Gene Symbol | cyk-4 |
Entrez Gene ID | 176815 |
Full Name | CYtoKinesis defect |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » cyk-4 cDNA ORF clone
Gene Symbol | cyk-4 |
Entrez Gene ID | 176815 |
Full Name | CYtoKinesis defect |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_067444.6 | NP_499845.1 | CYtoKinesis defect |
NM_067444.7 | NP_499845.1 | CYtoKinesis defect |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Thus, counterintuitively, CYK-4 RhoGAP activity promotes RhoA activation.
Title: The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis.
SPD-1-CYK-4 interaction through the CYK-4 C-terminal tail plays an important role in maintaining the mechanical integrity of the central spindle under tension
Title: Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle.
The membrane-binding C1 domain of CYK-4, a centralspindlin component, promotes furrow initiation in C. elegans embryos and human cells.
Title: Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane.
CYK-4 binding decreases the rate of ZEN-4-mediated microtubule gliding. These results constrain models for the molecular organization of centralspindlin.
Title: Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit.
CYK-4 subunit functions to recruit actin regulators and the scaffold anillin as well as to regulate RhoA and Rac via its intrinsic GAP domain, ultimately promoting actomyosin contractile ring assembly.
Title: A postmitotic function and distinct localization mechanism for centralspindlin at a stable intercellular bridge.
The following cyk-4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cyk-4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa340317 | |
Clone ID Related Accession (Same CDS sequence) | NM_067444.6 , NM_067444.7 | |
Accession Version | NM_067444.6 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2046bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | CYtoKinesis defect | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_067444.5. COMPLETENESS: incomplete on both ends. |
1 | ATGAAGTCCA GTACATCAAA AGAGAAGGTG TGCGGCGAAA ACTCGCGTCA CATTTTCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_499845.1 |
CDS | 1..2046 |
Translation |
Target ORF information:
Target ORF information:
|
NM_067444.6 |
1 | ATGAAGTCCA GTACATCAAA AGAGAAGGTG TGCGGCGAAA ACTCGCGTCA CATTTTCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa340317 | |
Clone ID Related Accession (Same CDS sequence) | NM_067444.6 , NM_067444.7 | |
Accession Version | NM_067444.7 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2046bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | CYtoKinesis defect | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_067444.6. |
1 | ATGAAGTCCA GTACATCAAA AGAGAAGGTG TGCGGCGAAA ACTCGCGTCA CATTTTCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_499845.1 |
CDS | 2..2047 |
Translation |
Target ORF information:
Target ORF information:
|
NM_067444.7 |
1 | ATGAAGTCCA GTACATCAAA AGAGAAGGTG TGCGGCGAAA ACTCGCGTCA CATTTTCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |