COMMD1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	COMMD1
Entrez Gene ID	403590
Full Name	copper metabolism domain containing 1
Synonyms	MURR1
General protein information	Preferred Names copper metabolism domain containing 1 Names COMM domain-containing protein 1 copper metabolism (Murr1) domain containing 1 protein Murr1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)
Genome	Chromosome: 10 Map Location: 10q26

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003055.1	NP_001003055.1	COMM domain-containing protein 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Commd1	NP_001108494.1
Mus musculus (house mouse)	Commd1	NP_653097.2
Pan troglodytes (chimpanzee)	COMMD1	XP_515503.1
Canis lupus familiaris (dog)	COMMD1	NP_001003055.1
Bos taurus (cattle)	COMMD1	NP_001039849.1
Xenopus tropicalis (tropical clawed frog)	commd1	NP_001116193.1
Homo sapiens (human)	COMMD1	NP_689729.1
	LOC719657	XP_001114221.1
Gallus gallus (chicken)	COMMD1	XP_001231776.1
Danio rerio (zebrafish)	commd1	NP_001038730.1

Gene Ontology
Bibliography

Related articles in PubMed

Prevalence and Clinical Relevance of Exon 2 Deletion of COMMD1 in Bedlington Terriers in Korea.
Kim YG, Kim SY, Kim JH, Lee KK, Yun YM
Journal of veterinary internal medicine30(6)1846-1850(2016 Nov)

Copper toxicosis in non-COMMD1 Bedlington terriers is associated with metal transport gene ABCA12.
Haywood S, Boursnell M, Loughran MJ, Trafford J, Isherwood D, Liu X, Olohan L, Carter SD
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)3583-9(2016 May)

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, van der Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B, Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH, van de Sluis B
Nature communications710961(2016 Mar)

Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs.
Favier RP, Spee B, Fieten H, van den Ingh TS, Schotanus BA, Brinkhof B, Rothuizen J, Penning LC
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)29347-53(2015 Jan)

COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis.
Favier RP, Spee B, Schotanus BA, van den Ingh TS, Fieten H, Brinkhof B, Viebahn CS, Penning LC, Rothuizen J
PloS one7(8)e42158(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The study has identified a significant disease association with a region on chromosome 37 containing identified single nucleotide polymorphism which are highly significantly associated with non-COMMD1 (del/del) Bedlington terrier copper toxicosis. This region contains the ABCA12 gene which bears a close functional relationship to ATP-ase 7B responsible for Wilson's disease in man.
Title: Copper toxicosis in non-COMMD1 Bedlington terriers is associated with metal transport gene ABCA12.

Commd1 loss of function mutation results in hypercholesterolemia.
Title: CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.

copper metabolism and oxidative stress related gene products were examined in COMMD1-deficient dogs.
Title: Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs.

COMMD1-deficient dogs develop chronic liver disease and cirrhosis comparable to human chronic hepatitis, although at much higher pace.
Title: COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis.

Prevalence of the exon 2 deletion of the COMMD1 gene in Australian Bedlington terriers as a possible marker of inherited copper toxicosis.
Title: Prevalence of the exon 2 deletion of the COMMD1 gene in Australian Bedlington terriers.

The following COMMD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMMD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe33781	NM_001003055.1 Latest version!	Canis lupus familiaris copper metabolism domain containing 1 (COMMD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COMMD1 ( NM_001003055.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003055.1 Canis lupus familiaris copper metabolism domain containing 1 (COMMD1), mRNA.

Price & Availability↑

CloneID	OCe33781
Clone ID Related Accession (Same CDS sequence)	NM_001003055.1
Accession Version	NM_001003055.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Canis lupus familiaris(dog)
Product	COMM domain-containing protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY047597.1. ##Evidence-Data-START## Transcript exon combination :: AY047597.1, DN393906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCCG AGCTCGAGGG CTCCAAGGCG CTGGGCGGGC TGCTGAGCGG CCTGGCCCAG 
GAAGCTTTCC ACGGGCACCA CGGCATCACG GAGGAGCTGC TGCGGAGCCA GCTCTATCCG 
GAGGTGTCCC TCGAGGAGTT CCGCCCCTTT CTGGCGAAGA TGAGGGGCAT CCTTAAGTCG 
ATTGCATCTG CAGACATGGA TTTCAACCAG CTGGAGGCAT TCTTGACTGC TCAAACCAAA 
AAGCAAGGTG GGATCACATC TGACCAAGCT GCTGTCATTT CCAAATTTTG GAAGAACCAT 
AAGACAAAAA TTCGAGAGAG CCTCATGAAC CAGAGCCGTT GGGACAGTGG GCTTCGGGGC 
CTGAGTTGGA GAGTTGACGG CAAATCACAG TCAAGGCATT CAGCTCAAAT ACATACCCCT 
GTTGCCATAA TGGAGCTGGA AATAGGAAAA AGTGGACAGG AATCAGAATT TCTGTGTTTG 
GAATTTGATG AAGTCAAGGT CAGTCAACTC CTAAAGAAGC TCTCAGAGGT AGAAGAAAGT 
ATCAGCACAC TGATGCAGCC AGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003055.1
CDS	19..585
Translation	MAAELEGSKALGGLLSGLAQEAFHGHHGITEELLRSQLYPEVSLEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKNHKTKIRESLMNQSRWDSGLRGLSWRVDGKSQSRHSAQIHTPVAIMELEIGKSGQESEFLCLEFDEVKVSQLLKKLSEVEESISTLMQPA

Target ORF information:

RefSeq Version	NM_001003055.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris copper metabolism domain containing 1 (COMMD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003055.1

ORF Insert Sequence:

ATGGCGGCCG AGCTCGAGGG CTCCAAGGCG CTGGGCGGGC TGCTGAGCGG CCTGGCCCAG 
GAAGCTTTCC ACGGGCACCA CGGCATCACG GAGGAGCTGC TGCGGAGCCA GCTCTATCCG 
GAGGTGTCCC TCGAGGAGTT CCGCCCCTTT CTGGCGAAGA TGAGGGGCAT CCTTAAGTCG 
ATTGCATCTG CAGACATGGA TTTCAACCAG CTGGAGGCAT TCTTGACTGC TCAAACCAAA 
AAGCAAGGTG GGATCACATC TGACCAAGCT GCTGTCATTT CCAAATTTTG GAAGAACCAT 
AAGACAAAAA TTCGAGAGAG CCTCATGAAC CAGAGCCGTT GGGACAGTGG GCTTCGGGGC 
CTGAGTTGGA GAGTTGACGG CAAATCACAG TCAAGGCATT CAGCTCAAAT ACATACCCCT 
GTTGCCATAA TGGAGCTGGA AATAGGAAAA AGTGGACAGG AATCAGAATT TCTGTGTTTG 
GAATTTGATG AAGTCAAGGT CAGTCAACTC CTAAAGAAGC TCTCAGAGGT AGAAGAAAGT 
ATCAGCACAC TGATGCAGCC AGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prevalence and Clinical Relevance of Exon 2 Deletion of COMMD1 in Bedlington Terriers in Korea.
Journal of veterinary internal medicine30(6)1846-1850(2016 Nov)
Kim YG,Kim SY,Kim JH,Lee KK,Yun YM

Copper toxicosis in non-COMMD1 Bedlington terriers is associated with metal transport gene ABCA12.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)3583-9(2016 May)
Haywood S,Boursnell M,Loughran MJ,Trafford J,Isherwood D,Liu X,Olohan L,Carter SD

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Nature communications710961(2016 Mar)
Bartuzi P,Billadeau DD,Favier R,Rong S,Dekker D,Fedoseienko A,Fieten H,Wijers M,Levels JH,Huijkman N,Kloosterhuis N,van der Molen H,Brufau G,Groen AK,Elliott AM,Kuivenhoven JA,Plecko B,Grangl G,McGaughran J,Horton JD,Burstein E,Hofker MH,van de Sluis B

Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)29347-53(2015 Jan)
Favier RP,Spee B,Fieten H,van den Ingh TS,Schotanus BA,Brinkhof B,Rothuizen J,Penning LC

COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis.
PloS one7(8)e42158(2012)
Favier RP,Spee B,Schotanus BA,van den Ingh TS,Fieten H,Brinkhof B,Viebahn CS,Penning LC,Rothuizen J

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

COMMD1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報