKRCVPLEDCLQTGCSDIDHEGNRVCTACCEGNICNLPLPRNETDAIFSTTSPINRSAQSTQTLPLLLLSVSITSLMLHSIN

Target ORF information:

RefSeq Version	NM_001004670.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio LY6/PLAUR domain containing 6 (lypd6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004670.1

ORF Insert Sequence:

ATGGAGCCCT GGCCTCTCAT GGCCTGGGGT CTGATGCTGA CCGCCATTAC CGGCTGGATC 
AAAGCCGTTC AATCACGCGA CTTCACCGAA AAAGACATCA TTTTCCTCCA TCCTTCAACA 
ACTCCATATC CAGGAGGATT TAAATGTTTT ACCTGTGAAG ACGCACCTGA CAACTATGAA 
TGCAACCGCT GGGCTCCAGA TCTCTACTGT CCACGAGAAA GCAGATATTG CTATACGCAT 
CATAAGATGA GCTGGGATGG AAACACGGTG TCAGTGACGA AGCGTTGTGT GCCGCTGGAG 
GACTGTCTCC AAACAGGCTG CTCTGACATT GACCATGAAG GAAACAGGGT TTGTACTGCC 
TGTTGTGAGG GGAACATCTG TAACCTGCCT CTCCCACGAA ACGAAACTGA TGCCATCTTT 
TCCACCACAT CACCCATTAA CAGGAGCGCA CAATCCACAC AGACTCTCCC ACTGCTGCTG 
CTTTCCGTCT CCATCACCAG CCTGATGCTC CACAGTATTA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

lypd6 ( XM_021478643.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_021334318.1 Danio rerio LY6/PLAUR domain containing 6 (lypd6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa143904
Clone ID Related Accession (Same CDS sequence)	XM_021478643.1
Accession Version	XM_021478643.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-14
Organism	Danio rerio(zebrafish)
Product	ly6/PLAUR domain-containing protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007120.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCCT GGCCTCTCAT GGCCTGGGGT CTGATGCTGA CCGCCATTAC CGGCTGGATC 
AAAGCCGTTC AATCACGCGA CTTCACCGAA AAAGACATCA TTTTCCTCCA TCCTTCAACA 
ACTCCATATC CAGGAGGATT TAAATGTTTT ACCTGTGAAG ACGCACCTGA CAACTATGAA 
TGCAACCGCT GGGCTCCAGA TCTCTACTGT CCACGAGAAA GCAGATATTG CTATACGCAT 
CATAAGATGA GCTGGGATGG AAACACGGTG TCAGTGACGA AGCGTTGTGT GCCGCTGGAG 
GACTGTCTCC AAACAGGCTG CTCTGACATT GACCATGAAG GAAACAGGGT TTGTACAGCC 
TGTTGTGAGG GGAACATCTG TAACCTGCCT CTCCCACGAA ACGAAACTGA TGCCATCTTT 
TCCACCACAT CACCCATTAA CAGGAGCGCA CAATCCACAC AGACTCTCCC ACTGCTGCTG 
CTTTCCGTCT CCATCACCAG CCTGATGCTC CACAGTATTA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_021334318.1
CDS	66..590
Translation	MEPWPLMAWGLMLTAITGWIKAVQSRDFTEKDIIFLHPSTTPYPGGFKCFTCEDAPDNYECNRWAPDLYCPRESRYCYTHHKMSWDGNTVSVTKRCVPLEDCLQTGCSDIDHEGNRVCTACCEGNICNLPLPRNETDAIFSTTSPINRSAQSTQTLPLLLLSVSITSLMLHSIN

Target ORF information:

RefSeq Version	XM_021478643.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio LY6/PLAUR domain containing 6 (lypd6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_021478643.1

ORF Insert Sequence:

ATGGAGCCCT GGCCTCTCAT GGCCTGGGGT CTGATGCTGA CCGCCATTAC CGGCTGGATC 
AAAGCCGTTC AATCACGCGA CTTCACCGAA AAAGACATCA TTTTCCTCCA TCCTTCAACA 
ACTCCATATC CAGGAGGATT TAAATGTTTT ACCTGTGAAG ACGCACCTGA CAACTATGAA 
TGCAACCGCT GGGCTCCAGA TCTCTACTGT CCACGAGAAA GCAGATATTG CTATACGCAT 
CATAAGATGA GCTGGGATGG AAACACGGTG TCAGTGACGA AGCGTTGTGT GCCGCTGGAG 
GACTGTCTCC AAACAGGCTG CTCTGACATT GACCATGAAG GAAACAGGGT TTGTACAGCC 
TGTTGTGAGG GGAACATCTG TAACCTGCCT CTCCCACGAA ACGAAACTGA TGCCATCTTT 
TCCACCACAT CACCCATTAA CAGGAGCGCA CAATCCACAC AGACTCTCCC ACTGCTGCTG 
CTTTCCGTCT CCATCACCAG CCTGATGCTC CACAGTATTA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Identification of a Ly-6 superfamily gene expressed in lateral line neuromasts in zebrafish.
Development genes and evolution225(1)47-53(2015 Jan)
Ji D,Li L,Zhang S,Li H

Lypd6 enhances Wnt/?-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.
Developmental cell26(4)331-45(2013 Aug)
?zhan G,Sezgin E,Wehner D,Pfister AS,K?hl SJ,Kagermeier-Schenk B,K?hl M,Schwille P,Weidinger G

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Nature communications42410(2013)
Baraban SC,Dinday MT,Hortopan GA