Gene Symbol | air-1 |
Entrez Gene ID | 179202 |
Full Name | Aurora/Ipl1 Related kinase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » air-1 cDNA ORF clone
Gene Symbol | air-1 |
Entrez Gene ID | 179202 |
Full Name | Aurora/Ipl1 Related kinase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_072718.7 | NP_505119.1 | Aurora/Ipl1 Related kinase |
NM_072718.8 | NP_505119.1 | Protein kinase domain-containing protein |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Aurora A kinases and PP6 phosphatases have an ancient function in modulating spindle positioning, thus contributing to faithful cell division.
Title: Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells.
human p37/p47 and their C. elegans orthologue UBXN-2 regulate centrosome function in prophase by limiting the recruitment of Aurora A
Title: The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
AIR-1 has a kinase-dependent role at centrosomes and a kinase-independent role for stabilizing spindle microtubules and that coordination of these two roles is crucial for the assembly of mitotic spindles
Title: A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos.
mitotic centrosomes generate a diffusible factor, which we propose is activated Aurora A, that promotes nuclear envelope breakdown (NEBD). A positive feedback loop, size may temporally couple centrosome maturation to NEBD during mitotic entry.
Title: A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown.
Centrosomes serve to focus the Aurora A kinase AIR-1, which is essential for timely mitotic entry.Our findings support a model in which centrosomes serve as integrative centers for mitotic regulators and thus trigger mitotic entry in a timely fashion.
Title: Centrosomes promote timely mitotic entry in C. elegans embryos.
The following air-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the air-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa347042 | |
Clone ID Related Accession (Same CDS sequence) | NM_072718.7 , NM_072718.8 | |
Accession Version | NM_072718.7 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Aurora/Ipl1 Related kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Jun 26, 2012 this sequence version replaced NM_072718.6. COMPLETENESS: incomplete on both ends. |
1 | ATGAGCGGAA AGGAAAATAC TGCTCCTGTG ATAGACGATC AGAAGGCCGA GGTTATTTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_505119.1 |
CDS | 1..981 |
Translation |
Target ORF information:
Target ORF information:
|
NM_072718.7 |
1 | ATGAGCGGAA AGGAAAATAC TGCTCCTGTG ATAGACGATC AGAAGGCCGA GGTTATTTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa347042 | |
Clone ID Related Accession (Same CDS sequence) | NM_072718.7 , NM_072718.8 | |
Accession Version | NM_072718.8 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Protein kinase domain-containing protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_072718.7. |
1 | ATGAGCGGAA AGGAAAATAC TGCTCCTGTG ATAGACGATC AGAAGGCCGA GGTTATTTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_505119.1 |
CDS | 14..994 |
Translation |
Target ORF information:
Target ORF information:
|
NM_072718.8 |
1 | ATGAGCGGAA AGGAAAATAC TGCTCCTGTG ATAGACGATC AGAAGGCCGA GGTTATTTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |